Molecular bases of morphometric composition in Glioblastoma multiforme

Proceedings - International Symposium on Biomedical Imaging

Volumn , Issue , 2012, Pages 1631-1634

  Han, Ju ^a   Chang, Hang ^a   Fontenay, Gerald V ^a   Spellman, Paul T ^b   Borowsky, Alexander ^c   Parvin, Bahram ^a  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

consensus clustering; Cox proportional hazards model; molecular association; Tumor architecture

Indexed keywords

CANCER GENOME; CLINICAL DATA; CONSENSUS CLUSTERING; GLIOBLASTOMA MULTIFORME; HAZARD RATIO; HISTOLOGICAL SECTION; HYPOTHESIS GENERATION; INTEGRATED ANALYSIS; INTERMEDIATE LEVEL; MOLECULAR ASSOCIATIONS; MOLECULAR BASIS; MOLECULAR DATA; NUCLEAR MORPHOLOGY; NUCLEUS SIZE; SURVIVAL ANALYSIS;

CHEMICAL BONDS; MEDICAL IMAGING; TISSUE;

GENES;

EID: 84864861860     PISSN: 19457928     EISSN: 19458452     Source Type: Conference Proceeding    
DOI: 10.1109/ISBI.2012.6235889     Document Type: Conference Paper

References (17)

1. H. Chang, G.V. Fontenay, J. Han, G. Cong, F.L. Baehner, J.W. Gray, P.T. Spellman, and B. Parvin, "Morphometric analysis of tcga glioblastoma multiforme," BMC Bioinformatics, vol. 12, no. 484, 2011.
2. H. Chang, L.A. Loss, P.T. Spellman, A. Borowsky, and B. Parvin, "Batch-invariant nuclear segmentation in whole mount tissue histology," in Proc. ISBI, 2012.
3. L.A. Cooper et. al, "An integrative approach for in silico glioma research," IEEE Trans Biomed Eng, vol. 57, no. 10, pp. 2617-2621, 2010.
4. L.A. Cooper et. al, "Integrated morphologic analysis for the identification and characterization of disease subtypes," J Am Med Inform Assoc, 2012, In Press.
5. S. Monti, P. Tamayo, J. Mesirov, and T.R. Golub, "Consensus clustering: a resampling-based method for class discovery and visualization of gene expression microarray data," Mach Learn, vol. 52, pp. 91-118, 2003.
6. P.J. Rousseeuw, "Silhouettes: A graphical aid to the interpretation and validation of cluster analysis," J Comput Appl Math, vol. 20, pp. 53-65, 1987.
7. R.G. Verhaak et. al, "Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in pdgfra, idh1, egfr, and nf1," Cancer Cell, vol. 17, no. 1, pp. 98-110, 2010.
8. J. Fox, Cox proportional-hazard regression for survival data, In R. Fox (Ed.), An R and S-PLUS companion to applied regression, Sage, Thousand Oaks, CA, 2002.
9. Y. Benjaminiand Y. Hochberg, "Controlling the false discovery rate: a practical and powerful approach to multiple testing," J R Stat Soc Series B, vol. 57, pp. 289-300, 1995.
10. A. Pierallini, M. Bonamini, P. Pantano, F. Palmeggiani, M. Raguso, M.F. Osti, G. Anaveri, and L. Bozzao, "Radiological assessment of necrosis in glioblastoma: variability and prognostic value," Neuroradiology, vol. 40, no. 3, pp. 150-153, 1998.
11. Y. Liu, C. Li, and J. Lin, "Stat3 as a therapeutic target for glioblastoma," Anticancer agents Med Chem, vol. 10, no. 7, pp. 512-519, 2010.
12. S.Rahman, P. Harbor, O. Chernova, G. Barnett, M. Vogelbaum, and S. Haque, "Inhinbition of constitutively active stat3 supresses proliferation and induces apoptosis in glioblastoma multiforme cells," Oncogene, vol. 21, no. 55, pp. 8404-8413, 2002.
13. Y. Kakinuma, H. Hama, F. Syugiyama, K. Goto, K. Murakami, and A. Fukamizu, "Anti-apoptotic action of angiotensin fragments to neuronal cells from angiotensinogen knock-out mice," Neuroscience Letters, vol. 232, pp. 167-170, 1997.
14. R. Stupp, M. Gander, S. Leyvraz, and E. Newland, "Current and future development in the use of temozolomide for the treatment of brain tumours," The Lancent Oncology, vol. 2, pp. 552-560, 2001.
15. M. Kazanietz, Protein Kinase C in cancer signaling and therapy, Humana Press, 2010.
16. P. Martin and I. JHussanini, "Pkc eta as a therapeutic target in glioblastoma multiforme," Expert Opin Ther Targets, vol. 9, no. 2, pp. 299-313, 2005.
17. T. Chen, D. Hinton, B. Sippy, and F. Hoffman, "Soluable tnf-alpha receptors are constitutively shed and down regulate adhesion molecule expression in malignant gliomas," Neuropathology, vol. 56, pp. 541-550, 1997.