The Microtubule-Associated Rho Activating Factor GEF-H1 Interacts with Exocyst Complex to Regulate Vesicle Traffic

Developmental Cell

Volumn 23, Issue 2, 2012, Pages 397-411

  Pathak, Ritu ^a   Delorme Walker, Violaine D ^a   Howell, Michael C ^a   Anselmo, Anthony N ^a   White, Michael A ^b   Bokoch, Gary M ^a   DerMardirossian, Céline ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; EXOCYST; GEF H1 PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; MICROTUBULE ASSOCIATED PROTEIN; RHO FACTOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL DIVISION; CELL MEMBRANE; CELL MOTILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; MEMBRANE TRANSPORT; MICROTUBULE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; TRANSPORT VESICLE;

BIOLOGICAL TRANSPORT; ENZYME ACTIVATION; EXOCYTOSIS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HELA CELLS; HUMANS; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULES; PROTEIN BINDING; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION;

EID: 84865078112     PISSN: 15345807     EISSN: 18781551     Source Type: Journal    
DOI: 10.1016/j.devcel.2012.06.014     Document Type: Article

References (42)

1. Birkenfeld J., Nalbant P., Bohl B.P., Pertz O., Hahn K.M., Bokoch G.M. GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Dev. Cell 2007, 12:699-712.
2. Birkenfeld J., Nalbant P., Yoon S.H., Bokoch G.M. Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF, is altered GEF-H1 activity a crucial determinant of disease pathogenesis?. Trends Cell Biol. 2008, 18:210-219.
3. Boyd C., Hughes T., Pypaert M., Novick P. Vesicles carry most exocyst subunits to exocytic sites marked by the remaining two subunits, Sec3p and Exo70p. J. Cell Biol. 2004, 167:889-901.
4. Caswell P., Norman J. Endocytic transport of integrins during cell migration and invasion. Trends Cell Biol. 2008, 18:257-263.
5. Chang Y.C., Nalbant P., Birkenfeld J., Chang Z.F., Bokoch G.M. GEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoA. Mol. Biol. Cell 2008, 19:2147-2153.
6. Chien Y., Kim S., Bumeister R., Loo Y.M., Kwon S.W., Johnson C.L., Balakireva M.G., Romeo Y., Kopelovich L., Gale M., et al. RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival. Cell 2006, 127:157-170.
7. Feng Y., Press B., Wandinger-Ness A. Rab 7: an important regulator of late endocytic membrane traffic. J. Cell Biol. 1995, 131:1435-1452.
8. Fielding A.B., Schonteich E., Matheson J., Wilson G., Yu X., Hickson G.R., Srivastava S., Baldwin S.A., Prekeris R., Gould G.W. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. EMBO J. 2005, 24:3389-3399.
9. Gildea J.J., Harding M.A., Seraj M.J., Gulding K.M., Theodorescu D. The role of Ral A in epidermal growth factor receptor-regulated cell motility. Cancer Res. 2002, 62:982-985.
10. Gilula N.B., Epstein M.L., Beers W.H. Cell-to-cell communication and ovulation. A study of the cumulus-oocyte complex. J. Cell Biol. 1978, 78:58-75.
11. Gromley A., Yeaman C., Rosa J., Redick S., Chen C.T., Mirabelle S., Guha M., Sillibourne J., Doxsey S.J. Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission. Cell 2005, 123:75-87.
12. Guo W., Sacher M., Barrowman J., Ferro-Novick S., Novick P. Protein complexes in transport vesicle targeting. Trends Cell Biol. 2000, 10:251-255.
13. Guo W., Tamanoi F., Novick P. Spatial regulation of the exocyst complex by Rho1 GTPase. Nat. Cell Biol. 2001, 3:353-360.
14. He B., Guo W. The exocyst complex in polarized exocytosis. Curr. Opin. Cell Biol. 2009, 21:537-542.
15. Hirschberg K., Miller C.M., Ellenberg J., Presley J.F., Siggia E.D., Phair R.D., Lippincott-Schwartz J. Kinetic analysis of secretory protein traffic and characterization of golgi to plasma membrane transport intermediates in living cells. J. Cell Biol. 1998, 143:1485-1503.
16. Ho T.T., Merajver S.D., Lapière C.M., Nusgens B.V., Deroanne C.F. RhoA-GDP regulates RhoB protein stability. Potential involvement of RhoGDIalpha. J. Biol. Chem. 2008, 283:21588-21598.
17. Jin R., Junutula J.R., Matern H.T., Ervin K.E., Scheller R.H., Brunger A.T. Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase. EMBO J. 2005, 24:2064-2074.
18. Jullien-Flores V., Dorseuil O., Romero F., Letourneur F., Saragosti S., Berger R., Tavitian A., Gacon G., Camonis J.H. Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. J. Biol. Chem. 1995, 270:22473-22477.
19. Kanzaki M., Pessin J.E. Insulin signaling: GLUT4 vesicles exit via the exocyst. Curr. Biol. 2003, 13:R574-R576.
20. Kawase K., Nakamura T., Takaya A., Aoki K., Namikawa K., Kiyama H., Inagaki S., Takemoto H., Saltiel A.R., Matsuda M. GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion. Dev. Cell 2006, 11:411-421.
21. Kornfeld S., Mellman I. The biogenesis of lysosomes. Annu. Rev. Cell Biol. 1989, 5:483-525.
22. Krendel M., Zenke F.T., Bokoch G.M. Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton. Nat. Cell Biol. 2002, 4:294-301.
23. Lefrancois L., Lyles D.S. The interaction of antibody with the major surface glycoprotein of vesicular stomatitis virus. II. Monoclonal antibodies of nonneutralizing and cross-reactive epitopes of Indiana and New Jersey serotypes. Virology 1982, 121:168-174.
24. Liu J., Zuo X., Yue P., Guo W. Phosphatidylinositol 4,5-bisphosphate mediates the targeting of the exocyst to the plasma membrane for exocytosis in mammalian cells. Mol. Biol. Cell 2007, 18:4483-4492.
25. Maxfield F.R., McGraw T.E. Endocytic recycling. Nat. Rev. Mol. Cell Biol. 2004, 5:121-132.
26. Mellman I. Endocytosis and molecular sorting. Annu. Rev. Cell Dev. Biol. 1996, 12:575-625.
27. Montagnac G., Echard A., Chavrier P. Endocytic traffic in animal cell cytokinesis. Curr. Opin. Cell Biol. 2008, 20:454-461.
28. Moskalenko S., Henry D.O., Rosse C., Mirey G., Camonis J.H., White M.A. The exocyst is a Ral effector complex. Nat. Cell Biol. 2002, 4:66-72.
29. Nalbant P., Chang Y.C., Birkenfeld J., Chang Z.F., Bokoch G.M. Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge. Mol. Biol. Cell 2009, 20:4070-4082.
30. Novick P., Guo W. Ras family therapy: Rab, Rho and Ral talk to the exocyst. Trends Cell Biol. 2002, 12:247-249.
31. Oztan A., Silvis M., Weisz O.A., Bradbury N.A., Hsu S.C., Goldenring J.R., Yeaman C., Apodaca G. Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cells. Mol. Biol. Cell 2007, 18:3978-3992.
32. Prekeris R., Gould G.W. Breaking up is hard to do - membrane traffic in cytokinesis. J. Cell Sci. 2008, 121:1569-1576.
33. Prigent M., Dubois T., Raposo G., Derrien V., Tenza D., Rossé C., Camonis J., Chavrier P. ARF6 controls post-endocytic recycling through its downstream exocyst complex effector. J. Cell Biol. 2003, 163:1111-1121.
34. Ren Y., Li R., Zheng Y., Busch H. Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. J. Biol. Chem. 1998, 273:34954-34960.
35. Ridley A.J. Rho proteins: linking signaling with membrane trafficking. Traffic 2001, 2:303-310.
36. Sever S., Damke H., Schmid S.L. Dynamin:GTP controls the formation of constricted coated pits, the rate limiting step in clathrin-mediated endocytosis. J. Cell Biol. 2000, 150:1137-1148.
37. Stenmark H., Aasland R., Toh B.H., D'Arrigo A. Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger. J. Biol. Chem. 1996, 271:24048-24054.
38. Stofega M., DerMardirossian C., Bokoch G.M. Affinity-based assay of Rho guanosine triphosphatase activation. Methods Mol. Biol. 2006, 332:269-279.
39. Ullrich O., Reinsch S., Urbé S., Zerial M., Parton R.G. Rab11 regulates recycling through the pericentriolar recycling endosome. J. Cell Biol. 1996, 135:913-924.
40. Urbé S., Huber L.A., Zerial M., Tooze S.A., Parton R.G. Rab11, a small GTPase associated with both constitutive and regulated secretory pathways in PC12 cells. FEBS Lett. 1993, 334:175-182.
41. Wittmann T., Waterman-Storer C.M. Cell motility: can Rho GTPases and microtubules point the way?. J. Cell Sci. 2001, 114:3795-3803.
42. Wu H., Rossi G., Brennwald P. The ghost in the machine: small GTPases as spatial regulators of exocytosis. Trends Cell Biol. 2008, 18:397-404.