Serum vitamin B12 levels as indicators of disease severity and mortality of patients with acute‐on‐chronic liver failure

Clinica Chimica Acta

Volumn 413, Issue 23-24, 2012, Pages 1809-1812

  Dou, JiuFeng ^a   Xu, WeiYi ^a   Ye, Bo ^a   Zhang, Yi ^a   Mao, WeiLin ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Acute on chronic liver failure (AoCLF); Mortality; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; BIOLOGICAL MARKER;

ACUTE ON CHRONIC LIVER FAILURE; ADULT; AGED; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; INTERNATIONAL NORMALIZED RATIO; KIDNEY FUNCTION; LIVER FUNCTION; MAJOR CLINICAL STUDY; MALE; MORTALITY RATE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; VITAMIN BLOOD LEVEL; ACUTE DISEASE; BLOOD; CASE CONTROL STUDY; END STAGE LIVER DISEASE; MIDDLE AGED; MORTALITY;

ACUTE DISEASE; ADULT; AGED; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; END STAGE LIVER DISEASE; FEMALE; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; VITAMIN B 12;

EID: 84864821903     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2012.07.008     Document Type: Article

References (25)

1. Bailey, S.W., Ayling, J.E., The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake. Proc Natl Acad Sci 106 (2009), 15424–15429.
2. Ermens, A.A., Vlasveld, L.T., Lindemans, J., Significance of elevated cobalamin (vitamin B12) concentrations in blood. Clin Biochem 36 (2003), 585–590.
3. Lildballe, D.L., Nguyen, K.Q., Poulsen, S.S., Nielsen, H.O., Nexo, E., Haptocorrin as marker of disease progression in fibrolamellar hepatocellular carcinoma. Eur J Surg Oncol 37 (2011), 72–79.
4. Baker, H., Frank, O., DeAngelis, B., Plasma vitamin B12 titres as indicators of disease severity and mortality of patients with alcoholic hepatitis. Alcohol 22 (1987), 1–5.
5. Lindemans, J., Abels, J., Neijens, H.J., Kerrebijn, K.F., Elevated vitamin B12 in cystic fibrosis. Acta Paediatr Scand 73 (1984), 768–771.
6. Majumdar, S.K., Shaw, G.K., O'Gorman, P., et al. Blood vitamin status (B1, B2, B6, folic acid and B12) in patients with alcoholic liver disease. Int J Vitam Nutr Res 52 (1982), 266–271.
7. Areekul, S., Panatampon, P., Doungbarn, J., Vitamin B12 and vitamin B12 binding proteins in liver disease. Southeast Asian J Trop Med Public Health 8 (1977), 322–328.
8. Hagelskjaer, L., Rasmussen, K., Methylmalonic acid concentration in serum not affected in hepatic disease. Clin Chem 38 (1992), 493–495.
9. Lin, C.Y., Kuo, C.S., Lu, C.L., Wu, M.Y., Huang, R.F., Elevated serum vitamin B12 concentrations in association with tumor markers as the prognostic factors predictive for poor survival in patients with hepatocellular carcinoma. Nutr Cancer 62 (2010), 190–197.
10. Jalan, R., Williams, R., Acute-on-chronic liver failure: pathophysiological basis of therapeutic options. Blood Purif 20 (2002), 252–261.
11. Marrero, J., Martinez, F.J., Hyzy, R., Advances in critical care hepatology. Am J Respir Crit Care Med 168 (2003), 1421–1426.
12. Katoonizadeh, A., Laleman, W., Verslype, C., et al. Early features of acute-on-chronic alcoholic liver failure: a prospective cohort study. Gut 59 (2010), 1561–1569.
13. Chen, L.G., Guleng, B., Ren, J.L., et al. Artificial liver support system in treatment of liver failure after acute poisoning. World J Emerg Med 4 (2011), 283–286.
14. Sarin, S.K., Kumar, A., Almeida, J.A., et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Hepatol Int 3 (2009), 269–282.
15. Cylwik, B., Czygier, M., Daniluk, M., Chrostek, L., Szmitkowski, M., Vitamin B12 concentration in the blood of alcoholics. Pol Merkur Lekarski 28 (2010), 122–125.
16. Fragasso, A., Mannarella, C., Ciancio, A., Sacco, A., Functional vitamin B12 deficiency in alcoholics: an intriguing finding in a retrospective study of megaloblastic anemic patients. Eur J Intern Med 21 (2010), 97–100.
17. Holdsworth, C.D., Atkinson, M., Dossett, J.A., Hall, R., An assessment of the diagnostic and prognostic value of serum vitamin B12 concentrations in liver disease. Gut 5 (1964), 601–606.
18. Djalali, M., Champigneulle, B., Guéant, J.L., et al. Increased serum corrinoids correlates with disease severity and IgA concentrations in alcoholic cirrhosis. Digestion 41 (1988), 215–222.
19. Kanazawa, S., Herbert, V., Total corrinoid, cobalamin and cobalamin analogue concentrations may be normal in serum despite cobalamin in liver depletion in patients with alcoholism. Lab Invest 53 (1985), 108–110.
20. Linnell, J.C., Quadros, E.V., Matthews, D.M., Morris, H.P., Poirier, L.A., Altered cobalamin distribution in rat hepatomas and in the livers of rats treated with diethylnitrosamine. Cancer Res 37 (1977), 2975–2978.
21. Freeman, R.B. Jr., Wiesner, R.H., Harper, A., et al. The new liver allocation system: moving toward evidence-based transplantation policy. Liver Transpl 8 (2002), 851–858.
22. Mao, W., Ye, B., Lin, S., et al. The prediction value of MELD scoring system on prognosis in the acute on chronic liver failure patients with artificial liver support system. ASAIO J 56 (2010), 475–478.
23. Chisari, F.V., Ferrari, C., Hepatitis B virus immunopathogenesis. Annu Rev Immunol 13 (1995), 29–60.
24. Bertoletti, A., D'Elios, M.M., Boni, C., et al. Different cytokine profiles of intrahepatic T cells in chronic hepatitis B and hepatitis C virus infections. Gastroenterology 112 (1997), 193–199.
25. Mao, W.L., Chen, Y., Chen, Y.M., Li, L.J., Changes of serum cytokine concentrations in patients with acute on chronic liver failure treated by artificial liver support system. J Clin Gastroenterol 45 (2011), 551–555.