5-HT2 receptor distribution shown by [18F] setoperone PET in high-functioning autistic adults

Journal of Neuropsychiatry and Clinical Neurosciences

Volumn 24, Issue 2, 2012, Pages 191-197

  Beversdorf, David Q ^a   Nordgren, Richard E ^b   Bonab, Ali A ^c   Fischman, Alan J ^c   Weise, Steven B ^c   Dougherty, Darin D ^c   Felopulos, Gretchen J ^c   Zhou, Feng C ^d   Bauman, Margaret L ^c  

^a UNIVERSITY OF MISSOURI   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORINE 18; SEROTONIN 2 RECEPTOR; SETOPERONE; DIAGNOSTIC AGENT; FLUORINE; PYRIMIDINONE DERIVATIVE; RADIOPHARMACEUTICAL AGENT;

ADULT; AGE DISTRIBUTION; ARTICLE; AUTISM; BINDING AFFINITY; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; IMAGE ANALYSIS; IN VIVO STUDY; LANGUAGE DISABILITY; MALE; PILOT STUDY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; THALAMUS; BRAIN; CASE CONTROL STUDY; FUNCTIONAL NEUROIMAGING; METABOLISM; METHODOLOGY; PSYCHOLOGICAL ASPECT; RADIOASSAY; SCINTISCANNING;

ADULT; AUTISTIC DISORDER; BRAIN; CASE-CONTROL STUDIES; FEMALE; FLUORINE RADIOISOTOPES; FUNCTIONAL NEUROIMAGING; HUMANS; LANGUAGE DISORDERS; MALE; PILOT PROJECTS; POSITRON-EMISSION TOMOGRAPHY; PYRIMIDINONES; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; RECEPTORS, SEROTONIN, 5-HT2; THALAMUS;

EID: 84865129695     PISSN: 08950172     EISSN: 15457222     Source Type: Journal    
DOI: 10.1176/appi.neuropsych.11080202     Document Type: Article

References (35)

1. American Psychiatric Association: Committee on Nomenclature and Statistics: Diagnostic and Statistical Manual of Mental Disorders, 4th Edition. Washington, DC, American Psychiatric Association, 1995
2. Kanner L: Autistic disturbances of affective contact. Nervous Child 1943; 2:217-250
3. Beversdorf DQ, Anderson JM, Manning SE, et al: The effect of semantic and emotional context on written recall for verbal language in high-functioning adults with autism spectrum disorder. J Neurol Neurosurg Psychiatry 1998; 65:685-692
4. Schain RJ, Freedman DX: Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children. J Pediatr 1961; 58:315-320
5. Anderson GM, Horne WC, Chatterjee D, et al: The hyper-serotonemia of autism. Ann N Y Acad Sci 1990; 600:331-340, discussion 341-342
6. Cook EH: Autism: review of neurochemical investigation. Synapse 1990; 6:292-308
7. McBride PA, Anderson GM, Mann JJ: Serotonin in autism, in Progress in Psychiatry, Vol. 21: Serotonin in Major Psychiatric Disorders. Edited by Coccaro EF, Murphy, DL. Washington, DC, American Psychiatric Press, 1990, pp 49-68
8. Gillberg C, Svennerholm L, Hamilton-Hellberg C: Childhood psychosis and monoamine metabolites in spinal fluid. J Autism Dev Disord 1983; 13:383-396
9. McBride PA, Anderson GM, Hertzig ME, et al: Serotonergic responsivity in male young adults with autistic disorder: results of a pilot study. Arch Gen Psychiatry 1989; 46:213-221
10. Sodhi MSK, Sanders-Bush E: Serotonin and brain development. Int Rev Neurobiol 2004; 59:111-174
11. Chugani DC, Muzik O, Behen M, et al: Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children. Ann Neurol 1999; 45:287-295
12. Makkonen I, Riikonen R, Kokki H, et al: Serotonin and dopamine transporter binding in children with autism determined by SPECT. Dev Med Child Neurol 2008; 50: 593-597
13. Murphy DGM, Daly E, Schmitz N, et al: Cortical serotonin 5-HT2A receptor binding and social communication in adults with Asperger's syndrome: an in-vivo SPECT study. Am J Psychiatry 2006; 163:934-936
14. Goldberg J, Anderson GM, Zwaigenbaum L, et al: Cortical serotonin type-2 receptor density in parents of children with autism spectrum disorders. J Autism Dev Disord 2009; 39:97-104
15. Whiteside SP, Port JD, Abramowitz JS: A meta-analysis of functional neuroimaging in obsessive-compulsive disorder. Psychiatry Res 2004; 132:69-79
16. Bauman ML: Microscopic neuroanatomic abnormalities in autism. Pediatrics 1991; 87(suppl):791-796
17. Gordon JA, Hen R: The serotonergic system and anxiety. Neuromolecular Med 2004; 5:27-40
18. Gross C, Hen R: The developmental origins of anxiety. Nat Rev Neurosci 2004; 5:545-552
19. Blier P, de Montigny C: Serotonin and drug-induceed therapeutic responses in major depression, obsessive-compulsive, and panic disorder. Neuropsychopharmacology 1999; 21: 91S-98S
20. Lesch K-P: Molecular foundation of anxiety disorders. J Neural Transm 2001; 108:717-746
21. Maron E, Kuikka JT, Shlik J, et al: Reduced brain serotonin transporter binding in patients with panic disorder. Psychiatry Res 2004; 132:173-181
22. Crouzel C, Guillaume M, Barré L, et al: Ligands and tracers for PET studies of the 5-HT system: current status. Int J Rad Appl Instrum B 1992; 19:857-870
23. Lord C, Rutter M, Le Couteur A: Autism Diagnostic Interview- Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 1994; 24:659-685
24. Mischoulon D, Dougherty DD, Bottonari KA, et al: An open pilot study of nefazodone in depression with anger attacks: relationship between clinical response and receptor binding. Psychiatry Res 2002; 116:151-161
25. Bonab AA, Fischman AJ, Alpert NM: Estimation of binding potential for the 5-HT2 receptor ligand [18F] setoperone by a noninvasive reference region graphical method, in Quantitative Functional Brain Imaging with Positron Emission Tomography. Edited by Carson RE, Daube-Witherspoon ME, Herscovitch P.San Diego, CA, Academic Press, 1998,pp421-425.
26. Fischman AJ, Bonab AA, Babich JW, et al: Positron emission tomographic analysis of central 5HT2 receptor occupancy in normal humans treated with the atypical neuroleptic, ziprasidone. J Pharmacol Exp Ther 1996; 279:939-947
27. Bigham MH, Lidow MS: Adrenergic and serotonergic receptors in aged monkey neocortex. Neurobiol Aging 1995; 16: 91-104
28. Wang G-J, Volkow ND, Logan J, et al: Evaluation of age-related changed in serotonin 5-HT2 and dopamine D2 receptor availability in human subjects. Life Sci 1995; 56:249-253
29. Pirker W, Asenbaum S, Hauk M, et al: Imaging serotonin and dopamine transporters with 123I-beta-CIT SPECT: binding kinetics and effects of normal aging. J Nucl Med 2000; 41:36-44
30. Veenstra-VanderWeele J, Kim SJ, Lord C, et al: Transmission disequilibrium studies of the serotonin 5-HT2A receptor gene (HTR2A) in autism. Am J Med Genet 2002; 114:277-283
31. Choi IH, Yoo HJ, Park M, et al: Family-based association study of 5-HTTLPR and the 5-HT2A receptor gene polymorphisms with autism spectrum disorder in Korean trios. Brain Res 2008; 1139:34-41
32. Sutcliffe JS, Delahanty RJ, Prasad HC, et al: Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors. Am J Hum Genet 2005; 77:265-279
33. Crosson B: Subcortical mechanisms in language: lexical-semantic mechanisms and the thalamus. Brain Cogn 1999; 40: 414-438
34. Connors SL, Matteson KJ, Sega GA, et al: Plasma serotonin in autism. Pediatr Neurol 2006; 35:182-186
35. Blatt GJ, Fitzgerald CM, Guptill JT, et al: Density and distribution of hippocampal receptors in autism: an autora-diographic study. J Autism Dev Disord 2001; 31:537-543