Biases and Errors on Allele Frequency Estimation and Disease Association Tests of Next-Generation Sequencing of Pooled Samples

Genetic Epidemiology

Volumn 36, Issue 6, 2012, Pages 549-560

  Chen, Xiaowei ^a   Listman, Jennifer B ^b   Slack, Frank J ^a   Gelernter, Joel ^b,c   Zhao, Hongyu ^a,b  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

Allele frequency estimation; Disease association tests; Next generation sequencing; Pooled sequencing

Indexed keywords

ACCURACY; ARTICLE; DISEASE ASSOCIATION; GENE FREQUENCY; GENE SEQUENCE; GENOTYPE; HUMAN; NEXT GENERATION SEQUENCING; POLYMERASE CHAIN REACTION; SAMPLING ERROR; SINGLE NUCLEOTIDE POLYMORPHISM; WORKFLOW;

AUTOMATIC DATA PROCESSING; BIAS (EPIDEMIOLOGY); COMPUTER SIMULATION; GENE FREQUENCY; GENETIC TESTING; HUMANS; MODELS, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RESEARCH DESIGN; SEQUENCE ANALYSIS, DNA; SOFTWARE;

EID: 84865075699     PISSN: 07410395     EISSN: 10982272     Source Type: Journal    
DOI: 10.1002/gepi.21648     Document Type: Article

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