Effect of the disease-causing R266K mutation on the heme and PLP environments of human cystathionine β-synthase

Biochemistry

Volumn 51, Issue 32, 2012, Pages 6360-6370

  Smith, Aaron T ^a   Su, Yang ^a   Stevens, Daniel J ^a   Majtan, Tomas ^b,c   Kraus, Jan P ^b   Burstyn, Judith N ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b Children's Hospital Colorado   (United States)

^c INSTITUTE OF CHEMISTRY   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; COFACTORS; FLUORESCENCE SPECTRA; GEOMETRIC DISTORTION; HEME COMPLEXES; HOMOCYSTEINES; SPECTROSCOPIC PROPERTY; SYNTHASES; THIOLATES;

AMINO ACIDS; ELECTRIC CIRCUIT BREAKERS; HYDROGEN; IRON COMPOUNDS; SYNTHESIS (CHEMICAL);

PORPHYRINS;

CYSTATHIONINE BETA SYNTHASE; HEME; PYRIDOXAL 5 PHOSPHATE;

AMINO ACID SYNTHESIS; ARTICLE; ENZYME ANALYSIS; ENZYME ISOLATION; ENZYME PURIFICATION; ENZYME STRUCTURE; HUMAN; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; SPECTROSCOPY; STRUCTURE ANALYSIS;

CATALYTIC DOMAIN; CIRCULAR DICHROISM; CYSTATHIONINE BETA-SYNTHASE; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME STABILITY; FERROUS COMPOUNDS; HEME; HOMOCYSTINURIA; HUMANS; MODELS, MOLECULAR; MUTATION; OXIDATION-REDUCTION; PROTEIN BINDING; PYRIDOXAL PHOSPHATE; SPECTROMETRY, FLUORESCENCE; SPECTRUM ANALYSIS, RAMAN; TEMPERATURE;

EID: 84865121607     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300421z     Document Type: Article

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