Ras family therapy: Rab, Rho and Ral talk to the exocyst

Trends in Cell Biology

Volumn 12, Issue 6, 2002, Pages 247-249

  Novick, Peter ^a   Guo, Wei ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANE PROTEIN; EXOCYST; RAB PROTEIN; RAL PROTEIN; RAS PROTEIN; RHO FACTOR; UNCLASSIFIED DRUG;

CELL MEMBRANE; CELL VACUOLE; EPITHELIUM CELL; EXOCYTOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SHORT SURVEY; SYNAPTIC TRANSMISSION;

EID: 0036608158     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8924(02)02293-6     Document Type: Review

References (24)

1. The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae
2. The exocyst is an effector for sec4p, targeting secretory vesicles to sites of exocytosis
3. The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarity
4. Rho3 of Saccharomyces cerevisiae, which regulates the actin cytoskeleton and exocytosis, is a GTPase which interacts with Myo2 and Exo70
5. Spatial regulation of the exocyst complex by Rho1 GTPase
6. Cdc42 interacts with the exocyst and regulates polarized secretion
7. The brain exocyst complex interacts with RalA in a GTP-dependent manner: Identification of a novel mammalian Sec3 gene and a second Sec15 gene
8. The exocyst is a Ral effector complex
9. The exocyst complex binds the small GTPase RalA to mediate filopodia formation
10. Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles
11. The mammalian brain rsec6/8 complex
12. Ordering the final events in yeast exocytosis
13. Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae
14. Sec3p is a spatial landmark for polarized secretion in budding yeast
15. The Sec15 protein responds to the function of the GTP binding protein, Sec4, to control vesicular traffic in yeast
16. The sec6/8 complex is located at neurite outgrowth and axonal synapse-assembly domains
17. Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells
18. Sec6/8 complexes on trans-Golgi network and plasma membrane regulate late stages of exocytosis in mammalian cells
19. Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteins
20. Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging bud
21. The Sec6/8 complex in mammalian cells: Characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells
22. A family of ras-like GTP-binding proteins expressed in electromotor neurons
23. Association of Ral GTP-binding protein with human platelet dense granules
24. New roles for the Snp1 and Exo84 proteins in yeast pre-mRNA splicing