Panax notoginseng saponins enhances the cytotoxicity of cisplatin via increasing gap junction intercellular communication

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 8, 2012, Pages 1230-1237

  Yu, Mei Ling ^a   Zhang, Cui Ling ^b   Yuan, Dong Dong ^a   Tong, Xu Hui ^b   Tao, Liang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b BENGBU MEDICAL COLLEGE   (China)

Author keywords

Cisplatin; Connexin; Gap junction; Panax notoginseng saponin

Indexed keywords

CISPLATIN; CONNEXIN 26; CONNEXIN 32; GINSENG SAPONIN; PANAX NOTOGINSENG SAPONIN; UNCLASSIFIED DRUG;

ARTICLE; CELL COMMUNICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENTIATION; GAP JUNCTION; HELA CELL; HUMAN; HUMAN CELL; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL COMMUNICATION; CISPLATIN; CONNEXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FEMALE; GAP JUNCTIONS; HELA CELLS; HERB-DRUG INTERACTIONS; HUMANS; PANAX NOTOGINSENG; PHYTOTHERAPY; PLANT EXTRACTS; SAPONINS; TRANSFECTION; UTERINE CERVICAL NEOPLASMS;

EID: 84864929738     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b110535     Document Type: Article

References (29)

1. Zhang CL, Yu ML, Tao L. Synergy and attenuation of panax notoginseng saponins on cyclophosphamide. Journal of Nanjing University of Traditional Chinese Medicine, 4, 254-256 (2008).
2. Wang CZ, Luo XJ, Zhang B, Song WX, Ni M, Mehendale S, Xie JT, Aung HH, He TC, Yuan CS. Notoginseng enhances anti-cancer effect of 5-fluorouracil on human colorectal cancer cells. Cancer Chemother. Pharmacol., 60, 69-79 (2007).
3. Wang CZ, Xie JT, Zhang B, Ni M, Fishbein A, Aung HH, Mehendale SR, Du W, He TC, Yuan CS. Chemopreventive effects of Panax notoginseng and its major constituents on SW480 human colorectal cancer cells. Int. J. Oncol., 31, 1149-1156 (2007).
4. Liu LL, Liu YE, Fang GT. Reversal effect of Panax Notoginseng Saponins on multidrug resistance breast cancer cell MCF/ADM. Li Shi Zhen Medicine and Materia Medica Research, 19, 954-956 (2008).
5. Li Y, Wang ZZ, Yu PF. In vitro study on the reversal of multidrug resistance in HL60/VCR cell line with ginsenoside-Rb1. Journal of Radioimmunology, 18, 362-365 (2005).
6. Procházka L, Turánek J, Tesarík R, Knotigová P, Polásková P, Andrysík Z, Kozubík A, Zák F, Sova P, Neuzil J, Machala M. Apoptosis and inhibition of gap-junctional intercellular communication induced by LA-12, a novel hydrophobic platinum(IV) complex. Arch. Biochem. Biophys., 462, 54-61 (2007).
7. Trosko JE, Chang CC. Mechanism of up-regulated gap junctional intercellular communication during chemoprevention and chemotherapy of cancer. Mutat. Res., 480-481, 219-229 (2001).
8. Lin JH, Weigel H, Cotrina ML, Liu S, Bueno E, Hansen AJ, Hansen TW, Goldman S, Nedergaard M. Gap-junction-mediated propagation and amplification of cell injury. Nat. Neurosci., 1, 494-500 (1998).
9. Krutovskikh VA, Piccoli C, Yamasaki H. Gap junction intercellular communication propagates cell death in cancerous cells. Oncogene, 21, 1989-1999 (2002).
10. Wang Q, You TH, Yuan D, Han X, Hong X, He B, Wang L, Tong X, Tao L, Harris AL. Cisplatin and oxaliplatin inhibit gap junctional communication by direct action and by reduction of connexin expression, thereby counteracting cytotoxic efficacy. J. Pharmacol. Exp. Ther., 333, 903-911 (2010).
11. Koreen IV, Elsayed WA, Liu YJ, Harris AL. Tetracycline-regulated expression enables purification and functional analysis of recombinant connexin channels from mammalian cells. Biochem. J., 383, 111-119 (2004).
12. Papazisis KT, Geromichalos GD, Dimitriadis KA, Kortsaris AH. Optimization of the sulforhodamine B colorimetric assay. J. Immunol. Methods, 208, 151-158 (1997).
13. Goldberg GS, Bechberger JF, Naus CC. A pre-loading method of evaluating gap junctional communication by fluorescent dye transfer. Biotechniques, 18, 490-497 (1995).
14. Jensen R, Glazer PM. Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions. Proc. Natl. Acad. Sci. U.S.A., 101, 6134-6139 (2004).
15. Erdlenbruch B, Nier M, Kern W, Hiddemann W, Pekrun A, Lakomek M. Pharmacokinetics of cisplatin and relation to nephrotoxicity in paediatric patients. Eur. J. Clin. Pharmacol., 57, 393-402 (2001).
16. Tao L, Harris AL. 2-aminoethoxydiphenyl borate directly inhibits channels composed of connexin26 and/or connexin32. Mol. Pharmacol., 71, 570-579 (2007).
17. Zhang X, Ren Z, Zuo J, Su C, Wang R, Chang Y, Fang F. The effect of all-trans retinoic acid on gap junctional intercellular communication and connexin43 gene expression in glioma cells. Chin. Med. Sci. J., 17, 22-26 (2002).
18. Tsujino T, Nagata T, Katoh F, Yamasaki H. Inhibition of Balb/c 3T3 cell transformation by synthetic acyclic retinoid NIK-333; possible involvement of enhanced gap junctional intercellular communication. Cancer Detect. Prev., 31, 332-338 (2007).
19. Huang RP, Hossain MZ, Huang R, Gano J, Fan Y, Boynton AL. Connexin 43 (cx43) enhances chemotherapy-induced apoptosis in human glioblastoma cells. Int. J. Cancer, 92, 130-138 (2001).
20. Tanaka M, Grossman HB. Connexin 26 gene therapy of human bladder cancer: induction of growth suppression, apoptosis, and synergy with cisplatin. Hum. Gene Ther., 12, 2225-2236 (2001).
21. Shi YQ, Tian TD. In vitro study on the reversal of multidrug resistance in K562/VCR cell line with panax notoginseng saponins. Chinese Journal of Traditional Medical Science and Technology, 5, 292-294 (2005).
22. Shi XK, Zhang YJ, Zhao CJ. Reversing effects of saponins Rb1 combined with VRE on human leukemic multi-drug resistant cell line K562/HHT. Chongqing Medicine, 6, 706-707 (2003).
23. Wang YH, Zhu Y, Zhang CL. Anti-tumor effect of panax notoginsenosides combined with cyclophosphamide metronomic chemotherapy. Journal of Beijing University of Traditional Chinese Medicine, 1, 36-40 (2010).
24. Jia L, Zhao YQ, Liang XJ. Current evaluation of the millennium phytomedicine-ginseng (II): Collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine. Curr. Med. Chem., 16, 2924-2942 (2009).
25. Wang M, Berthoud VM, Beyer EC. Connexin43 increases the sensitivity of prostate cancer cells to TNFalpha-induced apoptosis. J. Cell Sci., 120, 320-329 (2007).
26. Azzam EI, de Toledo SM, Little JB. Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect. Oncogene, 22, 7050-7057 (2003).
27. Pitts JD. Cancer gene therapy: a bystander effect using the gap junctional pathway. Mol. Carcinog., 11, 127-130 (1994).
28. Mesnil M, Yamasaki H. Bystander effect in herpes simplex virusthymidine kinase/ganciclovir cancer gene therapy: role of gap-junctional intercellular communication. Cancer Res., 60, 3989-3999 (2000).
29. Wu YJ, Muldoon LL, Neuwelt EA. The chemoprotective agent N-acetylcysteine blocks cisplatin-induced apoptosis through caspase signaling pathway. J. Pharmacol. Exp. Ther., 312, 424-431 (2005).