Apoptosis and inhibition of gap-junctional intercellular communication induced by LA-12, a novel hydrophobic platinum(IV) complex

Archives of Biochemistry and Biophysics

Volumn 462, Issue 1, 2007, Pages 54-61

  Procházka, Lubomír ^a   Turánek, Jaroslav ^a   Tesařík, Radek ^a   Knotigová, Pavlína ^a   Polášková, Pavlína ^a   Andrysík, Zdeněk ^b   Kozubík, Alois ^b   Žák, František ^c   Sova, Petr ^c   Neuzil, Jiri ^d,e   Machala, Miroslav ^a  

^a VETERINARY RESEARCH INSTITUTE   (Czech Republic)

^b INSTITUTE OF BIOPHYSICS   (Czech Republic)

^c Lachema sro   (Czech Republic)

^d GRIFFITH UNIVERSITY   (Australia)

^e INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

Author keywords

Cisplatin; Connexin 43; Gap junctional intercellular communication; LA 12; MEK ERK pathway; WB F344 cells

Indexed keywords

CASPASE 3; CISPLATIN DERIVATIVE; DNA; LA 12; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COMMUNICATION; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG PENETRATION; ENZYME ACTIVATION; EPITHELIUM CELL; GAP JUNCTION; HYDROPHOBICITY; LIVER CELL; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RAT;

AMANTADINE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE; CELL LINE, TUMOR; CISPLATIN; CONNEXIN 43; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; GAP JUNCTIONS; HYDROPHOBICITY; ORGANOPLATINUM COMPOUNDS; PHOSPHORYLATION; PLATINUM COMPOUNDS; RATS;

RATTUS;

EID: 34248593770     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2007.03.021     Document Type: Article

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