The membrane hypothesis of aging: Its relevance to recent progress in genetic research

Journal of Molecular Medicine

Volumn 75, Issue 10, 1997, Pages 703-714

  Zs Nagy, Imre ^a,b,c  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c Verzár International Laboratory for Experimental Gerontolgy   (Hungary)

Author keywords

Antioncogene products; Membrane hypothesis of aging; Mitotic regulation; Oncogene products; Plasma membrane structure and function

Indexed keywords

AGING; CELL MEMBRANE; COLLOID; CYTOLOGY; DEVELOPMENT; HUMAN; MATURATION; MEMBRANE STRUCTURE; MITOSIS; MOLECULAR GENETICS; ONCOGENE; PHYSICAL CHEMISTRY; REVIEW;

AGING; ANIMALS; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; COLLOIDS; HUMANS; LIPOFUSCIN; MODELS, BIOLOGICAL; PROTEIN BIOSYNTHESIS; TRANSCRIPTION, GENETIC;

EID: 14444268046     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090050157     Document Type: Review

References (155)

1. Strehler BL (1959) Origin and comparison of the effects of time and high energy radiations on living systems. Q Rev Biol 34:117-142
2. Zs.-Nagy I (1994) The membrane hypothesis of aging. CRC, Boca Raton
3. Strehler BL (1962) Time, cells and aging. Academic, New York
4. Barnett Y, King CM (1995) An investigation of antioxidant status, DNA repair capacity and mutation as a function of age in humans. Mutat Res 338:115-128
5. Allsopp RC, Chang E, Kashefi-Aazam M, Rogaev EI, Piatyszek MA, Shay JW, Harley CB (1995) Telomere shortening is associated with cell division in vitro and in vivo. Exp Cell Res 220:194-200
6. Ozawa T (1995) Mechanism of somatic mitochondrial DNA mutations associated with age and diseases. Biochim Biophys Acta 1271:177-189
7. Zs.-Nagy I (1978) A membrane hypothesis of aging. J Theor Biol 75:189-195
8. Zs.-Nagy I (1979) The role of membrane structure and function in cellular aging: a review. Mech Ageing Dev 9:237-246
9. Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11:298-300
10. Harman D (1981) The aging process. Proc Natl Acad Sci USA 78:7124-7128
11. Zs.-Nagy I (1992) A proposal for reconsideration of the role of oxygen free radicals in cell differentiation and aging. Ann NY Acad Sci 673:142-148
12. Zs.-Nagy I (1995) Semiconduction of proteins as an attribute of the living state: the ideas of Albert Szent-Györgyi revisited in the light of the recent knowledge regarding oxygen free radicals. Exp Gerontol 30:327-335
13. Tauber R, Reutter W (1981) Turnover of plasma membrane proteins and glycoproteins in normal and regenerating liver and Morris hepatoma 7777. Eur J Cell Biol 26:35-42
14. Ritchie JM (1973) Energetic aspects of nerve conduction: the relationships between heat production, electrical activity and metabolism. Prog Biophys Mol Biol 26:149-187
15. De Loof A (1986) The electrical dimension of cells as a miniature electrophoresis chamber. Int Rev Cytol 104:251-352
16. Shinitzky M (ed) (1984) Physiology of membrane fluidity. CRC, Boca Raton
17. Nagy K, Zs.-Nagy V, Bertoni-Freddari C, Zs.-Nagy I (1983) Alterations of the synaptosomal membrane microviscosity in the brain cortex of rats during aging and centrophenoxine treatment. Arch Gerontol Geriatr 2:23-39
18. Nagy K, Simon P, Zs.-Nagy I (1983) Spin label studies on synaptosomal membranes of rat brain cortex during aging. Biochem Biophys Res Commun 117:688-694
19. Nagy K, Zs.-Nagy I (1984) Alterations in the molecular weight distribution of proteins in rat brain synaptosomes during aging and centrophenoxine treatment. Mech Ageing Dev 28:171-176
20. Zs.-Nagy I, Ohta M, Kitani K, Imahori K (1984) An automated method for measuring lateral mobility of proteins in the plasma membrane of cells in compact tissues by means of fluorescence recovery after photobleaching. Mikroskopie 41: 12-25
21. Zs.-Nagy I, Kitani K, Ohta M, Zs.-Nagy V, Imahori K (1986) Age-dependent decrease of the lateral diffusion constant of proteins in the plasma membrane of hepatocytes as revealed by fluorescence recovery after photobleaching in tissue smears. Arch Gerontol Geriatr 5:131-146
22. Zs.-Nagy I, Kitani K, Ohta M, Zs.-Nagy V, Imahori K (1986) Age-estimations of rats based on the average lateral diffusion constant of hepatocyte membrane proteins as revealed by fluorescence recovery after photobleaching. Exp Gerontol 21: 555-563
23. Zs.-Nagy I, Kitani K, Ohta M (1989) Age dependence of the lateral mobility of proteins in the plasma membrane of hepa-tocytes in C57BL/6 mice: FRAP studies on liver smears. J Gerontol Biol Sci 44: B83-B87
24. Zs.-Nagy I, Cutler RG, Kitani K, Ohta M (1993) Comparison of the lateral diffusion constant of hepatocyte membrane proteins in two wild mouse strains of considerably different longevity: FRAP studies on liver smears. J Gerontol Biol Sci 48: B86-B92
25. Kitani K, Zs.-Nagy I, Kanai S, Sato Y, Ohta M (1988) Correlation between the biliary excretion of ouabain and the lateral mobility of hepatocyte plasma membrane proteins in the rat. The effects of age and spironolactone pretreatment. Hepatology 8:125-131
26. Zs.-Nagy I, Kitani K (1996) Age-dependence of the lateral mobility of lipids in hepatocyte plasma membrane of male rats and the effect of life-long dietary restriction. Arch Gerontol Geriatr 23:81-93
27. Zs.-Nagy I, Gyenes M, Lustyik Gy, Zs.-Nagy V, Jeney F (1982) Age-dependent decrease of cell membrane permeability of rat hepatocytes as revealed by in vivo Rb-uptake and release. In: Kitani K (ed) Liver and aging 1982. Elsevier Biomedical, Amsterdam, pp 215-229
28. + permeability of the nerve cell membranes in rat brain cortex as revealed by in vivo measurement of the Rb discrimination ratio. Arch Gerontol Geriatr 3:11-31
29. Zs.-Nagy I, Tóth S, Lustyik Gy (1985) Verification of the membrane hypothesis of aging on the identified giant neurons of the snail Lymnaea stagnalis L. (Gastropoda, Pulmonata) by a combined application of intracellular electrophysiology and X-ray microanalysis. Arch Gerontol Geriatr 4: 53-66
30. Frolkis VV, Martynenko OA, Timchenko AL (1989) Age-related changes in the function of somatic membrane potassium channels of neurons in the mollusc Lymnaea stagnalis. Mech Ageing Dev 47:47-54
31. Scott B, Leu J, Cinader B (1988) Effects of aging on neuronal electrical membrane properties. Mech Ageing Dev 44: 203-214
32. Bunting TA, Scott BS (1989) Aging and ethanol alter neuronal electric membrane properties. Brain Res 501:105-115
33. Scott BS, Petit TL, Becker LE, Edwards BAV (1982) Abnormal electric membrane properties of Down's syndrome DRG neurons in cell culture. Dev Brain Res 2:257-270
34. Sinex FM, Merril CR (1982) Alzheimer's disease, Down's syndrome and aging. Ann NY Acad Sci 396:3-14
35. St.Clair D, Blackwood D (1985) Premature senility in Down's syndrome. Lancet 2:34
36. De Luca A, Mambrini M, Conte-Camerino D (1990) Changes in membrane ionic conductances and excitability characteristics of rat skeletal muscle during aging. Pflugers Arch 415: 642-644
37. Zs.-Nagy I, Derecskei B, Lustyik Gy (1987) Age-dependent changes in the osmometric behavior of rat brain and liver. Arch Gerontol Geriatr 6:339-354
38. Desborders P, Cohadon F (1987) Brain water and aging. J Gerontol 42:655-659
39. Platt D (1976) Biologie des Alterns. Quelle et Meyer, Heidelberg
40. Damjanovich S, Somogyi B (1973) A molecular enzyme model based on oriented energy transfer. J Theor Biol 41: 567-569
41. Somogyi B, Damjanovich S (1975) Relationship between the lifetime of an ES-complex and the properties of molecular environment. J Theor Biol 51:393-401
42. Damjanovich S, Zs.-Nagy I, Somogyi B (1989) Application of a molecular enzyme kinetic model for aging cells and tissues. Arch Gerontol Geriatr 8:37-45
43. Demchenko AP, Rusyn OI, Saburova EA (1989) Kinetics of the lactate dehydrogenase reaction in high-viscosity media. Biochim Biophys Acta 998:196-203
44. Zs.-Nagy I, Floyd RA (1991) The effects of the molecular environment on the kinetics of catalase reaction and its relevance to cell aging. Arch Gerontol Geriatr 13:187-200
45. Van der Sanden MJT, Nagy K, Semsei I, Zs.-Nagy I (1995) An in vitro model of aging: the influence of increasing physical density on enzyme activities of trypsin, xanthine oxidase and superoxide dismutase. Arch Gerontol Geriatr 20: 273-282
46. Richardson A, Roberts MS, Rutherford MS (1985) Aging and gene expression. In: Rothstein M (ed) Review of biological research in aging, vol 2. Liss, New York, pp 395-419
47. Van Bezooijen CFA, Grell T, Knook DL (1977) The effect of age on protein synthesis by isolated liver parenchymal Cells. Mech Ageing Dev 6:293-304
48. Van Bezooijen CFA, Sakkee AN, Knook DL (1981) Sex and strain dependency of age related changes in protein synthesis of isolated rat hepatocytes. Mech Ageing Dev 17:11-18
49. Coniglio JJ, Liu DSH, Richardson A (1979) A comparison of protein synthesis by liver parenchymal cells isolated from Fischer 344 rats of various ages. Mech Ageing Dev 11:77-90
50. Van Bezooijen CFA, Knook DL (1977) Aging changes in bromsulfophtalein uptake, albumin and total protein synthesis in isolated hepatocytes. In: Platt D (ed) Liver and ageing. Schattauer, Stuttgart, pp 117-241
51. Everitt AV (1958) The urinary excretion of protein, nonprotein nitrogen and creatinine and uric acid in ageing male rats. Gerontologia 2:33-46
52. Berg BN (1965) Spontaneous nephrosis with proteinuria, hyperglobulinemia and hypercholesterolemia in the rat. Proc Soc Exp Biol Med 119:417-420
53. Perry SW (1965) Proteinuria in the Wistar rat. J Pathol Bacteriol 80:729-733
54. Beauchene RE, Roeder LM, Barrows CH (1970) The interrelationships of age, tissue protein synthesis and proteinuria. J Gerontol 25:359-363
55. Salatka K, Kresge D, Harris L, Edelstein D, Ove P (1971) Rat serum protein changes with age. Exp Gerontol 6:25-36
56. Ove P, Obenrader M, Lansing A (1972) Synthesis and degradation of liver proteins in young and old rats. Biochim Biophys Acta 277:211-221
57. Chen JC, Ove P, Lansing AI (1973) In vitro synthesis of microsomal protein and albumin in young and old rats. Biochim. Biophys Acta 312:598-607
58. Coleman GL, Barthold SW, Osbaldiston GW, Foster SJ, Jonas AM (1977) Pathological changes during aging in barrierreared Fischer 344 male rats. J Gerontol 32:258-278
59. Adelman RC (1975) Disruptions in enzyme regulation during aging. In: Parke DV (ed) Enzyme induction. Plenum, London, pp 303-311
60. Kanungo MS (1980) Biochemistry of ageing. Academic, New York
61. Kitani K (1991) Aging of the liver: facts and theories. Arch Gerontol Geriatr 12:133-154
62. Kitani K (1988) Drugs and the aging liver. Life Chem Rep 6: 143-230
63. Kitani K (1990) Aging and the liver. In: Popper H, Schaffner F (eds) Progress in liver diseases, vol IX. Saunders, Philadelphia, pp 603-623
64. Fujita S, Chiba M, Suzuki T, Kitani K (1986) Effect of senescence on the hepatic metabolism of drugs affecting the central nervous system in rats and mice. In: Kitani K (ed) Liver and aging 1986. Liver and brain. Elsevier, Amsterdam, pp 103-114
65. Kitani K, Ohta M, Kanai S, Sato Y, Nokubo M, Zs.-Nagy I (1991) Age-induced restricted mobility of proteins in the hepatocyte surface membranes. A possible determinant of membrane transport functions. In: Kitani K (ed) Liver and aging 1990. Elsevier, Amsterdam, pp 305-317
66. Hamlin JL, Leu T-H, Vaughn JP, Ma C, Dijkwel PA (1991) Amplification of DNA sequences in mammalian cells. Progr Nucl Acid Res Mol Biol 41:203-239
67. Gershon H, Gershon D (1970) Detection of inactive enzyme molecules in ageing organism. Nature 227:1214-1217
68. Gershon H, Gershon D (1973) Altered enzyme molecules in senescent organisms: mouse muscle aldolase. Mech Ageing Dev 2:33-41
69. Reiss U, Rothstein M (1974) Heat-labile isozymes of isocitrate lyase from aging Turbatrix aceti. Biochem Biophys Res Commun 61:1012-1015
70. Reznick AZ, Dovrat A, Rosenfelder L, Shpund S, Gershon D (1985) Defective enzyme molecules in cells of aging animals are partially denatured, totally inactive, normal degradation intermediates. In: Adelman RC, Dekker EE (eds) Modification of proteins during aging. Liss, New York, pp 69-81
71. Adelman RC, Roth GS (eds) (1983) Altered proteins and aging. CRC, Boca Raton
72. Verzár F (1965) Experimentelle Gerontologie. Enke, Stuttgart
73. Bjorksten J (1942) Chemistry of duplication. Chem Industr 49:2
74. Monnier VM (1990) Nonenzymatic glycosylation, the Maillard reaction and the aging process. J Gerontol Biol Sci 45: B105-B111
75. Cutler RG (1982) The dysdifferentiative hypothesis of mammalian aging and longevity. In: Giacobini E, Giacobini G, Filogamo G, Vernadakis A (eds) The aging Brain. Raven, New York, pp 1-18
76. Cutler RG (1984) Antioxidants, aging and longevity. In: Pryor WA (ed) Free radicals in biology, vol 6. Academic, New York, pp 371-428
77. Cutler RG (1985) Dysdifferentiative hypothesis of aging: a review. In: Sohal RS, Birnbaum LS, Cutler RG (eds) Molecular biology of aging: gene stability and gene expression. Raven, New York, pp 307-340
78. Zs.-Nagy I, Cutler RG, Semsei I (1988) Dysdifferentiation hypothesis of aging and cancer: a comparison with the membrane hypothesis of aging. Ann NY Acad Sci 521:215-225
79. Porta EA (1991) Advances in age pigment research. Arch Gerontol Geriatr 12:303-320
80. Ivy GO, Schottler F, Wenzel J, Baudry M, Lynch G (1984) Inhibitors of lysosomal enzymes: accumulation of lipofuscinlike dense bodies in the brain. Science 226:985-987
81. Ivy GO, Schottler F, Baudry M, Lynch G (1986) Leupeptin causes several manifestations of aging in brain and liver of young rats. In: Kitani K (ed) Liver and aging 1986. Elsevier, Amsterdam, pp 389-400
82. Ivy GO, Ihara Y, Kitani K (1991) The protease inhibitor leupeptin induces several signs of aging in brain, retina and internal organs of young rats. Arch Gerontol Geriatr 12: 119-131
83. Ivy GO (1987) A proteinase inhibitor model of aging: implications for decreased neuronal plasticity. In: Milgram NW, MacLeod CM (eds) Neuroplasticity, learning and memory. Liss, New York, pp 125-150
84. Ivy GO, Gurd JW (1988) A proteinase inhibitor model of lipofuscin formation. In: Zs.-Nagy I (ed) Lipofuscin 1987: state of the art. Akadémiai Kiadó, Budapest, and Elsevier, Amsterdam, pp 83-108
85. Wolfe. LS, Gauthier S, Durham HD (1988) Dolichols and phosphorylated dolichols in the neuronal ceroid lipofuscinoses, other lysosomal storage diseases and Alzheimer disease. Induction of autolysosomes in fibroblasts. In: Zs.-Nagy I (ed) Lipofuscin 1987: state of the art. Akadémiai Kiadó, Budapest, and Elsevier, Amsterdam, pp 389-411
86. Kitani K, Zs.-Nagy I, Ohta M, Kanai S, Sato Y, Ivy GO (1992) Effect of leupeptin on the lateral mobility of proteins in the plasma membrane of hepatocytes of C57BL/6 mice: FRAP studies on liver smears. Arch Gerontol Geriatr 14:27-45
87. Kay MMB (1991) Band 3 in aging and neurological disease. Ann NY Acad Sci 621:179-204
88. Kay MMB, Lake D, Cover C (1995) Band 3 and its peptides during aging, radiation exposure, and Alzheimer's disease: alterations and self-recognition. Adv Exp Biol Med 383: 167-193
89. Zs.-Nagy I, Ohta M, Kitani K, Cutler RG (1993) The effect of caloric restriction on the lateral diffusion constant of hepatocyte membrane proteins in C57BL/6 mice of different ages: FRAP studies on liver smears. Mech Ageing Dev 71:85-96
90. Yu BP, Yang R (1996) Critical evaluation of the free radical theory of aging. A proposal for the oxidative stress hypothesis. Ann NY Acad Sci 786:1-11
91. Joseph JA, Algeri S, De-Cesare A, Comuzio M, Erat S, Kelly J, Cagnotto A, Mennini T (1995) A reduced calorie-high fiber diet retards age-associated decreases in muscarinic receptor sensitivity. Neurobiol Aging 16:607-612
92. Conlon D, O'Malley K, Kilfeather SA (1992) The effect of donor age on human fibroblast beta-adrenergic receptor response and agonist-induced desensitization. Mech Ageing Dev 62:155-165
93. Kilfeather SA, Collins D, McCormack P, Cotter T, O'Malle K (1992) The effect of in vitro aging on human lung fibroblast beta-adrenergic receptor density, coupling and response. Mech Ageing Dev 63:247-256
94. Conlon D, Johnston A, O'Malley K, Turner P, Kilfeather SA (1995) Effect of ageing on and propanolol administration on myocardial beta-adrenoceptor receptor function in mature rats. Eur J Pharmacol 289:283-290
95. Packer JE, Slater TF, Wilson RL (1979) Direct observation of a free radical interaction between vitamin E and vitamin C. Nature 278:737-738
96. Boonstra J, Mummery CL, Van Zoelen EJJ, Van der Saag PT, De Laat SW (1982) Monovalent cation transport during the cell cycle. Anticancer Res 2:265-274
97. + exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation. Biochim Biophys Acta 988:73-97
98. + antiports. Med Hypotheses 42:385-389
99. Weiss RA (1982) Viral mechanisms of carcinogenesis. IARC Sci Publ 39:307-316
100. Gordon H (1985) Oncogenes. Mayo Clin Proc 60:697-713
101. Weinberg RA (1985) The action of oncogenes in the cytoplasm and nucleus. Science 230:770-776
102. Cooper GM (1987) Cellular oncogenes and cancer. Clin Physiol Biochem 5:122-129
103. Lynch DH (1987) Oncogenes and cancer. Am J Reprod Immunol Microbiol 15:24-28
104. Maher J, Baker D, Dibb N, Roberts I (1996) Mutant ras promotes haemopoietic cell proliferation or differentiation in a cell-specific manner. Leukemia 10:83-90
105. Gonos ES, Spandidos DA (1993) Oncogenes in cellular immortalisation and differentiation. Anticancer Res 13:1117-1122
106. Wistrom C, Villeponteau B (1992) Cloning and expression of SAG: a novel marker of cellular senescence. Exp Cell Res 199:355-362
107. Wadhwa R, Kaul SC, Mitsui Y (1994) Cellular mortality to immortalization: mortalin. Cell Struct Funct 19:1-10
108. Lutchman M, Rouleau GA (1995) The neurofibromatosis type 2 gene product, schwannomin, suppresses growth of NIH 3T3 cells. Cancer Res 55:2270-2274
109. McClung JK, Jupe ER, Liu XT, Dell'Orco RT (1996) Prohibitin: potential role in senescence, development, and tumor suppression. Exp Gerontol 30:99-124
110. Afshari CA, Vojta PJ, Annab LA, Futreal PA, Willard TB, Barrett JC (1993) Investigation of the role of G1/S cell cycle mediators in cellular senescence. Exp Cell Res 209:231-237
111. Di Leonardo A, Linke SP, Clarkin K, Wahl GM (1994) DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Devel 8:2540-2551
112. Atadja P, Wong H, Garkavtsev I, Veillette C, Riabowol K (1995) Increased activity of p53 in senescing fibroblasts. Proc Natl Acad Sei USA 92:8348-8352
113. Kulju KS, Lehman JM (1995) Increased p53 protein associated with aging in human diploid fibroblasts. Exp Cell Res 217:336-345
114. Linke SP, Clarkin KC, Di Leonardo A, Tsou A, Wahl GM (1996) A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Devel 10:934-947
115. Schipper HM, Liang JJ, Wang E (1993) Quiescent and cycling cell compartments in the senescent and Alzheimer-diseased human brain. Neurology 43:87-94
116. Wang E, Panday S (1995) Down-regulation of statin, a non-proliferation-specific nuclear protein, and up-regulation of cmyc after initiation of programmed cell death in mouse fibroblasts. J Cell Physiol 163:155-163
117. Rattan SIS (1995) Ageing - a biological perspective. Molec Aspects Med 16:439-508
118. Cowled PA, Ciccarelli C, Coccia E, Philipson L, Sorrentino V (1994) Expression of growth arrest-specific (gas) genes in senescent murine cells. Exp Cell Res 211:197-202
119. Sinkovics JG (1984) Retroviral and human cellular oncogenes. Ann Clin Lab Sci 14:343-354
120. Harford J (1984) An artefact explains the apparent association of the transferrin receptor with a ras gene product. Nature 311:673-675
121. Willumsen BM, Christensen A, Hubbert NL, Papageorge AG, Lowy DR (1984) The p21 ras C-terminus is required for transformation and membrane association. Nature 310: 583-586
122. Chen ZQ, Ulsh LS, DuBois G, Shih TY (1985) Posttranslational processing of p21 ras proteins involves palmitylation of the C-terminal tetrapeptide containing cysteine-186. J Vir0156:607-612
123. Papageorge A, Lowy D, Scolnick EM (1982) Comparative biochemical properties of p21 ras molecules coded for by viral and cellular ras genes. J Virol 44:509-519
124. Lowy DR, Willumsen BM (1986) The ras gene family. Cancer Surv 5:275-289
125. Wakelam MJ, Davies SA, Houslay MD, McKay I, Marshall CJ, Hall A (1986) Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production. Nature 323:173-176
126. Santos E, Nebreda AR (1989) Structural and functional properties of ras proteins. FASEB J 3:2151-2163
127. Lembo D, Angeretti A, Foresta P, Gribaudo G, Gariglio M, Landolfo S (1994) Trans-activation of the mouse cytomegalovirus immediate early gene enhancer by ras oncogenes. J Gen Virol 75:1685-1692
128. Kamata T, Feramisco JR (1984) Epidermal growth factor stimulates guanine nucleotide binding activity and phosphorylation of ras oncogene proteins. Nature 310:147-150
129. Ulsh LS, Shih TY (1984) Metabolic turnover of human crasH p21 protein of EJ bladder carcinoma and its normal cellular and viral homologs. Mol Cell Biol 4:1647-1652
130. Furth ME Aldrich TH, Cordon-Cardo C (1987) Expression of ras proto-oncogene proteins in normal human tissues. Oncogene 1:47-58
131. Stacey DW, Tsai MH, Yu CL, Smith JK (1988) Critical role of cellular ras proteins in proliferative signal transduction. Cold Spring Harb Symp Quant Biol 53, Part 2:871-881
132. Samid D, Miller AC, Rimoldi D, Gafner J, Clark EP (1991) Increased radiation resistance in transformed and nontransformed cells with elevated ras proto-oncogene expression. Radiat Res 126:244-250
133. Ruch RJ, Madhukar BV, Trosko JE, Klaunig JE (1993) Reversal of ras-induced inhibition of gap-junctional intercellular communication, transformation, and tumorgenesis by lovastatin. Mol Carcinog 7:50-59
134. Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U, Ullrich A (1987) Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 6: 3341-3351
135. Gutkind JS, Robbins KC (1989) Translocation of the FGR proteintyrosine kinase as a consequence of neutrophil activation. Proc Natl Acad Sci USA 86:8783-8787
136. Moss P, Radke K, Carter VC, Young J, Gilmore T, Martin GS (1984) Cellular localization of the transforming protein of wild-type and temperature-sensitive Fujinami sarcoma virus. J Virol 52:557-565
137. Garber EA, Hanafusa T, Hanafusa H (1985) Membrane association of the transforming protein of avian sarcoma virus UR2 and mutants temperature sensitive for cellular transformation and protein kinase activity. J Virol 56:790-797
138. Jong SM, Wang LH (1987) The transforming protein P68gag-ros of avian sarcoma virus UR2 is a transmembrane protein with the gag portion protruding extracellularly. Oncogene Res 1:7-21
139. Loganzo F Jr, Dosik JS, Zhao Y, Vidai MJ, Nanus DM, Sudol M, Albino AP (1993) Elevated expression of protein tyrosine kinase c-Yes, but not c-Src, in human malignant melanoma. Oncogene 8:2637-2644
140. Asai N, Iwashita T, Matsuyama M, Takahashi M (1995) Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations. Mol Cell Biol 15: 1613-1619
141. Grigioni WF, Fiorentino M, D'Errico A, Ponzetto A, Crepaldi T, Prat M, Comoglio PM (1995) Overexpression of c-met protooncogene product and raised Ki67 index in hepatocellular carcinomas with respect to benign liver conditions. Hepatology 21:1543-1546
142. Tibbetts M, Donovan M, Roe S, Stiltner AM, Hammond CI (1994) KIN1 and KIN2 protein kinases localize to the cytoplasmic face of the yeast plasma membrane. Exp Cell Res 213:93-99
143. Hayman MJ, Beug H (1984) Identification of a form of the avian erythroblastosis virus erb-B gene product at the cell surface. Nature 309:460-462
144. Martin GS (1986) The erb-B gene and the EGF receptor. Cancer Surv 5:199-219
145. Schatzman RC, Evan GI, Privalsky ML, Bishop JM (1986) Orientation of the v-erb-B gene product in the plasma membrane. Mol Cell Biol 6:1329-1333
146. Weiner DB, Liu J, Cohen JA, Williams WV, Greene MI (1989) A point mutation in the neu oncogene mimics ligand induction of receptor aggregation. Nature 339:230-231
147. Tsutsumi Y, Naber SP, DeLellis RA, Wolfe HJ, Marks PJ, Mc-Kenzie SJ, Yin S (1990) neu oncogene protein and epidermal growth factor receptor are independently expressed in benign and malignant breast tissues. Hum Pathol 21: 750-758
148. Takahashi M, Asai N, Iwashita T, Isomura T, Miyazaki K, Matsuyama M (1993) Characterization of the ret proto-oncogene products expressed in mouse L-cells. Oncogene 8: 2925-2929
149. Martin-Zanca D, Oskam R, Mitra G, Copeland T, Barbacid M (1989) Molecular and biochemical characterization of the human trk proto-oncogene. Mol Cell Biol 9:24-33
150. Zanellato A, Facci L, Petrelli L, Dal Toso R, Skaper SD (1994) Characterization and growth-dependent regulation of the nerve growth factor receptor gp140trk in rat C6 glioma cells. Brain Res Mol Brain Res 23:299-309
151. Anderson SJ, Gonda MA, Rettenmier CW, Sherr CJ (1984) Subcellular localization of glycoproteins encoded by the viral oncogene v-fms. J Virol 51:730-741
152. Roussel MF, Rettenmier CGV, Look AT, Sherr CJ (1984) Cell surface expression of v-fms-coded glycoproteins is required for transformation. Mol Cell Biol 4:1999-2009
153. Rettenmier CW, Roussel MF, Quinn CO, Kitchingman GR, Look AT, Sherr CJ (1985) Transmembrane orientation of glycoproteins encoded by the v-fms oncogene. Cell 40: 971-981
154. Rettenmier CW, Roussel MF, Ashmun RA, Ralph P, Price K, Sherr CJ (1987) Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes. Mol Cell Biol 7:2378-2387
155. Bortner DM, Langer SJ, Ostrowski MC (1993) Non-nuclear oncogenes and the regulation of gene expression in transformed cells. Crit Rev Oncog 4:137-160