Antiulcer activity of cod liver oil in rats

Indian Journal of Pharmacology

Volumn 40, Issue 5 SUPPL., 2008, Pages 209-214

  Khare, Salaj ^a   Asad, Mohammed ^a   Dhamanigi, Sunil ^a   Prasad, V ^b  

^a KRUPANIDHI COLLEGE OF PHARMACY   (India)

^b MNR Medical College   (India)

Author keywords

Cod liver oil; Duodenal ulcer; Gastric cytoprotection; Gastric secretion; Gastric ulcer

Indexed keywords

ACETIC ACID; ALCOHOL; CATALASE; COD LIVER OIL; INDOMETACIN; MERCAPTAMINE; MISOPROSTOL; MUCIN; PEPSIN A; PROTEIN; RANITIDINE; SUPEROXIDE DISMUTASE; ANTIULCER AGENT; AZAPERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIULCER ACTIVITY; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; DRUG PURITY; DUODENUM ULCER; IMMOBILIZATION STRESS; LOW DRUG DOSE; MALE; NONHUMAN; PYLORUS LIGATION; RAT; STOMACH ULCER; STRESS ULCER; TREATMENT DURATION; ULCER HEALING; DISEASE MODEL; DRUG EFFECT; STOMACH PROTECTION; STOMACH SECRETION; TREATMENT OUTCOME;

EID: 57349185797     PISSN: 02537613     EISSN: 19983751     Source Type: Journal    
DOI: 10.4103/0253-7613.44152     Document Type: Article

References (48)

1. Zamora A. Fatty acid composition of some common edible fats and oils. Available from: http://www.scientificpsychic.com. [last retrieved on 2005 Oct 16].
2. Wilton P. Cod-liver oil, vitamin D and the fight against rickets. CMAJ 1995;152:1516-7.
3. Olafsson SO, Hallgrimsson J, Gudbjarnason S. Dietary cod liver oil decreases arachidonic acid in rat gastric mucosa and increases stress-induced gastric erosions. Lipids 2000;35:601-5.
4. Manjari V, Das UN. Effect of polyunsaturated fatty acids on dexamethasone-induced gastric mucosal damage. Prostagland Leukot Essent Fatty Acids 2000;62:85-96.
5. Zaror-Behrens G, Mueller R, Greselin E, Behrens WA. Lack of vitamin E cytoprotective effects on indomethacin-induced gastric lesions. Res Commun Chem Pathol Pharmacol 1991;72:327-35.
6. Available from: http://www.mercola.com/forms/faq/carlsons.htm. [last retrieved on 2008 Aug 21].
7. Available from: http://en.wikipedia.org/wiki/Cod_liver_oil. [last retrieved on 2008 Aug 21].
8. Bernhard W, Postle AD, Linck M, Sewing KF. Rat gastric hydrophobic barrier: Modulation of phosphatidylcholine molecular species by dietary lipids. Lipids 1996;31:507-11.
9. British pharmacopoeia 1988;1:123.
10. United States Pharmacopoeia 2006; p-571.
11. Indian Pharmacopoeia 1996;2:A62-3.
12. Okabe S, Pfeiffer CJ, Roth JL. Experimental production of duodenal and antral ulcers in rats. Fed Proc 1970;29:255.
13. Asad M, Shewade DG, Koumaravelou K, Abraham BK, Vasu S, Ramaswamy S. Gastric anti-secretary anti-ulcer activity of oxytocin in rats and guinea pigs. Life Sci 2001;70:17-24.
14. el Tahir KE, Hamad EA, Ageel AM, Abu Nasif MA, Gadkarim EA. Effects of sesame and cod liver oils on prostacyclin synthesis by the rat thoracic aorta. Arch Int Pharmacodyn Ther 1988;292:182-8.
15. Ganguly AK. A method for quantitative assement of experimentally produced ulcers in stomach of rats. Experientia 1969;25:1124.
16. Shay H, Komarov SA, Fele SS, Meranze D, Gruenstein H, Siplet H. A simple method for uniform production of gastric ulceration in rat. Gastroenterology 1945;5:43-61.
17. Kulkarni SK. Hand book of experimental pharmacology. 3rd ed. New Delhi: Vallabh Prakashan; 1999. p. 148-50.
18. Hawk PB, Oser BL, Summerson HW. Practical physiological chemistry. 12th ed. London: Churchill; 1947. p. 347.
19. Debnath PK, Gode KO, Govinda DD, Sanyal AK. Effect of propranolol on gastric secretion in rats. Br J Pharmacol 1974;51:213-6.
20. Lowry CH, Roseborough NI, Farr AL, Randall RJ. Protein measurement with folin phenol reagent. J Biol Chem 1951;193:265-75.
21. Corne SJ, Morrissey SM, Woods RJ. A method for the quantitative estimation of gastric barrier mucus. J Physiol 1974;242:116-7.
22. Brzozowski T, Konturek SJ, Kwiecien S, Pajdo R, Brzozowski I, Hahn EG, et al. Involvement of endogenous cholecystokinin and somatostatin in gastro protection induced by intra duodenal fat. J Clin Gastroenterol 1998;27:125-37.
23. Majumdar B, Chaudhri SG, Ray A, Bandyopadhyay SK. Effect of ethanol extract of piper betle linn leaf on healing of NSAID-induced experimental ulcer-A novel role of free radical scavenging action. Indian J Exp Biol 2003;41:311-5.
24. Elstner EF, Heupel A. Inhibition of nitrite formation from hydroxyl ammonium chloride: A simple assay for super oxide dismutase. Anal Biochem 1976;70:616-20.
25. Eva ML. Mechanism of pH dependent hydrogen per oxide cytotoxicity invitro. Arch Biochem Biophy 1988;365:362-72.
26. Lacy ER, Hund P 3rd, Tietge J. Effects of misoprostol, cimetidine and ethanol on rat gastric plasma volume and morphology. J Clin Gastroenterol 1990;12:S158-69.
27. Parmar NS, Desai JK. A review of the current methodology for the evaluation of gastric and duodenal anti ulcer agents. Indian J Pharmacol 1993;25:120-35.
28. Vincent GP, Galvin GB, Rutkowski JL, Pare W. Body orientation, food deprivation and potentiation of restraint induced gastric lesions. Gastroenterol Clin Biol 1977;1:539-43.
29. Szabo S. Animal model for human disease: Duodenal ulcer disease. Am J Pathol 1978;73:273-6.
30. Desai JK, Goyal RK, Parmar NS. Characterization of dopamine receptor subtypes involved in experimentally induced gastric and duodenal ulcers in rats. J Pharm Pharmacol 1999;51:187-92.
31. Okabe S, Roth JL, Pfeiffer CJ. Differential healing periods of the acetic acid ulcer model in rats and cats. Experientia 1971;27:146-8.
32. Soll AH. Pathogenesis of peptic ulcers and implication for therapy. N Engl J Med 1990;322:909-16.
33. Surendra S. Evaluation of gastric anti-ulcer activity of fixed oil of tulsi and possible mechanism. Indian J Exp Biol 1999;36:253-7.
34. Vedavyasa S. Gastric mucosal cellular changes induced by indomethacin in male albino rats. Indian J Exp Biol 1999;37:365-9.
35. Peters MN, Richardson CT. Stressful life events, acid hyper secretion and ulcer disease. Gastroenterology 1983;84:114-9.
36. Brodie DA, Hanson HM. A study of the factors involved in the production of gastric ulcers by the restraint technique. Gastroenterology 1960;38:353-60.
37. Güzel C, Ulak G, Sermet A, Ci̧ek R, Ulak M. Effect of fish oil on indometacin-induced gastric lesions in rats. Arzneimittelforschung 1995;45:1172-3.
38. Riber C, Wojdemann M, Bisgaard T, Ingels H, Rehfeld JF, Olsen O. Fish oil reduces gastric acid secretion. Scand J Gastroenterol 1999;34:845-8.
39. Stenson WF, Cort D, Rodgers J, Burakoff R, DeSchryver-Kecskemeti K, Gramlich TL, et al. Dietary supplementation with fish oil in ulcerative colitis. Ann Intern Med 1992;11:609-14.
40. Al-Meshal MA, Lutfi KM, Tariq M. Cod liver oil inhibits indomethacin induced gastropathy without affecting its bioavailability and pharmacological activity. Life Sci 1991;48:1401-9.
41. Al-Harbi MM, Islam MW, al-Shabanah OA, al-Gharably NM. Effect of acute administration of fish oil (omega-3 marine triglyceride) on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats. Food Chem Toxicol 1995;33:553-8.
42. Takada H, Takahashi M, Takada H, Kuwayama H, Souma R. Omega.3 polyunsaturated fatty acid and ulcer healing. Dokkyo J Med Sci 2004;31:17-223.
43. Hasan E, Ersin F, Salih O, Sadik S, Birsen O, Omer A, et al. Effect of fish oil supplementation on plasma oxidant/antioxidant status in rats. Prostagland Leukot Essent Fatty Acids 2004;71:149-52.
44. Bhattacharya A, Ghosal S, Bhattacharya SK. Effect of fish oil on offensive and defensive factors in gastric ulceration in rats. Food Chem Toxicol 1995;33:553-8.
45. Ulak G, Ci̧ek R, Sermet A, Guzel C, Ulak M, Denli O. Protective effect of fish oil against stress-induced gastric injury in rats. Arzneimittelforschung 1995;45:1174-5.
46. Shimizu T, Suzuki M, Lee T, Igarashi J, Kaneko K, Yamashiro Y. Effects of n-3 polyunsaturated fatty acids on indomethacin-induced changes in eicosanoid production and blood flow in the gastric mucosa of rats. Prostagland Leukot Essent Fatty Acids 2003;69:33-7.
47. Grant HW, Palmer KR, Riermesma RR, Oliver MF. Duodenal ulcer is associated with low dietary linoleic acid intake. Gut 1990;31:997-8.
48. Hünkar T, Aktan F, Ceylan A, Karasu C; Antioxidants in Diabetes-Induced Complications (ADIC) Study Group. Effects of cod liver oil on tissue antioxidant pathways in normal and streptozotocin-diabetic rats. Cell Biochem Funct 2002;20:297-302.