S-52, a novel nootropic compound, protects against β-amyloid induced neuronal injury by attenuating mitochondrial dysfunction

Journal of Neuroscience Research

Volumn 90, Issue 10, 2012, Pages 1981-1988

  Gao, Xin ^a   Zheng, Chun Yan ^a   Qin, Guo Wei ^a   Tang, Xi Can ^a   Zhang, Hai Yan ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

amyloid; Alzheimer's disease; Mitochondrial dysfunction; Reactive oxygen species

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMYLOID BETA PROTEIN[25-35]; CITRATE SYNTHASE; CYTOCHROME C OXIDASE; FREE RADICAL; HYDROXYL RADICAL; NOOTROPIC AGENT; OXOGLUTARATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE COMPLEX; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); S 52; SCAVENGER; SUCCINATE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL STRAIN; CELL VIABILITY; CITRIC ACID CYCLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ELECTRON MICROSCOPY; ENERGY METABOLISM; ENZYME ACTIVITY; MEMBRANE STRUCTURE; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL TOXICITY; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN;

ADENOSINE TRIPHOSPHATE; AMYLOID BETA-PEPTIDES; ANIMALS; CELL SURVIVAL; ELECTRON TRANSPORT; FLUOROMETRY; FREE RADICAL SCAVENGERS; HYDROXYL RADICAL; MEMBRANE POTENTIALS; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; MORPHINANS; NEURONS; NOOTROPIC AGENTS; PC12 CELLS; PEPTIDE FRAGMENTS; RATS; REACTIVE OXYGEN SPECIES; SUPEROXIDES;

EID: 84864855052     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23086     Document Type: Article

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