Discovery of potent and selective rhodanine type IKKβ inhibitors by hit-to-lead strategy

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 17, 2012, Pages 5668-5674

  Song, Hyeseung ^c   Lee, Yun Suk ^c   Roh, Eun Joo ^b   Seo, Jae Hong ^a   Oh, Kwang Seok ^d   Lee, Byung Ho ^d   Han, Hogyu ^c   Shin, Kye Jung ^a  

^a The Catholic University of Korea   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

^c Korea University   (South Korea)

^d Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Hit to lead; IKK inhibitor; NF B; Reumatoid athritis; TNF

Indexed keywords

I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 11; MITOGEN ACTIVATED PROTEIN KINASE 12; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE P38; RHODANINE; STRESS ACTIVATED PROTEIN KINASE 1; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CHEMICAL STRUCTURE; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME INHIBITION; MOUSE; NONHUMAN;

ARTHRITIS, RHEUMATOID; DRUG DISCOVERY; HUMANS; I-KAPPA B KINASE; NF-KAPPA B; RHODANINE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84865133795     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.06.088     Document Type: Article

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