New insights on Dimethylaminoethanol (DMAE) features as a free radical scavenger

Drug Metabolism Letters

Volumn 6, Issue 1, 2012, Pages 54-59

  Malanga, Gabriela ^a   Aguiar, María Belén ^a   Martinez, Hugo D ^a   Puntarulo, Susana ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Antioxidant; Ascorbyl radical; Dimethylaminoethanol (DMAE); Hydroxyl radical; Lipid radicals

Indexed keywords

ACETYLCHOLINE; ASCORBIC ACID; DEANOL; HYDROXYL GROUP; NEUROTRANSMITTER; THIOBARBITURIC ACID REACTIVE SUBSTANCE; ANTIOXIDANT; DEHYDROASCORBIC ACID; DRUG DERIVATIVE; FREE RADICAL; HYDROXYL RADICAL; SCAVENGER; SEMIDEHYDROASCORBIC ACID;

ANTIOXIDANT ACTIVITY; ARTICLE; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); ELECTRON SPECTROSCOPIC RESONANCE; IC 50; LEARNING; LIVER MICROSOME; MEMORY; NONHUMAN; PEROXIDATION; PRIORITY JOURNAL; RAT; SPECTROSCOPY; ANIMAL; DOSE RESPONSE; ELECTRON SPIN RESONANCE; METABOLISM;

ANIMALS; ANTIOXIDANTS; DEANOL; DEHYDROASCORBIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICAL SCAVENGERS; FREE RADICALS; HYDROXYL RADICAL; MICROSOMES, LIVER; RATS;

EID: 84864930926     PISSN: 18723128     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231212800229282     Document Type: Article

References (39)

1. Kapoor, V.K.; Dureja, J.; Chadha, R. Synthetic drugs with antiageing effects. Drug Discov. Today, 2009, 14, 899-904.
2. Leon Oettinger Jr., M.D. The use of deanol in the treatment of disorders of behavior in children. J. Pediatr., 1958, 53(6), 671-675.
3. Pathak, M.A. Topical and systemic approaches for protection of human skin against harmful effects of solar radiation. J. Am. Acad. Dermatol., 1982, 7, 285-312.
4. Uhoda, I.; Faska, N.; Robert, C.; Cauwenbergh, G.; Piérard, G.E. Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel. Skin Res. Technol., 2002, 8(3), 164-167.
5. Puntarulo, S.; Cederbaum, A.I.; Comparison of the ability of the ferric complexes to catalyze microsomal chemiluminescence, lipid peroxidation and hydroxyl radical generation. Arch. Biochem. Biophys., 1988, 264, 482-491.
6. Boveris, A.D.; Puntarulo, S. Free-radical scavenging actions of natural antioxidants. Nutr. Res., 1998, 18, 1545-1557.
7. Boveris, A.D.; Galatro, A.; Puntarulo, S. Effect of nitric oxide and plant antioxidants on microsomal content of lipid radicals. Biol. Res., 2000, 33, 159-165.
8. Jurkiewicz, B.A.; Buettner, G.R. Ultraviolet light-induced free radical formation in skin: an electron paramagnetic resonance study. Photochem. Photobiol., 1994, 59, 1-4.
9. Kotake, Y.; Tanigawa, T.; Tanigawa, M.; Ueno, I.; Allen, D.R.; Lai, C. Continous monitoring of cellular nitric oxide generation by spin trapping with an iron-dithiocarbamate complex. Biochim. Biophys. Acta, 1996, 1289, 362-368.
10. Green, M.J., Hill, H.A. Chemistry of dioxygen. Meth. Enzymol., 1984, 105, 3-22.
11. McCay, P.B.; Reinke, L.A.; Rau, J.M. Hydroxyl radicals are generated by hepatic microsomes during NADPH oxidation: relationship to thenol metabolism. Free Radic. Res. Comm., 1992, 15, 335-346.
12. Giulivi, C.; Cadenas, E. The reaction of ascorbic acid with different heme iron redox states of myoglobin. FEBS Lett., 1993, 332, 287-290.
13. Buettner, G.R. Spin trapping: ESR parameters of spin adducts. Free Radic. Biol. Med., 1987, 3, 259-303.
14. Etienne, A.; Hecquet, F.; Clostre, F. Comparison des effects d'un extrail de Gingko biloba et de la chor-promazine sur la fragilité osmotique, in vitro, d'erytrocutes de rat. J. Pharmacol., 1982, 13, 291-298.
15. Re', O. 2-Dimethylaminoethanol (deanol): a brief review of its clinical efficacy and postulated mechanism of action. Curr. Ther. Res. Clin. Exp., 1974, 16, 1238-1242.
16. Knobel, M. Approach to a combined pharmacologic therapy of childhood hyperkinesis. Behav. Neuropsychiatry, 1974 Apr-1975 Mar, 6, 87-90.
17. Fisman, M.; Mersky, H.; Helmes, E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer's disease. Am. J. Psychiat., 1981, 138, 970-972.
18. Casey, D.E.; Denney, D. Dimethylaminoethanol in tardive dyskinesia [letter]. N. Engl. J. Med., 1974, 291, 797.
19. Alphs, L.; Davis, J.M. Noncatecholaminergic treatments of tardive dyskinesia. J. Clin. Psychopharmacol., 1982, 2, 380-385.
20. Soares, K.V.; McGrath, J.J. The treatment of tardive dyskinesia-a systematic review and meta-analysis. Schizophr. Res., 1999, 39, 1-18.
21. Caraceni, T.A.; Girotti, F.; Celano, I. 2-dimethylaminoethanol (deanol) in Huntington's chorea. J. Neurol. Neurosurg. Psychiat., 1978, 41, 1114-1118.
22. Tarsy, D.; Bralower, M. Deanol acetamidobenzoate treatment in choreiform movement disorders. Arch. Neurol., 1977, 34, 756-758.
23. Harman, D. Nutritional implications of the free-radical theory of aging. J. Am. Coll. Nutr., 1982, 1(1), 27-34.
24. Vendemiale, G.; Grattagliano, I; Altomare. E. An update on the role of free radicals and antioxidant defense in human disease. Int. J. Clin. Lab. Res., 1999, 29(2), 49-55.
25. Toyokumi, S. Reactive oxygen species-included molecular damage and its application in pathology. Phatol. Int., 1999, 49(2), 91-102.
26. Zs-Nagy, I. The membrane structure and function in cellular aging: a review. Mech. Aging Dev., 1979, 9(3-4), 237-246.
27. Terman, A. Garbage catastrophe theory of aging: imperfect removal of oxidative damage? Redox Rep., 2001, 1, 15-26.
28. Zs-Nagy, I. The membrane hypothesis of aging: its relevance to recent progress in genetic research. J. Mol. Med., 1997, 75(10), 703-714.
29. Zs-Nagy, I.; Semsei, I. Centrophenoxine increases the rates of total and mRNA synthesis in the brain cortex of old rats: an explanation of its action in terms of the membrane hypothesis of aging. Exp. Gerontol., 1984, 9(3), 171-178.
30. Wilhelm, J. Metabolic aspects of membrane lipid peroxidation. Acta Univ. Carol Med. Monogr., 1990, 137, 1-53.
31. Spiteller, G. Peroxidation of linolic acid and its relation to aging and age dependent diseases. Review. Mech. Ageing Dev., 2001, 122(7), 617-657.
32. Zs-Nagy, I.; Floyd, R.A. Electron spin resonance spectroscopic demonstration of the hydroxyl free radical scavenger properties of dimethylaminoethanol in spin trapping experiments conforming the molecular basis for the biological effects of centrophenoxine. Arch. Gerontol Geriatr., 1984, 3(4), 297-310.
33. Zahniser, N.R.; Chou, D.; Hanin, I. Is 2-dimthylaminoethanol (deanol) indeed a precursor of brain acetylcholine? A gas chromatographic evaluation. J. Pharmacol. Exp. Ther., 1977, 200, 545-559.
34. Gragnani, A.; Giannoccaro, F.B.; Moraes, A.A.; Franca, J.P.; Ferreira, A.T.; Ferreira, L.M. Dimethylaminoethanol affects viability of human cultured fibroblasts. Aesthetic. Plast. Surg., 2007, 31(6), 711-718.
35. Maitra, I.; Marcci, L.; Droy-Lefaix, M.T.; Packer, L. Peroxyl radical scavenging activity of Gingko biloba extract EGb 761. Biochem. Pharmacol., 1995, 49, 1649-1655.
36. Kose, K.; Dogan, P. Lipoperoxidation induced by hydrogen peroxide in human erytrocyt membranes. 2. Comparison of the antioxidant effect of Gingko biloba extract (EGb 761) with those of water-soluble and lipid antioxidants. J. Inter. Med Res., 1995, 23, 9-18.
37. Deby, C.; Pincernail, J. In: Rokan (Gingko biloba) Recent results in pharmacology and clinic; Funfgeld F.W., Ed.; Springer Verlag Berlin Heidelberg New York, 1988; 57-70.
38. Mix, J.A.; Crews, W.D. A double-lind, placebo controlled, randomized trial of Ginkgo Biloba extract EGb 761 in a sample of cognitibily intact older adults: neuropsychological findings. Human Psychopharmacol. Clin. Exp., 2002, 17, 267-277.
39. Grossman, R. The role of dimethylaminoethanol in cosmetic dermatology. Am. J. Clin. Derm., 2005, 6(9), 39-37.