메뉴 건너뛰기




Volumn 10, Issue 1, 2012, Pages

Combination of cilostazol and clopidogrel attenuates Rat critical limb ischemia

Author keywords

Angiogenesis; Apoptosis; Critical limb ischemia; Inflammation; Pharmacomodulation

Indexed keywords

CASPASE 3; CD31 ANTIGEN; CD68 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CILOSTAZOL; CLOPIDOGREL; CYTOCHROME C; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GELATINASE B; INTERLEUKIN 10; MESSENGER RNA; MICRORNA; MICRORNA 206; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN BAX; PROTEIN BCL 2; STEM CELL ANTIGEN 1; STEM CELL FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

EID: 84864959531     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-10-164     Document Type: Article
Times cited : (15)

References (37)
  • 1
    • 0035942767 scopus 로고    scopus 로고
    • Medical treatment of peripheral arterial disease and claudication
    • 10.1056/NEJM200105243442108, 11372014
    • Hiatt WR. Medical treatment of peripheral arterial disease and claudication. N Engl J Med 2001, 344:1608-1621. 10.1056/NEJM200105243442108, 11372014.
    • (2001) N Engl J Med , vol.344 , pp. 1608-1621
    • Hiatt, W.R.1
  • 2
    • 0033012553 scopus 로고    scopus 로고
    • Ankle-arm index as a predictor of cardiovascular disease and mortality in the Cardiovascular Health Study. The Cardiovascular Health Study Group
    • 10.1161/01.ATV.19.3.538, 10073955
    • Newman AB, Shemanski L, Manolio TA, Cushman M, Mittelmark M, Polak JF, Powe NR, Siscovick D. Ankle-arm index as a predictor of cardiovascular disease and mortality in the Cardiovascular Health Study. The Cardiovascular Health Study Group. Arterioscler Thromb Vasc Biol 1999, 19:538-545. 10.1161/01.ATV.19.3.538, 10073955.
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , pp. 538-545
    • Newman, A.B.1    Shemanski, L.2    Manolio, T.A.3    Cushman, M.4    Mittelmark, M.5    Polak, J.F.6    Powe, N.R.7    Siscovick, D.8
  • 4
    • 0035856220 scopus 로고    scopus 로고
    • Peripheral arterial disease
    • 10.1016/S0140-6736(01)06351-6, 11675083
    • Ouriel K. Peripheral arterial disease. Lancet 2001, 358:1257-1264. 10.1016/S0140-6736(01)06351-6, 11675083.
    • (2001) Lancet , vol.358 , pp. 1257-1264
    • Ouriel, K.1
  • 5
    • 0033042423 scopus 로고    scopus 로고
    • The fate of patients with critical leg ischemia
    • Dormandy JA, Heeck L, Vig S. The fate of patients with critical leg ischemia. Semin Vasc Surg 1999, 12:142-147.
    • (1999) Semin Vasc Surg , vol.12 , pp. 142-147
    • Dormandy, J.A.1    Heeck, L.2    Vig, S.3
  • 6
    • 25644453509 scopus 로고    scopus 로고
    • Serial changes in platelet activation in patients with unstable angina following coronary stenting: evaluation of the effect of clopidogrel loading dose in inhibiting platelet activation
    • 10.1253/circj.69.1208, 16195618
    • Yip HK, Wu CJ, Hang CL, Chang HW, Hung WC, Yeh KH, Yang CH. Serial changes in platelet activation in patients with unstable angina following coronary stenting: evaluation of the effect of clopidogrel loading dose in inhibiting platelet activation. Circ J 2005, 69:1208-1211. 10.1253/circj.69.1208, 16195618.
    • (2005) Circ J , vol.69 , pp. 1208-1211
    • Yip, H.K.1    Wu, C.J.2    Hang, C.L.3    Chang, H.W.4    Hung, W.C.5    Yeh, K.H.6    Yang, C.H.7
  • 7
    • 3042648318 scopus 로고    scopus 로고
    • Serial changes in platelet activation in patients after ischemic stroke: role of pharmacodynamic modulation
    • 10.1161/01.STR.0000131658.80951.c3, 15155956
    • Yip HK, Chen SS, Liu JS, Chang HW, Kao YF, Lan MY, Chang YY, Lai SL, Chen WH, Chen MC. Serial changes in platelet activation in patients after ischemic stroke: role of pharmacodynamic modulation. Stroke 2004, 35:1683-1687. 10.1161/01.STR.0000131658.80951.c3, 15155956.
    • (2004) Stroke , vol.35 , pp. 1683-1687
    • Yip, H.K.1    Chen, S.S.2    Liu, J.S.3    Chang, H.W.4    Kao, Y.F.5    Lan, M.Y.6    Chang, Y.Y.7    Lai, S.L.8    Chen, W.H.9    Chen, M.C.10
  • 8
    • 17744374250 scopus 로고    scopus 로고
    • Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) Study Investigators. The Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) trial programme; rationale, design and baseline characteristics including a meta-analysis of the effects of thienopyridines in vascular disease
    • Mehta SR, Yusuf S. Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) Study Investigators. The Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) trial programme; rationale, design and baseline characteristics including a meta-analysis of the effects of thienopyridines in vascular disease. Eur Heart J 2000, 21:2033-2041.
    • (2000) Eur Heart J , vol.21 , pp. 2033-2041
    • Mehta, S.R.1    Yusuf, S.2
  • 9
    • 6944222791 scopus 로고    scopus 로고
    • Comparative benefits of clopidogrel and aspirin in high-risk patient populations: lessons from the CAPRIE and CURE studies
    • 10.1001/archinte.164.19.2106, 15505123
    • Hirsh J, Bhatt DL. Comparative benefits of clopidogrel and aspirin in high-risk patient populations: lessons from the CAPRIE and CURE studies. Arch Intern Med 2004, 164:2106-2110. 10.1001/archinte.164.19.2106, 15505123.
    • (2004) Arch Intern Med , vol.164 , pp. 2106-2110
    • Hirsh, J.1    Bhatt, D.L.2
  • 10
    • 0028070508 scopus 로고
    • Synergistic interactions between selective pharmacological inhibitors of phosphodiesterase isoenzyme families PDE III and PDE IV to attenuate proliferation rate of vascular smooth muscle cells
    • Pan X, Arauz E, Krzanowski JJ, Fitzpatrick DF, Polson JB. Synergistic interactions between selective pharmacological inhibitors of phosphodiesterase isoenzyme families PDE III and PDE IV to attenuate proliferation rate of vascular smooth muscle cells. Biochem Pharmacol 1994, 48:827-835.
    • (1994) Biochem Pharmacol , vol.48 , pp. 827-835
    • Pan, X.1    Arauz, E.2    Krzanowski, J.J.3    Fitzpatrick, D.F.4    Polson, J.B.5
  • 11
    • 0028850075 scopus 로고
    • Pharmacologic treatment of intimal hyperplasia after metallic stent placement in the peripheral arteries: an experimental study
    • 10.1097/00004424-199509000-00004, 8537210
    • Kubota Y, Kichikawa K, Uchida H. Pharmacologic treatment of intimal hyperplasia after metallic stent placement in the peripheral arteries: an experimental study. Invest Radiol 1995, 30:532-537. 10.1097/00004424-199509000-00004, 8537210.
    • (1995) Invest Radiol , vol.30 , pp. 532-537
    • Kubota, Y.1    Kichikawa, K.2    Uchida, H.3
  • 13
    • 43049159100 scopus 로고    scopus 로고
    • Efficacy and safety of clopidogrel pretreatment before percutaneous coronary intervention with and without glycoprotein IIb/IIIa inhibitor use
    • 10.1016/j.ahj.2007.11.020, 18440341
    • Sabatine MS, Hamdalla HN, Mehta SR, Fox KA, Topol EJ, Steinhubl SR, Cannon CP. Efficacy and safety of clopidogrel pretreatment before percutaneous coronary intervention with and without glycoprotein IIb/IIIa inhibitor use. Am Heart J 2008, 155:910-917. 10.1016/j.ahj.2007.11.020, 18440341.
    • (2008) Am Heart J , vol.155 , pp. 910-917
    • Sabatine, M.S.1    Hamdalla, H.N.2    Mehta, S.R.3    Fox, K.A.4    Topol, E.J.5    Steinhubl, S.R.6    Cannon, C.P.7
  • 15
    • 54149089301 scopus 로고    scopus 로고
    • Stent thrombosis, clinical events, and influence of prolonged clopidogrel use after placement of drug-eluting stent data from an observational cohort study of drug-eluting versus bare-metal stents
    • 10.1016/j.jcin.2008.06.011, 19463351
    • Park DW, Yun SC, Lee SW, Kim YH, Lee CW, Hong MK, Cheong SS, Kim JJ, Park SW, Park SJ. Stent thrombosis, clinical events, and influence of prolonged clopidogrel use after placement of drug-eluting stent data from an observational cohort study of drug-eluting versus bare-metal stents. JACC Cardiovasc Interv 2008, 1:494-503. 10.1016/j.jcin.2008.06.011, 19463351.
    • (2008) JACC Cardiovasc Interv , vol.1 , pp. 494-503
    • Park, D.W.1    Yun, S.C.2    Lee, S.W.3    Kim, Y.H.4    Lee, C.W.5    Hong, M.K.6    Cheong, S.S.7    Kim, J.J.8    Park, S.W.9    Park, S.J.10
  • 16
    • 38149015637 scopus 로고    scopus 로고
    • Level and value of circulating endothelial progenitor cells in patients after acute ischemic stroke
    • 10.1161/STROKEAHA.107.489401, 18063830
    • Yip HK, Chang LT, Chang WN, Lu CH, Liou CW, Lan MY, Liu JS, Youssef AA, Chang HW. Level and value of circulating endothelial progenitor cells in patients after acute ischemic stroke. Stroke 2008, 39:69-74. 10.1161/STROKEAHA.107.489401, 18063830.
    • (2008) Stroke , vol.39 , pp. 69-74
    • Yip, H.K.1    Chang, L.T.2    Chang, W.N.3    Lu, C.H.4    Liou, C.W.5    Lan, M.Y.6    Liu, J.S.7    Youssef, A.A.8    Chang, H.W.9
  • 17
    • 8744312858 scopus 로고    scopus 로고
    • Levels and values of serum high-sensitivity C-reactive protein within six hours after the onset of an acute myocardial infarction
    • 10.1378/chest.126.5.1417, 15539707
    • Yip HK, Wu CJ, Chang HW, Yang CH, Yeh KH, Chua S, Fu M. Levels and values of serum high-sensitivity C-reactive protein within six hours after the onset of an acute myocardial infarction. Chest 2004, 126:1417-1422. 10.1378/chest.126.5.1417, 15539707.
    • (2004) Chest , vol.126 , pp. 1417-1422
    • Yip, H.K.1    Wu, C.J.2    Chang, H.W.3    Yang, C.H.4    Yeh, K.H.5    Chua, S.6    Fu, M.7
  • 18
    • 33745518439 scopus 로고    scopus 로고
    • Strong correlation between serum levels of inflammatory mediators and their distribution in infarct coronary
    • 10.1253/circj.70.838, 16799235
    • Yip HK, Sun CK, Chang LT, Wu CJ. Strong correlation between serum levels of inflammatory mediators and their distribution in infarct coronary. Circ J 2006, 70:838-845. 10.1253/circj.70.838, 16799235.
    • (2006) Circ J , vol.70 , pp. 838-845
    • Yip, H.K.1    Sun, C.K.2    Chang, L.T.3    Wu, C.J.4
  • 19
    • 0028085059 scopus 로고
    • Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology
    • 10.1161/01.CIR.89.1.36, 8281670
    • van der Wal AC, Becker AE, van der Loos CM, Das PK. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation 1994, 89:36-44. 10.1161/01.CIR.89.1.36, 8281670.
    • (1994) Circulation , vol.89 , pp. 36-44
    • van der Wal, A.C.1    Becker, A.E.2    van der Loos, C.M.3    Das, P.K.4
  • 20
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis: an inflammatory disease
    • 10.1056/NEJM199901143400207, 9887164
    • Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 1999, 340:115-126. 10.1056/NEJM199901143400207, 9887164.
    • (1999) N Engl J Med , vol.340 , pp. 115-126
    • Ross, R.1
  • 21
    • 0022380933 scopus 로고
    • Post cardiac injury syndrome and an increased humoral immune response against the major contractile proteins (actin and myosin)
    • 10.1016/0002-9149(85)91024-0, 4050699
    • De Scheerder I, Vandekerckhove J, Robbrecht J, Algoed L, De Buyzere M, De Langhe J, De Schrijver G, Clement D. Post cardiac injury syndrome and an increased humoral immune response against the major contractile proteins (actin and myosin). Am J Cardiol 1985, 56:631-633. 10.1016/0002-9149(85)91024-0, 4050699.
    • (1985) Am J Cardiol , vol.56 , pp. 631-633
    • De Scheerder, I.1    Vandekerckhove, J.2    Robbrecht, J.3    Algoed, L.4    De Buyzere, M.5    De Langhe, J.6    De Schrijver, G.7    Clement, D.8
  • 22
    • 0036136667 scopus 로고    scopus 로고
    • The inflammatory response in myocardial infarction
    • 10.1016/S0008-6363(01)00434-5, 11744011
    • Frangogiannis NG, Smith CW, Entman ML. The inflammatory response in myocardial infarction. Cardiovasc Res 2002, 53:31-47. 10.1016/S0008-6363(01)00434-5, 11744011.
    • (2002) Cardiovasc Res , vol.53 , pp. 31-47
    • Frangogiannis, N.G.1    Smith, C.W.2    Entman, M.L.3
  • 23
    • 54949106928 scopus 로고    scopus 로고
    • Macrophage roles following myocardial infarction
    • 10.1016/j.ijcard.2008.04.059, 2857604, 18656272
    • Lambert JM, Lopez EF, Lindsey ML. Macrophage roles following myocardial infarction. Int J Cardiol 2008, 130:147-158. 10.1016/j.ijcard.2008.04.059, 2857604, 18656272.
    • (2008) Int J Cardiol , vol.130 , pp. 147-158
    • Lambert, J.M.1    Lopez, E.F.2    Lindsey, M.L.3
  • 24
    • 77953940699 scopus 로고    scopus 로고
    • Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats
    • 10.1186/1479-5876-8-63, 2913939, 20584315
    • Leu S, Lin YC, Yuen CM, Yen CH, Kao YH, Sun CK, Yip HK. Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats. J Transl Med 2010, 8:63. 10.1186/1479-5876-8-63, 2913939, 20584315.
    • (2010) J Transl Med , vol.8 , pp. 63
    • Leu, S.1    Lin, Y.C.2    Yuen, C.M.3    Yen, C.H.4    Kao, Y.H.5    Sun, C.K.6    Yip, H.K.7
  • 25
    • 79951727149 scopus 로고    scopus 로고
    • Intra-coronary administration of cyclosporine limits infarct size, attenuates remodeling and preserves left ventricular function in porcine acute anterior infarction
    • Sheu JJ, Chua S, Sun CK, Chang LT, Yen CH, Wu CJ, Fu M, Yip HK. Intra-coronary administration of cyclosporine limits infarct size, attenuates remodeling and preserves left ventricular function in porcine acute anterior infarction. In J Cardiol 2011, 147:79-87.
    • (2011) In J Cardiol , vol.147 , pp. 79-87
    • Sheu, J.J.1    Chua, S.2    Sun, C.K.3    Chang, L.T.4    Yen, C.H.5    Wu, C.J.6    Fu, M.7    Yip, H.K.8
  • 26
    • 70349092330 scopus 로고    scopus 로고
    • Early combined therapy with cilostazol and bone marrow-derived endothelial progenitor cells markedly attenuates pulmonary arterial hypertension in rats
    • 10.1124/jpet.109.154328, 19528354
    • Sun CK, Lee FY, Sheu JJ, Yuen CM, Chua S, Chung SY, Chai HT, Chen YT, Kao YH, Chang LT, Yip HK. Early combined therapy with cilostazol and bone marrow-derived endothelial progenitor cells markedly attenuates pulmonary arterial hypertension in rats. J Pharmacol Exp Ther 2009, 330:718-726. 10.1124/jpet.109.154328, 19528354.
    • (2009) J Pharmacol Exp Ther , vol.330 , pp. 718-726
    • Sun, C.K.1    Lee, F.Y.2    Sheu, J.J.3    Yuen, C.M.4    Chua, S.5    Chung, S.Y.6    Chai, H.T.7    Chen, Y.T.8    Kao, Y.H.9    Chang, L.T.10    Yip, H.K.11
  • 27
    • 31344456454 scopus 로고    scopus 로고
    • Impact of clopidogrel on suppression of circulating levels of soluble CD40 ligand in patients with unstable angina undergoing coronary stenting
    • 10.1016/j.amjcard.2005.08.023, 16442361
    • Yip HK, Chang LT, Sun CK, Yang CH, Hung WC, Cheng CI, Chua S, Yeh KH, Wu CJ, Fu M. Impact of clopidogrel on suppression of circulating levels of soluble CD40 ligand in patients with unstable angina undergoing coronary stenting. Am J Cardiol 2006, 97:192-194. 10.1016/j.amjcard.2005.08.023, 16442361.
    • (2006) Am J Cardiol , vol.97 , pp. 192-194
    • Yip, H.K.1    Chang, L.T.2    Sun, C.K.3    Yang, C.H.4    Hung, W.C.5    Cheng, C.I.6    Chua, S.7    Yeh, K.H.8    Wu, C.J.9    Fu, M.10
  • 28
    • 80051824683 scopus 로고    scopus 로고
    • The effect of the duration of clopidogrel use on hsCRP levels after stenting the target vessel in patients with acute coronary syndrome
    • Cekici Y, Korkmaz H, Celik A, Bilen MN, Bulut M, Akbulut M. The effect of the duration of clopidogrel use on hsCRP levels after stenting the target vessel in patients with acute coronary syndrome. Clin Invest Med 2011, 34:E211.
    • (2011) Clin Invest Med , vol.34
    • Cekici, Y.1    Korkmaz, H.2    Celik, A.3    Bilen, M.N.4    Bulut, M.5    Akbulut, M.6
  • 29
    • 80052444820 scopus 로고    scopus 로고
    • Clopidogrel protects from cell apoptosis and oxidative damage in a mouse model of renal ischaemia-reperfusion injury
    • 10.1002/path.2916, 21630270
    • Hu H, Batteux F, Chereau C, Kavian N, Marut W, Gobeaux C, Borderie D, Dinh-Xuan AT, Weill B, Nicco C. Clopidogrel protects from cell apoptosis and oxidative damage in a mouse model of renal ischaemia-reperfusion injury. J Pathol 2011, 225:265-275. 10.1002/path.2916, 21630270.
    • (2011) J Pathol , vol.225 , pp. 265-275
    • Hu, H.1    Batteux, F.2    Chereau, C.3    Kavian, N.4    Marut, W.5    Gobeaux, C.6    Borderie, D.7    Dinh-Xuan, A.T.8    Weill, B.9    Nicco, C.10
  • 30
    • 77958130607 scopus 로고    scopus 로고
    • Prognostic value of circulating dead monocytes in patients with acute ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention
    • 10.1159/000320208, 20975265
    • Tsai TH, Lin YC, Sun CK, Chung SY, Chai HT, Yang CH, Chen SM, Hang CL, Chen CJ, Chua S, Wu CJ, Leu S, Yip HK. Prognostic value of circulating dead monocytes in patients with acute ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Cardiology 2010, 117:131-139. 10.1159/000320208, 20975265.
    • (2010) Cardiology , vol.117 , pp. 131-139
    • Tsai, T.H.1    Lin, Y.C.2    Sun, C.K.3    Chung, S.Y.4    Chai, H.T.5    Yang, C.H.6    Chen, S.M.7    Hang, C.L.8    Chen, C.J.9    Chua, S.10    Wu, C.J.11    Leu, S.12    Yip, H.K.13
  • 32
    • 80052618800 scopus 로고    scopus 로고
    • Cilostazol activates function of bone marrow-derived endothelial progenitor cell for re-endothelialization in a carotid balloon injury model
    • 10.1371/journal.pone.0024646, 3171459, 21931795
    • Kawabe-Yako R, Masaaki I, Masuo O, Asahara T, Itakura T. Cilostazol activates function of bone marrow-derived endothelial progenitor cell for re-endothelialization in a carotid balloon injury model. PLoS One 2011, 6:e24646. 10.1371/journal.pone.0024646, 3171459, 21931795.
    • (2011) PLoS One , vol.6
    • Kawabe-Yako, R.1    Masaaki, I.2    Masuo, O.3    Asahara, T.4    Itakura, T.5
  • 33
    • 77953960682 scopus 로고    scopus 로고
    • A phosphodiesterase-5 inhibitor vardenafil enhances angiogenesis through a protein kinase G-dependent hypoxia-inducible factor-1/vascular endothelial growth factor pathway
    • 10.1161/ATVBAHA.109.201327, 20413734
    • Sahara M, Sata M, Morita T, Nakajima T, Hirata Y, Nagai R. A phosphodiesterase-5 inhibitor vardenafil enhances angiogenesis through a protein kinase G-dependent hypoxia-inducible factor-1/vascular endothelial growth factor pathway. Arterioscler Thromb Vasc Biol 2010, 30:1315-1324. 10.1161/ATVBAHA.109.201327, 20413734.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 1315-1324
    • Sahara, M.1    Sata, M.2    Morita, T.3    Nakajima, T.4    Hirata, Y.5    Nagai, R.6
  • 34
    • 64049094289 scopus 로고    scopus 로고
    • Clopidogrel attenuates atheroma formation and induces a stable plaque phenotype in apolipoprotein E knockout mice
    • 10.1016/j.mvr.2009.01.009, 19323972
    • Afek A, Kogan E, Maysel-Auslender S, Mor A, Regev E, Rubinstein A, Keren G, George J. Clopidogrel attenuates atheroma formation and induces a stable plaque phenotype in apolipoprotein E knockout mice. Microvasc Res 2009, 77:364-369. 10.1016/j.mvr.2009.01.009, 19323972.
    • (2009) Microvasc Res , vol.77 , pp. 364-369
    • Afek, A.1    Kogan, E.2    Maysel-Auslender, S.3    Mor, A.4    Regev, E.5    Rubinstein, A.6    Keren, G.7    George, J.8
  • 35
    • 84857615158 scopus 로고    scopus 로고
    • Endothelial progenitor cell mobilization and platelet microparticle release are influenced by clopidogrel plasma levels in stable coronary artery disease
    • 10.1253/circj.CJ-11-1145, 22214900
    • França CN, Pinheiro LF, Izar MC, Brunialti MK, Salomão R, Bianco HT, Kasmas SH, Barbosa SP, de Nucci G, Fonseca FA. Endothelial progenitor cell mobilization and platelet microparticle release are influenced by clopidogrel plasma levels in stable coronary artery disease. Circ J 2012, 76:729-736. 10.1253/circj.CJ-11-1145, 22214900.
    • (2012) Circ J , vol.76 , pp. 729-736
    • França, C.N.1    Pinheiro, L.F.2    Izar, M.C.3    Brunialti, M.K.4    Salomão, R.5    Bianco, H.T.6    Kasmas, S.H.7    Barbosa, S.P.8    de Nucci, G.9    Fonseca, F.A.10
  • 36
    • 79955547957 scopus 로고    scopus 로고
    • Clopidogrel improves endothelial function and NO bioavailability by sensitizing adenylyl cyclase in rats with congestive heart failure
    • 10.1007/s00395-011-0153-4, 21287353
    • Schäfer A, Fraccarollo D, Pförtsch S, Loch E, Neuser J, Vogt C, Bauersachs J. Clopidogrel improves endothelial function and NO bioavailability by sensitizing adenylyl cyclase in rats with congestive heart failure. Basic Res Cardiol 2011, 106:485-494. 10.1007/s00395-011-0153-4, 21287353.
    • (2011) Basic Res Cardiol , vol.106 , pp. 485-494
    • Schäfer, A.1    Fraccarollo, D.2    Pförtsch, S.3    Loch, E.4    Neuser, J.5    Vogt, C.6    Bauersachs, J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.