Antiproliferative activity of aucubin is through cell cycle arrest and apoptosis in human non-small cell lung cancer A549 cells

Clinical and Experimental Pharmacology and Physiology

Volumn 35, Issue 9, 2008, Pages 995-1001

  Hung, Jen Yu ^a   Yang, Chih Jen ^a   Tsai, Ying Ming ^a   Huang, Hurng Wern ^b   Huang, Ming Shyan ^a,b  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Aucubin; Cell cycle; Fas; Fas ligand; p53

Indexed keywords

AUCUBIN; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; BETA ACTIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; FAS ANTIGEN; FAS LIGAND; IRIDOID; PROTEIN P21; PROTEIN P53;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUCUBA JAPONICA; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; MEDICINAL PLANT; PLANT LEAF; PROTEIN INDUCTION;

ANTIBODIES; ANTIGENS, CD95; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DRUG EVALUATION, PRECLINICAL; FAS LIGAND PROTEIN; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; GLUCOSIDES; HUMANS; IRIDOIDS; LUNG NEOPLASMS;

EID: 48749127517     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2008.04935.x     Document Type: Article

References (28)

1. Raez LE, Lilenbaum R. Chemotherapy for advanced non-small-cell lung cancer. Clin. Adv. Hematol. Oncol. 2004 2 : 173 8.
2. Kelly K. The role of targeted agents in adjuvant therapy for non-small cell lung cancer. Clin. Cancer Res. 2005 11 (Suppl s5027 9.
3. Kasibhatla S, Tseng B. Why target apoptosis in cancer treatment? Mol. Cancer Ther. 2003 2 : 573 80.
4. Igney FH, Krammer PH. Death and anti-death: Tumour resistance to apoptosis. Nat. Rev. Cancer 2002 2 : 277 88.
5. Shimizu M, Tomoo T. Anti-inflammatory constituents of topically applied crude drugs. V. Constituents and anti-inflammatory effect of Aoki, Aucuba japonica Thunb. Biol. Pharm. Bull. 1994 17 : 665 7.
6. Park KS, Chang IM. Anti-inflammatory activity of aucubin by inhibition of tumor necrosis factor-alpha production in RAW 264.7 cells. Planta Med. 2004 70 : 778 9.
7. Chang IM, Ryu JC, Park YC, Yun HS, Yang KH. Protective activities of aucubin against carbon tetrachloride-induced liver damage in mice. Drug Chem. Toxicol. 1983 6 : 443 53.
8. Chang LM, Yun HS, Kim YS, Ahn JW. Aucubin: Potential antidote for alpha-amanitin poisoning. J. Toxicol. Clin. Toxicol. 1984 22 : 77 85.
9. Hsu YL, Kuo YC, Kuo PL, Ng LT, Kuo YH, Lin CC. Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines. Cancer Lett. 2005 221 : 77 89.
10. Hsu YL, Kuo PL, Tzeng WS, Lin CC. Chalcone inhibits the proliferation of human breast cancer cell by blocking cell cycle progression and inducing apoptosis. Food Chem. Toxicol. 2006 44 : 704 13.
11. Lehman TA, Bennett WP, Metcalf RA et al. p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines. Cancer Res. 1991 51 : 4090 6.
12. May P, May E. Twenty years of p53 research: Structural and functional aspects of the p53 protein. Oncogene 1999 18 : 7621 36.
13. Kim PK, Park SY, Koty PP, Hua Y, Luketich JD, Billiar TR. Fas-associating death domain protein overexpression induces apoptosis in lung cancer cells. J. Thorac. Cardiovasc. Surg. 2003 125 : 1336 42.
14. Liu X, Yue P, Khuri FR, Sun SY. Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity. Cancer Res. 2005 65 : 9169 75.
15. Brown JM, Wouters BG. Apoptosis, p53, and tumor cell sensitivity to anticancer agents. Cancer Res. 1999 59 : 1391 9.
16. Gartel AL, Tyner AL. The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol. Cancer Ther. 2002 1 : 639 49.
17. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D. p21 is a universal inhibitor of cyclin kinases. Nature 1993 366 : 701 4.
18. Gu Y, Turck CW, Morgan DO. Inhibition of CDK2 activity in vivo by an associated 20 K regulatory subunit. Nature 1993 366 : 707 10.
19. Dulic V, Kaufmann WK, Wilson SJ et al. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 1994 76 : 1013 23.
20. el-Deiry WS, Tokino T, Velculescu VE et al. WAF1, a potential mediator of p53 tumor suppression. Cell 1993 75 : 817 25.
21. Macleod KF, Sherry N, Hannon G et al. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev. 1995 9 : 935 44.
22. Michieli P, Chedid M, Lin D, Pierce JH, Mercer E, Givol D. Induction of Waf1/CIP1 by a p53-independent pathway. Cancer Res. 1994 54 : 3391 5.
23. Nagata S, Golstein P. The Fas death factor. Science 1995 267 : 1449 56.
24. Hengartner MO. The biochemistry of apoptosis. Nature 2000 407 : 770 6.
25. Suda T, Takahashi T, Golstein P, Nagata S. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 1993 75 : 1169 78.
26. Kayagaki N, Kawasaki A, Ebata T et al. Metalloproteinase-mediated release of human Fas ligand. J. Exp. Med. 1995 182 : 1777 83.
27. Fujita T, Maruyama M, Araya J et al. Hydrogen peroxide induces upregulation of Fas in human airway epithelial cells via the activation of PARP-p53 pathway. Am. J. Respir. Cell Mol. Biol. 2002 27 : 542 52.
28. Serrao KL, Fortenberry JD, Owens ML, Harris FL, Brown LA. Neutrophils induce apoptosis of lung epithelial cells via release of soluble Fas ligand. Am. J. Physiol. Lung Cell Mol. Physiol. 2001 280 : L298 305.