Detection of pancreatic cancer tumours and precursor lesions by cathepsin E activity in mouse models

Gut

Volumn 61, Issue 9, 2012, Pages 1315-1322

  Cruz Monserrate, Zobeida ^a   Abd Elgaliel, Wael R ^b   Grote, Tobias ^a   Deng, Defeng ^a   Ji, Baoan ^a   Arumugam, Thiruvengadam ^a   Wang, Huamin ^a   Tung, Ching Hsuan ^b   Logsdon, Craig D ^a,c  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN E; TUMOR MARKER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER DIAGNOSIS; CARCINOGENESIS; DIAGNOSTIC IMAGING; EARLY DIAGNOSIS; ENZYME ACTIVITY; EX VIVO STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; XENOGRAFT;

ANIMALS; CARCINOMA IN SITU; CARCINOMA, PANCREATIC DUCTAL; CATHEPSIN E; CELL LINE, TUMOR; DIAGNOSTIC IMAGING; DISEASE MODELS, ANIMAL; DNA PRIMERS; EARLY DIAGNOSIS; FEASIBILITY STUDIES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; OLIGONUCLEOTIDE PROBES; PANCREATIC NEOPLASMS; PRECANCEROUS CONDITIONS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 84865008800     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2011-300544     Document Type: Article

References (40)

1. Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010. CA Cancer J Clin 2010;60:277-300.
2. Yeo CJ, Cameron JL, Sohn TA, et al. Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications, and outcomes. Ann Surg 1997;226:248-60.
3. Harsha HC, Kandasamy K, Ranganathan P, et al. A compendium of potential biomarkers of pancreatic cancer. PLoS Med 2009;6:e1000046.
4. Krishna NB, Mehra M, Reddy AV, et al. EUS/EUS-FNA for suspected pancreatic cancer: influence of chronic pancreatitis and clinical presentation with or without obstructive jaundice on performance characteristics. Gastrointest Endosc 2009;70:70-9.
5. Varadarajulu S, Tamhane A, Eloubeidi MA. Yield of EUS-guided FNA of pancreatic masses in the presence or the absence of chronic pancreatitis. Gastrointest Endosc 2005;62:728-36. (Pubitemid 41503000)
6. Goggins M. Markers of pancreatic cancer: working toward early detection. Clin Cancer Res 2011;17:635-7.
7. Goggins M. Identifying molecular markers for the early detection of pancreatic neoplasia. Semin Oncol 2007;34:303-10. (Pubitemid 47176618)
8. Hawes RH, Xiong Q, Waxman I, et al. A multispecialty approach to the diagnosis and management of pancreatic cancer. Am J Gastroenterol 2000;95:17-31. (Pubitemid 30041530)
9. Chari ST. Detecting early pancreatic cancer: problems and prospects. Semin Oncol 2007;34:284-94. (Pubitemid 47176620)
10. Abd-Elgaliel WR, Cruz-Monserrate Z, Logsdon CD, et al. Molecular imaging of Cathepsin E-positive tumours in mice using novel protease-activatable fluorescent probe. Mol Biosyst 2011;7:3207-13.
11. Sakai H, Saku T, Kato Y, et al. Quantitation and immunohistochemical localisation of cathepsins E and D in rat tissues and blood cells. Biochim Biophys Acta 1989;991:367-75. (Pubitemid 19136744)
12. Sastradipura DF, Nakanishi H, Tsukuba T, et al. Identification of cellular compartments involved in processing of cathepsin E in primary cultures of rat microglia. J Neurochem 1998;70:2045-56. (Pubitemid 28207829)
13. Chain BM, Free P, Medd P, et al. The expression and function of cathepsin E in dendritic cells. J Immunol 2005;174:1791-800. (Pubitemid 40223918)
14. Finzi G, Cornaggia M, Capella C, et al. Cathepsin E in follicle associated epithelium of intestine and tonsils: localisation to M cells and possible role in antigen processing. Histochemistry 1993;99:201-11. (Pubitemid 23103534)
15. Kageyama T, Takahashi K. A cathepsin D-like acid proteinase from human gastric mucosa. Purification and characterization. J Biochem 1980;87:725-35. (Pubitemid 10119671)
16. Yoshimine Y, Tsukuba T, Isobe R, et al. Specific immunocytochemical localisation of cathepsin E at the ruffled border membrane of active osteoclasts. Cell Tissue Res 1995;281:85-91.
17. Prasad NB, Biankin AV, Fukushima N, et al. Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells. Cancer Res 2005;65:1619-26. (Pubitemid 40478583)
18. Azuma T, Yamada M, Murakita H, et al. Cathepsin E expressed in pancreatic cancer. Adv Exp Med Biol 1995;362:363-6.
19. Uno K, Azuma T, Nakajima M, et al. Clinical significance of cathepsin E in pancreatic juice in the diagnosis of pancreatic ductal adenocarcinoma. J Gastroenterol Hepatol 2000;15:1333-8.
20. Peiper M, Nagoshi M, Patel D, et al. Human pancreatic cancer cells (MPanc-96) recognized by autologous tumour-infiltrating lymphocytes after in vitro as well as in vivo tumour expansion. Int J Cancer 1997;71:993-9. (Pubitemid 27252882)
21. Ji B, Tsou L, Wang H, et al . Ras activity levels control the development of pancreatic diseases. Gastroenterology 2009;137:1072-82.
22. Jackson EL, Willis N, Mercer K, et al. Analysis of lung tumour initiation and progression using conditional expression of oncogenic K-ras. Genes Dev 2001;15:3243-8. (Pubitemid 34008190)
23. Jonkers J, Meuwissen R, van der Gulden H, et al. Synergistic tumour suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet 2001;29:418-25. (Pubitemid 34326692)
24. Hingorani SR, Petricoin EF, Maitra A, et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 2003;4:437-50. (Pubitemid 38050041)
25. Olive KP, Tuveson DA. The use of targeted mouse models for preclinical testing of novel cancer therapeutics. Clin Cancer Res 2006;12:5277-87. (Pubitemid 44497240)
26. Bardeesy N, Aguirre AJ, Chu GC, et al . Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A 2006;103:5947-52.
27. Kim MP, Evans DB, Wang H, et al. Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient mice. Nat Protoc 2009;4:1670-80.
28. Tung CH, Bredow S, Mahmood U, et al. Preparation of a cathepsin D sensitive nearinfrared fluorescence probe for imaging. Bioconjug Chem 1999;10:892-6. (Pubitemid 29456379)
29. Abd-Elgaliel WR, Tung CH. Selective detection of cathepsin E proteolytic activity. Biochim Biophys Acta 2010;1800:1002-8.
30. von Burstin J, Eser S, Seidler B, et al. Highly sensitive detection of early-stage pancreatic cancer by multimodal near-infrared molecular imaging in living mice. Int J Cancer 2008;123:2138-47.
31. Eser S, Messer M, Eser P, et al. In vivo diagnosis of murine pancreatic intraepithelial neoplasia and early-stage pancreatic cancer by molecular imaging. Proc Natl Acad Sci U S A 2011;108:9945-50.
32. Gounaris E, Tung CH, Restaino C, et al. Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. PLoS One 2008;3:e2916.
33. Bogdanov AA Jr, Lin CP, Simonova M, et al. Cellular activation of the self-quenched fluorescent reporter probe in tumour microenvironment. Neoplasia 2002;4:228-36. (Pubitemid 34525254)
34. Funovics M, Weissleder R, Tung CH. Protease sensors for bioimaging. Anal Bioanal Chem 2003;377:956-63. (Pubitemid 40877826)
35. Bausch D, Thomas S, Mino-Kenudson M, et al . Plectin-1 as a novel biomarker for pancreatic cancer. Clin Cancer Res 2010;17:302-9.
36. Kelly KA, Bardeesy N, Anbazhagan R, et al. Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma. PLoS Med 2008;5:e85.
37. Flores LG, Bertolini S, Yeh HH, et al. Detection of pancreatic carcinomas by imaging lactose-binding protein expression in peritumoral pancreas using [18F]fluoroethyldeoxylactose PET/CT. PLoS One 2009;4:e7977.
38. Fendrich V, Schneider R, Maitra A, et al. Detection of precursor lesions of pancreatic adenocarcinoma in PETeCT in a genetically engineered mouse model of pancreatic cancer. Neoplasia 2011;13:180-6.
39. Izuishi K, Yamamoto Y, Sano T, et al. Impact of 18-fluorodeoxyglucose positron emission tomography on the management of pancreatic cancer. J Gastrointest Surg 2010;14:1151-8.
40. Yang L, Mao H, Cao Z, et al. Molecular imaging of pancreatic cancer in an animal model using targeted multifunctional nanoparticles. Gastroenterology 2009;136:1514-25 e2.