The cytotoxicity of methylmercury in human microvascular endothelial cells and pericytes in culture

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 8, 2012, Pages 1201-1205

  Hirooka, Takashi ^a   Kaji, Toshiyuki ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Endothelial cell; Methylmercury; Microvascular; Neurotoxicity; Pericyte

Indexed keywords

AMINO ACID TRANSPORTER; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; L TYPE LARGE NEUTRAL AMINO ACID TRANSPORTER 1; METALLOTHIONEIN I; METALLOTHIONEIN II; METHYLMERCURY; UNCLASSIFIED DRUG;

BIOACCUMULATION; BRAIN CELL; CELL CULTURE; CELL DAMAGE; CELL DENSITY; CELL PROLIFERATION; CELL TYPE; CYTOTOXICITY; HUMAN; MICROVASCULAR ENDOTHELIAL CELL; NEUROTOXICITY; PERICYTE; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW;

BRAIN; EDEMA; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; METHYLMERCURY COMPOUNDS; NEUROTOXINS; PERICYTES;

EID: 84864949247     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b12-00394     Document Type: Review

References (33)

1. Abbott NJ, Rönnbäck L, Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat. Rev. Neurosci., 7, 41-53 (2006).
2. Rucker HK, Wynder HJ, Thomas WE. Cellular mechanisms of CNS pericytes. Brain Res. Bull., 51, 363-369 (2000).
3. von Tell D, Armulik A, Betsholtz C. Pericytes and vascular stability. Exp. Cell Res., 312, 623-629 (2006).
4. Hawkins BT, Davis TP. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol. Rev., 57, 173-185 (2005).
5. Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron, 57, 178-201 (2008).
6. Zheng W, Aschner M, Ghersi-Egea JF. Brain barrier systems: a new frontier in metal neurotoxicological research. Toxicol. Appl. Pharmacol., 192, 1-11 (2003).
7. Sanfeliu C, Sebastià J, Cristòfol R, Rodríguez- Farré E. Neurotoxicity of organomercurial compounds. Neurotox. Res., 5, 283-305 (2003).
8. Eto K. Pathology of Minamata disease. Toxicol. Pathol., 25, 614-623 (1997).
9. Hughes WL. A physicochemical rationale for the biological activity of mercury and its compounds. Ann. N. Y. Acad. Sci., 65, 454-460 (1957).
10. Mokrzan EM, Kerper LE, Ballatori N, Clarkson TW. Methylmercury- thiol uptake into cultured brain capillary endothelial cells on amino acid system L. J. Pharmacol. Exp. Ther., 272, 1277-1284 (1995).
11. Simmons-Willis TA, Koh AS, Clarkson TW, Ballatori N. Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2. Biochem. J., 367, 239-246 (2002).
12. Eto K, Yasutake A, Kuwana T, Korogi Y, Akima M, Shimozeki T, Tokunaga H, Kaneko Y. Methylmercury poisoning in common marmosets - a study of selective vulnerability within the cerebral cortex. Toxicol. Pathol., 29, 565-573 (2001).
13. Marmarou A. The pathophysiology of brain edema and elevated intracranial pressure. Cleve. Clin. J. Med., 71, S6-S8 (2004).
14. Hirooka T, Fujiwara Y, Yamamoto C, Yasutake A, Kaji T. Methylmercury retards the repair of wounded monolayer of human brain microvascular endothelial cells by inhibiting their proliferation without nonspecific cell damage. J. Health Sci., 53, 450-456 (2007).
15. Hirooka T, Fujiwara Y, Inoue S, Shinkai Y, Yamamoto C, Satoh M, Yasutake A, Eto K, Kaji T. Suppression of fibroblast growth factor-2 expression: possible mechanism underlying methylmercury-induced inhibition of the repair of wounded monolayers of cultured human brain microvascular endothelial cells. J. Toxicol. Sci., 34, 433-439 (2009).
16. Sato Y, Rifkin DB. Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis. J. Cell Biol., 107, 1199-1205 (1988).
17. Bikfalvi A, Klein S, Pintucci G, Rifkin DB. Biological roles of fibroblast growth factor-2. Endocr. Rev., 18, 26-45 (1997).
18. Rifkin DB, Moscatelli D. Recent developments in the cell biology of basic fibroblast growth factor. J. Cell Biol., 109, 1-6 (1989).
19. Yayon A, Klagsbrun M, Esko JD, Leder P, Ornitz DM. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell, 64, 841-848 (1991).
20. Fujiwara Y, Kaji T, Sakurai S, Sakamoto M, Kozuka H. Inhibitory effect of lead on the repair of wounded monolayers of cultured vascular endothelial cells. Toxicology, 117, 193-198 (1997).
21. Kaji T, Fujiwara Y, Hoshino M, Yamamoto C, Sakamoto M, Kozuka H. Inhibitory effect of lead on the proliferation of cultured vascular endothelial cells. Toxicology, 95, 87-92 (1995).
22. Fujiwara Y, Kaji T. Possible mechanism for lead inhibition of vascular endothelial cell proliferation: a lower response to basic fibroblast growth factor through inhibition of heparan sulfate synthesis. Toxicology, 133, 147-157 (1999).
23. Fujiwara Y, Kaji T. Lead inhibits the core protein synthesis of a large heparan sulfate proteoglycan perlecan by proliferating vascular endothelial cells in culture. Toxicology, 133, 159-169 (1999).
24. Choi AL, Weihe P, Budtz-Jørgensen E, Jørgensen PJ, Salonen JT, Tuomainen TP, Murata K, Nielsen HP, Petersen MS, Askham J, Grandjean P. Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men. Environ. Health Perspect., 117, 367-372 (2009).
25. Hirooka T, Fujiwara Y, Minami Y, Ishii A, Ishigooka M, Shinkai Y, Yamamoto C, Satoh M, Yasutake A, Eto K, Kaji T. Cell-density-dependent methylmercury susceptibility of cultured human brain microvascular pericytes. Toxicol. In Vitro, 24, 835-841 (2010).
26. Kromidas L, Trombetta LD, Jamall IS. The protective effects of glutathione against methylmercury cytotoxicity. Toxicol. Lett., 51, 67-80 (1990).
27. McIntyre TM, Curthoys NP. The interorgan metabolism of glutathione. Int. J. Biochem., 12, 545-551 (1980).
28. Griffith OW. Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free Radic. Biol. Med., 27, 922-935 (1999).
29. + release. Brain Res., 813, 254-261 (1998).
30. Yao CP, Allen JW, Mutkus LA, Xu SB, Tan KH, Aschner M. Foreign metallothionein-I expression by transient transfection in MT-I and MT-II null astrocytes confers increased protection against acute methylmercury cytotoxicity. Brain Res., 855, 32-38 (2000).
31. Hirooka T, Fujiwara Y, Shinkai Y, Yamamoto C, Yasutake A, Satoh M, Eto K, Kaji T. Resistance of human brain microvascular endothelial cells in culture to methylmercury: cell-density-dependent defense mechanisms. J. Toxicol. Sci., 35, 287-294 (2010).
32. Liu XM, Reyna SV, Ensenat D, Peyton KJ, Wang H, Schafer AI, Durante W. Platelet-derived growth factor stimulates LAT1 gene expression in vascular smooth muscle: role in cell growth. FASEB J., 18, 768-770 (2004).
33. Duelli R, Enerson BE, Gerhart DZ, Drewes LR. Expression of large amino acid transporter LAT1 in rat brain endothelium. J. Cereb. Blood Flow Metab., 20, 1557-1562 (2000).