100 gram scale synthesis of a key intermediate of matrix metalloproteinase inhibitor in a continuous-flow system based on a copper-free sonogashira reaction using an ionic liquid as a catalyst support

Synlett

Volumn 23, Issue 15, 2012, Pages 2279-2283

  Fukuyama, Takahide ^a   Rahman, Md Taifur ^a   Sumino, Yukihito ^b   Ryu, Ilhyong ^a  

^a Osaka Prefecture University   (Japan)

^b SHIONOGI AND CO LTD   (Japan)

Author keywords

flow reaction; ionic liquids; matrix metalloproteinase inhibitor; microreactor; palladium; Sonogashira coupling

Indexed keywords

COPPER; IONIC LIQUID; MATRIX METALLOPROTEINASE INHIBITOR; PALLADIUM;

ARTICLE; CATALYST; CHEMICAL STRUCTURE; CONTINUOUS FLOW REACTOR; REACTION ANALYSIS; RECYCLING; SOLVENT EFFECT; SONOGASHIRA REACTION; SYNTHESIS;

EID: 84864931518     PISSN: 09365214     EISSN: 14372096     Source Type: Journal    
DOI: 10.1055/s-0031-1290456     Document Type: Article

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