Development of prilocaine gels for enhanced local anesthetic action

Archives of Pharmacal Research

Volumn 35, Issue 7, 2012, Pages 1197-1204

  Kang, Chung ^a   Shin, Sang Chul ^a  

^a Chonnam National University   (South Korea)

Author keywords

Bioadhesive; Local anesthetic action; Penetration enhancer; Prilocaine; Topical

Indexed keywords

2 PYRROLIDONE DERIVATIVE; CARBOXYMETHYLCELLULOSE; FATTY ACID; NONIONIC SURFACTANT; PRILOCAINE; PROPYLENE GLYCOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG PENETRATION; DRUG RELEASE; GEL; LOCAL ANESTHESIA; MALE; NONHUMAN; RAT; SKIN PERMEABILITY; TAIL FLICK TEST; TEMPERATURE SENSITIVITY; VISCOSITY;

ADHESIVENESS; ADMINISTRATION, CUTANEOUS; ADMINISTRATION, TOPICAL; ANESTHETICS, LOCAL; ANIMALS; CARBOXYMETHYLCELLULOSE SODIUM; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; EXCIPIENTS; GELS; IMIDAZOLES; KINETICS; MALE; PAIN THRESHOLD; POLYETHYLENE GLYCOLS; PRILOCAINE; RATS; RATS, SPRAGUE-DAWLEY; SKIN; SKIN ABSORPTION; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; VISCOSITY;

EID: 84864934894     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0710-x     Document Type: Article

References (36)

1. Adrian, C. W. and Barry, B. W., Penetration enhancers. Adv. Drug Deliv. Rev., 56, 603-618 (2004). (Pubitemid 38326936)
2. Aungst, B. J. and Rogers, N. J., Comparison of the feects of various transmucosal absorption promoters on buccal insulin delivery. Int. J. Pharm., 53, 227-235 (1989). (Pubitemid 19198390)
3. Barry, B. W. and Bennett, S. L., Effect of penetration enhancers on the permeation of mannitol, hydrocortisone and progesterone through human-skin. J. Pharm. Pharmacol., 39, 535-546 (1987). (Pubitemid 17120953)
4. Barry. B. W., Breaching the skin's barrier to drugs. Nat. Biotechnol., 22, 165-167 (2004). (Pubitemid 38160527)
5. Bhatia, K. S. and Singh, J., Synergistic effect of iontophoresis and a series of fatty acids on LHRH permeability through porcine skin, J. Pharm. Sci., 87, 462-469 (1998). (Pubitemid 28175808)
6. Burkman, R. T., Transdermal hormonal contraception: benefits and risks. Am. J. Obstet. Gynecol., 197, 134-136 (2007).
7. Chi, S. C., Park, E. S., and Kim, H., Effect of penetration enhancers on flurbiprofen permeation through rat skin. Int. J. Pharm., 126, 267-274 (1995). (Pubitemid 26015642)
8. Cho, C. W., Choi, J. S., and Shin, S. C., Enhanced local anesthetic efficacy of bioadhesive ropivacaine gels. Biomol. Therap., 19, 357-363 (2011).
9. Choi, J. S. and Shin, S. C., Enhanced bioavability of ambroxol by transdermal administration of the EVA matrix containing penetration enhancer in rats. Biomol. Therap., 18, 106-110 (2010).
10. D'Amour, F. E. and Smith, D. L., A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther., 72, 74-79 (1941).
11. Ding, N., Xu, J., Yao, Y., Wegner, G., Lieberwirth, I., and Chen, C., Improvement of cyclability of Si as anode for Liion batteries. J. Power Sources, 192, 644-651 (2009).
12. Esposito, E., Carotta, V., Scabbia, A., Trombelli, L., Antona, P. D., Menegatti, E., and Nastruzzi, C., Comparative analysis of tetracycline containing dental gels: poloxamer and monoglyceride-based formulations. Int. J. Pharm., 142, 9-23 (1996). (Pubitemid 26343826)
13. Gao, Z., Crowley, W. R., Shukla, A. J., Johnson, J. R., and Reger, J. F., Controlled release of contraceptive steroids from biodegradable and injectable gel formulations; in vivo evaluation. Pharm. Res., 12, 864-868 (1995).
14. Green, P. G., Guy, R. H., and Hadgraft, J., In vitro and in vivo enhancement of skin permeation with oleic-acid and lauric acids. Int. J. Pharm., 37, 251-255 (1988).
15. Hadgraft, J. and Walters, K. A., Pharmaceutical Skin Penetration Enhancement. Marcel Dekker, New York, pp. 3-4, (1993).
16. Jokinen, H. M., Niinimaki, J., and Ammala, A. J., The effect of an anionic polymer additive on fractionation of paper pulp. Appita J., 59, 459-464 (2006). (Pubitemid 44758068)
17. Jungbauer, F. H. W., Coenraads, P. J., and Kardaun, S. H., Toxic hygroscopic contact reaction to N-methyl-2-pyrrolidone. Contact Dermatitis, 45, 303-304 (2001). (Pubitemid 33032976)
18. Kandimalla, K., Kanikkannan, N., Andega, S., and Singh, M., Effect of fatty acids on the permeation of melatonin across rat and pig skin in-vitro and on the transepidermal water loss in rats in-vivo. J. Pharm. Pharmacol., 51, 783-790 (1999). (Pubitemid 29377949)
19. Lee, J., Lee, S., Paik, U., and Choi, Y., Aqueous processing of natural graphite particulates for lithium-ion battery anodes and their electrochemical performance. J. Power Sources, 147, 249-255 (2005).
20. Lopez, A., Llinares, F., Cortell, C., and Herraez, M., Comparative enhancer effects of span 20 with Tween 20 and Azone on the in vitro percutaneous penetration of compounds with different lipophilicities. Int. J. Pharm., 202, 133-140 (2000). (Pubitemid 30466239)
21. Ness, T. J. and Gebhart, G. F., Centrifugal modulation of the rat tail flick evoked by graded noxious heating of the tail. Brain Res., 386, 41-52 (1986). (Pubitemid 17181458)
22. Miyazaki, S., Takeuchi, S., Yokouchi, C., and Takada, M., Pluronic F-127 gels as a vehicle for topical administration of anticancer agents. Chem. Pharm. Bull., 32, 4205-4208 (1984). (Pubitemid 15208373)
23. Naik, A., Pechtold, L., Potts, R. O., and Guy, R. H., Mechanism of oleic acid induced skin penetration enhancement in vivo in humans, J. Control. Release, 37, 299-306 (1995). (Pubitemid 26007540)
24. Oh, S. Y., Jeong, S. Y., Park, T. G., and Lee, J. H., Enhanced transdermal delivery of AZT (Zidovudine) using iontophoresis and penetration enhancer. J. Control. Release, 51, 161-168 (1998). (Pubitemid 28252867)
25. Ossipov, M. H. and Gebhart, G. F., Adrenergenic influences on the modulation of nociception from the lateral nucleus of the rat. Brain Res., 384, 282-293 (1986). (Pubitemid 16008339)
26. Prausnitz, M. R., Mitragotri, S., and Langer, R., Current status and future potential of transdermal drug delivery. Nat. Rev. Drug Discov., 3, 115-124 (2004). (Pubitemid 38239773)
27. Shin, S. C., Cho, C. W., and Oh, I. J., Effects of non-ionic surfactants as permeation enhancers towards piroxicam from the poloxamer gel through rat skins. Int. J. Pharm., 222, 199-203 (2001).
28. Squillante, E., Needham, T., Maniar, A., Kislaliglu, S., and Zia, H., Codiffusion of propylene glycol and dimethyl isosorbide in hairless mouse skin. Eur. J. Pharm. Biopharm., 46, 265-271 (1998). (Pubitemid 29057672)
29. Sinha, V. R. and Kaur, M. P., Permeation enhancers for transdermal drug delivery. Drug Dev. Ind. Pharm., 26, 1131-1140 (2000).
30. Shokri, J., Nokhodchi, A., Kashbolaghi, A., Hassan-Zadeh, K., Ghafourian, T., and Barzegar-Jalali, M., The effect of surfactants on the skin penetration of diazepam, Int. J. Pharm., 228, 99-107 (2001). (Pubitemid 32905369)
31. Takeuchi, Y., Yamaoka, Y., Jukushima, S., Miyawaki, K., Taguchi, K., Yasuka, H., Kishimoto, S., and Suzuki, M., Skin penetration enhancing action of cis-unsaturated fatty acids with ù-9 and ù-12 chain lengths. Biol. Pharm. Bull., 21, 462-469 (1998).
32. Tanojo, H., Bouwstra, J. A., Junginger, H. E., and Bodde, H. E., In vitro human skin barrier modulation by fatty acid : skin permeation and thermal analysis studies. Pharm. Res., 14, 42-49 (1997). (Pubitemid 27113313)
33. Verma, D. D., Blume, S. G., and Fahr, A., Particle size of liposomes influences dermal delivery of substances into skin. Int. J. Pharm., 258, 141-151 (2003). (Pubitemid 36712878)
34. Watanabe, M., Gondo, T., and Kitao, O., Advance wet end system with carboxymethyl cellulose. TAPPI J., 3, 15-19 (2004).
35. Yamada, M., Uda, Y., and Tanigawara, Y., Mechanism of enhancement of percutaneous absorption of molsidomine by oleic acid. Chem. Pharm. Bull., 35, 3399-3406 (1987). (Pubitemid 17133558)
36. Zhang, L. M., Cellulosic associative thickeners. Carbohydr. Polym., 45, 1-10 (2001).