Automated multistep continuous flow synthesis of 2-(1H-indol-3-yl)thiazole derivatives

Synthesis (Germany)

Volumn 44, Issue 16, 2012, Pages 2537-2546

  Pagano, Nicholas ^a   Heil, Marintha L ^b   Cosford, Nicholas D P ^a  

^a BURNHAM INSTITUTE   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

condensation; heterocycles; indoles; microfluidic synthesis; microreactor; tandem reactions

Indexed keywords

HETEROCYCLES; INDOLES; MICRO-REACTOR; MICROFLUIDIC SYNTHESIS; TANDEM REACTION;

CONDENSATION; SPEECH SYNTHESIS;

CHEMISTRY;

2 (1 BENZYL 2 METHYL 1H INDOL 3 YL) 4 PHENYLTHIAZOLE; 2 (1,2 DIMETHYL 1H INDOL 3 YL) 4 PHENYLTHIAZOLE; 2 (1H INDOL 3 YL) 4 PHENYLTHIAZOLE; 2 (1H INDOL 3 YL)THIAZOLE DERIVATIVE; 2 (2 METHYL 1H BENZO[G]INDOL 3 YL) 4 PHENYLTHIAZOLE; 2 (2 METHYL 1H INDOL 3 YL) 4 (4 TOLYL)THIAZOLE; 2 (2 METHYL 1H INDOL 3 YL) 4 (NAPHTHALEN 2 YL)THIAZOLE; 2 (2 METHYL 1H INDOL 3 YL) 4 (THIOPHEN 2 YL)THIAZOLE; 2 (2 METHYL 1H INDOL 3 YL) 4 [(4 TRIFLUOROMETHYL)PHENYL]THIAZOLE; 2 (2 METHYL 1H INDOL 3 YL) 4 PHENYLTHIAZOLE; 2 (2,5 DIMETHYL 1H INDOL 3 YL) 4 PHENYLTHIAZOLE; 2 (5 BROMO 2 METHYL 1H INDOL 3 YL) 4 PHENYLTHIAZOLE; 2 (5 CHLORO 2 METHYL 1H INDOL 3 YL) 4 PHENYLTHIAZOLE; 2 (5 FLUORO 1H INDOL 3 YL) 4 PHENYLTHIAZOLE; 2 (5 FLUORO 2 METHYL 1H INDOL 3 YL) 4 PHENYLTHIAZOLE; 2 (5 METHOXY 1H INDOL 3 YL) 4 PHENYLTHIAZOLE; 2 (5 METHOXY 2 METHYL 1H INDOL 3 YL) 4 PHENYLTHIAZOLE; 2 (5,5 DIMETHYL 1,3 DIOXAN 2 YL)ACETAMIDE; 2 (5,5 DIMETHYL 1,3 DIOXAN 2 YL)ETHANETHIOAMIDE; 2 [5 (BENZYLOXY) 2 METHYL 1H INDOL 3 YL] 4 PHENYLTHIAZOLE; 2 [5 (TERT BUTYL) 2 METHYL 1H INDOL 3 YL] 4 PHENYLTHIAZOLE; 3 [2 (2 METHYL 1H INDOL 3 YL)THIAZOL 4 YL]PHENOL; 4 (4 BROMOPHENYL) 2 (2 METHYL 1H INDOL 3 YL)THIAZOLE; 4 (4 CHLOROPHENYL) 2 (2 METHYL 1H INDOL 3 YL)THIAZOLE; 4 (4 FLUOROPHENYL) 2 (2 METHYL 1H INDOL 3 YL)THIAZOLE; 4 (4 METHOXYPHENYL) 2 (2 METHYL 1H INDOL 3 YL)THIAZOLE; 4 [(1,1' BIPHENYL) 4 YL] 2 (2 METHYL 1H INDOL 3 YL)THIAZOLE; 4 [2 (2 METHYL 1H INDOL 3 YL)THIAZOL 4 YL]BENZONITRILE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; COMPLEX FORMATION; CONTINUOUS FLOW REACTOR; DEKETALIZATION; FISCHER INDOLE SYNTHESIS; FLOW KINETICS; ONE POT SYNTHESIS; REACTION TIME;

EID: 84864875407     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0031-1290953     Document Type: Article

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