Brain death induced by cerebral haemorrhage A new porcine model evaluated by CT angiography

Acta Anaesthesiologica Scandinavica

Volumn 56, Issue 8, 2012, Pages 995-1005

  Hvas, C L ^a   Nielsen, T K ^a   Barklin, A ^a   Sorensen J C H ^a   Pedersen, M ^a   Andersen, G ^a   Tonnesen E ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; IODIXANOL; IOMEPROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CIRCULATION; BRAIN DEATH; BRAIN HEMORRHAGE; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CONTROLLED STUDY; CORNEA REFLEX; EXPERIMENTAL PIG; FEMALE; FLUID THERAPY; HEART RATE; HEMODYNAMICS; INTRACRANIAL PRESSURE; MEAN ARTERIAL PRESSURE; METABOLIC PARAMETERS; MULTIDETECTOR COMPUTED TOMOGRAPHY; NONHUMAN; PRIORITY JOURNAL; PUPIL REFLEX;

ANIMALS; ARTERIAL PRESSURE; ATROPINE; BLOOD GAS ANALYSIS; BRAIN DEATH; CARDIAC OUTPUT; CEREBRAL ANGIOGRAPHY; CEREBRAL HEMORRHAGE; DISEASE MODELS, ANIMAL; FEMALE; HEMODYNAMICS; HORMONES; INTRACRANIAL PRESSURE; LACTIC ACID; MUSCARINIC ANTAGONISTS; OXYGEN CONSUMPTION; REFLEX; RESUSCITATION; SWINE; TOMOGRAPHY, X-RAY COMPUTED; WATER-ELECTROLYTE BALANCE;

EID: 84865117713     PISSN: 00015172     EISSN: 13996576     Source Type: Journal    
DOI: 10.1111/j.1399-6576.2012.02682.x     Document Type: Article

References (40)

1. Pratschke J, Wilhelm MJ, Kusaka M, Basker M, Cooper DK, Hancock WW, Tilney NL,. Brain death and its influence on donor organ quality and outcome after transplantation. Transplantation 1999; 67: 343-348. (Pubitemid 29094001)
2. Barklin A,. Systemic inflammation in the brain-dead organ donor. Acta Anaesthesiol Scand 2009; 53: 425-435.
3. Barklin A, Larsson A, Vestergaard C, Kjaergaard A, Wogensen L, Schmitz O, Tonnesen E,. Insulin alters cytokine content in two pivotal organs after brain death: a porcine model. Acta Anaesthesiol Scand 2008; 52: 628-634. (Pubitemid 351549566)
4. Barklin A, Tonnesen E, Ingerslev J, Sorensen B, Fenger-Eriksen C,. Coagulopathy during induced severe intracranial hypertension in a porcine donor model. Anesthesiology 2009; 110: 1287-1292.
5. Pratschke J, Neuhaus P, Tullius SG,. What can be learned from brain-death models? Transpl Int 2005; 18: 15-21. (Pubitemid 41742940)
6. Birkeland SA, Bjerre P, Rohr N, Larsen KE, Jorgensen K,. Organ donation: number of brain deaths, refusal rate, actual donation, and multiorgan transplantation 1990-1994 in a Danish population of 1 million compared to the whole of Denmark. Transplant Proc 1995; 27: 3521-3524.
7. Hua Y, Wu J, Keep RF, Nakamura T, Hoff JT, Xi G,. Tumor necrosis factor-alpha increases in the brain after intracerebral hemorrhage and thrombin stimulation. Neurosurgery 2006; 58: 542-550; discussion 42-50.
8. Xi G, Keep RF, Hoff JT,. Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol 2006; 5: 53-63. (Pubitemid 41790696)
9. Barklin A, Larsson A, Vestergaard C, Koefoed-Nielsen J, Bach A, Nyboe R, Wogensen L, Tonnesen E,. Does brain death induce a pro-inflammatory response at the organ level in a porcine model? Acta Anaesthesiol Scand 2008; 52: 621-627. (Pubitemid 351549567)
10. Bittner HB, Kendall SW, Campbell KA, Montine TJ, Van Trigt P,. A valid experimental brain death organ donor model. J Heart Lung Transplant 1995; 14: 308-317.
11. Chiari P, Hadour G, Michel P, Piriou V, Rodriguez C, Budat C, Ovize M, Jegaden O, Lehot JJ, Ferrera R,. Biphasic response after brain death induction: prominent part of catecholamines release in this phenomenon. J Heart Lung Transplant 2000; 19: 675-682. (Pubitemid 30621680)
12. Purins K, Sedigh A, Molnar C, Jansson L, Korsgren O, Lorant T, Tufveson G, Wennberg L, Wiklund L, Lewen A, Enblad P,. Standardized experimental brain death model for studies of intracranial dynamics, organ preservation, and organ transplantation in the pig. Crit Care Med 2011; 39: 512-517.
13. Latronico N,. Brain death models: solutions in search for problems. Crit Care Med 2011; 39: 595-596.
14. Frampas E, Videcoq M, de, Kerviler E, Ricolfi F, Kuoch V, Mourey F, Tenaillon A, Dupas B,. CT angiography for brain death diagnosis. AJNR Am J Neuroradiol 2009; 30: 1566-1570.
15. Escudero D, Otero J, Marques L, Parra D, Gonzalo JA, Albaiceta GM, Cofino L, Blanco A, Vega P, Murias E, Meilan A, Roger RL, Taboada F,. Diagnosing brain death by CT perfusion and multislice CT angiography. Neurocrit Care 2009; 11: 261-271.
16. Clark JD, Gebhart GF, Gonder JC, Keeling ME, Kohn DF,. Special report: the 1996 guide for the care and use of laboratory animals. ILAR J 1997; 38: 41-48.
17. Johansson J, Gedeborg R, Basu S, Rubertsson S,. Increased cortical cerebral blood flow by continuous infusion of adrenaline (epinephrine) during experimental cardiopulmonary resuscitation. Resuscitation 2003; 57: 299-307. (Pubitemid 36694637)
18. Bjarkam CR, Cancian G, Larsen M, Rosendahl F, Ettrup KS, Zeidler D, Blankholm AD, Ostergaard L, Sunde N, Sorensen JC,. A MRI-compatible stereotaxic localizer box enables high-precision stereotaxic procedures in pigs. J Neurosci Methods 2004; 139: 293-298. (Pubitemid 39377737)
19. Carstensen E, Yudkin JS,. Platelet catecholamine concentrations after short-term stress in normal subjects. Clin Sci (Lond) 1994; 86: 35-41. (Pubitemid 24034705)
20. Lustenberger T, Talving P, Kobayashi L, Inaba K, Lam L, Plurad D, Demetriades D,. Time course of coagulopathy in isolated severe traumatic brain injury. Injury 2010; 41: 924-928.
21. Dominguez-Roldan JM, Barrera-Chacon JM, Martin-Bermudez R, Murillo-Cabezas F, Garcia-Alfaro C, Rincon-Ferrari MD,. Changes in the intracranial pulse pressure waveform associated with brain death. Transplant Proc 1999; 31: 2597-2598. (Pubitemid 29434067)
22. Combes JC, Chomel A, Ricolfi F, d'Athis P, Freysz M,. Reliability of computed tomographic angiography in the diagnosis of brain death. Transplant Proc 2007; 39: 16-20. (Pubitemid 46175963)
23. Leclerc X, Taschner CA, Vidal A, Strecker G, Savage J, Gauvrit JY, Pruvo JP,. The role of spiral CT for the assessment of the intracranial circulation in suspected brain-death. J Neuroradiol 2006; 33: 90-95.
24. Burbridge B, Matte G, Remedios A,. Complex intracranial arterial anatomy in swine is unsuitable for cerebral infarction projects. Can Assoc Radiol J 2004; 55: 326-329. (Pubitemid 40188181)
25. Mori S, Obata T, Nakajima N, Ichihara N, Endo M,. Volumetric perfusion CT using prototype 256-detector row CT scanner: preliminary study with healthy porcine model. AJNR Am J Neuroradiol 2005; 26: 2536-2541.
26. Huttemann E, Schelenz C, Sakka SG, Reinhart K,. Atropine test and circulatory arrest in the fossa posterior assessed by transcranial Doppler. Intensive Care Med 2000; 26: 422-425. (Pubitemid 30301523)
27. Pratschke J, Wilhelm MJ, Kusaka M, Laskowski I, Tilney NL,. A model of gradual onset brain death for transplant-associated studies in rats. Transplantation 2000; 69: 427-430. (Pubitemid 30118126)
28. Lyons JM, Pearl JM, McLean KM, Akhter SA, Wagner CJ, Pandalai PK, Duffy JY,. Glucocorticoid administration reduces cardiac dysfunction after brain death in pigs. J Heart Lung Transplant 2005; 24: 2249-2254. (Pubitemid 41814753)
29. Guerit JM,. Electroencephalography: the worst traditionally recommended tool for brain death confirmation. Intensive Care Med 2007; 33: 9-10.
30. Nau R, Prange HW, Klingelhofer J, Kukowski B, Sander D, Tchorsch R, Rittmeyer K,. Results of four technical investigations in fifty clinically brain dead patients. Intensive Care Med 1992; 18: 82-88.
31. Grigg MM, Kelly MA, Celesia GG, Ghobrial MW, Ross ER,. Electroencephalographic activity after brain death. Arch Neurol 1987; 44: 948-954. (Pubitemid 17133694)
32. Sato T, Asanuma Y, Yasui O, Kurokawa T, Shibata S, Koyama K,. Impaired hepatic mitochondrial function reserve in brain-dead pigs. Transplant Proc 1998; 30: 4351-4355. (Pubitemid 29013244)
33. Meyers CH, D'Amico TA, Peterseim DS, Jayawant AM, Steenbergen C, Sabiston DC, Jr, Van Trigt P,. Effects of triiodothyronine and vasopressin on cardiac function and myocardial blood flow after brain death. J Heart Lung Transplant 1993; 12: 68-79; discussion 79-80.
34. Shivalkar B, Van Loon J, Wieland W, Tjandra-Maga TB, Borgers M, Plets C, Flameng W,. Variable effects of explosive or gradual increase of intracranial pressure on myocardial structure and function. Circulation 1993; 87: 230-239. (Pubitemid 23019354)
35. Belzberg H, Shoemaker WC, Wo CC, Nicholls TP, Dang AB, Zelman V, Gruen JP, Berne TV, Demetriades D,. Hemodynamic and oxygen transport patterns after head trauma and brain death: implications for management of the organ donor. J Trauma 2007; 63: 1032-1042. (Pubitemid 350098523)
36. Perez Lopez S, Otero Hernandez J, Vazquez Moreno N, Escudero Augusto D, Alvarez Menendez F, Astudillo Gonzalez A,. Brain death effects on catecholamine levels and subsequent cardiac damage assessed in organ donors. J Heart Lung Transplant 2009; 28: 815-820.
37. Dominguez-Roldan JM, Jimenez-Gonzalez PI, Garcia-Alfaro C, Hernandez-Hazanas F, Fernandez-Hinojosa E, Bellido-Sanchez R,. Electrolytic disorders, hyperosmolar states, and lactic acidosis in brain-dead patients. Transplant Proc 2005; 37: 1987-1989. (Pubitemid 40956353)
38. Kolkert JL, t Hart NA, van, Dijk A, Ottens PJ, Ploeg RJ, Leuvenink HG,. The gradual onset brain death model: a relevant model to study organ donation and its consequences on the outcome after transplantation. Lab Anim 2007; 41: 363-371. (Pubitemid 47195608)
39. Baldwin AS, Jr,. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 1996; 14: 649-683. (Pubitemid 26130197)
40. Barklin A, Theodorsson E, Tyvold SS, Larsson A, Granfeldt A, Sloth E, Tonnesen E,. Alteration of neuropeptides in the lung tissue correlates brain death-induced neurogenic edema. J Heart Lung Transplant 2009; 28: 725-732.