Effect of a fermented nutraceutical on thioredoxin level and TNF-α signalling in cirrhotic patients

Journal of Biological Regulators and Homeostatic Agents

Volumn 25, Issue 1, 2011, Pages 37-45

  Marotta, F ^a   Chui, D H ^b   Jain, S ^c   Polimeni, A ^a   Koike, K ^d   Zhou, L ^b   Lorenzetti, A ^a   Shimizu, H ^d   Yang, H ^b  

^a ReGenera Research Group for Aging Intervention   (Italy)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d Osato Research Institute and Bioscience Lab   (Japan)

Author keywords

Fermented papaya preparation; Liver cirrhosis; Reactive oxygen species; Thioredoxin; TNF

Indexed keywords

ALPHA TOCOPHEROL; FERMENTED PAPAYA PREPARATION; GLUTATHIONE; GLUTATHIONE DISULFIDE; LIPOPOLYSACCHARIDE; MESSENGER RNA; NUTRACEUTICAL; THIOREDOXIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIOXIDANT;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DIET; DOWN REGULATION; HUMAN; HUMAN CELL; INFLAMMATION; LIFESTYLE; LIVER CIRRHOSIS; MONOCYTE; OXIDATION REDUCTION REACTION; UPREGULATION; BLOOD; CLINICAL TRIAL; DIET SUPPLEMENTATION; DRUG EFFECT; FEMALE; HEPATITIS B; HEPATITIS C; MALE; METABOLISM; MIDDLE AGED; PAPAYA; SIGNAL TRANSDUCTION; TIME;

CARICA PAPAYA; HEPATITIS C VIRUS;

AGED; ALPHA-TOCOPHEROL; ANTIOXIDANTS; CARICA; DIETARY SUPPLEMENTS; FEMALE; GLUTATHIONE; HEPATITIS B; HEPATITIS C; HUMANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; MONOCYTES; OXIDATION-REDUCTION; SIGNAL TRANSDUCTION; THIOREDOXINS; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 79955654438     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Lamb RE, Goldstein BJ. Modulating an oxidative-inflammatory cascade: potential new treatment strategy for improving glucose metabolism, insulin resistance, and vascular function. Int J Clin Pract 2008; 62:1087-95. (Pubitemid 351793598)
2. Kundu JK, Surh YJ. Inflammation: gearing the journey to cancer. Mutat Res 2008; 659:15-30.
3. Yoshida T, Oka S, Masutani H, Nakamura H, Yodoi J. The role of thioredoxin in the aging process: involvement of oxidative stress. Antioxid Redox Signal 2003; 5:563-70. (Pubitemid 37315143)
4. Noguchi T, Takeda K, Matsuzawa A, Saegusa K, Nakano H, Gohda J, Inoue J, Ichijo H. Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death. J Biol Chem 2005; 280:37033-40. (Pubitemid 41587787)
5. Sengupta R, Ryter SW, Zuckerbraun BS, Tzeng E, Billiar TR, Stoyanovsky DA. Thioredoxin catalyzes the denitrosation of low-molecular mass and protein S-nitrosothiols. Biochemistry 2007; 46:8472-83. (Pubitemid 47075984)
6. Koháryová M, Kolárová M. Oxidative stress and thioredoxin system. Gen Physiol Biophys 2008; 27:71-84.
7. Nakashima T, Sumida Y, Furutani M, Hirohama A, Okita M, Mitsuyoshi H, Itoh Y, Okanoue T. Elevation of serum thioredoxin levels in patients with non-alcoholic steatohepatitis. Hepatol Res 2005; 33:135-7. (Pubitemid 41799791)
8. Sumida Y, Nakashima T, Yoh T, et al. Serum thioredoxin levels as an indicator of oxidative stress in patients with hepatitis C virus infection. J Hepatol. 2000; 33:616-22.
9. Kato A, Odamaki M, Nakamura H, Yodoi J, Hishida A. Elevation of blood thioredoxin in hemodialysis patients with hepatitis C virus infection. Kidney Int 2003; 63:2262-8. (Pubitemid 36605840)
10. Lau AT, Wang Y, Chiu JF. Reactive oxygen species: current knowledge and applications in cancer research and therapeutic. J Cell Biochem 2008; 104:657-67. (Pubitemid 351671652)
11. Chuma M, Hige S, Nakanishi M, Ogawa K, Natsuizaka M, Yamamoto Y, Asaka M. 8-Hydroxy-2′-deoxy-guanosine is a risk factor for development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection. J Gastroenterol Hepatol 2008; 23:1431-6.
12. Oettl K, Stadibauer V, Petter F, Greilberger J, Putz-Bankuti C, Hallström S, Lackner C, Stauber RE. Oxidative damage of albumin in advanced liver disease. Biochim Biophys Acta 2008; 1782:469-73.
13. Tanaka H, Fujita N, Sugimoto R, et al. Hepatic oxidative DNA damage is associated with increased risk for hepatocellular carcinoma in chronic hepatitis C. Br J Cancer 2008; 98:580-6. (Pubitemid 351214532)
14. Tazi KA, Quioc JJ, Saada V, Bezeaud A, Lebrec D, Moreau R. Upregulation of TNF-alpha production signaling pathways in monocytes from patients with advanced cirrhosis: possible role of Akt and IRAK-M. J Hepatol 2006; 45:280-9. (Pubitemid 44026567)
15. Aruoma OI, Colognato R, Fontana I, et al. Molecular effects of fermented papaya preparation on oxidative damage, MAP Kinase activation and modulation of the benzo[a]pyrene mediated genotoxicity. Biofactors 2006; 26:147-59. (Pubitemid 43979366)
16. Osato JA, Korkina LG, Santiago AL, Afanas'ev I. Effects of fermented papaya preparation on free radical production by human blood neutrophils, erythrocytes and rat peritoneal macrophages. Nutrition 1995; 11:568-72. (Pubitemid 26006226)
17. Marotta F, Yoshida C, Barreto R, Naito Y, Packer L. Oxidative- inflammatory damage in cirrhosis: effect of vitamin E and a fermented papaya preparation. J Gastroenterol Hepatol 2007; 22:697-703. (Pubitemid 46608394)
18. Adinolfi LE, Durante-Mangoni E, Zampino R, Ruggiero G. Review article: hepatitis C virus-associated steatosis - pathogenic mechanisms and clinical implications. Aliment Pharmacol Ther 2005; 22(S)2:52-55.
19. Subar AF, Thompson FE, Kipnis V, Midthune D, Hurwitz P, McNutt S, Mcintosh A, Rosenfeld S. Comparative validation of the Block, Willett, and National Cancer Institute food frequency questionnaires: the Eating at America's Table Study. Am J Epidemiol 2001; 154:1089-99. (Pubitemid 33140629)
20. Esterbauer H, Cheeseman KH. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Meth Enzymol 1990; 186:407-21. (Pubitemid 20279982)
21. Urtasun R, de la Rosa LC, Nieto N. Oxidative and nitrosative stress and fibrogenic response. Clin Liver Dis 2008; 12:769-90.
22. Nakamura H. Extracellular functions of thioredoxin.Novartis Found Symp 2008; 291:184-92.
23. Rigobello MP, Vianello F, Folda A, Roman C, Scutari G, Bindoli A. Differential effect of calcium ions on the cytosolic and mitochondrial thioredoxin reductase. Biochem Biophys Res Commun 2006; 343:873-8.
24. Okuyama H, Son A, Ahsan MK, Masutani H, Nakamura H, Yodoi J. Thioredoxin and thioredoxin binding protein 2 in the liver. IUBMB Life 2008; 60:656-60.
25. Mahmood S, Yamada G, Niiyama G, et al. Effect of vitamin E on serum aminotransferase and thioredoxin levels in patients with viral hepatitis C. Free Radic Res 2003; 37:781-5. (Pubitemid 36626438)
26. Takagi H, Kakizaki S, Sohara N, et al. Pilot clinical trial of the use of alpha-tocopherol for the prevention of hepatocellular carcinoma in patients with liver cirrhosis. Int J Vitam Nutr Res 2003; 73:411-5. (Pubitemid 38009807)
27. Saeki T, Ichiba M, Tanabe N, et al. Expression of oxidative stress-related molecules in circulating leukocytes and urine in patients with chronic viral hepatitis. Liver Int 2006; 26:157-65.
28. Hamano K, Seo Y, Kato H, Kato M, Yano Y, Ninomiya T, Kasuga M. Expression of thioredoxin and thioredoxin-binding protein-2 in the liver of patients with chronic hepatitis C as a predictor of response to interferon therapy. Int J Mol Med 2006; 17:989-95.
29. Kang SW, Chae HZ, Seo MS, Kim K, Baines IC, Rhee SG. Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha. J Biol Chem 1998; 273:6297-302. (Pubitemid 28144719)
30. Sumida Y, Nakashima T, Yoh T, et al. Serum thioredoxin elucidates the significance of serum ferritin as a marker of oxidative stress in chronic liver diseases. Liver 2001; 21:295-9. (Pubitemid 32910553)
31. Mitsuyoshi H, Itoh Y, Sumida Y, Minami M, Yasui K, Nakashima T, Okanoue T. Evidence of oxidative stress as a cofactor in the development of insulin resistance in patients with chronic hepatitis C. Hepatol Res 2008; 38:348-53. (Pubitemid 351321177)
32. Danese C, Esposito D, D'Alfonso V, Cirene M, Ambrosino M, Colotto M. Plasma glucose level decreases as collateral effect of fermented papaya preparation use. Clin Ter 2006; 157:195-8. (Pubitemid 44898212)
33. Nakashima T, Sumida Y, Yoh T, et al. Thioredoxin levels in the sera of untreated viral hepatitis patients and those treated with glycyrrhizin or ursodeoxycholic acid. Antioxid Redox Signal 2000; 2:687-94. (Pubitemid 32062320)