Escherichia coli expressing EAST1 toxin did not cause an increase of cAMP or cGMP levels in cells, and no diarrhea in 5-day old gnotobiotic pigs

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Ruan, Xiaosai ^a   Crupper, Scott S ^b   Schultz, Bruce D ^c   Robertson, Donald C ^c   Zhang, Weiping ^a  

^a SOUTH DAKOTA STATE UNIVERSITY   (United States)

^b EMPORIA STATE UNIVERSITY   (United States)

^c KANSAS STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC GMP; ENTEROAGGREGATIVE HEAT STABLE TOXIN I; ESCHERICHIA COLI ENTEROTOXIN; HEAT LABILE TOXIN; HEAT STABLE TOXIN I; HEAT STABLE TOXIN II; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTA GENE; BACTERIAL COLONIZATION; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CELL LINE; CONTROLLED STUDY; DIARRHEA; ENTEROTOXIGENIC ESCHERICHIA COLI; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI INFECTION; GENE DOSAGE; GNOTOBIOTICS; NONHUMAN; PIGLET; TOXICITY TESTING; TOXIN ANALYSIS;

ANIMALS; BACTERIAL TOXINS; CELL LINE; CLONING, MOLECULAR; CYCLIC AMP; CYCLIC GMP; DIARRHEA; ENTEROTOXIGENIC ESCHERICHIA COLI; ENTEROTOXINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; PLASMIDS; PREVALENCE; SWINE; TIME FACTORS; VIRULENCE;

EID: 84865049059     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043203     Document Type: Article

References (54)

1. Black RE, Cousens S, Johnson HL, Lawn JE, Rudan I, et al. (2010) Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet 375: 1969-1987.
2. WHO (2006) Future directions for research on enterotoxigenic Escherichia coli vaccines for developing countries. Wkly Epidemiol Rec 81: 97-107.
3. USDA (2002) USDA:APHIS:VS, CEAH, Nat. Anim. Health Monitoring Syst. Part II: Reference for swine health and health management in the United States, 2000, Ft. Collins, CO.
4. Nataro JP, Kaper JB, (1998) Diarrheagenic Escherichia coli. Clinical microbiology reviews 11: 142-201.
5. Frydendahl K, (2002) Prevalence of serogroups and virulence genes in Escherichia coli associated with postweaning diarrhoea and edema disease in pigs and a comparison of diagnostic approaches. Veterinary microbiology 85: 169-182.
6. Zhang W, Zhao M, Ruesch L, Omot A, Francis D, (2007) Prevalence of virulence genes in Escherichia coli strains recently isolated from young pigs with diarrhea in the US. Veterinary microbiology 123: 145-152.
7. Berberov EM, Zhou Y, Francis DH, Scott MA, Kachman SD, et al. (2004) Relative importance of heat-labile enterotoxin in the causation of severe diarrheal disease in the gnotobiotic piglet model by a strain of enterotoxigenic Escherichia coli that produces multiple enterotoxins. Infection and immunity 72: 3914-3924.
8. Erume J, Berberov EM, Kachman SD, Scott MA, Zhou Y, et al. (2008) Comparison of the contributions of heat-labile enterotoxin and heat-stable enterotoxin b to the virulence of enterotoxigenic Escherichia coli in F4ac receptor-positive young pigs. Infection and immunity 76: 3141-3149.
9. Zhang W, Berberov EM, Freeling J, He D, Moxley RA, et al. (2006) Significance of heat-stable and heat-labile enterotoxins in porcine colibacillosis in an additive model for pathogenicity studies. Infection and immunity 74: 3107-3114.
10. Zhang W, Robertson DC, Zhang C, Bai W, Zhao M, et al. (2008) Escherichia coli constructs expressing human or porcine enterotoxins induce identical diarrheal diseases in a piglet infection model. Applied and environmental microbiology 74: 5832-5837.
11. Nishikawa Y, Zhou Z, Hase A, Ogasawara J, Cheasty T, et al. (2000) Relationship of genetic type of Shiga toxin to manifestation of bloody diarrhea due to enterohemorrhagic Escherichia coli serogroup O157 isolates in Osaka City, Japan. Journal of clinical microbiology 38: 2440-2442.
12. Harrington SM, Dudley EG, Nataro JP, (2006) Pathogenesis of enteroaggregative Escherichia coli infection. FEMS microbiology letters 254: 12-18.
13. Nataro JP, Kaper JB, Robins-Browne R, Prado V, Vial P, et al. (1987) Patterns of adherence of diarrheagenic Escherichia coli to HEp-2 cells. The Pediatric infectious disease journal 6: 829-831.
14. Tzipori S, Smith M, Birch C, Barnes G, Bishop R, (1983) Cryptosporidiosis in hospital patients with gastroenteritis. The American journal of tropical medicine and hygiene 32: 931-934.
15. Yamamoto T, Echeverria P, (1996) Detection of the enteroaggregative Escherichia coli heat-stable enterotoxin 1 gene sequences in enterotoxigenic E. coli strains pathogenic for humans. Infection and immunity 64: 1441-1445.
16. Howell A, Harland RN, Barnes DM, Hayward E, Redford J, et al. (1987) Endocrine therapy for advanced carcinoma of the breast: effect of tumor heterogeneity and site of biopsy on the predictive value of progesterone receptor estimations. Cancer research 47: 296-299.
17. Vial PA, Robins-Browne R, Lior H, Prado V, Kaper JB, et al. (1988) Characterization of enteroadherent-aggregative Escherichia coli, a putative agent of diarrheal disease. The Journal of infectious diseases 158: 70-79.
18. Bhan MK, Raj P, Levine MM, Kaper JB, Bhandari N, et al. (1989) Enteroaggregative Escherichia coli associated with persistent diarrhea in a cohort of rural children in India. The Journal of infectious diseases 159: 1061-1064.
19. Gascon J, Vargas M, Schellenberg D, Urassa H, Casals C, et al. (2000) Diarrhea in children under 5 years of age from Ifakara, Tanzania: a case-control study. Journal of clinical microbiology 38: 4459-4462.
20. Gascon J, Vargas M, Quinto L, Corachan M, Jimenez de Anta MT, et al. (1998) Enteroaggregative Escherichia coli strains as a cause of traveler's diarrhea: a case-control study. The Journal of infectious diseases 177: 1409-1412.
21. Itoh Y, Nagano I, Kunishima M, Ezaki T, (1997) Laboratory investigation of enteroaggregative Escherichia coli O untypeable:H10 associated with a massive outbreak of gastrointestinal illness. Journal of clinical microbiology 35: 2546-2550.
22. Fujihara S, Arikawa K, Aota T, Tanaka H, Nakamura H, et al. (2009) Prevalence and properties of diarrheagenic Escherichia coli among healthy individuals in Osaka City, Japan. Japanese journal of infectious diseases 62: 318-323.
23. Savarino SJ, McVeigh A, Watson J, Cravioto A, Molina J, et al. (1996) Enteroaggregative Escherichia coli heat-stable enterotoxin is not restricted to enteroaggregative E. coli. The Journal of infectious diseases 173: 1019-1022.
24. Dougan G, Sellwood R, Maskell D, Sweeney K, Liew FY, et al. (1986) In vivo properties of a cloned K88 adherence antigen determinant. Infection and immunity 52: 344-347.
25. Yamamoto T, Nakazawa M, (1997) Detection and sequences of the enteroaggregative Escherichia coli heat-stable enterotoxin 1 gene in enterotoxigenic E. coli strains isolated from piglets and calves with diarrhea. Journal of clinical microbiology 35: 223-227.
26. Choi C, Kwon D, Chae C, (2001) Prevalence of the enteroaggregative Escherichia coli heat-stable enterotoxin 1 gene and its relationship with fimbrial and enterotoxin genes in E. coli isolated from diarrheic piglets. Journal of veterinary diagnostic investigation: official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 13: 26-29.
27. Choi C, Cho W, Chung H, Jung T, Kim J, et al. (2001) Prevalence of the enteroaggregative Escherichia coli heat-stable enterotoxin 1 (EAST1) gene in isolates in weaned pigs with diarrhea and/or edema disease. Veterinary microbiology 81: 65-71.
28. Ngeleka M, Pritchard J, Appleyard G, Middleton DM, Fairbrother JM, (2003) Isolation and association of Escherichia coli AIDA-I/STb, rather than EAST1 pathotype, with diarrhea in piglets and antibiotic sensitivity of isolates. Journal of veterinary diagnostic investigation: official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 15: 242-252.
29. Noamani BN, Fairbrother JM, Gyles CL, (2003) Virulence genes of O149 enterotoxigenic Escherichia coli from outbreaks of postweaning diarrhea in pigs. Veterinary microbiology 97: 87-101.
30. Osek J, (2003) Detection of the enteroaggregative Escherichia coli heat-stable enterotoxin 1 (EAST1) gene and its relationship with fimbrial and enterotoxin markers in E. coli isolates from pigs with diarrhoea. Veterinary microbiology 91: 65-72.
31. Veilleux S, Dubreuil JD, (2006) Presence of Escherichia coli carrying the EAST1 toxin gene in farm animals. Veterinary research 37: 3-13.
32. Tzipori S, Montanaro J, Robins-Browne RM, Vial P, Gibson R, et al. (1992) Studies with enteroaggregative Escherichia coli in the gnotobiotic piglet gastroenteritis model. Infection and immunity 60: 5302-5306.
33. Sackett DL, (1980) Hypertension VI. Follow-up of the treated hypertensive patient. Can J Public Health 71: 225-230.
34. Paiva de Sousa C, Dubreuil JD, (2001) Distribution and expression of the astA gene (EAST1 toxin) in Escherichia coli and Salmonella. International journal of medical microbiology: IJMM 291: 15-20.
35. Savarino SJ, Fasano A, Watson J, Martin BM, Levine MM, et al. (1993) Enteroaggregative Escherichia coli heat-stable enterotoxin 1 represents another subfamily of E. coli heat-stable toxin. Proceedings of the National Academy of Sciences of the United States of America 90: 3093-3097.
36. Veilleux S, Holt N, Schultz BD, Dubreuil JD, (2008) Escherichia coli EAST1 toxin toxicity of variants 17-2 and O 42. Comparative immunology, microbiology and infectious diseases 31: 567-578.
37. Yamamoto T, Taneike I, (2000) The sequences of enterohemorrhagic Escherichia coli and Yersinia pestis that are homologous to the enteroaggregative E. coli heat-stable enterotoxin gene: cross-species transfer in evolution. FEBS letters 472: 22-26.
38. Francis DH, Willgohs JA, (1991) Evaluation of a live avirulent Escherichia coli vaccine for K88+, LT+ enterotoxigenic colibacillosis in weaned pigs. American journal of veterinary research 52: 1051-1055.
39. Kung M, Tachmes L, Birch SJ, Fernandez RJ, Abraham WM, et al. (1980) Hemodynamics at rest and during exercise in comfortable, hot and cold environments. Measurement with a rebreathing technique. Bulletin europeen de physiopathologie respiratoire 16: 429-441.
40. Zhang C, Zhang W, (2010) Escherichia coli K88ac fimbriae expressing heat-labile and heat-stable (STa) toxin epitopes elicit antibodies that neutralize cholera toxin and STa toxin and inhibit adherence of K88ac fimbrial E. coli. Clinical and vaccine immunology: CVI 17: 1859-1867.
41. Zhang W, Zhang C, Francis DH, Fang Y, Knudsen D, et al. (2010) Genetic fusions of heat-labile (LT) and heat-stable (ST) toxoids of porcine enterotoxigenic Escherichia coli elicit neutralizing anti-LT and anti-STa antibodies. Infection and immunity 78: 316-325.
42. Erickson AK, Willgohs JA, McFarland SY, Benfield DA, Francis DH, (1992) Identification of two porcine brush border glycoproteins that bind the K88ac adhesin of Escherichia coli and correlation of these glycoproteins with the adhesive phenotype. Infection and immunity 60: 983-988.
43. Som P, Atkins HL, Bandoypadhyay D, Fowler JS, MacGregor RR, et al. (1980) A fluorinated glucose analog, 2-fluoro-2-deoxy-D-glucose (F-18): nontoxic tracer for rapid tumor detection. J Nucl Med 21: 670-675.
44. Nishikawa Y, Ogasawara J, Helander A, Haruki K, (1999) An outbreak of gastroenteritis in Japan due to Escherichia coli O166. Emerging infectious diseases 5: 300.
45. Nataro JP, Deng Y, Cookson S, Cravioto A, Savarino SJ, et al. (1995) Heterogeneity of enteroaggregative Escherichia coli virulence demonstrated in volunteers. The Journal of infectious diseases 171: 465-468.
46. Bijlsma IG, de Nijs A, van der Meer C, Frik JF, (1982) Different pig phenotypes affect adherence of Escherichia coli to jejunal brush borders by K88ab, K88ac, or K88ad antigen. Infection and immunity 37: 891-894.
47. Sellwood R, Gibbons RA, Jones GW, Rutter JM, (1975) Adhesion of enteropathogenic Escherichia coli to pig intestinal brush borders: the existence of two pig phenotypes. Journal of medical microbiology 8: 405-411.
48. Zhang W, Robertson DC, Zhang C, Bai W, Zhao M, et al. (2008) Escherichia coli constructs expressing human or porcine enterotoxins induce identical diarrheal diseases in a piglet infection model. Appl Environ Microbiol 74: 5832-5837.
49. McVeigh A, Fasano A, Scott DA, Jelacic S, Moseley SL, et al. (2000) IS1414, an Escherichia coli insertion sequence with a heat-stable enterotoxin gene embedded in a transposase-like gene. Infection and immunity 68: 5710-5715.
50. Piva IC, Pereira AL, Ferraz LR, Silva RSN, Vieira AC, et al. (2003) Virulence markers of enteroaggregative Escherichia coli isolated from children and adults with diarrhea in Brasilia, Brazil. Journal of clinical microbiology 41: 1827-1832.
51. Greenberg DE, Jiang ZD, Steffen R, Verenker MP, DuPont HL, (2002) Markers of inflammation in bacterial diarrhea among travelers, with a focus on enteroaggregative Escherichia coli pathogenicity. The Journal of infectious diseases 185: 944-949.
52. Steiner TS, Lima AA, Nataro JP, Guerrant RL, (1998) Enteroaggregative Escherichia coli produce intestinal inflammation and growth impairment and cause interleukin-8 release from intestinal epithelial cells. The Journal of infectious diseases 177: 88-96.
53. Chaudhuri RR, Sebaihia M, Hobman JL, Webber MA, Leyton DL, et al. (2010) Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042. PloS one 5: e8801.
54. Yamamoto T, Wakisaka N, Sato F, Kato A, (1997) Comparison of the nucleotide sequence of enteroaggregative Escherichia coli heat-stable enterotoxin 1 genes among diarrhea-associated Escherichia coli. FEMS microbiology letters 147: 89-95.