Inhibition of chlorine-induced lung injury by the type 4 phosphodiesterase inhibitor rolipram

Toxicology and Applied Pharmacology

Volumn 263, Issue 2, 2012, Pages 251-258

  Chang, Weiyuan ^a,d   Chen, Jing ^a   Schlueter, Connie F ^a   Rando, Roy J ^b   Pathak, Yashwant V ^c   Hoyle, Gary W ^a  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b TULANE UNIVERSITY   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

^d Center for Drug Evaluation   (Taiwan)

Author keywords

Acute lung injury; Airway hyperreactivity; Pulmonary edema

Indexed keywords

CHLORINE; CXCL1 CHEMOKINE; CYCLIC AMP; IMMUNOGLOBULIN M; ROLIPRAM;

AIRWAY HYPERREACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DEGRADATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; LUNG EDEMA; LUNG FUNCTION TEST; LUNG INJURY; LUNG LAVAGE; MOUSE; NANOEMULSION; NEUTROPHIL; NONHUMAN; PNEUMONIA; RESPIRATORY TRACT DISEASE; SIGNAL TRANSDUCTION;

ACUTE LUNG INJURY; ADMINISTRATION, INTRANASAL; ANIMALS; BRONCHIAL HYPERREACTIVITY; CHLORINE; CYCLIC AMP; EMULSIONS; INHALATION EXPOSURE; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAPERITONEAL; MICE; NANOPARTICLES; PHOSPHODIESTERASE 4 INHIBITORS; ROLIPRAM;

MUS;

EID: 84865077468     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.06.017     Document Type: Article

References (48)

1. Allen G.B., Leclair T.R., von Reyn J., Larrabee Y.C., Cloutier M.E., Irvin C.G., Bates J.H. Acid aspiration-induced airways hyperresponsiveness in mice. J. Appl. Physiol. 2009, 107:1763-1770.
2. Batchinsky A.I., Martini D.K., Jordan B.S., Dick E.J., Fudge J., Baird C.A., Hardin D.E., Cancio L.C. Acute respiratory distress syndrome secondary to inhalation of chlorine gas in sheep. J. Trauma 2006, 60:944-956.
3. Bates J.H., Wagers S.S., Norton R.J., Rinaldi L.M., Irvin C.G. Exaggerated airway narrowing in mice treated with intratracheal cationic protein. J. Appl. Physiol. 2006, 100:500-506.
4. Bessac B.F., Jordt S.E. Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures. Proc. Am. Thorac. Soc. 2010, 7:269-277.
5. Bessac B.F., Sivula M., von Hehn C.A., Escalera J., Cohn L., Jordt S.E. TRPA1 is a major oxidant sensor in murine airway sensory neurons. J. Clin. Invest. 2008, 118:1899-1910.
6. Calverley P.M., Rabe K.F., Goehring U.M., Kristiansen S., Fabbri L.M., Martinez F.J. Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials. Lancet 2009, 374:685-694.
7. Deshpande D.A., Penn R.B. Targeting G protein-coupled receptor signaling in asthma. Cell. Signal. 2006, 18:2105-2120.
8. Evans R.B. Chlorine: state of the art. Lung 2005, 183:151-167.
9. Gagnaire F., Azim S., Bonnet P., Hecht G., Hery M. Comparison of the sensory irritation response in mice to chlorine and nitrogen trichloride. J. Appl. Toxicol. 1994, 14:405-409.
10. Giembycz M.A., Field S.K. Roflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD. Drug Des. Devel. Ther. 2010, 4:147-158.
11. Gunnarsson M., Walther S.M., Seidal T., Bloom G.D., Lennquist S. Exposure to chlorine gas: effects on pulmonary function and morphology in anaesthetised and mechanically ventilated pigs. J. Appl. Toxicol. 1998, 18:249-255.
12. Hantos Z., Daroczy B., Suki B., Nagy S., Fredberg J.J. Input impedance and peripheral inhomogeneity of dog lungs. J. Appl. Physiol. 1992, 72:168-178.
13. Hasan F.M., Gehshan A., Fuleihan F.J. Resolution of pulmonary dysfunction following acute chlorine exposure. Arch. Environ. Health 1983, 38:76-80.
14. Herbert C., Hettiaratchi A., Webb D.C., Thomas P.S., Foster P.S., Kumar R.K. Suppression of cytokine expression by roflumilast and dexamethasone in a model of chronic asthma. Clin. Exp. Allergy 2008, 38:847-856.
15. Hertz A.L., Bender A.T., Smith K.C., Gilchrist M., Amieux P.S., Aderem A., Beavo J.A. Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:21978-21983.
16. Hoyle G.W. Mitigation of chlorine lung injury by increasing cyclic AMP levels. Proc. Am. Thorac. Soc. 2010, 7:284-289.
17. Hoyle G.W., Chang W., Chen J., Schlueter C.F., Rando R.J. Deviations from Haber's law for multiple measures of acute lung injury in chlorine-exposed mice. Toxicol. Sci. 2010, 118:696-703.
18. Hoyle G.W., Hoyle C.I., Chen J., Chang W., Williams R.W., Rando R.J. Identification of triptolide, a natural diterpenoid compound, as an inhibitor of lung inflammation. Am. J. Physiol. Lung Cell. Mol. Physiol. 2010, 298:L830-L836.
19. Institute of Laboratory Animal Resources, Commission of Life Sciences, National Research Council Guide for the Care and Use of Laboratory Animals 1996, National Academy Press, Washington, D.C.
20. Johnson M. Molecular mechanisms of beta(2)-adrenergic receptor function, response, and regulation. J. Allergy Clin. Immunol. 2006, 117:18-24.
21. Jones R.N., Hughes J.M., Glindmeyer H., Weill H. Lung function after acute chlorine exposure. Am. Rev. Respir. Dis. 1986, 134:1190-1195.
22. Joyner R.E., Durel E.G. Accidental liquid chlorine spill in a rural community. J. Occup. Med. 1962, 4:152-154.
23. Lemiere C., Malo J.L., Boutet M. Reactive airways dysfunction syndrome due to chlorine: sequential bronchial biopsies and functional assessment. Eur. Respir. J. 1997, 10:241-244.
24. Leustik M., Doran S., Bracher A., Williams S., Squadrito G.L., Schoeb T.R., Postlethwait E., Matalon S. Mitigation of chlorine-induced lung injury by low-molecular-weight antioxidants. Am. J. Physiol. Lung Cell. Mol. Physiol. 2008, 295:L733-L743.
25. Litvan J., Briva A., Wilson M.S., Budinger G.R., Sznajder J.I., Ridge K.M. Beta-adrenergic receptor stimulation and adenoviral overexpression of superoxide dismutase prevent the hypoxia-mediated decrease in Na, K-ATPase and alveolar fluid reabsorption. J. Biol. Chem. 2006, 281:19892-19898.
26. Malo J.L., L'Archeveque J., Castellanos L., Lavoie K., Ghezzo H., Maghni K. Long-term outcomes of acute irritant-induced asthma. Am. J. Respir. Crit. Care Med. 2009, 179:923-928.
27. Martin J.G., Campbell H.R., Iijima H., Gautrin D., Malo J.L., Eidelman D.H., Hamid Q., Maghni K. Chlorine-induced injury to the airways in mice. Am. J. Respir. Crit. Care Med. 2003, 168:568-574.
28. Matthay M.A., Robriquet L., Fang X. Alveolar epithelium: role in lung fluid balance and acute lung injury. Proc. Am. Thorac. Soc. 2005, 2:206-213.
29. Matthay M.A., Brower R., Thompson B.T., Schoenfeld D., Eisner M.D., Carson S., Moss M., Douglas I., Hite D., MacIntyre N., Liu K.D. Randomized, placebo-controlled trial of an aerosolized beta-2 adrenergic agonist (albuterol) for the treatment of acute lung injury. Am. J. Respir. Crit. Care Med. 2009, 179:A2166.
30. McAuley D.F., Frank J.A., Fang X., Matthay M.A. Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury. Crit. Care Med. 2004, 32:1470-1476.
31. McCluskie K., Klein U., Linnevers C., Ji Y.H., Yang A., Husfeld C., Thomas G.R. Phosphodiesterase type 4 inhibitors cause proinflammatory effects in vivo. J. Pharmacol. Exp. Ther. 2006, 319:468-476.
32. McGovern T.K., Powell W.S., Day B.J., White C.W., Govindaraju K., Karmouty-Quintana H., Lavoie N., Tan J.J., Martin J.G. Dimethylthiourea protects against chlorine induced changes in airway function in a murine model of irritant induced asthma. Respir. Res. 2010, 11:138.
33. Morris J.B., Wilkie W.S., Shusterman D.J. Acute respiratory responses of the mouse to chlorine. Toxicol. Sci. 2005, 83:380-387.
34. Perkins G.D., McAuley D.F., Thickett D.R., Gao F. The beta-agonist lung injury trial (BALTI): a randomized placebo-controlled clinical trial. Am. J. Respir. Crit. Care Med. 2006, 173:281-287.
35. Rando R.J., Hammad Y.Y. A diffusive sampler for gaseous chlorine utilizing an aqueous sulfamic acid collection medium and specific ion electrode analysis. Appl. Occup. Environ. Hyg. 1990, 5:700-706.
36. Rennard S., Knobil K., Rabe K.F., Morris A., Schachter N., Locantore N., Canonica W.G., Zhu Y., Barnhart F. The efficacy and safety of cilomilast in COPD. Drugs 2008, 68(Suppl. 2):3-57.
37. Schwartz D.A., Smith D.D., Lakshminarayan S. The pulmonary sequelae associated with accidental inhalation of chlorine gas. Chest 1990, 97:820-825.
38. Song W., Wei S., Liu G., Yu Z., Estell K., Yadav A.K., Schwiebert L.M., Matalon S. Postexposure administration of a {beta}2-agonist decreases chlorine-induced airway hyperreactivity in mice. Am. J. Respir. Cell Mol. Biol. 2011, 45:88-94.
39. Souness J.E., Aldous D., Sargent C. Immunosuppressive and anti-inflammatory effects of cyclic AMP phosphodiesterase (PDE) type 4 inhibitors. Immunopharmacology 2000, 47:127-162.
40. Spina D. PDE4 inhibitors: current status. Br. J. Pharmacol. 2008, 155:308-315.
41. Squadrito G.L., Postlethwait E.M., Matalon S. Elucidating mechanisms of chlorine toxicity: reaction kinetics, thermodynamics, and physiological implications. Am. J. Physiol. Lung Cell. Mol. Physiol. 2010, 299:L289-L300.
42. Su X., Camerer E., Hamilton J.R., Coughlin S.R., Matthay M.A. Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. J. Immunol. 2005, 175:2598-2605.
43. Tian X., Tao H., Brisolara J., Chen J., Rando R.J., Hoyle G.W. Acute lung injury induced by chlorine inhalation in C57BL/6 and FVB/N mice. Inhal. Toxicol. 2008, 20:783-793.
44. Tomioka S., Bates J.H., Irvin C.G. Airway and tissue mechanics in a murine model of asthma: alveolar capsule vs. forced oscillations. J. Appl. Physiol. 2002, 93:263-270.
45. Torphy T.J. Phosphodiesterase isozymes: molecular targets for novel antiasthma agents. Am. J. Respir. Crit. Care Med. 1998, 157:351-370.
46. Van Sickle D., Wenck M.A., Belflower A., Drociuk D., Ferdinands J., Holguin F., Svendsen E., Bretous L., Jankelevich S., Gibson J.J., Garbe P., Moolenaar R.L. Acute health effects after exposure to chlorine gas released after a train derailment. Am. J. Emerg. Med. 2009, 27:1-7.
47. Wang J., Zhang L., Walther S.M. Administration of aerosolized terbutaline and budesonide reduces chlorine gas-induced acute lung injury. J. Trauma 2004, 56:850-862.
48. Winternitz M.C., Lambert R.A., Jackson L., Smith G.H. The Pathology of Chlorine Poisoning 1920, Yale University School of Medicine, New Haven.