Obesity, Inflammation and Acute Myocardial Infarction - Expression of leptin, IL-6 and high sensitivity-CRP in Chennai based population

Thrombosis Journal

Volumn 10, Issue , 2012, Pages

  Rajendran, Karthick ^a   Devarajan, Nalini ^a   Ganesan, Manohar ^b   Ragunathan, Malathi ^a  

^a UNIVERSITY OF MADRAS   (India)

^b STANLEY MEDICAL COLLEGE   (India)

Author keywords

Acute myocardial infarction; Cardiovascular disease; CRP; IL 6; Leptin; Obesity

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 6; LEPTIN;

ACUTE HEART INFARCTION; ARTICLE; BODY MASS; CONTROLLED STUDY; HUMAN; INDIA; INFLAMMATION; MAJOR CLINICAL STUDY; OBESITY; PROTEIN EXPRESSION; UPREGULATION;

EID: 84864941472     PISSN: None     EISSN: 14779560     Source Type: Journal    
DOI: 10.1186/1477-9560-10-13     Document Type: Article

References (24)

1. Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, McQueen M, Budaj A, Pais P, Varigos J, Lisheng L, , . on behalf of the INTERHEART Study Investigators, on behalf of the INTERHEART Study Investigators Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 2004, 364:937-952. 10.1016/S0140-6736(04)17018-9, 15364185, on behalf of the INTERHEART Study Investigators, on behalf of the INTERHEART Study Investigators.
2. Kenchaiah S, Evans JC, Levy D, Wilson PW, Benjamin EJ, Larson MG, Kannel WB, Vasan RS. Obesity and the risk of heart failure. N Engl J Med 2002, 347:305-313. 10.1056/NEJMoa020245, 12151467.
3. Christian Schulze P, Kratzsch J, Linke A, Schoene N, Adams V, Gielen S, Erbs S, Moebius-Winkler S, Schuler G. Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic heart failure. Eur J Hear Fail 2003, 5:33-40.
4. Fruhbeck G, Jebb SA, Prentice AM. Leptin: physiology and pathophysiology. Clin Physiol 1998, 18:399-419. 10.1046/j.1365-2281.1998.00129.x, 9784936.
5. Sierra-Honigmann MR, Nath AK, Murakami C, Garcia-Cardeña G, Papapetropoulos A, Sessa WC, Madge LA, Schechner JS, Schwabb MB, Polverini PJ, Flores-Riveros JR. Biological action of leptin as an angiogenic factor. Science 1998, 281:1683-1686.
6. Cooke JP, Oka RK. Does leptin cause vascular disease. Circulation 2002, 106:1904-1905. 10.1161/01.CIR.0000036864.14101.1B, 12370209.
7. Kofler S, Nickel T, Weis M. Role of cytokines in cardiovascular diseases: a focus on endothelial responses to inflammation. Clin Sci 2005, 108:205-213. 10.1042/CS20040174, 15540988.
8. Valgimigli M, Merli E, Malagutti P, Soukhomovskaia O, Cicchitelli G, Macrì G, Ferrari R. Endothelial dysfunction in acute and chronic coronary syndromes: evidence for a pathogenetic role of oxidative stress. Arch Biochem Biophys 2003, 420(2):255-261. 10.1016/j.abb.2003.07.006, 14654064.
9. Dubey L, Zeng HS, Wang HJ, Liu RY. Potential Role of Adipocytokine Leptin in Acute Coronary Syndrome. Asian Cardiovasc Thorac Ann 2008, 16:124-128.
10. Iràculis E, Cequier A, Gómez-Hospital JA, Sabaté M, Mauri J, Fernández-Nofrerias E, del Blanco BG, Jara F, Esplugas E. Early dysfunction and long-term improvement in endothelium-dependent vasodilation in the infarct-related artery after thrombolysis. J Am Coll Cardiol 2002, 40:257-265. 10.1016/S0735-1097(02)01953-8, 12106929.
11. Fan ZX, Hua Q, Tan J, Gao J, Liu R-K, Yang Z. Interleukin-6 but not soluble adhesion molecules has short-term prognostic value on mortality in patients with acute ST-segment elevation myocardial infarction. Afr J Biotechnol 2011, 10(8):1454-1459.
12. Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004, 92:347-355. 10.1079/BJN20041213, 15469638.
13. Mathur KS, Patney NL, Kumar V. Atherosclerosis in India: An Autopsy Study of the Aorta and the Coronary, Cerebral, Renal, and Pulmonary Arteries. Circulation 1961, 24:68-75. 10.1161/01.CIR.24.1.68, 13768143.
14. Tracy RP. Thrombin, Inflammation, and Cardiovascular Disease : An Epidemiologic Perspective. Chest 2003, 124:49S-57S. 10.1378/chest.124.3_suppl.49S, 12970124.
15. Bahathiq AOS. Relationship of Leptin Hormones with Body Mass Index and Waist Circumference in Saudi Female Population of the Makkah Community. The Open Obesity Journal 2010, 2:95-100.
16. Zabrocka L, Raczynska S, Goyke E, Sledzinski Z, Swierczynski J. BMI Is the Main Determinant of the Circulating Leptin in Women after Vertical Banded Gastroplasty. Obes Res 2004, 12(3):505-512. 10.1038/oby.2004.57, 15044668.
17. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF. Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans. N Engl J Med 1996, 334:292-295. 10.1056/NEJM199602013340503, 8532024.
18. Halle M, Persson PB. Role of leptin and leptin receptor in inflammation. Am J Physiol Regul Integr Comp Physiol 2003, 284:R760-R762.
19. Frisullo G, Angelucci F, Mirabella M, Caggiula M, Patanella K, Nociti V, Tonali PA, Batocchi AP. Leptin Enhances the Release of Cytokines by Peripheral Blood Mononuclear Cells from Relapsing Multiple Sclerosis Patient. J Clin Immunol 2004, 24(3):287-293.
20. Matarese G, Di Giacomo A, Sanna V, Lord GM, Howard JK, Di Tuoro A, Bloom SR, Lechler RI, Zappacosta S, Fontana S. Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. J Immunol 2001, 166:5909-5916.
21. Martin-Romero C, Santos-Alvarez J, Goberna R, Sanchez-Margalet V. Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol 2000, 199:15-24. 10.1006/cimm.1999.1594, 10675271.
22. Toth MJ, Gottlieb SS, Fisher ML, Ryan AS, Nicklas BJ, Poehlman ET. Plasma leptin concentrations and energy expenditure in heart failure patients. Metabolism 1997, 46(4):450-453. 10.1016/S0026-0495(97)90065-2, 9109853.
23. Leyva F, Anker SD, Egerer K, Stevenson JC, Kox WJ, Coats AJS. Hyperleptinaemia in chronic heart failure. Relationships with insulin. Eur Heart J 1998, 19:1547-1551. 10.1053/euhj.1998.1045, 9820994.
24. Smith CC, Mocanu MM, Davidson SM, Wynne AM, Simpkin JC, Yellon DM. Leptin, the obesity-associated hormone, exhibits direct cardioprotective effects. Br J Pharmacol 2006, 149:5-13. 10.1038/sj.bjp.0706834, 1629412, 16847434.