-
1
-
-
0023266532
-
Results of the cooperative north scandinavian enalapril survival study (CONSENSUS)
-
Effects of enalapril on mortality in severe congestive heart failure. The CONSENSUS Trial Study Group
-
Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). The CONSENSUS Trial Study Group. N Engl J Med, 1987. 316(23): p. 1429-35.
-
(1987)
N Engl J Med
, vol.316
, Issue.23
, pp. 1429-1435
-
-
-
2
-
-
0025913812
-
Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. The SOLVD investigators
-
Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. The SOLVD Investigators. N Engl J Med, 1991. 325(5): p. 293-302.
-
(1991)
N Engl J Med
, vol.325
, Issue.5
, pp. 293-302
-
-
-
3
-
-
0026786643
-
Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE investigators
-
Pfeffer MA, et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. N Engl J Med. 1992;327(10):669-77.
-
(1992)
N Engl J Med.
, vol.327
, Issue.10
, pp. 669-677
-
-
Pfeffer, M.A.1
-
4
-
-
0034688194
-
Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
-
Yusuf S, et al. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000;342(3):145-53.
-
(2000)
N Engl J Med.
, vol.342
, Issue.3
, pp. 145-153
-
-
Yusuf, S.1
-
5
-
-
77956895723
-
Renin inhibitors in chronic heart failure: The Aliskiren Observation of Heart Failure Treatment study in context
-
Krum H, Maggioni A. Renin inhibitors in chronic heart failure: the Aliskiren Observation of Heart Failure Treatment study in context. Clin Cardiol. 2010;33(9):536-41.
-
(2010)
Clin Cardiol
, vol.33
, Issue.9
, pp. 536-541
-
-
Krum, H.1
Maggioni, A.2
-
6
-
-
0034612118
-
Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: Randomised trial - The Losartan Heart Failure Survival Study ELITE II
-
Pitt B, et al. Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial-the Losartan Heart Failure Survival Study ELITE II. Lancet. 2000;355 (9215):1582-7. (Pubitemid 30240502)
-
(2000)
Lancet
, vol.355
, Issue.9215
, pp. 1582-1587
-
-
Pitt, B.1
Poole-Wilson, P.A.2
Segal, R.3
Martinez, F.A.4
Dickstein, K.5
Camm, A.J.6
Konstam, M.A.7
Riegger, G.8
Klinger, G.H.9
Neaton, J.10
Sharma, D.11
Thiyagarajan, B.12
-
7
-
-
0033517302
-
The effect of spironolactone on morbidity and mortality in patients with severe heart failure
-
DOI 10.1056/NEJM199909023411001
-
Pitt B, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med. 1999;341(10):709-17. (Pubitemid 29407370)
-
(1999)
New England Journal of Medicine
, vol.341
, Issue.10
, pp. 709-717
-
-
Pitt, B.1
Zannad, F.2
Remme, W.J.3
Cody, R.4
Castaigne, A.5
Perez, A.6
Palensky, J.7
Wittes, J.8
-
8
-
-
0037417252
-
Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
-
DOI 10.1056/NEJMoa030207
-
Pitt B, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 2003;348(14):1309-21. (Pubitemid 36384098)
-
(2003)
New England Journal of Medicine
, vol.348
, Issue.14
, pp. 1309-1321
-
-
Pitt, B.1
Remme, W.2
Zannad, F.3
Neaton, J.4
Martinez, F.5
Roniker, B.6
Bittman, R.7
Hurley, S.8
Kleiman, J.9
Gatlin, M.10
-
9
-
-
78650399880
-
Eplerenone in patients with systolic heart failure and mild symptoms
-
Zannad F, et al. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med. 2011;364(1):11-21.
-
(2011)
N Engl J Med
, vol.364
, Issue.1
, pp. 11-21
-
-
Zannad, F.1
-
10
-
-
22544448655
-
The AT2 receptor - A matter of love and hate
-
DOI 10.1016/j.peptides.2005.03.010, PII S0196978105001257, International Symposium on Peptides Receptors, from Gene to Therapy
-
Steckelings UM, Kaschina E, Unger T. The AT2 receptor-a matter of love and hate. Peptides. 2005;26(8):1401-9. (Pubitemid 41021474)
-
(2005)
Peptides
, vol.26
, Issue.8
, pp. 1401-1409
-
-
Steckelings, U.M.1
Kaschina, E.2
Unger, Th.3
-
11
-
-
77950472601
-
Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB
-
This study reports the positive findings of in vitro application of the novel angiotensin II type 2 receptor agonist
-
Rompe, F., et al., Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB. Hypertension, 2010. 55(4): p. 924-31. This study reports the positive findings of in vitro application of the novel angiotensin II type 2 receptor agonist.
-
(2010)
Hypertension
, vol.55
, Issue.4
, pp. 924-931
-
-
Rompe, F.1
-
13
-
-
0036748132
-
Contrasting effects of angiotensin type 1 and 2 receptors on nitric oxide release under pressure
-
Harada S, et al. Contrasting effects of angiotensin type 1 and 2 receptors on nitric oxide release under pressure. Hypertens Res. 2002;25(5):779-86. (Pubitemid 35153768)
-
(2002)
Hypertension Research
, vol.25
, Issue.5
, pp. 779-786
-
-
Harada, S.1
Nakata, T.2
Oguni, A.3
Kido, H.4
Hatta, T.5
Fukuyama, R.6
Fushiki, S.7
Sasaki, S.8
Takeda, K.9
-
14
-
-
0037340033
-
Cardioprotective role of AT2 receptor in postinfarction left ventricular remodeling
-
DOI 10.1161/01.HYP.0000048340.53100.43
-
Oishi Y, et al. Cardioprotective role of AT2 receptor in postinfarction left ventricular remodeling. Hypertension. 2003;41(3 Pt 2):814-8. (Pubitemid 36314596)
-
(2003)
Hypertension
, vol.41
, Issue.3 PART 2
, pp. 814-818
-
-
Oishi, Y.1
Ozono, R.2
Yano, Y.3
Teranishi, Y.4
Akishita, M.5
Horiuchi, M.6
Oshima, T.7
Kambe, M.8
-
15
-
-
0027439938
-
Renal actions of the selective angiotensin AT2 receptor ligands CGP 42112B and PD 123319 in the sodiumdepleted rat
-
Macari D, et al. Renal actions of the selective angiotensin AT2 receptor ligands CGP 42112B and PD 123319 in the sodiumdepleted rat. Eur J Pharmacol. 1993;249(1):85-93.
-
(1993)
Eur J Pharmacol
, vol.249
, Issue.1
, pp. 85-93
-
-
MacAri, D.1
-
16
-
-
8644281991
-
2 receptor agonist
-
DOI 10.1021/jm049715t
-
Wan Y, et al. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem. 2004;47(24):5995-6008. (Pubitemid 39507341)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.24
, pp. 5995-6008
-
-
Wan, Y.1
Wallinder, C.2
Plouffe, B.3
Beaudry, H.4
Mahalingam, A.K.5
Wu, X.6
Johansson, B.7
Holm, M.8
Botoros, M.9
Karlen, A.10
Pettersson, A.11
Nyberg, F.12
Fandriks, L.13
Gallo-Payet, N.14
Hallberg, A.15
Alterman, M.16
-
17
-
-
58149375072
-
Angiotensin II type 2 receptor stimulation: A novel option of therapeutic interference with the reninangiotensin system in myocardial infarction?
-
Kaschina E, et al. Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the reninangiotensin system in myocardial infarction? Circulation. 2008;118(24):2523-32.
-
(2008)
Circulation
, vol.118
, Issue.24
, pp. 2523-2532
-
-
Kaschina, E.1
-
18
-
-
19944426690
-
Endothelial cell activation in patients with decompensated heart failure
-
DOI 10.1161/01.CIR.0000151611.89232.3B
-
Colombo PC, et al. Endothelial cell activation in patients with decompensated heart failure. Circulation. 2005;111(1):58-62. (Pubitemid 40070844)
-
(2005)
Circulation
, vol.111
, Issue.1
, pp. 58-62
-
-
Colombo, P.C.1
Banchs, J.E.2
Celaj, S.3
Talreja, A.4
Lachmann, J.5
Malla, S.6
DuBois, N.B.7
Ashton, A.W.8
Latif, F.9
Jorde, U.P.10
Ware, J.A.11
LeJemtel, T.H.12
-
19
-
-
80255141746
-
Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: Results of a randomized, double-blind, placebo- and active-controlled phase 2 trial
-
This study is the first phase 2 clinical trial to provide evidence for the cardiovascular benefit of the novel aldosterone synthase inhibitor
-
Calhoun, D.A., et al., Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: results of a randomized, double-blind, placebo- and active-controlled phase 2 trial. Circulation, 2011. 124(18): p. 1945-55. This study is the first phase 2 clinical trial to provide evidence for the cardiovascular benefit of the novel aldosterone synthase inhibitor.
-
(2011)
Circulation
, vol.124
, Issue.18
, pp. 1945-1955
-
-
Calhoun, D.A.1
-
20
-
-
67349208215
-
New aspects of rapid aldosterone signaling
-
Grossmann C, Gekle M. New aspects of rapid aldosterone signaling. Mol Cell Endocrinol. 2009;308(1-2):53-62.
-
(2009)
Mol Cell Endocrinol
, vol.308
, Issue.1-2
, pp. 53-62
-
-
Grossmann, C.1
Gekle, M.2
-
21
-
-
34047222286
-
Nongenomic actions of aldosterone on the renal tubule
-
DOI 10.1161/01.HYP.0000259797.48382.b2
-
Good DW. Nongenomic actions of aldosterone on the renal tubule. Hypertension. 2007;49(4):728-39. (Pubitemid 351664211)
-
(2007)
Hypertension
, vol.49
, Issue.4
, pp. 728-739
-
-
Good, D.W.1
-
22
-
-
18144418605
-
Nongenomic effects of mineralocorticoid receptor activation in the cardiovascular system
-
DOI 10.1016/j.steroids.2005.02.004
-
Mihailidou AS, Funder JW. Nongenomic effects of mineralocorticoid receptor activation in the cardiovascular system. Steroids. 2005;70(5-7):347-51. (Pubitemid 40616031)
-
(2005)
Steroids
, vol.70
, Issue.5-7 SPEC. ISS.
, pp. 347-351
-
-
Mihailidou, A.S.1
Funder, J.W.2
-
23
-
-
42649109044
-
Prorenin and (pro)renin receptor: A review of available data from in vitro studies and experimental models in rodents
-
DOI 10.1113/expphysiol.2007.040030
-
Nguyen G, Danser AH. Prorenin and (pro)renin receptor: a review of available data from in vitro studies and experimental models in rodents. Exp Physiol. 2008;93(5):557-63. (Pubitemid 351595066)
-
(2008)
Experimental Physiology
, vol.93
, Issue.5
, pp. 557-563
-
-
Nguyen, G.1
Danser, A.H.J.2
-
24
-
-
0036266596
-
Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
-
DOI 10.1172/JCI200214276
-
Nguyen G, et al. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest. 2002;109(11):1417-27. (Pubitemid 34596167)
-
(2002)
Journal of Clinical Investigation
, vol.109
, Issue.11
, pp. 1417-1427
-
-
Nguyen, G.1
Delarue, F.2
Burckle, C.3
Bouzhir, L.4
Giller, T.5
Sraer, J.-D.6
-
25
-
-
0037591344
-
Human prorenin has "gate and handle" regions for its non-proteolytic activation
-
DOI 10.1074/jbc.M302579200
-
Suzuki F, et al. Human prorenin has "gate and handle" regions for its non-proteolytic activation. J Biol Chem. 2003;278(25):22217-22. (Pubitemid 36830267)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.25
, pp. 22217-22222
-
-
Suzuki, F.1
Hayakawa, M.2
Nakagawa, T.3
Nasir, U.M.4
Ebihara, A.5
Iwasawa, A.6
Ishida, Y.7
Nakamura, Y.8
Murakami, K.9
-
26
-
-
9644283069
-
Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin
-
DOI 10.1172/JCI200421398
-
Ichihara A, et al. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin. J Clin Invest. 2004;114(8):1128-35. (Pubitemid 39578702)
-
(2004)
Journal of Clinical Investigation
, vol.114
, Issue.8
, pp. 1128-1135
-
-
Ichihara, A.1
Hayashi, M.2
Kaneshiro, Y.3
Suzuki, F.4
Nakagawa, T.5
Tada, Y.6
Koura, Y.7
Nishiyama, A.8
Okada, H.9
Uddin, M.N.10
Nabi, A.H.M.N.11
Ishida, Y.12
Inagami, T.13
Saruta, T.14
-
27
-
-
33646160993
-
Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension
-
DOI 10.1161/01.HYP.0000215838.48170.0b, PII 0000426820060500000019
-
Ichihara A, et al. Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension. 2006;47(5):894-900. (Pubitemid 44297561)
-
(2006)
Hypertension
, vol.47
, Issue.5
, pp. 894-900
-
-
Ichihara, A.1
Kaneshiro, Y.2
Takemitsu, T.3
Sakoda, M.4
Suzuki, F.5
Nakagawa, T.6
Nishiyama, A.7
Inagami, T.8
Hayashi, M.9
-
28
-
-
34447521458
-
Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: A randomised, double-blind trial
-
DOI 10.1016/S0140-6736(07)61124-6, PII S0140673607611246
-
Oparil S, et al. Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomised, doubleblind trial. Lancet. 2007;370(9583):221-9. (Pubitemid 47069535)
-
(2007)
Lancet
, vol.370
, Issue.9583
, pp. 221-229
-
-
Oparil, S.1
Yarows, S.A.2
Patel, S.3
Fang, H.4
Zhang, J.5
Satlin, A.6
-
29
-
-
9644287897
-
Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption
-
DOI 10.1097/01.ASN.0000146686.35541.29
-
Azizi M, et al. Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption. J Am Soc Nephrol. 2004;15(12):3126-33. (Pubitemid 39578845)
-
(2004)
Journal of the American Society of Nephrology
, vol.15
, Issue.12
, pp. 3126-3133
-
-
Azizi, M.1
Menard, J.2
Bissery, A.3
Guyenne, T.-T.4
Bura-Riviere, A.5
Vaidyanathan, S.6
Camisasca, R.P.7
-
30
-
-
79959713470
-
Prognostic value of plasma renin activity in heart failure
-
Vergaro G, et al. Prognostic value of plasma renin activity in heart failure. Am J Cardiol. 2011;108(2):246-51.
-
(2011)
Am J Cardiol
, vol.108
, Issue.2
, pp. 246-251
-
-
Vergaro, G.1
-
31
-
-
10744232800
-
The comparative prognostic value of plasma neurohormones at baseline in patients with heart failure enrolled in Val-HeFT
-
DOI 10.1016/j.ehj.2003.10.030
-
Latini R, et al. The comparative prognostic value of plasma neurohormones at baseline in patients with heart failure enrolled in Val-HeFT. Eur Heart J. 2004;25(4):292-9. (Pubitemid 38295437)
-
(2004)
European Heart Journal
, vol.25
, Issue.4
, pp. 292-299
-
-
Latini, R.1
Masson, S.2
Anand, I.3
Salio, M.4
Hester, A.5
Judd, D.6
Barlera, S.7
Maggioni, A.P.8
Tognoni, G.9
Cohn, J.N.10
-
33
-
-
50349094508
-
Aliskiren
-
Brown MJ. Aliskiren. Circulation. 2008;118(7):773-84.
-
(2008)
Circulation
, vol.118
, Issue.7
, pp. 773-784
-
-
Brown, M.J.1
-
34
-
-
57449084151
-
Renin inhibition improves cardiac function and remodeling after myocardial infarction independent of blood pressure
-
Westermann D, et al. Renin inhibition improves cardiac function and remodeling after myocardial infarction independent of blood pressure. Hypertension. 2008;52(6):1068-75.
-
(2008)
Hypertension
, vol.52
, Issue.6
, pp. 1068-1075
-
-
Westermann, D.1
-
35
-
-
25444454353
-
Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats
-
DOI 10.1161/01.HYP.0000179573.91016.3f
-
Pilz B, et al. Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats. Hypertension. 2005;46 (3):569-76. (Pubitemid 41376839)
-
(2005)
Hypertension
, vol.46
, Issue.3
, pp. 569-576
-
-
Pilz, B.1
Shagdarsuren, E.2
Wellner, M.3
Fiebeler, A.4
Dechend, R.5
Gratze, P.6
Meiners, S.7
Feldman, D.L.8
Webb, R.L.9
Garrelds, I.M.10
Danser, A.H.J.11
Luft, F.C.12
Muller, D.N.13
-
36
-
-
77956920177
-
The direct renin inhbitor, aliskerin, improves cardiac function via direct renin inhibition and via renin receptor modulation in a rodent model of diabetic diastolic heart failure
-
Abstract 6248
-
Connelly, K., et al., The direct renin inhbitor, aliskerin, improves cardiac function via direct renin inhibition and via renin receptor modulation in a rodent model of diabetic diastolic heart failure. Circulation, 2008. 118: p. S1166. Abstract 6248.
-
(2008)
Circulation
, vol.118
-
-
Connelly, K.1
-
37
-
-
35449001223
-
Neurohumoral effects of the new orally active renin inhibitor, aliskiren, in chronic heart failure
-
DOI 10.1016/j.ejheart.2007.09.002, PII S1388984207003625
-
Seed A, et al. Neurohumoral effects of the new orally active renin inhibitor, aliskiren, in chronic heart failure. Eur J Heart Fail. 2007;9(11):1120-7. (Pubitemid 47633316)
-
(2007)
European Journal of Heart Failure
, vol.9
, Issue.11
, pp. 1120-1127
-
-
Seed, A.1
Gardner, R.2
McMurray, J.3
Hillier, C.4
Murdoch, D.5
MacFadyen, R.6
Bobillier, A.7
Mann, J.8
McDonagh, T.9
-
38
-
-
79958249630
-
Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure
-
McMurray JJ, et al. Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure. Circ Heart Fail. 2008;1(1):17-24.
-
(2008)
Circ Heart Fail
, vol.1
, Issue.1
, pp. 17-24
-
-
McMurray, J.J.1
-
39
-
-
61349170589
-
Effect of the direct Renin inhibitor aliskiren, the Angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy
-
Solomon SD, et al. Effect of the direct Renin inhibitor aliskiren, the Angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy. Circulation. 2009;119(4):530-7.
-
(2009)
Circulation
, vol.119
, Issue.4
, pp. 530-537
-
-
Solomon, S.D.1
-
40
-
-
0032499670
-
Indications for ACE inhibitors in the early treatment of acute myocardial infarction: Systematic overview of individual data from 100, 000 patients in randomized trials
-
ACE Inhibitor Myocardial Infarction Collaborative Group
-
Indications for ACE inhibitors in the early treatment of acute myocardial infarction: systematic overview of individual data from 100,000 patients in randomized trials. ACE Inhibitor Myocardial Infarction Collaborative Group. Circulation, 1998. 97(22): p. 2202-12.
-
(1998)
Circulation
, vol.97
, Issue.22
, pp. 2202-2212
-
-
-
41
-
-
0035818884
-
A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure
-
DOI 10.1056/NEJMoa010713
-
Cohn JN, Tognoni G. A randomized trial of the angiotensinreceptor blocker valsartan in chronic heart failure. N Engl J Med. 2001;345(23):1667-75. (Pubitemid 33126822)
-
(2001)
New England Journal of Medicine
, vol.345
, Issue.23
, pp. 1667-1675
-
-
Cohn, J.N.1
Tognoni, G.2
-
42
-
-
0141892837
-
Effects of early and late administration of angiotensin-converting enzyme inhibitors on mortality after myocardial infarction
-
DOI 10.1016/S0002-9343(03)00435-2
-
Rodrigues EJ, Eisenberg MJ, Pilote L. Effects of early and late administration of angiotensin-converting enzyme inhibitors on mortality after myocardial infarction. Am J Med. 2003;115 (6):473-9. (Pubitemid 37237561)
-
(2003)
American Journal of Medicine
, vol.115
, Issue.6
, pp. 473-479
-
-
Rodrigues, E.J.1
Eisenberg, M.J.2
Pilote, L.3
-
43
-
-
17544390753
-
Early versus delayed angiotensin-converting enzyme inhibition therapy in acute myocardial infarction: The healing and early afterload reducing therapy trial
-
Pfeffer MA, et al. Early versus delayed angiotensin-converting enzyme inhibition therapy in acute myocardial infarction. The healing and early afterload reducing therapy trial. Circulation. 1997;95(12):2643-51. (Pubitemid 27255493)
-
(1997)
Circulation
, vol.95
, Issue.12
, pp. 2643-2651
-
-
Pfeffer, M.A.1
Greaves, S.C.2
Arnold, J.M.O.3
Glynn, R.J.4
LaMotte, F.S.5
Lee, R.T.6
Menapace Jr., F.J.7
Rapaport, E.8
Ridker, P.M.9
Rouleau, J.-L.10
Solomon, S.D.11
Hennekens, C.H.12
-
44
-
-
0028998875
-
When a question has an answer: Rationale for our early termination of the HEART Trial
-
Pfeffer MA, Hennekens CH. When a question has an answer: rationale for our early termination of the HEART Trial. Am J Cardiol. 1995;75(16):1173-5.
-
(1995)
Am J Cardiol
, vol.75
, Issue.16
, pp. 1173-1175
-
-
Pfeffer, M.A.1
Hennekens, C.H.2
-
45
-
-
0028819673
-
ACE inhibitor use in patients with myocardial infarction. Summary of evidence from clinical trials
-
Latini R, et al. ACE inhibitor use in patients with myocardial infarction. Summary of evidence from clinical trials. Circulation. 1995;92(10):3132-7.
-
(1995)
Circulation
, vol.92
, Issue.10
, pp. 3132-3137
-
-
Latini, R.1
-
46
-
-
0041408235
-
Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: The CHARM-added trial
-
DOI 10.1016/S0140-6736(03)14283-3
-
McMurray JJ, et al. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial. Lancet. 2003;362(9386):767-71. (Pubitemid 37093916)
-
(2003)
Lancet
, vol.362
, Issue.9386
, pp. 767-771
-
-
McMurray, J.J.V.1
Ostergren, J.2
Swedberg, K.3
Granger, C.B.4
Held, P.5
Michelson, E.L.6
Olofsson, B.7
Yusuf, S.8
Pfeffer, M.A.9
-
47
-
-
0242490542
-
Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both
-
DOI 10.1056/NEJMoa032292
-
Pfeffer MA, et al. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med. 2003;349(20):1893-906. (Pubitemid 37409706)
-
(2003)
New England Journal of Medicine
, vol.349
, Issue.20
, pp. 1893-1906
-
-
Pfeffer, M.A.1
McMurray, J.J.V.2
Velazquez, E.J.3
Rouleau, J.-L.4
Kober, L.5
Maggioni, A.P.6
Solomon, S.D.7
Swedberg, K.8
Van De Werf, F.9
White, H.10
Leimberger, J.D.11
Henis, M.12
Edwards, S.13
Zelenkofske, S.14
Sellers, M.A.15
Califf, R.M.16
-
48
-
-
41149101190
-
Safety and tolerability of angiotensin-converting enzyme inhibitor versus the combination of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker in patients with left ventricular dysfunction: A systematic review and meta-analysis of randomized controlled trials
-
DOI 10.1016/j.cardfail.2007.11.008, PII S1071916407011591
-
Lakhdar R, Al-Mallah MH, Lanfear DE. Safety and tolerability of angiotensin-converting enzyme inhibitor versus the combination of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker in patients with left ventricular dysfunction: a systematic review and meta-analysis of randomized controlled trials. J Card Fail. 2008;14(3):181-8. (Pubitemid 351434594)
-
(2008)
Journal of Cardiac Failure
, vol.14
, Issue.3
, pp. 181-188
-
-
Lakhdar, R.1
Al-Mallah, M.H.2
Lanfear, D.E.3
-
49
-
-
49149087718
-
Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): A multicentre, randomised, double-blind, controlled trial
-
Mann JF, et al. Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial. Lancet. 2008;372(9638):547-53.
-
(2008)
Lancet
, vol.372
, Issue.9638
, pp. 547-553
-
-
Mann, J.F.1
-
50
-
-
52449122086
-
Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways
-
Montezano AC, et al. Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways. Arterioscler Thromb Vasc Biol. 2008;28(8):1511-8.
-
(2008)
Arterioscler Thromb Vasc Biol.
, vol.28
, Issue.8
, pp. 1511-1518
-
-
Montezano, A.C.1
-
51
-
-
70349251477
-
Aliskiren enhances the protective effects of valsartan against cardiovascular and renal injury in endothelial nitric oxide synthase-deficient mice
-
Yamamoto E, et al. Aliskiren enhances the protective effects of valsartan against cardiovascular and renal injury in endothelial nitric oxide synthase-deficient mice. Hypertension. 2009;54(3):633-8.
-
(2009)
Hypertension
, vol.54
, Issue.3
, pp. 633-638
-
-
Yamamoto, E.1
-
52
-
-
77954383099
-
Aliskiren enhances protective effects of valsartan against type 2 diabetic nephropathy in mice
-
Dong YF, et al. Aliskiren enhances protective effects of valsartan against type 2 diabetic nephropathy in mice. J Hypertens. 2010;28 (7):1554-65.
-
(2010)
J Hypertens
, vol.28
, Issue.7
, pp. 1554-1565
-
-
Dong, Y.F.1
-
53
-
-
38649102508
-
Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension
-
DOI 10.3317/jraas.2007.028
-
Uresin Y, et al. Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension. J Renin Angiotensin Aldosterone Syst. 2007;8(4):190-8. (Pubitemid 351166266)
-
(2007)
JRAAS - Journal of the Renin-Angiotensin-Aldosterone System
, vol.8
, Issue.4
, pp. 190-198
-
-
Uresin, Y.1
Taylor, A.A.2
Kilo, C.3
Tschope, D.4
Santonastaso, M.5
Ibram, G.6
Fang, H.7
Satlin, A.8
-
54
-
-
0035007236
-
Dose-dependent blockade of the angiotensin II type 1 receptor with losartan in normal volunteers
-
DOI 10.1097/00005344-200106000-00006
-
Berlowitz MS, et al. Dose-dependent blockade of the angiotensin II type 1 receptor with losartan in normal volunteers. J Cardiovasc Pharmacol. 2001;37(6):692-6. (Pubitemid 32480437)
-
(2001)
Journal of Cardiovascular Pharmacology
, vol.37
, Issue.6
, pp. 692-696
-
-
Berlowitz, M.S.1
Latif, F.2
Hankins, S.R.3
Ennezat, P.V.4
Moskowitz, R.5
Tandon, S.6
Colombo, P.C.7
Le Jemtel, T.H.8
-
55
-
-
44849114597
-
Aliskiren combined with losartan in type 2 diabetes and nephropathy
-
Parving HH, et al. Aliskiren combined with losartan in type 2 diabetes and nephropathy. N Engl J Med. 2008;358(23):2433-46.
-
(2008)
N Engl J Med
, vol.358
, Issue.23
, pp. 2433-2446
-
-
Parving, H.H.1
-
57
-
-
33947182655
-
Aliskiren, an oral renin inhibitor, provides dosedependent efficacy and sustained 24-hour blood pressure control in patients with hypertension
-
Oh BH, et al. Aliskiren, an oral renin inhibitor, provides dosedependent efficacy and sustained 24-hour blood pressure control in patients with hypertension. J Am Coll Cardiol. 2007;49(11):1157-63.
-
(2007)
J Am Coll Cardiol.
, vol.49
, Issue.11
, pp. 1157-1163
-
-
Oh, B.H.1
-
58
-
-
3042731163
-
Serum aldosterone and the incidence of hypertension in nonhypertensive persons
-
Vasan RS, et al. Serum aldosterone and the incidence of hypertension in nonhypertensive persons. N Engl J Med. 2004;351(1):33-41.
-
(2004)
N Engl J Med.
, vol.351
, Issue.1
, pp. 33-41
-
-
Vasan, R.S.1
-
59
-
-
66549130863
-
Narrative review: The emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension
-
Sowers JR, Whaley-Connell A, Epstein M. Narrative review: the emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension. Ann Intern Med. 2009;150(11):776-83.
-
(2009)
Ann Intern Med
, vol.150
, Issue.11
, pp. 776-783
-
-
Sowers, J.R.1
Whaley-Connell, A.2
Epstein, M.3
-
61
-
-
0022532461
-
Interaction between the adrenergic and renin-angiotensin-aldosterone- systems
-
van Zwieten PA, de Jonge A. Interaction between the adrenergic and renin-angiotensin-aldosterone-systems. Postgrad Med J. 1986;62 Suppl 1:23-7. (Pubitemid 16057508)
-
(1986)
Postgraduate Medical Journal
, vol.62
, Issue.SUPPL. 1
, pp. 23-27
-
-
Van Zwieten, P.A.1
De Jonge, A.2
-
62
-
-
0021748527
-
Interaction between sympathetic and renin-angiotensin system
-
DOI 10.1097/00004872-198412000-00002
-
Zimmerman BG, Sybertz EJ, Wong PC. Interaction between sympathetic and renin-angiotensin system. J Hypertens. 1984;2 (6):581-7. (Pubitemid 15188008)
-
(1984)
Journal of Hypertension
, vol.2
, Issue.6
, pp. 581-587
-
-
Zimmerman, B.G.1
Sybertz, E.J.2
Wong, P.C.3
-
63
-
-
33745462980
-
1-adrenoceptor blockade
-
DOI 10.1097/01.hjh.0000234116.17778.63, PII 0000487220060700000021
-
Batenburg, W.W., et al., Carvedilol-induced antagonism of angiotensin II: a matter of alpha1-adrenoceptor blockade. J Hypertens, 2006. 24(7): p. 1355-63. This elegant study mechanistically proves the crosstalk phenomenon between the AT1R and the α-1R. (Pubitemid 43948335)
-
(2006)
Journal of Hypertension
, vol.24
, Issue.7
, pp. 1355-1363
-
-
Batenburg, W.W.1
Van Esch, J.H.2
Garrelds, I.M.3
Jorde, U.4
Lamers, J.M.5
Dekkers, D.H.6
Walther, T.7
Kellett, E.8
Milligan, G.9
Van Kats, J.P.10
Danser, A.H.J.11
-
65
-
-
0028875839
-
Catecholamine response to chronic ANG II infusion and its role in myocyte and coronary vascular damage
-
Henegar JR, et al. Catecholamine response to chronic ANG II infusion and its role in myocyte and coronary vascular damage. Am J Physiol. 1995;269(5 Pt 2):H1564-9.
-
(1995)
Am J Physiol.
, vol.269
, Issue.5 PART 2
-
-
Henegar, J.R.1
-
66
-
-
0027989853
-
1- adrenoceptor-mediated presser responses in the rat
-
DOI 10.1016/0014-2999(94)90309-3
-
Marano G, Argiolas L. Postjunctional regulation by angiotensin II of alpha 1-adrenoceptor-mediated pressor responses in the rat. Eur J Pharmacol. 1994;261(1-2):121-6. (Pubitemid 24263211)
-
(1994)
European Journal of Pharmacology
, vol.261
, Issue.1-2
, pp. 121-126
-
-
Marano, G.1
Argiolas, L.2
-
67
-
-
0026495788
-
Prazosin blunts the antinatriuretic effect of circulating angiotensin II in man
-
Lang CC, et al. Prazosin blunts the antinatriuretic effect of circulating angiotensin II in man. J Hypertens. 1992;10(11):1387-95.
-
(1992)
J Hypertens
, vol.10
, Issue.11
, pp. 1387-1395
-
-
Lang, C.C.1
-
68
-
-
0028910026
-
Angiotensin II induces transcription and expression of alpha 1-adrenergic receptors in vascular smooth muscle cells
-
Hu ZW, et al. Angiotensin II induces transcription and expression of alpha 1-adrenergic receptors in vascular smooth muscle cells. Am J Physiol. 1995;268(3 Pt 2):H1006-14.
-
(1995)
Am J Physiol.
, vol.268
, Issue.3 PART 2
-
-
Hu, Z.W.1
-
69
-
-
0037458065
-
Vasopressor response to angiotensin II infusion in patients with chronic heart failure receiving β-blockers
-
DOI 10.1161/01.CIR.0000045666.04794.14
-
Vittorio, T.J., et al., Vasopressor response to angiotensin II infusion in patients with chronic heart failure receiving beta-blockers. Circulation, 2003. 107(2): p. 290-3. This study provides clinical evidence for the crosstalk phenomenon between the AT1R and the α-1R in patients with chronic heart failure. (Pubitemid 36135226)
-
(2003)
Circulation
, vol.107
, Issue.2
, pp. 290-293
-
-
Vittorio, T.J.1
Lang, C.C.2
Katz, S.D.3
Packer, M.4
Mancini, D.M.5
Jorde, U.P.6
-
70
-
-
0029937949
-
The effect of carvedilol on morbidity and mortality in patients with chronic heart failure
-
DOI 10.1056/NEJM199605233342101
-
Packer M, et al. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group. N Engl J Med. 1996;334(21):1349-55. (Pubitemid 26152713)
-
(1996)
New England Journal of Medicine
, vol.334
, Issue.21
, pp. 1349-1355
-
-
Packer, M.1
Bristow, M.R.2
Cohn, J.N.3
Colucci, W.S.4
Fowler, M.B.5
Gilbert, E.M.6
Shusterman, N.H.7
-
71
-
-
3142776467
-
Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): Randomised controlled trial
-
DOI 10.1016/S0140-6736(03)13800-7
-
Poole-Wilson PA, et al. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial. Lancet. 2003;362(9377):7-13. (Pubitemid 36835815)
-
(2003)
Lancet
, vol.362
, Issue.9377
, pp. 7-13
-
-
Poole-Wilson, P.A.1
Swedberg, K.2
Cleland, J.G.F.3
Di Lenarda, A.4
Hanrath, P.5
Komajda, M.6
Lubsen, J.7
Lutiger, B.8
Metra, M.9
Remme, W.J.10
Torp-Pedersen, C.11
Scherhag, A.12
Skene, A.13
-
72
-
-
0033617108
-
2 receptors, regulates STAT activation by negative crosstalk
-
Horiuchi M, et al. Stimulation of different subtypes of angiotensin II receptors, AT1 and AT2 receptors, regulates STAT activation by negative crosstalk. Circ Res. 1999;84(8):876-82. (Pubitemid 29196731)
-
(1999)
Circulation Research
, vol.84
, Issue.8
, pp. 876-882
-
-
Horiuchi, M.1
Hayashida, W.2
Akishita, M.3
Tamura, K.4
Daviet, L.5
Lehtonen, J.Y.A.6
Dzau, V.J.7
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