Cerebralcare Granule® attenuates blood-brain barrier disruption after middle cerebral artery occlusion in rats

Experimental Neurology

Volumn 237, Issue 2, 2012, Pages 453-463

  Huang, Ping ^a,b   Zhou, Chang Man ^a   Qin Hu, ^a   Liu, Yu Ying ^a,b   Hu, Bai He ^a,b   Chang, Xin ^a,b   Zhao, Xin Rong ^a,b   Xu, Xiang Shun ^a,b   Li, Quan ^a,b   Wei, Xiao Hong ^a,b   Mao, Xiao Wei ^a,b   Wang, Chuan She ^a,b   Fan, Jing Yu ^a,b   Han, Jing Yan ^a,b,c  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b State Administration of Traditional Chinese Medicine of the People's Republic of China   (China)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Blood brain barrier; Caveolin 1; Chinese medicine; Ischemic stroke; Tight junction proteins

Indexed keywords

ALBUMIN; CAVEOLIN 1; CEREBRALCARE GRANULE; CHINESE DRUG; CLAUDIN 5; EVANS BLUE; OCCLUDIN; PROTEIN ZO1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN WATER; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG DOSE COMPARISON; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ANIMALS; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; BRAIN EDEMA; CAPILLARY PERMEABILITY; CEREBROVASCULAR CIRCULATION; DRUGS, CHINESE HERBAL; INFARCTION, MIDDLE CEREBRAL ARTERY; MAGNETIC RESONANCE IMAGING; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84865052738     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.07.017     Document Type: Article

References (54)

1. Abbott N.J., Patabendige A.A., Dolman D.E., Yusof S.R., Begley D.J. Structure and function of the blood-brain barrier. Neurobiol. Dis. 2010, 37:13-25.
2. Arnold M., Nedeltchev K., Mattle H.P., Loher T.J., Stepper F., Schroth G., Brekenfeld C., Sturzenegger M., Remonda L. Intra-arterial thrombolysis in 24 consecutive patients with internal carotid artery T occlusions. J. Neurol. Neurosurg. Psychiatry 2003, 74:739-742.
3. Ballabh P., Braun A., Nedergaard M. The blood-brain barrier: an overview: structure, regulation, and clinical implications. Neurobiol. Dis. 2004, 16:1-13.
4. Bazzoni G., Dejana E. Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol. Rev. 2004, 84:869-901.
5. Bernatchez P.N., Bauer P.M., Yu J., Prendergast J.S., He P., Sessa W.C. Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:761-766.
6. Bratton S.L., Chestnut R.M., Ghajar J., McConnell Hammond F.F., Harris O.A., Hartl R., Manley G.T., Nemecek A., Newell D.W., Rosenthal G., Schouten J., Shutter L., Timmons S.D., Ullman J.S., Videtta W., Wilberger J.E., Wright D.W. Guidelines for the management of severe traumatic brain injury. XI. Anesthetics, analgesics, and sedatives. J. Neurotrauma 2007, 24(Suppl. 1):S71-S76.
7. Coisne C., Engelhardt B. Tight junctions in brain barriers during central nervous system inflammation. Antioxid. Redox Signal. 2011, 15:1285-1303.
8. Cruz-Flores S., Thompson D.W., Boiser J.R. Massive cerebral edema after recanalization post-thrombolysis. J. Neuroimaging 2001, 11:447-451.
9. Davalos A., Toni D., Iweins F., Lesaffre E., Bastianello S., Castillo J. Neurological deterioration in acute ischemic stroke: potential predictors and associated factors in the European cooperative acute stroke study (ECASS) I. Stroke 1999, 30:2631-2636.
10. Engelman J.A., Chu C., Lin A., Jo H., Ikezu T., Okamoto T., Kohtz D.S., Lisanti M.P. Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain. FEBS Lett. 1998, 428:205-211.
11. Feng J.L., Zeng A.Y., Du Y.P. Effect of yangxue qingnao granule on microcirculation and cerebral blood flow in patients with migraine. Zhongguo Zhong Xi Yi Jie He Za Zhi 2004, 24:357-358.
12. Furuse M., Hirase T., Itoh M., Nagafuchi A., Yonemura S., Tsukita S. Occludin: a novel integral membrane protein localizing at tight junctions. J. Cell Biol. 1993, 123:1777-1788.
13. Gao D., Zhang X., Jiang X., Peng Y., Huang W., Cheng G., Song L. Resveratrol reduces the elevated level of MMP-9 induced by cerebral ischemia-reperfusion in mice. Life Sci. 2006, 78:2564-2570.
14. Ghitescu L., Fixman A., Simionescu M., Simionescu N. Specific binding sites for albumin restricted to plasmalemmal vesicles of continuous capillary endothelium: receptor-mediated transcytosis. J. Cell Biol. 1986, 102:1304-1311.
15. Gonzalez-Mariscal L., Betanzos A., Avila-Flores A. MAGUK proteins: structure and role in the tight junction. Semin. Cell Dev. Biol. 2000, 11:315-324.
16. Gu X.X., Cai D.F., Yang Y.K., Teng Y., Chen Y.P., Wen M. Study on Yangxue Qingnao granule in treating chronic cerebrovascular insufficiency. Chin. J. Integr. Med. 2005, 11:22-26.
17. Hacke W., Brott T., Caplan L., Meier D., Fieschi C., von Kummer R., Donnan G., Heiss W.D., Wahlgren N.G., Spranger M., Boysen G., Marler J.R. Thrombolysis in acute ischemic stroke: controlled trials and clinical experience. Neurology 1999, 53:S3-S14.
18. Han J.Y., Miura S., Akiba Y., Higuchi H., Kato S., Suzuki H., Yokoyama H., Ishii H. Chronic ethanol consumption exacerbates microcirculatory damage in rat mesentery after reperfusion. Am. J. Physiol. Gastrointest. Liver Physiol. 2001, 280:G939-G948.
19. Hawkins B.T., Davis T.P. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol. Rev. 2005, 57:173-185.
20. Honda M., Nakagawa S., Hayashi K., Kitagawa N., Tsutsumi K., Nagata I., Niwa M. Adrenomedullin improves the blood-brain barrier function through the expression of claudin-5. Cell. Mol. Neurobiol. 2006, 26:109-118.
21. Hu Q., Chen C., Yan J., Yang X., Shi X., Zhao J., Lei J., Yang L., Wang K., Chen L., Huang H., Han J., Zhang J.H., Zhou C. Therapeutic application of gene silencing MMP-9 in a middle cerebral artery occlusion-induced focal ischemia rat model. Exp. Neurol. 2009, 216:35-46.
22. Hu Q., Ma Q., Zhan Y., He Z., Tang J., Zhou C., Zhang J. Isoflurane enhanced hemorrhagic transformation by impairing antioxidant enzymes in hyperglycemic rats with middle cerebral artery occlusion. Stroke 2011, 42:1750-1756.
23. Huang P., Qi Z., Bu X., Zhang N., Han S., Fang L., Li J. Neuron-specific phosphorylation of mitogen- and stress-activated protein kinase-1 involved in cerebral hypoxic preconditioning of mice. J. Neurosci. Res. 2007, 85:1279-1287.
24. Hunter A.J., Hatcher J., Virley D., Nelson P., Irving E., Hadingham S.J., Parsons A.A. Functional assessments in mice and rats after focal stroke. Neuropharmacology 2000, 39:806-816.
25. Jiao H., Wang Z., Liu Y., Wang P., Xue Y. Specific role of tight junction proteins claudin-5, occludin, and ZO-1 of the blood-brain barrier in a focal cerebral ischemic insult. J. Mol. Neurosci. 2011, 44:130-139.
26. Jung J.E., Kim G.S., Chen H., Maier C.M., Narasimhan P., Song Y.S., Niizuma K., Katsu M., Okami N., Yoshioka H., Sakata H., Goeders C.E., Chan P.H. Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection. Mol. Neurobiol. 2010, 41:172-179.
27. Kuhlmann C.R., Zehendner C.M., Gerigk M., Closhen D., Bender B., Friedl P., Luhmann H.J. MK801 blocks hypoxic blood-brain-barrier disruption and leukocyte adhesion. Neurosci. Lett. 2009, 449:168-172.
28. Li D. The effect of yang xue qing nao granule on chronic cerebral ischemia. Zhong Yao Cai 2003, 26:689-691.
29. Liang H.W., Qiu S.F., Shen J., Sun L.N., Wang J.Y., Bruce I.C., Xia Q. Genistein attenuates oxidative stress and neuronal damage following transient global cerebral ischemia in rat hippocampus. Neurosci. Lett. 2008, 438:116-120.
30. Lin Z., Zhu D., Yan Y., Yu B., Wang Q., Shen P., Ruan K. An antioxidant phytotherapy to rescue neuronal oxidative stress. Evid Based Complement Alternat Med 2008.
31. Longa E.Z., Weinstein P.R., Carlson S., Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989, 20:84-91.
32. Marmarou A. Increased intracranial pressure in head injury and influence of blood volume. J. Neurotrauma 1992, 9(Suppl. 1):S327-S332.
33. Marmarou A. A review of progress in understanding the pathophysiology and treatment of brain edema. Neurosurg. Focus 2007, 22:E1.
34. Minshall R.D., Sessa W.C., Stan R.V., Anderson R.G., Malik A.B. Caveolin regulation of endothelial function. Am. J. Physiol. Lung Cell. Mol. Physiol. 2003, 285:L1179-L1183.
35. Moulin D.E., Lo R., Chiang J., Barnett H.J. Prognosis in middle cerebral artery occlusion. Stroke 1985, 16:282-284.
36. Nitta T., Hata M., Gotoh S., Seo Y., Sasaki H., Hashimoto N., Furuse M., Tsukita S. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J. Cell Biol. 2003, 161:653-660.
37. Paris D., Quadros A., Humphrey J., Patel N., Crescentini R., Crawford F., Mullan M. Nilvadipine antagonizes both Abeta vasoactivity in isolated arteries, and the reduced cerebral blood flow in APPsw transgenic mice. Brain Res. 2004, 999:53-61.
38. Rothberg K.G., Heuser J.E., Donzell W.C., Ying Y.S., Glenney J.R., Anderson R.G. Caveolin, a protein component of caveolae membrane coats. Cell 1992, 68:673-682.
39. Sandoval K.E., Witt K.A. Blood-brain barrier tight junction permeability and ischemic stroke. Neurobiol. Dis. 2008, 32:200-219.
40. Schubert W., Frank P.G., Razani B., Park D.S., Chow C.W., Lisanti M.P. Caveolae-deficient endothelial cells show defects in the uptake and transport of albumin in vivo. J. Biol. Chem. 2001, 276:48619-48622.
41. Simard J.M., Kent T.A., Chen M., Tarasov K.V., Gerzanich V. Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications. Lancet Neurol. 2007, 6:258-268.
42. Stiver S.I. Complications of decompressive craniectomy for traumatic brain injury. Neurosurg. Focus 2009, 26:E7.
43. Sugawara T., Chan P.H. Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia. Antioxid. Redox Signal. 2003, 5:597-607.
44. Sun K., Hu Q., Zhou C.M., Xu X.S., Wang F., Hu B.H., Zhao X.Y., Chang X., Chen C.H., Huang P., An L.H., Liu Y.Y., Fan J.Y., Wang C.S., Yang L., Han J.Y. Cerebralcare Granule, a Chinese herb compound preparation, improves cerebral microcirculatory disorder and hippocampal CA1 neuron injury in gerbils after ischemia-reperfusion. J. Ethnopharmacol. 2010, 130:398-406.
45. Timofeev I., Czosnyka M., Nortje J., Smielewski P., Kirkpatrick P., Gupta A., Hutchinson P. Effect of decompressive craniectomy on intracranial pressure and cerebrospinal compensation following traumatic brain injury. J. Neurosurg. 2008, 108:66-73.
46. Tsubokawa T., Jadhav V., Solaroglu I., Shiokawa Y., Konishi Y., Zhang J.H. Lecithinized superoxide dismutase improves outcomes and attenuates focal cerebral ischemic injury via antiapoptotic mechanisms in rats. Stroke 2007, 38:1057-1062.
47. Wang Y.J., Zhou H.D., Li J.C. Clinical observation on effect of yangxue qingnao granule in treating patients with cerebral arteriosclerosis. Zhongguo Zhong Xi Yi Jie He Za Zhi 2004, 24:202-204.
48. Weber C., Fraemohs L., Dejana E. The role of junctional adhesion molecules in vascular inflammation. Nat. Rev. Immunol. 2007, 7:467-477.
49. Wolburg H., Noell S., Mack A., Wolburg-Buchholz K., Fallier-Becker P. Brain endothelial cells and the glio-vascular complex. Cell Tissue Res. 2009, 335:75-96.
50. Xiong L., Zhang J.J., Sun D., Liu H. Therapeutic benefit of Yangxue Qingnao Granule on cognitive impairment induced by chronic cerebral hypoperfusion in rats. Chin. J. Integr. Med. 2011, 17:134-140.
51. Xu X.S., Ma Z.Z., Wang F., Hu B.H., Wang C.S., Liu Y.Y., Zhao X.R., An L.H., Chang X., Liao F.L., Fan J.Y., Niimi H., Han J.Y. The antioxidant Cerebralcare Granule attenuates cerebral microcirculatory disturbance during ischemia-reperfusion injury. Shock 2009, 32:201-209.
52. Yeung D., Manias J.L., Stewart D.J., Nag S. Decreased junctional adhesion molecule-a expression during blood-brain barrier breakdown. Acta Neuropathol. 2008, 115:635-642.
53. Zehendner C.M., Luhmann H.J., Kuhlmann C.R. Studying the neurovascular unit: an improved blood-brain barrier model. J. Cereb. Blood Flow Metab. 2009, 29:1879-1884.
54. Zhang J., Takahashi H.K., Liu K., Wake H., Liu R., Maruo T., Date I., Yoshino T., Ohtsuka A., Mori S., Nishibori M. Anti-high mobility group box-1 monoclonal antibody protects the blood-brain barrier from ischemia-induced disruption in rats. Stroke 2011, 42:1420-1428.