Study protocol: EXERcise and Cognition In Sedentary adults with Early-ONset dementia (EXERCISE-ON)

BMC Neurology

Volumn 12, Issue , 2012, Pages

  Hooghiemstra, Astrid M ^a,b   Eggermont, Laura H P ^a   Scheltens, Philip ^b   van der Flier, Wiesje M ^b   Bakker, Jet ^c   de Greef, Mathieu H G ^d   Koppe, Peter A ^c   Scherder, Erik J A ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c AMSTELLAND HOSPITAL   (Netherlands)

^d UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Dementia; Early onset dementia; Exercise; Intervention; Physical activity; Presenile dementia; Randomized controlled trial

Indexed keywords

AGED; ARTICLE; COGNITIVE REHABILITATION; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DEMENTIA; EARLY ONSET DEMENTIA; EXECUTIVE FUNCTION; HEALTH PROGRAM; HUMAN; KINESIOTHERAPY; MAJOR CLINICAL STUDY; NEUROPSYCHOLOGY; PEDOMETRY; PSYCHOMOTOR PERFORMANCE; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SEDENTARY LIFESTYLE; TREATMENT OUTCOME;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; COGNITION DISORDERS; DEMENTIA; EXERCISE THERAPY; FEASIBILITY STUDIES; HUMANS; MALE; MIDDLE AGED; NETHERLANDS; PREVALENCE; TREATMENT OUTCOME;

EID: 84864917186     PISSN: None     EISSN: 14712377     Source Type: Journal    
DOI: 10.1186/1471-2377-12-75     Document Type: Article

References (74)

1. Lambert JC, Amouyel P. Genetic heterogeneity of Azheimer's disease: Complexity and advances. Psychoneuroendocrinology 2007, 32(Suppl 1):S62-S70.
2. Harvey RJ, Skelton-Robinson M, Rossor MN. The prevalence and causes of dementia in people under the age of 65 years. J Neurol Neurosurg Psychiatry 2003, 74:1206-1209. 10.1136/jnnp.74.9.1206, 1738690, 12933919.
3. Sampson EL, Warren JD, Rossor MN. Young onset dementia. Postgrad Med J 2004, 80:125-139. 10.1136/pgmj.2003.011171, 1742955, 15016933.
4. Vraamaak Elberling TV, Stokholm J, Hogh P, Waldemar G. Diagnostic profile of young and middle-aged memory clinic patients. Neurol 2002, 59:1259-1262.
5. Frisoni GB, Pievani M, Testa C, Sabattoli F, Bresciani L, Bonetti M, Beltramello A, Hayashi KM, Toga AW, Thompson PM. The topography of grey matter involvement in early and late onset Alzheimer's disease. Brain 2007, 130:720-730. 10.1093/brain/awl377, 17293358.
6. Froelich-Fabre S, Skoglund L, Ostojic J, Kilander L, Lindau M, Glaser A, Basun H, Lannfelt L. Clinical and molecular aspects of frontotemporal dementia. Neurodegener Dis 2004, 1:218-224. 10.1159/000080989, 16908993.
7. Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, Freedman M, Kertesz A, Robert PH, Albert M, Boone K, Miller BL, Cummings J, Benson DF. Frontotemporal lobar degeneration - A consensus on clinical diagnostic criteria. Neurology 1998, 51:1546-1554. 10.1212/WNL.51.6.1546, 9855500.
8. Neary D, Snowden J, Mann D. Frontotemporal dementia. Lancet Neurol 2005, 4:771-780. 10.1016/S1474-4422(05)70223-4, 16239184.
9. Snowden JS, Stopford CL, Julien CL, Thompson JC, Davidson Y, Gibbons L, Pritchard A, Lendon CL, Richardson AM, Varma A, Neary D, Mann D. Cognitive phenotypes in Alzheimer's disease and genetic risk. Cortex 2007, 43:835-845. 10.1016/S0010-9452(08)70683-X, 17941342.
10. Shinagawa S, Ikeda M, Toyota Y, Matsumoto T, Matsumoto N, Mori T, Ishikawa T, Fukuhara R, Komori K, Hokoishi K, Tanabe H. Frequency and clinical characteristics of early-onset dementia in consecutive patients in a memory clinic. Dement Geriatr Cogn Dis 2007, 24:42-47.
11. Heyman A, Schmechel D, Wilkinson W, Rogers H, Krishnan R, Holloway D, Schultz K, Gwyther L, Peoples R, Utley C, Haynes C. Failure of long term high-dose lecithin to retard progression of early-onset Alzheimer's disease. J Neural Transm 1987, 24:279-286.
12. Thal LJ, Calvani M, Amato A, Carta A. A 1-year controlled trial of acetyl-L-carnitine in early-onset AD. Neurol 2000, 55:805-810.
13. Van Gool WA, Weinstein HC, Scheltens PK, Walstra GJM. Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: an 18-month randomised, double-blind, placebo-controlled study. Lancet 2001, 358:455-460. 10.1016/S0140-6736(01)05623-9, 11513909.
14. Colcombe S, Kramer AF. Fitness effects on the cognitive function of older adults: A meta-analytic study. Psychol Sci 2003, 14:125-130. 10.1111/1467-9280.t01-1-01430, 12661673.
15. Scherder EJA, Van Paasschen J, Deijen JB, Van Der Knokke S, Orlebeke JFK, Burgers I, Devriese PP, Swaab DF, Sergeant JA. Physical activity and executive functions in the elderly with mild cognitive impairment. Aging Ment Health 2005, 9:272-280. 10.1080/13607860500089930, 16019281.
16. Eggermont LHP, Swaab DF, Hol EM, Scherder EJA. Walking the line: a randomised trial on the effects of a short term walking programme on cognition in dementia. J Neurol Neurosurg Psychiatry 2009, 80:802-804. 10.1136/jnnp.2008.158444, 19531688.
17. Kipps CM, Mioshi E, Hodges JR. Emotion, social functioning and activities of daily living in frontotemporal dementia. Neurocase 2009, 15:182-189. 10.1080/13554790802632892, 19172432.
18. Konstantakopoulos G, Ploumidis D, Oulis P, Patrikelis P, Soumani A, Papadimitriou GN, Politis AM. Apathy, cognitive deficits and functional impairment in schizophrenia. Schizophr Res 2011, 133:193-198. 10.1016/j.schres.2011.07.003, 21788116.
19. Landes AM, Sperry SD, Strauss ME, Geldmacher DS. Apathy in Alzheimer's disease. J Am Geriatr Soc 2001, 49:1700-1707. 10.1046/j.1532-5415.2001.49282.x, 11844006.
20. Stuss DT, Alexander MP. Executive functions and the frontal lobes: a conceptual view. Psychol Res-Psychol Forsch 2000, 63:289-298.
21. Colcombe SJ, Erickson KI, Raz N, Webb AG, Cohen NJ, McAuley E, Kramer AF. Aerobic fitness reduces brain tissue loss in aging humans. J Gerontol A Biol Sci Med Sci 2003, 58:176-180. 10.1093/gerona/58.2.M176, 12586857.
22. Rosano C, Venkatraman VK, Guralnik J, Newman AB, Glynn NW, Launer L, Taylor CA, Williamson J, Studenski S, Pahor M, Aizenstein H. Psychomotor Speed and Functional Brain MRI 2 Years After Completing a Physical Activity Treatment. J Gerontol A Biol Sci Med Sci 2010, 65:639-647. 2869531, 20348185.
23. Colcombe SJ, Kramer AF, Erickson KI, Scalf P, Mcauley E, Cohen NJ, Webb A, Jerome GJ, Marquez DX, Elavsky S. Cardiovascular fitness, cortical plasticity, and aging. Proc Natl Acad Sci USA 2004, 101:3316-3321. 10.1073/pnas.0400266101, 373255, 14978288.
24. Mosconi L, Herholz K, Prohovnik I, Nacmias B, De Cristofaro MTR, Fayyaz M, Bracco L, Sorbi S, Pupi A. Metabolic interaction between ApoE genotype and onset age in Alzheimer's disease: implications for brain reserve. J Neurol Neurosurg Psychiatry 2005, 76:15-23. 10.1136/jnnp.2003.030882, 1739315, 15607989.
25. Seo SW, Im K, Lee JM, Kim ST, Ahn HJ, Go SM, Kim SH, NA DL. Effects of demographic factors on cortical thickness in Alzheimer's disease. Neurobiol Aging 2011, 32:200-209. 10.1016/j.neurobiolaging.2009.02.004, 19321233.
26. Seltzer B, Sherwin I. A comparison of clinical-features in early-onset and late-onset primary degenerative dementia - one entity or 2. Arch Neurol 1983, 40:143-146. 10.1001/archneur.1983.04050030037006, 6830452.
27. Rolland Y, van Kan GA, Vellas B. Physical activity and Alzheimer's disease: From prevention to therapeutic perspectives. J Am Med Dir Assoc 2008, 9:390-405. 10.1016/j.jamda.2008.02.007, 18585641.
28. Hooghiemstra AM, Eggermont LHP, Scheltens P, van der Flier WM, Scherder EJA. Exercise and early-onset Alzheimer's disease: theoretical considerations. Dement Geriatr Cogn Dis Extra 2012, 2:132-145. 10.1159/000335493, 3347875, 22590474.
29. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) 2000, American Psychiatric Association, Washington DC, 4, Text Revision, American Psychiatric Association.
30. McKhann G, Drachman DA, Folstein M, Katzman R, Price DL, Stadlan EM. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurol 1984, 34:939-944.
31. Pohjasvaara T, Mantyla R, Ylikoski R, Kaste M, Erkinjuntti T. Comparison of different clinical criteria (DSM-III, ADDTC, ICD-10, NINDS-AIREN, DSM-IV) for the diagnosis of vascular dementia. Stroke 2000, 31:2952-2957. 10.1161/01.STR.31.12.2952, 11108755.
32. Folstein MF, Folstein SE, Mchugh PR. Mini-Mental State - Practical Method for Grading Cognitive State of Patients for Clinician. J Psychiatr Res 1975, 12:189-198. 10.1016/0022-3956(75)90026-6, 1202204.
33. American College of Sports Medicine Position Stand The recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness, and flexibility in healty adults. Med Sci Sports Exerc 1998, 30:975-991. 10.1097/00005768-199806000-00032, 9624661, American College of Sports Medicine Position Stand.
34. de Blok BMJ, de Greef MHG, ten Hacken NHT, Sprenger SR, Postema K, Wempe JB. The effects of a lifestyle physical activity counseling program with feedback of a pedometer during pulmonary rehabilitation in patients with COPD: A pilot study. Patient Educ Couns 2006, 61:48-55. 10.1016/j.pec.2005.02.005, 16455222.
35. Hospes G, Bossenbroek L, ten Hacken NHT, van Hengel P, de Greef MHG. Enhancement of daily physical activity increases physical fitness of outclinic COPD patients: Results of an exercise counseling program. Patient Educ Couns 2009, 75:274-278. 10.1016/j.pec.2008.10.005, 19036552.
36. Ryan RM, Deci EL. Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. Am Psychol 2000, 55:68-78.
37. van den Broek MD. Why does neurorehabilitation fail?. J Head Trauma Rehabil 2005, 20:464-473. 10.1097/00001199-200509000-00007, 16170254.
38. Markland D, Ryan RM, Tobin VJ, Rollnick S. Motivational interviewing and self-determination theory. J Soc Clin Psychol 2005, 24:811-831.
39. Achtziger A, Gollwitzer PM, Sheeran P. Implementation intentions and shielding goal striving from unwanted thoughts and feelings. Pers Soc Psychol Bull 2008, 34:381-393. 10.1177/0146167207311201, 18272806.
40. Gollwitzer PM. Implementation intentions - Strong effects of simple plans. Am Psychol 1999, 54:493-503.
41. Rosen WG, Mohs RC, Davis KL. A New Rating-Scale for Alzheimers-Disease. Am J Psychiatry 1984, 141:1356-1364.
42. Connor DJ, Sabbagh MN. Administration and Scoring Variance on the ADAS-Cog. J Alzheimers Dis 2008, 15:461-464. 2727511, 18997299.
43. Doraiswamy PM, Bieber F, Kaiser L, Krishnan KR, ReuningScherer J, Gulanski B. The Alzheimer's disease assessment scale: Patterns and predictors of baseline cognitive performance in multicenter Alzheimer's disease trials. Neurol 1997, 48:1511-1517.
44. Reitan RM. The Relation of the Trail Making Test to Organic Brain Damage. J Consult Psychol 1955, 19:393-394.
45. Gelinas I, Gauthier L, McIntyre M, Gauthier S. Development of a functional measure for persons with Alzheimer's disease: The disability assessment for dementia. Am J Occup Ther 1999, 53:471-481. 10.5014/ajot.53.5.471, 10500855.
46. Brod M, Stewart AL, Sands L, Walton P. Conceptualization and measurement of quality of life in dementia: The dementia quality of life instrument (DQoL). Gerontologist 1999, 39:25-35. 10.1093/geront/39.1.25, 10028768.
47. Van der Steen JT, van Campen C, Bosboom PR, Gerritsen DL, Kleemans AH, Schrijver TL, Jonker C. Quality of life and dementia. II. Selection of a measurement instrument for well-being appropriate for the reference model. Tijdschr Gerontol Geriatr 2001, 32:259-264.
48. Takken T. Inspanningstests 2004, Elsevier Gezondheidszorg, Maarssen.
49. Du H, Newton PJ, Salamonson Y, Carrieri-Kohlman VL, Davidson PM. A review of the six-minute walk test: Its implication as a self-administered assessment tool. Eur J Cardiovasc Nurs 2009, 8:2-8. 10.1016/j.ejcnurse.2008.07.001, 18694656.
50. Jones CJ, Rikli RE, Beam WC. A 30-s chair-stand test as a measure of lower body strength in community-residing older adults. Res Q Exerc Sport 1999, 70:113-119.
51. Melanson EL, Knoll JR, Bell ML, Donahoo WT, Hill JO, Nysse LJ, Lanningham-Foster L, Peters JC, Levine JA. Commercially available pedometers: considerations for accurate step counting. Prev Med 2004, 39:361-368. 10.1016/j.ypmed.2004.01.032, 15226047.
52. Sugden JA, Sniehotta FF, Donnan PT, Boyle P, Johnston DW, Mcmurdo MET. The feasibility of using pedometers and brief advice to increase activity in sedentary older women - a pilot study. BMC Health Serv Res 2008, 8:169. 10.1186/1472-6963-8-169, 2527003, 18691392.
53. Schuit AJ, Schouten EG, Westerterp KR, Saris WHM. Validity of the physical activity scale for the elderly (PASE): According to energy expenditure assessed by the doubly labeled water method. J Clin Epidemiol 1997, 50:541-546. 10.1016/S0895-4356(97)00010-3, 9180646.
54. Wilson B, Cockburn J, Baddely A. The Rivermead Behavioural Memory Test 1987, Thames Valley Test Company, Titchfield.
55. Wechsler D. Manual for the Wechsler Adult Intelligence Scale-Revised 1981, Psychological Corporation, New York.
56. Luteijn F, van der Ploeg FAE. Handleiding Groninger Intelligentie Test (Manual Groningen Intelligence Test) 1983, Swets & Zeitlinger, Lisse, The Netherlands.
57. Macleod CM. Half A Century of Research on the Stroop Effect - An Integrative Review. Psychol Bull 1991, 109:163-203.
58. Kreiner DS, Ryan JJ. Memory and motor skill components of the WAIS-III Digit Symbol-Coding subtest. Clin Neuropsychol 2001, 15:109-113. 10.1076/clin.15.1.109.1906, 11778571.
59. Bosscher RJ, Smit JH, Kempen GIJM. Algemene competentieverwachtingen bij ouderen; een onderzoek naar de psychometrische kenmerken van de algemene competentieschaal (ALCOS) (general competency expectations in elderly; a study into the psychometric properties of the general competency scale). Ned Tijdschr Psychol 1997, 52:239-248.
60. Oosterman JM, Van Someren EJW, Vogels RLC, van Harten B, Scherder EJA. Fragmentation of the rest-activity rhythm correlates with age-related cognitive deficits. J Sleep Res 2009, 18:129-135. 10.1111/j.1365-2869.2008.00704.x, 19250179.
61. Verhage F. Intelligence and Age: Study With Dutch People Aged 12-77 [in Dutch] 1964, Van Gorcum, Assen.
62. Gatz JL, Tyas SL. St John P, Montgomery P: Do depressive symptoms predict Alzheimer's disease and dementia?. J Gerontol A Biol Sci Med Sci 2005, 60:744-747. 10.1093/gerona/60.6.744, 15983177.
63. Potter GG, Steffens DC. Contribution of depression to cognitive impairment and dementia in older adults. Neurologist 2007, 13:105-117. 10.1097/01.nrl.0000252947.15389.a9, 17495754.
64. Radloff LA. The CES-D scale: A self-report depression scale for research in the general population. Appl Psychol Meas 1977, 1:385-401.
65. Bizzarro A, Marra C, Acciarri A, Valenza A, Tiziano FD, Brahe C, Masullo C. Apolipoprotein E epsilon 4 allele differentiates the clinical response to donepezil in Alzheimer's disease. Dement Geriatr Cogn Dis 2005, 20:254-261.
66. Podewils LJ, Guallar E, Kuller LH, Fried LP, Lopez OL, Carlson M, Lyketsos CG. Physical activity, APOE genotype, and dementia risk: Findings from the Cardiovascular Health Cognition Study. Am J Epidemiol 2005, 161:639-651. 10.1093/aje/kwi092, 15781953.
67. Porta N, Bonet C, Cobo E. Discordance between reported intention-to-treat and per protocol analyses. J Clin Epidemiol 2007, 60:663-669. 10.1016/j.jclinepi.2006.09.013, 17573981.
68. Faul F, Erdfelder E, Lang A-G, Buchner A. G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007, 39:175-191. 10.3758/BF03193146, 17695343.
69. Heyn P, Abreu BC, Ottenbacher KJ. The effects of exercise training on elderly persons with cognitive impairment and dementia: A meta-analysis. Arch Phys Med Rehabil 2004, 85:1694-1704. 10.1016/j.apmr.2004.03.019, 15468033.
70. Lautenschlager NT, Cox KL, Flicker L, Foster JK, van Bockxmeer FM, Xiao JG, Greenop KR, Almeida OP. Effect of Physical Activity on Cognitive Function in Older Adults at Risk for Alzheimer Disease: A Randomized Trial. JAMA 2008, 300:1027-1037. 10.1001/jama.300.9.1027, 18768414.
71. van Uden-Kraan C, Drossaert C, Taal E, Smit W. Bernelot Moens H, van de Laar M: Determinants of engagement in face-to-face and online patient support groups. J Med Internet Res 2011, 13:e106. 10.2196/jmir.1718, 3278092, 22155649.
72. McMurtray A, Clark DG, Christine D, Mendez MF. Early-onset dementia: Frequency and causes compared to late-onset dementia. Dement Geriatr Cogn Dis 2006, 21:59-64.
73. Yokota O, Sasaki K, Fujisawa Y, Takahashi J, Terada S, Ishihara T, Nakashima H, Kugo A, Ata T, Ishizu H, Kuroda S. Frequency of early and late-onset dementias in a Japanese memory disorders clinic. Eur J Neurol 2005, 12:782-790. 10.1111/j.1468-1331.2005.01072.x, 16190916.
74. Shaw BA, Liang J, Krause N, Gallant M, McGeever K. Age Differences and Social Stratification in the Long-Term Trajectories of Leisure-Time Physical Activity. J Gerontol B Psychol Sci Soc Sci 2010, 65:756-766. 2954334, 20855534.