Insulin alters cytokine content in two pivotal organs after brain death: A porcine model

Acta Anaesthesiologica Scandinavica

Volumn 52, Issue 5, 2008, Pages 628-634

  Barklin, A ^a,b   Larsson, A ^b,c   Vestergaard, C ^a,b   Kjaergaard, A ^a   Wogensen, L ^a,b   Schmitz, O ^a,b   Tonnesen E ^a,b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c AALBORG UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Brain death; Catecholamines; Cytokines; Experimental animal model; Heart; Hyperinsulinemia; Inflammation; Insulin; Kidney; Liver; Organ

Indexed keywords

CATECHOLAMINE; CYTOKINE; FATTY ACID; GLUCAGON; GLUCOSE; INSULIN; INTERLEUKIN 10; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; BRAIN DEATH; CATECHOLAMINE BLOOD LEVEL; CYTOKINE PRODUCTION; FATTY ACID BLOOD LEVEL; FEMALE; GLUCAGON BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HEART GRAFT; HEART MUSCLE BIOPSY; HEART RIGHT VENTRICLE; HYPERGLYCEMIA; INSULIN INFUSION; INSULIN TREATMENT; KIDNEY BIOPSY; KIDNEY CORTEX; KIDNEY GRAFT; KIDNEY MEDULLA; LIVER BIOPSY; LIVER GRAFT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; SWINE;

ANIMALS; BLOOD GLUCOSE; BRAIN DEATH; CATECHOLAMINES; CLINICAL PROTOCOLS; CYTOKINES; DISEASE MODELS, ANIMAL; FATTY ACIDS, NONESTERIFIED; GLUCAGON; INSULIN; KIDNEY; LIVER; MYOCARDIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SWINE;

EID: 42249104700     PISSN: 00015172     EISSN: 13996576     Source Type: Journal    
DOI: 10.1111/j.1399-6576.2008.01606.x     Document Type: Article

References (22)

1. Sheehy E, Conrad SL, Brigham LE et al. Estimating the number of potential organ donors in the United States. N Engl J Med 2003 349 (7) : 667 74.
2. Rosendale JD, Chabalewski FL, McBride MA et al. Increased transplanted organs from the use of a standardized donor management protocol. Am J Transplant 2002 2 (8) : 761 8.
3. Nijboer WN, Schuurs TA, van der Hoeven JA et al. Effect of brain death on gene expression and tissue activation in human donor kidneys. Transplantation 2004 78 (7) : 978 86.
4. Birks EJ, Owen VJ, Burton PB et al. Tumor necrosis factor-alpha is expressed in donor heart and predicts right ventricular failure after human heart transplantation. Circulation 2000 102 (3) : 326 31.
5. Hansen TK, Thiel S, Wouters PJ et al. Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannose-binding lectin levels. J Clin Endocrinol Metab 2003 88 (3) : 1082 8.
6. Brix-Christensen V, Gjedsted J, Andersen SK et al. Inflammatory response during hyperglycemia and hyperinsulinemia in a porcine endotoxemic model: the contribution of essential organs. Acta Anaesthesiol Scand 2005 49 (7) : 991 8.
7. Koskenkari JK, Kaukoranta PK, Rimpilainen J et al. Anti-inflammatory effect of high-dose insulin treatment after urgent coronary revascularization surgery. Acta Anaesthesiol Scand 2006 50 (8) : 962 9.
8. Van den BG, Wouters P, Weekers F et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001 345 (19) : 1359 67.
9. Van den BG, Wilmer A, Hermans G et al. Intensive insulin therapy in the medical ICU. N Engl J Med 2006 354 (5) : 449 61.
10. Van den BG, Schoonheydt K, Becx P et al. Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology 2005 64 (8) : 1348 53.
11. Barklin A, Larsson A, Vestergaard C et al. Does brain death induce a pro-inflammatory response at the organ level in a porcine model? Acta Anaesthesiol Scand 2008 52 : 621 7.
12. Brix-Christensen V, Andersen SK, Andersen R et al. Acute hyperinsulinemia restrains endotoxin-induced systemic inflammatory response: an experimental study in a porcine model. Anesthesiology 2004 100 (4) : 861 70.
13. Carstensen E, Yudkin JS. Platelet catecholamine concentrations after short-term stress in normal subjects. Clin Sci (London) 1994 86 (1) : 35 41.
14. Eriksson BM, Persson BA. Determination of catecholamines in rat heart tissue and plasma samples by liquid chromatography with electrochemical detection. J Chromatogr 1982 228 : 143 54.
15. McCormack G, Moriarty D, O'Donoghue DP et al. Tissue cytokine and chemokine expression in inflammatory bowel disease. Inflamm Res 2001 50 (10) : 491 5.
16. Brix-Christensen V, Vestergaard C, Chew M et al. Plasma cytokines do not reflect expression of pro- and anti-inflammatory cytokine mRNA at organ level after cardiopulmonary bypass in neonatal pigs. Acta Anaesthesiol Scand 2003 47 (5) : 525 31.
17. Brix-Christensen V, Vestergaard C, Andersen SK et al. Evidence that acute hyperinsulinaemia increases the cytokine content in essential organs after an endotoxin challenge in a porcine model. Acta Anaesthesiol Scand 2005 49 (10) : 1429 35.
18. Pathan N, Hemingway CA, Alizadeh AA et al. Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock. Lancet 2004 363 (9404) : 203 9.
19. Aljada A, Ghanim H, Saadeh R et al. Insulin inhibits NFkappaB and MCP-1 expression in human aortic endothelial cells. J Clin Endocrinol Metab 2001 86 (1) : 450 3.
20. Dandona P, Aljada A, Mohanty P et al. Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? J Clin Endocrinol Metab 2001 86 (7) : 3257 65.
21. Christman JW, Lancaster LH, Blackwell TS. Nuclear factor kappa B: a pivotal role in the systemic inflammatory response syndrome and new target for therapy. Intensive Care Med 1998 24 (11) : 1131 8.
22. Dandona P, Chaudhuri A, Ghanim H et al. Proinflammatory effects of glucose and anti-inflammatory effect of insulin: relevance to cardiovascular disease. Am J Cardiol 2007 99 (4A) : 15B 26B.