Neuronal apoptosis and synaptic density in the dentate gyrus of ischemic rats' response to chronic mild stress and the effects of notch signaling

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Wang, Shaohua ^a   Yuan, Yang ^a   Xia, Wenqing ^a   Li, Fengfei ^a   Huang, Yan ^a   Zhou, Yi ^a   Guo, Yijing ^a  

^a AFFILIATED ZHONGDA HOSPITAL OF SOUTHEAST UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH1 RECEPTOR; PROTEIN BAX; PROTEIN BCL 2; SYNAPTOPHYSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN SURGERY; CHRONIC STRESS; CONTROLLED STUDY; DENTATE GYRUS; GENE EXPRESSION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEWBORN; NONHUMAN; OPEN FIELD TEST; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUGAR INTAKE; SYNAPSE; SYNAPTIC DENSITY;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BRAIN ISCHEMIA; DENTATE GYRUS; DEPRESSION; MALE; NEURONS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; STRESS, PSYCHOLOGICAL; STROKE; SYNAPSES; TIME FACTORS;

EID: 84864977811     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042828     Document Type: Article

References (40)

1. Gainotti G, Barbier A, Marra C, ((2003)) Slowly progressive defect in recognition of familiar people in a patient with right anterior temporal atrophy. Brain 126:: 792--803.
2. House A, ((1996)) Depression associated with stroke. J Neuropsychiatry Clin Neurosci 8:: 453--7.
3. Abrous DN, Koehl M, Le MM, ((2005)) Adult neurogenesis: from precursors to network and physiology. Physiol Rev 85:: 523--69.
4. Lledo PM, Alonso M, Grubb MS, ((2006)) Adult neurogenesis and functional plasticity in neuronal circuits. Nat Rev Neurosci 7:: 179--93.
5. Dranovsky A, Hen R, ((2006)) Hippocampal neurogenesis: regulation by stress and antidepressants. Biol Psychiatry 59:: 1136--43.
6. Jacobs BL, Praag H, Gage FH, ((2000)) Adult brain neurogenesis and psychiatry: a novel theory of depression. Mol Psychiatry 5:: 262--9.
7. Kempermann G, Kronenberg G, ((2003)) Depressed new neurons-adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression. Biol Psychiatry 54:: 499--503.
8. Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, et al. ((2003)) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301:: 805--9.
9. Liu J, Solway K, Messing RO, Sharp FR, ((1998)) Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J Neurosci 18:: 7768--78.
10. Jin K, Minami M, Lan JQ, Mao XO, Batteur S, et al. ((2001)) Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat. Proc Natl Acad Sci USA 98:: 4710--5.
11. Zhu DY, Liu SH, Sun SH, Lu YM, ((2003)) Expression of inducible nitric oxide synthase after focal ischemia stimulates neurogenesis in the adult rodent dentate gyrus. J Neurosci 23:: 223--9.
12. Wang SH, Zhang ZJ, Guo YJ, Teng GJ, Chen BA, ((2008)) Hippocampal neurogenesis and behavioural studies on adult ischemic rat response to chronic mild stress. Behavioural Brain Research 189:: 9--16.
13. Guo YJ, Zhang ZJ, Wang SH, Sui YX, Sun Y, ((2009)) Notch1 signaling, hippocampal neurogenesis and behavioral responses to chronic unpredicted mild stress in adult ischemic rats. Progress in neuro-psychopharmacology & biological psychiatry 33:: 688--94.
14. Costa RM, Drew C, Silva AJ, ((2005)) Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Trends Neurosci 28:: 429--35.
15. Selkoe D, Kopan R, Annu Rev, ((2003)) Notch Signaling, γ-Secretase Inhibitors, and Cancer Therapy. Neurosci 26:: 565--97.
16. Yoon K, Gaiano N, ((2005)) Notch signaling in the mammalian central nervous system: insights from mouse mutants. Nat. Neurosci 8:: 709--15.
17. Choi D, ((1996)) Ischemia-induced neuronal apoptosis. Curr Opin Neurobiol 6:: 667--72.
18. MacManus J, Linnik M, ((1997)) Gene expression induced by cerebral ischemia: an apoptotic perspective. J Cereb Blood Flow Metab 17:: 815--32.
19. Longa EZ, Weinstein PR, Carlson S, Cummins R, ((1989)) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:: 84--91.
20. Wang SH, Zhang ZJ, Guo YJ, Zhou H, Teng GJ, et al. ((2009)) Anhedonia and activity deficits in rats: Impact of post stroke depression. Journal of Psychopharmacology 23:: 295--304.
21. Livak KJ, Schmittgen TD, ((2001)) Analysis of relative gene expression data using realtime quantitative PCR and the 2 (-Delta Delta C (T)) method. Methods 25:: 402--8.
22. Gainotti G, Azzoni A, Marra C, ((1999)) Frequency, phenomenology and anatomical-clinical correlates of major post-stroke depression. Br J Psychiatry 175:: 163--7.
23. House A, ((1996)) Depression associated with stroke. J Neuropsychiatry Clin Neurosci 8:: 453--7.
24. Kuida K, Zheng TS, Na S, Kuan C, Yang D, et al. ((1996)) Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384:: 368--72.
25. Renolleau S, Aggoun-Zouaoui D, Ben-Ari Y, Charriaut-Marlangue C, ((1998)) A model of transient unilaterial focal ischemia with reperfusion in the P7 neonatal rat: morphological changes indicative of apoptosis. Stroke. 29:: 1454--60.
26. Woolley CS, Gould E, Sakai RR, Spencer RL, McEwen BS, ((1991)) Effects of aldosterone or RU28362 treatment on adrenalectomy-induced cell death in the dentate gyrus of the adult rat. Brain Res 554:: 312--5.
27. Sloviter RS, Sollas A, Dean E, Neubort S, ((1993)) Adrenalectomy-induced granule cell degeneration in the rat hippocampal dentate gyrus: characterization of an in vivo model of controlled neuronal death. J Comp Neurol 330:: 324--36.
28. Stroemer P, Rothwell NJ, ((1998)) Exacerbation of the ischaemic brain damage by localised striatal injection of IL-1b in the rat. J Cereb Blood Flow Metab 18:: 833--9.
29. Barinaga M, ((1998)) Stroke-damaged neurons may commit cellular suicide. Science 281:: 1302--3.
30. Adams JM, Cory S, ((1998)) The Bcl-2 protein family: Arbiters of cell survival. Science 281:: 1322--6.
31. Bercovich B, Stancovski I, Mayer A, Blumenfeld N, Laszlo A, et al. ((1997)) Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone Hsp70. J Biol Chem 272:: 9002--10.
32. Villa PG, Henzel WJ, Sensenbrenner M, Henderson CD, Pettmann B, ((1998)) Calpain inhibitors, but not caspase inhibitors, prevent actin proteolysis and DNA fragmentation during apoptosis. J Cell Sci 111:: 713--22.
33. Cameron HA, McKay RD, ((2001)) Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J Comp Neurol 435:: 406--17.
34. Hastings NB, Gould E, ((1999)) Rapid extension of axons into the CA3 region by adult-generated granule cells. J Comp Neurol 413:: 146--54.
35. Kaplan MS, Hinds JW, ((1997)) Neurogenesis in the adult rat: electron microscopic analysis of light radioautographs. Science 197:: 1092--4.
36. Markakis EA, Gage FH, ((1999)) Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles. J Comp Neurol 406:: 449--60.
37. Stanfield BB, Trice JE, ((1988)) Evidence that granule cells generated in the dentate gyrus of adult rats extend axonal projections. Exp Brain Res 72:: 399--406.
38. Carlen M, Cassidy RM, Brismar H, Smith GA, Enquist LW, et al. ((2002)) Functional integration of adult-born neurons. Curr Biol 12:: 606--8.
39. Wang S, Scott BW, Wojtowicz JM, ((2000)) Heterogeneous properties of dentate granule neurons in the adult rat. J Neurobiol 42:: 248--57.
40. Hama S, Yamashita H, Yamawaki S, Kurisu K, ((2011)) Post-stroke depression and apathy: Interactions between functional recovery, lesion location, and emotional response. Psychogeriatrics 1:: 68--76.