메뉴 건너뛰기




Volumn 28, Issue 4, 2012, Pages 1045-1054

Dynamics of diffusivity and pressure drop in flow-through and parallel-flow bioreactors during tissue regeneration

Author keywords

3D scaffold; Bioreactor design; Chitosan; Diffusivity; Gelatin; Porosity

Indexed keywords

3D SCAFFOLDS; ALTERNATIVE DESIGNS; BIOREACTOR DESIGN; CELL DENSITY; CHANNEL POSITION; CHITOSAN-GELATIN SCAFFOLDS; EFFECTIVE DIFFUSIVITIES; FLOWTHROUGH; GELATIN; HOLD UP; LOW POROSITY; LOWER PRESSURES; NEW DESIGN; NUTRIENT DISTRIBUTIONS; SCAFFOLD THICKNESS; SIMULATION STUDIES; SMOOTH MUSCLE CELLS; TISSUE REGENERATION; TRANSPORT CHARACTERISTICS;

EID: 84864833474     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1547     Document Type: Article
Times cited : (10)

References (43)
  • 1
    • 0021972202 scopus 로고
    • Flow effects on prostacyclin production by cultured human endothelial cells
    • Frangos JA, Eskin SG, McIntire LV, Ives CL. Flow effects on prostacyclin production by cultured human endothelial cells. Science. 1985; 227: 1477-1479.
    • (1985) Science. , vol.227 , pp. 1477-1479
    • Frangos, J.A.1    Eskin, S.G.2    McIntire, L.V.3    Ives, C.L.4
  • 4
    • 34548134850 scopus 로고    scopus 로고
    • Bioreactor development for stem cell expansion and controlled differentiation
    • King JA, Miller WM. Bioreactor development for stem cell expansion and controlled differentiation. Curr Opin Chem Biol. 2007; 11: 394-398.
    • (2007) Curr Opin Chem Biol. , vol.11 , pp. 394-398
    • King, J.A.1    Miller, W.M.2
  • 5
    • 33646364803 scopus 로고    scopus 로고
    • Fluid flow increases type II collagen deposition and tensile mechanical properties in bioreactor-grown tissue-engineered cartilage
    • Gemmiti CV, Guldberg RE. Fluid flow increases type II collagen deposition and tensile mechanical properties in bioreactor-grown tissue-engineered cartilage. Tissue Eng. 2006; 12: 469-479.
    • (2006) Tissue Eng. , vol.12 , pp. 469-479
    • Gemmiti, C.V.1    Guldberg, R.E.2
  • 6
    • 23244434168 scopus 로고    scopus 로고
    • Effects of oxygen transport on 3-d human mesenchymal stem cell metabolic activity in perfusion and static cultures: experiments and mathematical model
    • Zhao F, Pathi P, Grayson W, Xing Q, Locke BR, Ma T. Effects of oxygen transport on 3-d human mesenchymal stem cell metabolic activity in perfusion and static cultures: experiments and mathematical model. Biotechnol Prog. 2005; 21: 1269-1280.
    • (2005) Biotechnol Prog. , vol.21 , pp. 1269-1280
    • Zhao, F.1    Pathi, P.2    Grayson, W.3    Xing, Q.4    Locke, B.R.5    Ma, T.6
  • 7
    • 84859159420 scopus 로고    scopus 로고
    • A novel recirculating flow-perfusion bioreactor for periosteal chondrogenesis
    • Tarng Y-W, Huang B-F, Su F-C. A novel recirculating flow-perfusion bioreactor for periosteal chondrogenesis. Int Orthop. 2012;36:863-868.
    • (2012) Int Orthop. , vol.36 , pp. 863-868
    • Tarng, Y.-W.1    Huang, B.-F.2    Su, F.-C.3
  • 8
    • 0141596127 scopus 로고    scopus 로고
    • Oscillating perfusion of cell suspensions through three-dimensional scaffolds enhances cell seeding efficiency and uniformity
    • Wendt D, Marsano A, Jakob M, Heberer M, Martin I. Oscillating perfusion of cell suspensions through three-dimensional scaffolds enhances cell seeding efficiency and uniformity. Biotechnol Bioeng. 2003; 84: 205-214.
    • (2003) Biotechnol Bioeng. , vol.84 , pp. 205-214
    • Wendt, D.1    Marsano, A.2    Jakob, M.3    Heberer, M.4    Martin, I.5
  • 9
    • 0035372005 scopus 로고    scopus 로고
    • Effect of convection on osteoblastic cell growth and function in biodegradable polymer foam scaffolds
    • Goldstein AS, Juarez TM, Helmke CD, Gustin MC, Mikos AG. Effect of convection on osteoblastic cell growth and function in biodegradable polymer foam scaffolds. Biomaterials. 2001; 22: 1279-1288.
    • (2001) Biomaterials. , vol.22 , pp. 1279-1288
    • Goldstein, A.S.1    Juarez, T.M.2    Helmke, C.D.3    Gustin, M.C.4    Mikos, A.G.5
  • 10
    • 3843112154 scopus 로고    scopus 로고
    • Bioreactor-based bone tissue engineering: the influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization
    • Yu X, Botchwey EA, Levine EM, Pollack SR, Laurencin CT. Bioreactor-based bone tissue engineering: the influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization. Proc Natl Acad Sci USA. 2004; 101: 11203-11208.
    • (2004) Proc Natl Acad Sci USA. , vol.101 , pp. 11203-11208
    • Yu, X.1    Botchwey, E.A.2    Levine, E.M.3    Pollack, S.R.4    Laurencin, C.T.5
  • 11
    • 33644517215 scopus 로고    scopus 로고
    • In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation
    • Datta N, Pham QP, Sharma U, Sikavitsas VI, Jansen JA, Mikos AG. In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation. Proc Natl Acad Sci USA. 2006; 103: 2488-2493.
    • (2006) Proc Natl Acad Sci USA. , vol.103 , pp. 2488-2493
    • Datta, N.1    Pham, Q.P.2    Sharma, U.3    Sikavitsas, V.I.4    Jansen, J.A.5    Mikos, A.G.6
  • 12
    • 32544432849 scopus 로고    scopus 로고
    • Modeling evaluation of the fluid-dynamic microenvironment in tissue-engineered constructs: a micro-CT based model
    • Cioffi M, Boschetti F, Raimondi MT, Dubini G. Modeling evaluation of the fluid-dynamic microenvironment in tissue-engineered constructs: a micro-CT based model. Biotechnol Bioeng. 2006; 93: 500-510.
    • (2006) Biotechnol Bioeng. , vol.93 , pp. 500-510
    • Cioffi, M.1    Boschetti, F.2    Raimondi, M.T.3    Dubini, G.4
  • 13
    • 40849112959 scopus 로고    scopus 로고
    • Computational fluid dynamics for improved bioreactor design and 3D culture
    • Hutmacher DW, Singh H. Computational fluid dynamics for improved bioreactor design and 3D culture. Trends Biotechnol. 2008; 26: 166-172.
    • (2008) Trends Biotechnol. , vol.26 , pp. 166-172
    • Hutmacher, D.W.1    Singh, H.2
  • 14
    • 12344284982 scopus 로고    scopus 로고
    • 3-D computational modeling of media flow through scaffolds in a perfusion bioreactor
    • Porter B, Zauel R, Stockman H, Guldberg R, Fyhrie D. 3-D computational modeling of media flow through scaffolds in a perfusion bioreactor. J Biomech. 2005; 38: 543-549.
    • (2005) J Biomech. , vol.38 , pp. 543-549
    • Porter, B.1    Zauel, R.2    Stockman, H.3    Guldberg, R.4    Fyhrie, D.5
  • 15
    • 57649185476 scopus 로고    scopus 로고
    • Investigating the effects of fluid shear forces on cellular responses to profiled surfaces in-vitro: a computational and experimental investigation
    • Brown A, Meenan BJ. Investigating the effects of fluid shear forces on cellular responses to profiled surfaces in-vitro: a computational and experimental investigation. Conf Proc IEEE Eng Med Biol Soc. 2007; 2007: 5387-5390.
    • (2007) Conf Proc IEEE Eng Med Biol Soc. , vol.2007 , pp. 5387-5390
    • Brown, A.1    Meenan, B.J.2
  • 16
    • 0346154824 scopus 로고    scopus 로고
    • Permeability of musculoskeletal tissues and scaffolding materials: experimental results and theoretical predictions
    • Sander EA, Nauman EA. Permeability of musculoskeletal tissues and scaffolding materials: experimental results and theoretical predictions. Crit Rev Biomed Eng. 2003; 31: 1-26.
    • (2003) Crit Rev Biomed Eng. , vol.31 , pp. 1-26
    • Sander, E.A.1    Nauman, E.A.2
  • 17
    • 64349090469 scopus 로고    scopus 로고
    • Compartmental models for continuous flow reactors derived from CFD simulations
    • Gresch M, Brugger R, Meyer A, Gujer W. Compartmental models for continuous flow reactors derived from CFD simulations. Environ Sci Technol. 2009; 43: 2381-2387.
    • (2009) Environ Sci Technol. , vol.43 , pp. 2381-2387
    • Gresch, M.1    Brugger, R.2    Meyer, A.3    Gujer, W.4
  • 18
    • 0036751969 scopus 로고    scopus 로고
    • Computational fluid dynamics modeling of steady-state momentum and mass transport in a bioreactor for cartilage tissue engineering
    • Williams KA, Saini S, Wick TM. Computational fluid dynamics modeling of steady-state momentum and mass transport in a bioreactor for cartilage tissue engineering. Biotechnol Prog. 2002; 18: 951-963.
    • (2002) Biotechnol Prog. , vol.18 , pp. 951-963
    • Williams, K.A.1    Saini, S.2    Wick, T.M.3
  • 19
    • 67650796913 scopus 로고    scopus 로고
    • Modeling nutrient consumptions in large flow-through bioreactors for tissue engineering
    • Devarapalli M, Lawrence BJ, Madihally SV. Modeling nutrient consumptions in large flow-through bioreactors for tissue engineering. Biotechnol Bioeng. 2009; 103: 1003-1015.
    • (2009) Biotechnol Bioeng. , vol.103 , pp. 1003-1015
    • Devarapalli, M.1    Lawrence, B.J.2    Madihally, S.V.3
  • 20
    • 60349087986 scopus 로고    scopus 로고
    • Flow dynamics in bioreactors containing tissue engineering scaffolds
    • Lawrence BJ, Devarapalli M, Madihally SV. Flow dynamics in bioreactors containing tissue engineering scaffolds. Biotechnol Bioeng. 2009; 102: 935-947.
    • (2009) Biotechnol Bioeng. , vol.102 , pp. 935-947
    • Lawrence, B.J.1    Devarapalli, M.2    Madihally, S.V.3
  • 21
    • 34547613758 scopus 로고    scopus 로고
    • Enhancement of cell growth in tissue-engineering constructs under direct perfusion: modeling and simulation
    • Chung CA, Chen CW, Chen CP, Tseng CS. Enhancement of cell growth in tissue-engineering constructs under direct perfusion: modeling and simulation. Biotechnol Bioeng. 2007; 97: 1603-1616.
    • (2007) Biotechnol Bioeng. , vol.97 , pp. 1603-1616
    • Chung, C.A.1    Chen, C.W.2    Chen, C.P.3    Tseng, C.S.4
  • 23
    • 0001045918 scopus 로고
    • The Lattice Boltzmann-equation-a new tool for computational fluid-dynamics
    • Succi S, Benzi R, Higuera F. The Lattice Boltzmann-equation-a new tool for computational fluid-dynamics. Physica D. 1991; 47: 219-230.
    • (1991) Physica D. , vol.47 , pp. 219-230
    • Succi, S.1    Benzi, R.2    Higuera, F.3
  • 24
    • 84887920846 scopus 로고    scopus 로고
    • Computational simulation modelling of bioreactor configurations for regenerating human bladder
    • In press. DOI: 10.1080/10255842.2011.641177.
    • Pok S, Dhane DV, Madihally SV. Computational simulation modelling of bioreactor configurations for regenerating human bladder. Comput Methods Biomech Biomed Eng. In press. DOI: 10.1080/10255842.2011.641177.
    • Comput Methods Biomech Biomed Eng.
    • Pok, S.1    Dhane, D.V.2    Madihally, S.V.3
  • 28
    • 0036499692 scopus 로고    scopus 로고
    • A natural protective mechanism against hyperglycaemia in vascular endothelial and smooth-muscle cells: role of glucose and 12-hydroxyeicosatetraenoic acid
    • Alpert E, Gruzman A, Totary H, Kaiser N, Reich R, Sasson S. A natural protective mechanism against hyperglycaemia in vascular endothelial and smooth-muscle cells: role of glucose and 12-hydroxyeicosatetraenoic acid. Biochem J. 2002; 362: 413-422.
    • (2002) Biochem J. , vol.362 , pp. 413-422
    • Alpert, E.1    Gruzman, A.2    Totary, H.3    Kaiser, N.4    Reich, R.5    Sasson, S.6
  • 29
    • 0141625187 scopus 로고
    • Diffusion in a cation exchanger resin II
    • Mackie JS, Meares P. Diffusion in a cation exchanger resin II. Proc R Soc. 1955; 232: 495-505.
    • (1955) Proc R Soc. , vol.232 , pp. 495-505
    • Mackie, J.S.1    Meares, P.2
  • 30
    • 23244457579 scopus 로고    scopus 로고
    • Computational study of culture conditions and nutrient supply in cartilage tissue engineering
    • Sengers BG, van Donkelaar CC, Oomens CW, Baaijens FP. Computational study of culture conditions and nutrient supply in cartilage tissue engineering. Biotechnol Prog. 2005; 21: 1252-1261.
    • (2005) Biotechnol Prog. , vol.21 , pp. 1252-1261
    • Sengers, B.G.1    van Donkelaar, C.C.2    Oomens, C.W.3    Baaijens, F.P.4
  • 31
    • 23944463701 scopus 로고    scopus 로고
    • In vitro characterization of chitosan-gelatin scaffolds for tissue engineering
    • Huang Y, Onyeri S, Siewe M, Moshfeghian A, Madihally SV. In vitro characterization of chitosan-gelatin scaffolds for tissue engineering. Biomaterials. 2005; 26: 7616-7627.
    • (2005) Biomaterials. , vol.26 , pp. 7616-7627
    • Huang, Y.1    Onyeri, S.2    Siewe, M.3    Moshfeghian, A.4    Madihally, S.V.5
  • 32
    • 30944440442 scopus 로고    scopus 로고
    • Effect of spatial architecture on cellular colonization
    • Huang Y, Siewe M, Madihally SV. Effect of spatial architecture on cellular colonization. Biotechnol Bioeng. 2006; 93: 64-75.
    • (2006) Biotechnol Bioeng. , vol.93 , pp. 64-75
    • Huang, Y.1    Siewe, M.2    Madihally, S.V.3
  • 33
    • 84858447110 scopus 로고    scopus 로고
    • Increased matrix synthesis by fibroblasts with decreased proliferation on synthetic chitosan-gelatin porous structures
    • Iyer P, Walker KJ, Madihally SV. Increased matrix synthesis by fibroblasts with decreased proliferation on synthetic chitosan-gelatin porous structures. Biotechnol Bioeng. 2012; 109: 1314-1325.
    • (2012) Biotechnol Bioeng. , vol.109 , pp. 1314-1325
    • Iyer, P.1    Walker, K.J.2    Madihally, S.V.3
  • 35
    • 23244452726 scopus 로고    scopus 로고
    • Perfusion bioreactor system for human mesenchymal stem cell tissue engineering: dynamic cell seeding and construct development
    • Zhao F, Ma T. Perfusion bioreactor system for human mesenchymal stem cell tissue engineering: dynamic cell seeding and construct development. Biotechnol Bioeng. 2005; 91: 482-493.
    • (2005) Biotechnol Bioeng. , vol.91 , pp. 482-493
    • Zhao, F.1    Ma, T.2
  • 37
    • 0014837680 scopus 로고
    • Respiratory gases of synovial fluids. An approach to synovial tissue circulatory-metabolic imbalance in rheumatoid arthritis
    • Falchuk KH, Goetzl EJ, Kulka JP. Respiratory gases of synovial fluids. An approach to synovial tissue circulatory-metabolic imbalance in rheumatoid arthritis. Am J Med. 1970; 49: 223-231.
    • (1970) Am J Med. , vol.49 , pp. 223-231
    • Falchuk, K.H.1    Goetzl, E.J.2    Kulka, J.P.3
  • 39
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: role of the HIF system
    • Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med. 2003; 9: 677-684.
    • (2003) Nat Med. , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 42
    • 25844499745 scopus 로고    scopus 로고
    • Starting from building blocks: tissue engineering using stem cells
    • Andrews PW, Benvenisty N. Starting from building blocks: tissue engineering using stem cells. Curr Opin Biotechnol. 2005; 16: 485-486.
    • (2005) Curr Opin Biotechnol. , vol.16 , pp. 485-486
    • Andrews, P.W.1    Benvenisty, N.2
  • 43
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P. Angiogenesis in health and disease. Nat Med. 2003; 9: 653-660.
    • (2003) Nat Med. , vol.9 , pp. 653-660
    • Carmeliet, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.