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Volumn 66, Issue 4, 2012, Pages 317-324

Novel domain-selective ACE-inhibiting activity of synthetic growth hormone secretagogues

Author keywords

Amyloid; ACE inhibitors; Alzheimer's dementia; EP80317; Ghrelin; Vascular dementia

Indexed keywords

ALDOSTERONE; AMYLOID BETA PROTEIN; ANGIOTENSIN; CD36 ANTIGEN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DESACYL GHRELIN; DIPEPTIDYL CARBOXYPEPTIDASE; ENALAPRIL; EP 80317; GHRELIN; GHRELIN RECEPTOR; GROWTH HORMONE SECRETAGOGUE; HEXARELIN; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; IBUTAMOREN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RENIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84864998047     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2012.06.006     Document Type: Article
Times cited : (10)

References (52)
  • 4
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 402 1999 656 660 (Pubitemid 129516334)
    • (1999) Nature , vol.402 , Issue.6762 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 5
    • 73449090824 scopus 로고    scopus 로고
    • Ghrelin gene products and the regulation of food intake and gut motility
    • C.Y. Chen, A. Asakawa, M. Fujimiya, S.D. Lee, and A. Inui Ghrelin gene products and the regulation of food intake and gut motility Pharmacological Review 61 2009 430 481
    • (2009) Pharmacological Review , vol.61 , pp. 430-481
    • Chen, C.Y.1    Asakawa, A.2    Fujimiya, M.3    Lee, S.D.4    Inui, A.5
  • 6
    • 29144466031 scopus 로고    scopus 로고
    • Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man
    • DOI 10.1016/j.cardiores.2005.09.001, PII S0008636305004360
    • M.J. Kleinz, J.J. Maguire, J.N. Skepper, and A.P. Davenport Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man Cardiovascular Research 69 2006 227 235 (Pubitemid 41814824)
    • (2006) Cardiovascular Research , vol.69 , Issue.1 , pp. 227-235
    • Kleinz, M.J.1    Maguire, J.J.2    Skepper, J.N.3    Davenport, A.P.4
  • 9
    • 33747231180 scopus 로고    scopus 로고
    • Novel angiotensin I-converting enzyme inhibitory peptides isolated from alcalase hydrolysate of mung bean protein
    • G.H. Li, J.Z. Wan, G.W. Le, and Y.H. Shi Novel angiotensin I-converting enzyme inhibitory peptides isolated from alcalase hydrolysate of mung bean protein Journal of Peptide Science 12 2006 509 514
    • (2006) Journal of Peptide Science , vol.12 , pp. 509-514
    • Li, G.H.1    Wan, J.Z.2    Le, G.W.3    Shi, Y.H.4
  • 11
    • 0042490795 scopus 로고    scopus 로고
    • Roles of the two active sites of somatic angiotensin-converting enzyme in the cleavage of angiotensin I and bradykinin insights from selective inhibitors
    • DOI 10.1161/01.RES.0000081593.33848.FC
    • D. Georgiadis, F. Beau, B. Czarny, J. Cotton, A. Yiotakis, and V. Dive Roles of the two active sites of somatic angiotensin-converting enzyme in the cleavage of angiotensin I and bradykinin: insights from selective inhibitors Circulation Research 93 2003 148 154 (Pubitemid 36919702)
    • (2003) Circulation Research , vol.93 , Issue.2 , pp. 148-154
    • Georgiadis, D.1    Beau, F.2    Czarny, B.3    Cotton, J.4    Yiotakis, A.5    Dive, V.6
  • 14
    • 0028872740 scopus 로고
    • Differential degeneration of the cerebral microvasculature in Alzheimer's disease
    • R.N. Kalaria, and P. Hedera Differential degeneration of the cerebral microvasculature in Alzheimer's disease Neuroreport 6 1995 477 480
    • (1995) Neuroreport , vol.6 , pp. 477-480
    • Kalaria, R.N.1    Hedera, P.2
  • 17
    • 0036077536 scopus 로고    scopus 로고
    • Amyloid catabolism: Roles for neprilysin (NEP) and other metallopeptidases?
    • DOI 10.1046/j.1471-4159.2002.00855.x
    • J.A. Carson, and A.J. Turner Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases Journal of Neurochemistry 81 2002 1 8 (Pubitemid 34808849)
    • (2002) Journal of Neurochemistry , vol.81 , Issue.1 , pp. 1-8
    • Carson, J.A.1    Turner, A.J.2
  • 19
    • 27844534846 scopus 로고    scopus 로고
    • Amyloid -protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor
    • DOI 10.1074/jbc.M508460200
    • M.L. Hemming, and D.J. Selkoe Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor Journal of Biological Chemistry 280 2005 37644 37650 (Pubitemid 41642372)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.45 , pp. 37644-37650
    • Hemming, M.L.1    Selkoe, D.J.2
  • 20
    • 0035930538 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta); Retards A beta aggregation, deposition, fibril formation; And inhibits cytotoxicity
    • J. Hu, A. Igarashi, M. Kamata, and H. Nakagawa Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity Journal of Biological Chemistry 276 2001 47863 47868
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 47863-47868
    • Hu, J.1    Igarashi, A.2    Kamata, M.3    Nakagawa, H.4
  • 21
    • 0035816707 scopus 로고    scopus 로고
    • Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme
    • E.A. Eckman, D.K. Reed, and C.B. Eckman Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme Journal of Biological Chemistry 276 2001 24540 24548
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 24540-24548
    • Eckman, E.A.1    Reed, D.K.2    Eckman, C.B.3
  • 22
    • 0029852887 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40)
    • J.R. Backstrom, G.P. Lim, M.J. Cullen, and Z.A. Tokes Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40) Journal of Neuroscience 16 1996 7910 7919 (Pubitemid 26405054)
    • (1996) Journal of Neuroscience , vol.16 , Issue.24 , pp. 7910-7919
    • Backstrom, J.R.1    Lim, G.P.2    Cullen, M.J.3    Tokes, Z.A.4
  • 23
    • 0034974108 scopus 로고    scopus 로고
    • Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementia
    • DOI 10.1016/S0197-4580(00)00259-1, PII S0197458000002591
    • E. Savaskan, C. Hock, G. Olivieri, S. Bruttel, C. Rosenberg, and C. Hulette Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementia Neurobiology of Aging 22 2001 541 546 (Pubitemid 32607737)
    • (2001) Neurobiology of Aging , vol.22 , Issue.4 , pp. 541-546
    • Savaskan, E.1    Hock, C.2    Olivieri, G.3    Bruttel, S.4    Rosenberg, C.5    Hulette, C.6    Muller-Spahn, F.7
  • 24
    • 40149093247 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy
    • DOI 10.1111/j.1365-2990.2007.00885.x
    • J.S. Miners, E. Ashby, Z. Van Helmond, K.A. Chalmers, L.E. Palmer, and S. Love Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy Neuropathology and Applied Neurobiology 34 2008 181 193 (Pubitemid 351327960)
    • (2008) Neuropathology and Applied Neurobiology , vol.34 , Issue.2 , pp. 181-193
    • Miners, J.S.1    Ashby, E.2    Van Helmond, Z.3    Chalmers, K.A.4    Palmer, L.E.5    Love, S.6    Kehoe, P.G.7
  • 25
    • 67649665617 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme levels and activity in Alzheimer's disease: Differences in brain and CSF ACE and association with ACE1 genotypes
    • S. Miners, E. Ashby, S. Baig, R. Harrison, H. Tayler, and E. Speedy Angiotensin-converting enzyme levels and activity in Alzheimer's disease: differences in brain and CSF ACE and association with ACE1 genotypes American Journal of Translational Research 1 2009 163 177
    • (2009) American Journal of Translational Research , vol.1 , pp. 163-177
    • Miners, S.1    Ashby, E.2    Baig, S.3    Harrison, R.4    Tayler, H.5    Speedy, E.6
  • 26
    • 14944340658 scopus 로고    scopus 로고
    • The N-terminal active centre of human angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide
    • DOI 10.1111/j.1460-9568.2005.03912.x
    • R. Oba, A. Igarashi, M. Kamata, K. Nagata, S. Takano, and H. Nakagawa The N-terminal active centre of human angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide European Journal of Neuroscience 21 2005 733 740 (Pubitemid 40363508)
    • (2005) European Journal of Neuroscience , vol.21 , Issue.3 , pp. 733-740
    • Oba, R.1    Igarashi, A.2    Kamata, M.3    Nagata, K.4    Takano, S.5    Nakagawa, H.6
  • 29
    • 0028102129 scopus 로고
    • Impaired brain microcirculation may trigger Alzheimer's disease
    • DOI 10.1016/0149-7634(94)90052-3
    • J.C. de la Torre Impaired brain microcirculation may trigger Alzheimer's disease Neuroscience and Biobehavioral Reviews 18 1994 397 401 (Pubitemid 24258711)
    • (1994) Neuroscience and Biobehavioral Reviews , vol.18 , Issue.3 , pp. 397-401
    • De La Torre, J.C.1
  • 30
    • 0030452414 scopus 로고    scopus 로고
    • Cerebral vessels in ageing and Alzheimer's disease
    • DOI 10.1016/S0163-7258(96)00116-7, PII S0163725896001167
    • R.N. Kalaria Cerebral vessels in ageing and Alzheimer's disease Pharmacology & Therapeutics 72 1996 193 214 (Pubitemid 26425810)
    • (1996) Pharmacology and Therapeutics , vol.72 , Issue.3 , pp. 193-214
    • Kalaria, R.N.1
  • 33
    • 0021954201 scopus 로고
    • An improved fluorometric assay of rat serum and plasma converting enzyme
    • R.A. Santos, E.M. Krieger, and L.J. Greene An improved fluorometric assay of rat serum and plasma converting enzyme Hypertension 7 1985 244 252 (Pubitemid 15093650)
    • (1985) Hypertension , vol.7 , Issue.2 , pp. 244-252
    • Santos, R.A.S.1    Krieger, E.M.2    Greene, L.J.3
  • 35
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease
    • G. McKhann, D. Drachman, M. Folstein, R. Katzman, D. Price, and E.M. Stadlan Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of department of Health and Human Services Task Force on Alzheimer's disease Neurology 34 1984 939 944 (Pubitemid 14076461)
    • (1984) Neurology , vol.34 , Issue.7 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3
  • 36
    • 70449460896 scopus 로고    scopus 로고
    • Desacyl-ghrelin and synthetic GH-secretagogues modulate the production of inflammatory cytokines in mouse microglia cells stimulated by beta-amyloid fibrils
    • I. Bulgarelli, L. Tamiazzo, E. Bresciani, D. Rapetti, S. Caporali, and D. Lattuada Desacyl-ghrelin and synthetic GH-secretagogues modulate the production of inflammatory cytokines in mouse microglia cells stimulated by beta-amyloid fibrils Journal of Neuroscience Research 87 2009 2718 2727
    • (2009) Journal of Neuroscience Research , vol.87 , pp. 2718-2727
    • Bulgarelli, I.1    Tamiazzo, L.2    Bresciani, E.3    Rapetti, D.4    Caporali, S.5    Lattuada, D.6
  • 40
    • 0034741715 scopus 로고    scopus 로고
    • 9]-Ghrelin, a novel radioligand for localizing GHS orphan receptors in human and rat tissue; up-regulation of receptors with atherosclerosis
    • S.D. Katugampola, Z. Pallikaros, and A.P. Davenport [125i-His(9)]- ghrelin, a novel radioligand for localizing GHS orphan receptors in human and rat tissue: up-regulation of receptors with atherosclerosis British Journal of Pharmacology 134 2001 143 149 (Pubitemid 32835477)
    • (2001) British Journal of Pharmacology , vol.134 , Issue.1 , pp. 143-149
    • Katugampola, S.D.1    Pallikaros, Z.2    Davenport, A.P.3
  • 42
    • 77953461949 scopus 로고    scopus 로고
    • Characterization of domain-selective inhibitor binding in angiotensin-converting enzyme using a novel derivative of lisinopril
    • J.M. Watermeyer, W.L. Kroger, H.G. O'Neill, B.T. Sewell, and E.D. Sturrock Characterization of domain-selective inhibitor binding in angiotensin-converting enzyme using a novel derivative of lisinopril Biochemical Journal 428 2010 67 74
    • (2010) Biochemical Journal , vol.428 , pp. 67-74
    • Watermeyer, J.M.1    Kroger, W.L.2    O'Neill, H.G.3    Sewell, B.T.4    Sturrock, E.D.5
  • 47
    • 33847140273 scopus 로고    scopus 로고
    • Serum TNF-alpha levels are increased and correlate negatively with free IGF-I in Alzheimer disease
    • DOI 10.1016/j.neurobiolaging.2006.02.012, PII S0197458006000819
    • A. Alvarez, R. Cacabelos, C. Sanpedro, M. Garcia-Fantini, and M. Aleixandre Serum TNF-alpha levels are increased and correlate negatively with free IGF-I in Alzheimer disease Neurobiology of Aging 28 2007 533 536 (Pubitemid 46282207)
    • (2007) Neurobiology of Aging , vol.28 , Issue.4 , pp. 533-536
    • Alvarez, A.1    Cacabelos, R.2    Sanpedro, C.3    Garcia-Fantini, M.4    Aleixandre, M.5
  • 48
    • 20344393856 scopus 로고    scopus 로고
    • 1-42 and inflammatory cytokines in patients with Alzheimer's disease and vascular dementia
    • DOI 10.1016/j.neulet.2005.03.051, PII S0304394005003575
    • J.P. Jia, R. Meng, Y.X. Sun, W.J. Sun, X.M. Ji, and L.F. Jia Cerebrospinal fluid tau, Abeta1-42 and inflammatory cytokines in patients with Alzheimer's disease and vascular dementia Neuroscience Letters 383 2005 12 16 (Pubitemid 40779947)
    • (2005) Neuroscience Letters , vol.383 , Issue.1-2 , pp. 12-16
    • Jia, J.P.1    Meng, R.2    Sun, Y.X.3    Sun, W.J.4    Ji, X.M.5    Jia, L.F.6
  • 50
    • 33750049661 scopus 로고    scopus 로고
    • Serum BDNF, TNF-alpha and IL-1beta levels in dementia patients: Comparison between Alzheimer's disease and vascular dementia
    • DOI 10.1007/s00406-006-0652-8
    • C. Yasutake, K. Kuroda, T. Yanagawa, T. Okamura, and H. Yoneda Serum BDNF, TNF-alpha and IL-1beta levels in dementia patients: comparison between Alzheimer's disease and vascular dementia European Archives of Psychiatry and Clinical Neuroscience 256 2006 402 406 (Pubitemid 44584054)
    • (2006) European Archives of Psychiatry and Clinical Neuroscience , vol.256 , Issue.7 , pp. 402-406
    • Yasutake, C.1    Kuroda, K.2    Yanagawa, T.3    Okamura, T.4    Yoneda, H.5
  • 51
    • 0036917631 scopus 로고    scopus 로고
    • Serum insulin-like growth factor I regulates brain amyloid-beta levels
    • DOI 10.1038/nm793
    • E. Carro, J.L. Trejo, T. Gomez-Isla, D. LeRoith, and I. Torres-Aleman Serum insulin-like growth factor I regulates brain amyloid-beta levels Nature Medicine 8 2002 1390 1397 (Pubitemid 36019424)
    • (2002) Nature Medicine , vol.8 , Issue.12 , pp. 1390-1397
    • Carro, E.1    Trejo, J.L.2    Gomez-Isla, T.3    LeRoith, D.4    Torres-Aleman, I.5
  • 52
    • 58149260966 scopus 로고    scopus 로고
    • Growth hormone secretagogue MK-677: No clinical effect on AD progression in a randomized trial
    • J.J. Sevigny, J.M. Ryan, C.H. van Dyck, Y. Peng, C.R. Lines, and M.L. Nessly Growth hormone secretagogue MK-677: no clinical effect on AD progression in a randomized trial Neurology 71 2008 1702 1708
    • (2008) Neurology , vol.71 , pp. 1702-1708
    • Sevigny, J.J.1    Ryan, J.M.2    Van Dyck, C.H.3    Peng, Y.4    Lines, C.R.5    Nessly, M.L.6


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