The antioxidant effect of fermented papaya preparation involves iron chelation

Journal of Biological Regulators and Homeostatic Agents

Volumn 26, Issue 2, 2012, Pages 203-210

  Prus, E ^a   Fibach, Eitan ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Iron chelation; Iron overload; Oxidative stress

Indexed keywords

CARICA PAPAYA EXTRACT; FERROUS AMMONIUM SULFATE; FREE RADICAL; IRON; IRON DERIVATIVE; LABILE IRON POOL; REACTIVE OXYGEN METABOLITE; TRANSFERRIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; ERYTHROCYTE; FERMENTED PRODUCT; FLOW CYTOMETRY; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IRON BINDING CAPACITY; IRON BLOOD LEVEL; IRON CHELATION; IRON OVERLOAD; LIVER CELL; LIVER TOXICITY; MORBIDITY; MORTALITY; NONHUMAN; OXIDATIVE STRESS; PAPAYA; THALASSEMIA;

ANTIOXIDANTS; CARICA; DOSE-RESPONSE RELATIONSHIP, DRUG; FERMENTATION; FLOW CYTOMETRY; HUMANS; IRON; IRON CHELATING AGENTS; REACTIVE OXYGEN SPECIES;

EID: 84865046933     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Weinberg ED. The hazards of iron loading. Metallomics 2010; 2:732-40.
2. Porter JB, Shah FT. Iron overload in thalassemia and related conditions: therapeutic goals and assessment of response to chelation therapies. Hematol Oncol Clin North Am 2010; 24:1109-30.
3. Gardenghi S, Grady RW, Rivella S. Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in beta-thalassemia. Hematol Oncol Clin North Am 2010; 24:1089-107.
4. Ganz T, Nemeth E. Hepcidin and disorders of iron metabolism. Annu Rev Med 2011; 62:347-60.
5. Camaschella C, Poggiali E. Inherited disorders of iron metabolism. Curr Opin Pediatr 2011; 23:14-20.
6. Wang J, Pantopoulos K. Regulation of cellular iron metabolism. Biochem J 2011; 434:365-81.
7. Breuer W, Hershko C, Cabantchik ZI. The importance of non-transferrin bound iron in disorders of iron metabolism. Transfus Sci 2000; 23:185-92.
8. Konijn AM, Meyron-Holtz EG, Fibach E, Gelvan D. Cellular ferritin uptake: a highly regulated pathway for iron assimilation in human erythroid precursor cells. Adv Exp Med Biol 1994; 356:189-97. (Pubitemid 24348503)
9. Jacobs A. Low molecular weight intracellular iron transport compounds. Blood 1977; 50:433-9. (Pubitemid 8180426)
10. Prus E, Fibach E. The labile iron pool in human erythroid cells. Br J Haematol 2008; 142:301-7. (Pubitemid 351987327)
11. Fibach E, Rachmilewitz EA. The role of antioxidants and iron chelators in the treatment of oxidative stress in thalassemia. Ann NY Acad Sci 2010; 1202:10-16.
12. Avery SV. Molecular targets of oxidative stress. Biochem J 2011; 434:201-10.
13. Fibach E, Rachmilewitz E. The role of oxidative stress in hemolytic anemia. Curr Mol Med 2008; 8:609-19.
14. Kohgo Y, Ikuta K, Ohtake T, Torimoto Y, Kato J. Body iron metabolism and pathophysiology of iron overload. Int J Hematol 2008; 88:7-15.
15. Fraga CG, Galleano M, Verstraeten SV, Oteiza PI. Basic biochemical mechanisms behind the health benefits of polyphenols. Mol Aspects Med 2010; 31:435-45.
16. Perron NR, Brumaghim JL. A review of the antioxidant mechanisms of polyphenol compounds related to iron binding. Cell Biochem Biophys 2009; 53:75-100.
17. Marotta F, Chui DH, Jain S, Polimeni A, Koike K, Zhou L, Lorenzetti A, Shimizu H, Yang H. Effect of a fermented nutraceutical on thioredoxin level and TNF-alpha signalling in cirrhotic patients. J Biol Regul Homeost Agents 2011; 25:37-45.
18. Danese C, Esposito D, D'Alfonso V, Cirene M, Ambrosino M, Colotto M. Plasma glucose level decreases as collateral effect of fermented papaya preparation use. Clin Ter 2006; 157:195-8. (Pubitemid 44898212)
19. Marotta F, Koike K, Lorenzetti A, Naito Y, Fayet F, Shimizu H, Marandola P. Nutraceutical strategy in aging: targeting heat shock protein and inflammatory profile through understanding interleukin-6 polymorphism. Ann NY Acad Sci 2007; 1119:196-202. (Pubitemid 350191229)
20. Aruoma OI, Hayashi Y, Marotta F, Mantello P, Rachmilewitz E, Montagnier L. Applications and bioefficacy of the functional food supplement fermented papaya preparation. Toxicology 2010; 278:6-16.
21. Amer J, Goldfarb A, Rachmilewitz EA, Fibach E. Fermented papaya preparation as redox regulator in blood cells of beta-thalassemic mice and patients. Phytother Res 2008; 22:820-8. (Pubitemid 351955583)
22. Ghoti H, Rosenbaum H, Fibach E, Rachmilewitz EA. Decreased hemolysis following administration of antioxidant-fermented papaya preparation (FPP) to a patient with PNH. Ann Hematol 2010; 89:429-430.
23. Brittenham GM. Iron-chelating therapy for transfusional iron overload. N Engl J Med 2011; 364:146-56.
24. Rimbach G, Guo Q, Akiyama T, Matsugo S, Moini H, Virgili F, Packer L. Ferric nitrilotriacetate induced DNA and protein damage: inhibitory effect of a fermented papaya preparation. Anticancer Res 2000; 20:2907-14.
25. Knowles BB, Howe CC, Aden DP. Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science 1980; 209:497-99.
26. Kimes BW, Brandt BL. Properties of a clonal muscle cell line from rat heart. Exp Cell Res 1976; 98:367-81.
27. Fibach E, Tan ES, Jamuar S, Ng I, Amer J, Rachmilewitz EA. Amelioration of oxidative stress in red blood cells from patients with beta-thalassemia major and intermedia and E-beta-thalassemia following administration of a fermented papaya preparation. Phytother Res 2010; 24:1334-8.
28. Weston SA, Parish CR. New fluorescent dyes for lymphocyte migration studies. Analysis by flow cytometry and fluorescence microscopy. J Immunol Meth 1990; 133:87-97. (Pubitemid 20334488)
29. Shvartsman M, Fibach E, Cabantchik ZI. Transferriniron routing to the cytosol and mitochondria as studied by live and real-time fluorescence. Biochem J 2010; 429:185-93.
30. Bass DA, Parce JW, Dechatelet LR, Szejda P, Seeds MC, Thomas M. Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. J Immunol 1983; 130:1910-17. (Pubitemid 13091657)
31. Prus E, Fibach E. Flow cytometry measurement of the labile iron pool in human hematopoietic cells. Cytometry A 2008; 73:22-7.
32. Murphy CJ, Oudit GY. Iron-overload cardiomyopathy: pathophysiology, diagnosis, and treatment. J Card Fail 2010; 16:888-900.
33. Ramm GA, Ruddell RG. Iron homeostasis, hepatocellular injury, and fibrogenesis in hemochromatosis: the role of inflammation in a noninflammatory liver disease. Semin Liver Dis 2010; 30:271-87.
34. Rivella S. Ineffective erythropoiesis and thalassemias. Curr Opin Hematol 2009; 16:187-94.