Variation in Toll-like receptor 9 gene modifies the risk of infection in children treated for acute lymphoblastic leukemia

Leukemia and Lymphoma

Volumn 53, Issue 9, 2012, Pages 1828-1830

  Bhadri, Vivek A ^a   Beckett, Sara M ^b   Duncan, Catriona ^a   Marshall, Glenn M ^a,b   Ashton, Lesley J ^b  

^a SYDNEY CHILDREN'S HOSPITAL   (Australia)

^b CHILDREN S CANCER INSTITUTE AUSTRALIA FOR MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; IMMUNOSUPPRESSIVE AGENT; TOLL LIKE RECEPTOR 9;

ACUTE LYMPHOBLASTIC LEUKEMIA; CANCER INCIDENCE; CANCER REGRESSION; CENTRAL VENOUS CATHETER; CHI SQUARE TEST; CONFIDENCE INTERVAL; DISEASE COURSE; DNA POLYMORPHISM; FISHER EXACT TEST; GENE EXPRESSION; GENETIC VARIABILITY; GENOTYPE; GRAM NEGATIVE SEPSIS; HOSPITAL ADMISSION; HUMAN; IMMUNE RESPONSE; INFECTION RISK; INTENSIVE CARE; LETTER; MEDICAL RECORD REVIEW; MORBIDITY; NEUTROPENIA; NONHUMAN; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; TOXOPLASMOSIS;

BACILLUS; BACTERIAL INFECTIONS; CHILD; CHILD, PRESCHOOL; FEMALE; GENE FREQUENCY; GENOTYPE; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE COCCI; HUMANS; INFANT; MALE; NEUTROPENIA; POLYMORPHISM, SINGLE NUCLEOTIDE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; REGRESSION ANALYSIS; REMISSION INDUCTION; RISK FACTORS; TOLL-LIKE RECEPTOR 9;

EID: 84864995496     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2012.661858     Document Type: Letter

References (15)

1. A uletta JJ, O'Riordan MA, Nieder ML. Infections in children with cancer: A continued need for the comprehensive physical examination. J Pediatr Hematol Oncol 1999;21:501-508.
2. S antolaya ME, Alvarez AM, Becker A, et al. Prospective, multicenter evaluation of risk factors associated with invasive bacterial infection in children with cancer, neutropenia, and fever. J Clin Oncol 2001; 19:3415-3421.
3. A fzal S, Ethier MC, Dupuis LL, et al. Risk factors for infection-related outcomes during induction therapy for childhood acute lymphoblastic leukemia. Pediatr Infect Dis J 2009;28:1064-1068.
4. A kira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006;124:783-801.
5. N ieters A, Beckmann L, Deeg E, et al. Gene polymorphisms in Toll-like receptors, interleukin-10, and interleukin-10 receptor alpha and lymphoma risk. Genes Immun 2006;7:615-624.
6. P eixoto-Rangel AL, Miller EN, Castellucci L, et al. Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9). Memorias Do Instituto Oswaldo Cruz 2009;104:1187-1190.
7. Bochud PY, Chien JW, Marr KA, et al. Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation. N Engl J Med 2008;359:1766-1777.
8. L anciotti M, Pigullo S, Lanza T, et al. Possible role of toll-like receptor 9 polymorphism in chemotherapy-related invasive mold infections in children with hematological malignancies. Pediatr Blood Cancer 2008;50:944.
9. A gnese DM, Calvano JE, Hahm SJ, et al. Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J Infect Dis 2002;186: 1522-1525.
10. Sutherland AM, Walley KR, Russell JA. Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults. Crit Care Med 2005;33:638-644.
11. M arshall GM, Haber M, Kwan E, et al. Importance of minimal residual disease testing during the second year of therapy for children with acute lymphoblastic leukemia. J Clin Oncol 2003;21:704-709.
12. P erneger T. What's wrong with Bonferroni adjustments. BMJ 1998;316:1236-1238.
13. Soriano-Sarabia N, Vallejo A, Ramirez-Lorca R, et al. Infl uence of the Toll-like receptor 9 1635A/G polymorphism on the CD4 count, HIV viral load, and clinical progression. J Acquir Immune Defi c Syndr 2008;49:128-135.
14. L ehrnbecher T, Bernig T, Hanisch M, et al. Common genetic variants in the interleukin-6 and chitotriosidase genes are associated with the risk for serious infection in children undergoing therapy for acute myeloid leukemia. Leukemia 2005;19:1745-1750.
15. Miedema KG, te Poele EM, Tissing WJ, et al. Association of polymorphisms in the TLR4 gene with the risk of developing neutropenia in children with leukemia. Leukemia 2011;25:995-1000.