Anticonvulsive effect of Paeoniflorin on experimental febrile seizures in immature rats: Possible application for febrile seizures in children

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Hino, Hitomi ^a   Takahashi, Hisaaki ^a,b   Suzuki, Yuka ^a   Tanaka, Junya ^a,b   Ishii, Eiichi ^a   Fukuda, Mitsumasa ^a,b  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b EHIME UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; AMPA RECEPTOR; ANTICONVULSIVE AGENT; CALCIUM ION; GLUTAMIC ACID; KEISHIKASHAKUYAKU TO; METABOTROPIC RECEPTOR 5; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PAEONIFOLORIN; UNCLASSIFIED DRUG;

4 AMINOBUTYRIC ACID BRAIN LEVEL; 4 AMINOBUTYRIC ACID RELEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN NERVE CELL; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; EMBRYO; FEBRILE CONVULSION; HIPPOCAMPUS; MALE; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; RAT;

ANIMALS; ANTICONVULSANTS; BENZOATES; BRIDGED COMPOUNDS; CALCIUM; CELLS, CULTURED; CHILD; GAMMA-AMINOBUTYRIC ACID; GLUCOSIDES; GLUTAMIC ACID; HIPPOCAMPUS; HUMANS; MALE; NEURONS; RATS; SEIZURES, FEBRILE;

EID: 84865089244     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042920     Document Type: Article

References (44)

1. Hauser WA, (1994) The prevalence and incidence of convulsive disorders in children. Epilepsia 35: S1-S6.
2. Camfield C, Camfield P (2005) Febrile seizures. In: Roger J, Bureau M, Dravet C, Genton P, Tassinari CA, Wolf P, editors. Epileptic syndrome in infancy, childhood and adolescence 4th edition: Montrouge: John Libbey Eurotext. pp. 159-169.
3. Cendes F, Kahane P, Brodie M, Andermann F (2005) The mesio-temporal lobe epilepsy syndrome. In: Rojer J, Bureau M, Dravet C, Genton P, Tassinari CA, Wolf P, editors. Epileptic syndromes in infancy, childhood and adolescence 4th edition. Montrouge: John Libbey Eurotext. pp. 555-575.
4. Lux AL, (2010) Treatment of febrile seizures: historical perspective, current opinions, and potential future directions. Brain Dev 32: 42-50.
5. Zhang LL, Zeng LN, Li YP, (2011) Side effects of phenobarbital in epilepsy: a systematic review. Epileptic Disord 13: 349-365.
6. Anderson GD, (2002) Children versus adults: pharmacokinetic and adverse-effect differences. Epilepsia 43: 53-9.
7. Nagakubo S, Niwa S, Kumagai N, Fukuda M, Anzai N, et al. (1993) Effects of TJ-960 on Sternberg's paradigm results in epileptic patients. Jpn J Psychiatry Neurol 47: 609-620.
8. Hiratsuka T, Matsuzaki S, Miyata S, Kinoshita M, Kakehi K, et al. (2010) Yokukansan inhibits neuronal death during ER stress by regulating the unfolded protein response. PLoS One. 5: e13280.
9. Dezaki K, Kimura I, Miyahara K, Kimura M, (1995) Complementary effects of paeoniflorin and glycyrrhizin on intracellular Ca2+ mobilization in the nerve-stimulated skeletal muscle of mice. Jpn J Pharmacol 69: 281-284.
10. Watanabe H, (1997) Candidates for cognitive enhancer extracted from medicinal plants: paeoniflorin and tetramethylpyrazine. Behav Brain Res 83: 135-141.
11. Tang NY, Liu CH, Hsieh CT, Hsieh CL, (2010) The anti-inflammatory effect of paeoniflorin on cerebral infarction induced by ischemia-reperfusion injury in Sprague-Dawley rats. Am J Chin Med 38: 51-64.
12. Hjeresen DL, Diaz J, (1988) Ontogeny of susceptibility to experimental febrile seizures in rats. Dev Psychobiol 21: 261-275.
13. Baram TZ, Schultz L, (1991) Corticotropin-releasing hormone is a rapid and potent convulsant in the infant rat. Dev Brain Res 61: 97-101.
14. Fukuda M, Morimoto T, Nagao H, Kida K, (1997) The effect of GABAergic system activity on hyperthermia-induced seizures in rat. Dev Brain Res 104: 197-199.
15. Siesjö BK, Bengtsson F, Grampp W, Theander S, (1989) Calcium, excitotoxins, and neuronal death in the brain. Ann N Y Acad Sci 568: 234-251.
16. Shigemoto R, Kinoshita A, Wada E, Nomura S, Ohishi H, et al. (1997) Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. J Neurosci 17: 7503-7522.
17. Verrotti A, D'Egidio C, Mohn A, Coppola G, Chiarelli F, (2011) Weight gain following treatment with valproic acid: pathogenetic mechanisms and clinical implications. Obes Rev 12: 32-43.
18. Zarate CA, Jr Tohen M, Narendran R, Tomassini EC, McDonald J, et al. (1999) The adverse effect profile and efficacy of divalproex sodium compared with valproic acid: a pharmacoepidemiology study. J Clin Psychiatry 60: 232-236.
19. Castro-Gago M, Pérez-Gay L, Gómez-Lado C, Castiñeiras-Ramos DE, Otero-Martínez S, et al. (2011) The influence of valproic acid and carbamazepine treatment on serum biotin and zinc levels and on biotinidase activity. J Child Neurol 26: 1522-1524.
20. Sugaya E, Ishige A, Sekiguchi K, Iizuka S, Sugimoto A, et al. (1988) Inhibitory effect of a mixture of herbal drugs (TJ-960, SK) on pentylenetetrazol-induced convulsions in E1 mice. Epilepsy Res 2: 337-339.
21. Sugaya E, Ishige A, Sekiguchi K, Iizuka S, Ito K, et al. (1988) Inhibitory effect of TJ-960 (SK) on pentylenetetrazol-induced EEG power spectrum changes. Epilepsy Res 2: 27-31.
22. Abdel-Hafez AA, Meselhy MR, Nakamura N, Hattori M, Watanabe H, et al. (1999) Anticonvulsant activity of Paeonimetabolin-I Adducts obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis. Chem Pharm Bull (Tokyo) 22: 491-497.
23. Sugaya A, Suzuki T, Sugaya E, Yuyama N, Yasuda K, et al. (1991) Inhibitory effect of peony root extract on pentylenetetrazol-induced EEG power spectrum changes and extracellular calcium concentration changes in rat cerebral cortex. J Ethnopharmacol 33: 159-167.
24. Tsuda T, Sugaya A, Ohguchi H, Kishida N, Sugaya E, (1997) Protective effects of peony root extract and its components on neuron damage in the hippocampus induced by the cobalt focus epilepsy model. Exp Neurol 146: 518-525.
25. Dobbing J, (1973) Nutrition and the developing brain. Lancet 1: 48.
26. Neville B, Gindner D, (2010) Febrile seizures are a syndrome of secondarily generalized hippocampal epilepsy. Dev Med Child Neurol 52: 1151-1153.
27. Dube C, Vezzani A, Behrens M, Bartfai T, Baram TZ, (2005) Interleukin-1beta contributes to the generation of experimental febrile seizures. Ann Neurol 57: 152-155.
28. Rating D, Siemes H, Löscher W, (1983) Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitis. J Neurol 230: 217-225.
29. Audenaert D, Schwartz E, Claeys KG, Claes L, Deprez L, et al. (2006) A novel GABRG2 mutation associated with febrile seizures. Neurology 67: 687-690.
30. Qu L, Leung LS, (2008) Mechanisms of hyperthermia-induced depression of GABAergic synaptic transmission in the immature rat hippocampus. J Neurochem 106: 2158-2169.
31. Knight M, Ebert J, Parish RA, Berry H, Fogelson MH, (1985) Gamma-Aminobutyric acid in CSF of children with febrile seizures. Arch Neurol 42: 474-475.
32. Freeman AR, (1976) Polyfunctional role of glutamic acid in excitatory synaptic transmission. Prog Neurobiol 13: 137-153.
33. Morimoto T, Kida K, Nagao H, Yoshida K, Fukuda M, et al. (1995) The pathogenic role of the NMDA receptor in hyperthermia-induced seizures in developing rats. Dev Brain Res 84: 204-207.
34. Frandsen A, Schousboe A, (1993) Excitatory amino acid-mediated cytotoxicity and calcium homeostasis in cultured neurons, J Neurochem. 60: 1202-1211.
35. Raza M, Pal S, Rafiq A, DeLorenzo RJ, (2001) Long-term alteration of calcium homeostatic mechanisms in the pilocarpine model of temporal lobe epilepsy. Brain Res 903: 1-12.
36. Pal S, Sun D, Limbrick D, Rafiq A, DeLorenzo RJ, (2001) Epileptogenesis induces long-term alterations in intracellular calcium release and sequestration mechanisms in the hippocampal neuronal culture model of epilepsy. Cell Calcium 30: 285-296.
37. Shitak R, Sahai AK, Hota D, Chakrabarti A, (2007) Evaluation of the modulatory role of nimodipine in seizures induced by kainic acid and pentylenetetrazole in mice. Methods Find Exp Clin Pharmacol 29: 11-17.
38. Mao QQ, Zhong XM, Feng CR, Pan AJ, Li ZY, et al. (2010) Protective effects of paeoniflorin against glutamate-induced neurotoxicity in PC12 cells via antioxidant mechanisms and Ca2+ antagonism. Cell Mol Neurobiol 30: 1059-1066.
39. Bender RA, Dubé C, Gonzalez-Vega R, Mina EW, Baram TZ, (2003) Mossy fiber plasticity and enhanced hippocampal excitability, without hippocampal cell loss or altered neurogenesis, in an animal model of prolonged febrile seizures. Hippocampus 13: 399-412.
40. Tanabe T, Hara K, Shimakawa S, Fukui M, Tamai H, (2011) Hippocampal damage after prolonged febrile seizure: one case in a consecutive prospective series. Epilepsia 52: 837-840.
41. Nakanishi S, Nakajima Y, Masu M, Ueda Y, Nakahara K, et al. (1998) Glutamate receptors: brain function and signal transduction. Brain Res Rev 26: 230-235.
42. Nicoletti F, Bruno V, Copani A, Casabona G, Knopfel T, (1996) Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? Trends Neurosci 19: 267-271.
43. Lu YM, Jia Z, Janus C, Henderson JT, Gerlai R, et al. (1997) Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J Neurosci 17: 5196-5205.
44. Suzuki Y, Takahashi H, Fukuda M, Hino H, Kobayashi K, et al. (2009) Beta-hydroxybutyrate alters GABA-transaminase activity in cultured astrocytes. Brain Res 1: 17-23.