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Volumn 12, Issue , 2012, Pages

Hypotensive effect of Gentiana floribunda is mediated through Ca++ antagonism pathway

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; ATROPINE; FLAVONOID; GENTIANA FLORIBUNDA EXTRACT; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; PHENYLEPHRINE; PLANT EXTRACT; POTASSIUM ION; SAPONIN DERIVATIVE; STEROL DERIVATIVE; TANNIN DERIVATIVE; TERPENE DERIVATIVE; UNCLASSIFIED DRUG; VASODILATOR AGENT; VERAPAMIL;

EID: 84864808063     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-12-121     Document Type: Article
Times cited : (19)

References (38)
  • 1
    • 0025234906 scopus 로고
    • Blood pressure, stroke, and coronary heart disease. Part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias
    • 10.1016/0140-6736(90)90878-9, 1969518
    • MacMahon S, Peto R, Cutler J, Collins R, Sorlie P, Neaton J, Abbott R, Godwin G, Dyer A, Stamler J. Blood pressure, stroke, and coronary heart disease. Part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet 1990, 335(8692):765-774. 10.1016/0140-6736(90)90878-9, 1969518.
    • (1990) Lancet , vol.335 , Issue.8692 , pp. 765-774
    • MacMahon, S.1    Peto, R.2    Cutler, J.3    Collins, R.4    Sorlie, P.5    Neaton, J.6    Abbott, R.7    Godwin, G.8    Dyer, A.9    Stamler, J.10
  • 2
    • 84869489360 scopus 로고
    • Antihypertensive drugs
    • New York: McGraw-Hill, Di-Palma JR, Di-Gregorio GJ
    • Di-Palma JR. Antihypertensive drugs. Basic Pharmacology in Medicine 1990, 421-435. New York: McGraw-Hill, Di-Palma JR, Di-Gregorio GJ.
    • (1990) Basic Pharmacology in Medicine , pp. 421-435
    • Di-Palma, J.R.1
  • 3
    • 0038205771 scopus 로고    scopus 로고
    • Prevention of hypertension and its complications: theoretical basis and guidelines for treatment
    • Flack JM, Peters R, Shafi T, Alrefai H, Nasser SA, Crook E. Prevention of hypertension and its complications: theoretical basis and guidelines for treatment. J Am Soc Nephrol 2003, 14(7 Suppl. 2):S92-S98.
    • (2003) J Am Soc Nephrol , vol.14 , Issue.7 SUPPL. 2
    • Flack, J.M.1    Peters, R.2    Shafi, T.3    Alrefai, H.4    Nasser, S.A.5    Crook, E.6
  • 4
    • 1442299102 scopus 로고    scopus 로고
    • Cardiovascular risk profile and blood pressure control in Italian hypertensive patients under specialist care
    • 10.1097/00004872-200401000-00012, 15106794
    • Mancia G, Volpe R, Boros S, Ilardi M, Giannattsio C. Cardiovascular risk profile and blood pressure control in Italian hypertensive patients under specialist care. J Hypertens 2004, 22(1):51-57. 10.1097/00004872-200401000-00012, 15106794.
    • (2004) J Hypertens , vol.22 , Issue.1 , pp. 51-57
    • Mancia, G.1    Volpe, R.2    Boros, S.3    Ilardi, M.4    Giannattsio, C.5
  • 5
    • 77649119595 scopus 로고    scopus 로고
    • A natural way to cardiovascular health
    • Ghayur MN, Janssen LJ. A natural way to cardiovascular health. Nat Rev Cardiol 2010, 7(3):1-2.
    • (2010) Nat Rev Cardiol , vol.7 , Issue.3 , pp. 1-2
    • Ghayur, M.N.1    Janssen, L.J.2
  • 6
    • 23044452749 scopus 로고    scopus 로고
    • Trends in ethnopharmacology
    • Atta-ur-Rahman
    • Gilani AH, . Atta-ur-Rahman Trends in ethnopharmacology. J Ethnophamracol 2005, 100(1-2):43-49. Atta-ur-Rahman.
    • (2005) J Ethnophamracol , vol.100 , Issue.1-2 , pp. 43-49
    • Gilani, A.H.1
  • 7
    • 0031921882 scopus 로고    scopus 로고
    • Hypotensive Effect of Gentiana olivieri and its alkaloid Gentianine in Rats
    • Mansoor A, Samad A, Zaidi MI, Aftab K. Hypotensive Effect of Gentiana olivieri and its alkaloid Gentianine in Rats. Pharm Pharmacol Commun 1998, 4(4):229-230.
    • (1998) Pharm Pharmacol Commun , vol.4 , Issue.4 , pp. 229-230
    • Mansoor, A.1    Samad, A.2    Zaidi, M.I.3    Aftab, K.4
  • 8
    • 0036178302 scopus 로고    scopus 로고
    • Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae)
    • 10.1016/S0378-8741(01)00405-6, 11849844
    • Baragatti B, Calderone V, Testai L, Martinotti E, Chericoni S, Morelli I. Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae). J Ethnopharmacol 2002, 79(3):369-372. 10.1016/S0378-8741(01)00405-6, 11849844.
    • (2002) J Ethnopharmacol , vol.79 , Issue.3 , pp. 369-372
    • Baragatti, B.1    Calderone, V.2    Testai, L.3    Martinotti, E.4    Chericoni, S.5    Morelli, I.6
  • 11
    • 45449097265 scopus 로고    scopus 로고
    • Nitric oxide pathway-mediated relaxant effect of aqueous sesame leaves extract (Sesamum radiatum Schum. & Thonn.) in the guinea-pig isolated aorta smooth muscle
    • 10.1186/1472-6882-8-23, 2426668, 18505582
    • Konan AB, Datte JY, Yapo PA. Nitric oxide pathway-mediated relaxant effect of aqueous sesame leaves extract (Sesamum radiatum Schum. & Thonn.) in the guinea-pig isolated aorta smooth muscle. BMC Complement Altern Med 2008, 8:23. 10.1186/1472-6882-8-23, 2426668, 18505582.
    • (2008) BMC Complement Altern Med , vol.8 , pp. 23
    • Konan, A.B.1    Datte, J.Y.2    Yapo, P.A.3
  • 12
    • 22744433521 scopus 로고    scopus 로고
    • Phytochemical constituents of some Nigerian medicinal plants
    • Edeoga HO, Okwu DE, Mbaebie BO. Phytochemical constituents of some Nigerian medicinal plants. Afr J Biotechnol 2005, 4(7):685-688.
    • (2005) Afr J Biotechnol , vol.4 , Issue.7 , pp. 685-688
    • Edeoga, H.O.1    Okwu, D.E.2    Mbaebie, B.O.3
  • 13
    • 0003633755 scopus 로고    scopus 로고
    • Washington: National Academy Press, National Research Council
    • National Research Council Guide for the Care and Use of Laboratory Animals 1996, Washington: National Academy Press, National Research Council.
    • (1996) Guide for the Care and Use of Laboratory Animals
  • 14
    • 52649131241 scopus 로고    scopus 로고
    • Cardiovascular inhibitory effects of Hyoscyamus niger
    • 10.1358/mf.2008.30.4.1186075, 18773124
    • Khan A, Gilani AH. Cardiovascular inhibitory effects of Hyoscyamus niger. Methods Find Exp Clin Pharmacol 2008, 30(4):295-300. 10.1358/mf.2008.30.4.1186075, 18773124.
    • (2008) Methods Find Exp Clin Pharmacol , vol.30 , Issue.4 , pp. 295-300
    • Khan, A.1    Gilani, A.H.2
  • 15
    • 0242667857 scopus 로고    scopus 로고
    • Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta
    • 10.1016/j.lfs.2003.06.039, 14623031
    • Ajay M, Gilani AH, Mustafa MR. Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life Sci 2003, 74(5):603-612. 10.1016/j.lfs.2003.06.039, 14623031.
    • (2003) Life Sci , vol.74 , Issue.5 , pp. 603-612
    • Ajay, M.1    Gilani, A.H.2    Mustafa, M.R.3
  • 16
    • 50449099459 scopus 로고    scopus 로고
    • Pharmacodynamic evaluation of Terminalia bellerica for its antihypertensive effect
    • Khan A, Gilani AH. Pharmacodynamic evaluation of Terminalia bellerica for its antihypertensive effect. J Food Drug Anal 2008, 16(3):6-14.
    • (2008) J Food Drug Anal , vol.16 , Issue.3 , pp. 6-14
    • Khan, A.1    Gilani, A.H.2
  • 17
    • 0022888328 scopus 로고
    • Calcium antagonism and calcium entry blockade
    • Godfraind T, Miller R, Wibo M. Calcium antagonism and calcium entry blockade. Pharmacol Rev 1986, 38(4):321-416.
    • (1986) Pharmacol Rev , vol.38 , Issue.4 , pp. 321-416
    • Godfraind, T.1    Miller, R.2    Wibo, M.3
  • 18
    • 0035082110 scopus 로고    scopus 로고
    • Calcium channel blockade in vascular smooth muscle cells: major hypotensive mechanism of S-petasin, a hypotensive sesquiterpene from Petasites formosanus
    • Wang GJ, Shum AY, Lin YL, Liao JF, Wu XC, Ren J, Chen CF. Calcium channel blockade in vascular smooth muscle cells: major hypotensive mechanism of S-petasin, a hypotensive sesquiterpene from Petasites formosanus. J Pharmacol Exp Ther 2001, 297(1):240-246.
    • (2001) J Pharmacol Exp Ther , vol.297 , Issue.1 , pp. 240-246
    • Wang, G.J.1    Shum, A.Y.2    Lin, Y.L.3    Liao, J.F.4    Wu, X.C.5    Ren, J.6    Chen, C.F.7
  • 19
    • 59449089681 scopus 로고    scopus 로고
    • Blood pressure lowering and vasomodulator effects of piperine
    • 10.1097/FJC.0b013e31818d07c0, 19033825
    • Taqvi SIH, Shah AJ, Gilani AH. Blood pressure lowering and vasomodulator effects of piperine. J Cardiovasc Pharmacol 2008, 52(5):452-458. 10.1097/FJC.0b013e31818d07c0, 19033825.
    • (2008) J Cardiovasc Pharmacol , vol.52 , Issue.5 , pp. 452-458
    • Taqvi, S.I.H.1    Shah, A.J.2    Gilani, A.H.3
  • 20
    • 0023726691 scopus 로고
    • The effects of EGTA on vascular smooth muscle contractility in calcium free medium
    • 10.1139/y88-172, 3141028
    • Guan YY, Kwan CY, Daniel EE. The effects of EGTA on vascular smooth muscle contractility in calcium free medium. Can J Physiol Pharmacol 1988, 66(8):1053-1056. 10.1139/y88-172, 3141028.
    • (1988) Can J Physiol Pharmacol , vol.66 , Issue.8 , pp. 1053-1056
    • Guan, Y.Y.1    Kwan, C.Y.2    Daniel, E.E.3
  • 21
    • 0021187398 scopus 로고
    • Induction of calcium influx and calcium release in isolated rat aorta and mesenteric resistance vessels by norepinephrine activation of α-receptors
    • Cauvin C, Malik S. Induction of calcium influx and calcium release in isolated rat aorta and mesenteric resistance vessels by norepinephrine activation of α-receptors. J Pharmacol Exp Ther 1984, 230(2):413-418.
    • (1984) J Pharmacol Exp Ther , vol.230 , Issue.2 , pp. 413-418
    • Cauvin, C.1    Malik, S.2
  • 23
    • 0019195506 scopus 로고
    • The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
    • 10.1038/288373a0, 6253831
    • Furchgott RF, Zawadski JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980, 288(5789):373-376. 10.1038/288373a0, 6253831.
    • (1980) Nature , vol.288 , Issue.5789 , pp. 373-376
    • Furchgott, R.F.1    Zawadski, J.V.2
  • 24
    • 77954522199 scopus 로고    scopus 로고
    • Antispasmodic, bronchodilator and blood pressure lowering properties of Hypericum oblongifolium-possible mechanism of action
    • Khan A, Khan M, Subhan F, Gilani AH. Antispasmodic, bronchodilator and blood pressure lowering properties of Hypericum oblongifolium-possible mechanism of action. Phytother Res 2010, 24(7):1027-1032.
    • (2010) Phytother Res , vol.24 , Issue.7 , pp. 1027-1032
    • Khan, A.1    Khan, M.2    Subhan, F.3    Gilani, A.H.4
  • 25
    • 33645031783 scopus 로고    scopus 로고
    • Direct effects of quercetin on impaired reactivity of spontaneously hypertensive rat aorta: comparative study with ascorbic acid
    • 10.1111/j.1440-1681.2006.04373.x, 16620299
    • Ajay M, Achike FI, Mustafa AM, Mustafa MR. Direct effects of quercetin on impaired reactivity of spontaneously hypertensive rat aorta: comparative study with ascorbic acid. Clin Exp Pharmacol Physiol 2006, 33(4):345-350. 10.1111/j.1440-1681.2006.04373.x, 16620299.
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , Issue.4 , pp. 345-350
    • Ajay, M.1    Achike, F.I.2    Mustafa, A.M.3    Mustafa, M.R.4
  • 26
    • 11144281935 scopus 로고    scopus 로고
    • Ginger lowers blood pressure through blockade of voltage-dependent calcium channels
    • 10.1097/00005344-200501000-00013, 15613983
    • Ghayur MN, Gilani AH. Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. J Cardiovasc Pharmacol 2005, 45(1):74-80. 10.1097/00005344-200501000-00013, 15613983.
    • (2005) J Cardiovasc Pharmacol , vol.45 , Issue.1 , pp. 74-80
    • Ghayur, M.N.1    Gilani, A.H.2
  • 27
    • 77649121685 scopus 로고    scopus 로고
    • Antispasmodic and vasodilator activities of Morinda citrifolia root extract are mediated through blockade of voltage dependent calcium channels
    • 10.1186/1472-6882-10-2, 2829485, 20070879
    • Gilani AH, Mandukhail SR, Iqbal J, Yasinzai M, Aziz N, Khan A, Rehman N. Antispasmodic and vasodilator activities of Morinda citrifolia root extract are mediated through blockade of voltage dependent calcium channels. BMC Complement Altern Med 2010, 10(1):2. 10.1186/1472-6882-10-2, 2829485, 20070879.
    • (2010) BMC Complement Altern Med , vol.10 , Issue.1 , pp. 2
    • Gilani, A.H.1    Mandukhail, S.R.2    Iqbal, J.3    Yasinzai, M.4    Aziz, N.5    Khan, A.6    Rehman, N.7
  • 28
    • 25644435485 scopus 로고    scopus 로고
    • A phenoxazine compound, 2-amino-4,4α-dihydro-4α-7-dimethyl-3 H-phenoxazine-3-one reverses the phenylephrine or high-K+ induced contractions of smooth muscles in rat aorta and guinea-pig tenia cecum
    • 10.1248/bpb.28.1521, 16079506
    • Musha S, Watanabe M, Ishida Y, Kato S, Konishi M, Tomoda A. A phenoxazine compound, 2-amino-4,4α-dihydro-4α-7-dimethyl-3 H-phenoxazine-3-one reverses the phenylephrine or high-K+ induced contractions of smooth muscles in rat aorta and guinea-pig tenia cecum. Biol Pharm Bull 2005, 28(8):1521-1523. 10.1248/bpb.28.1521, 16079506.
    • (2005) Biol Pharm Bull , vol.28 , Issue.8 , pp. 1521-1523
    • Musha, S.1    Watanabe, M.2    Ishida, Y.3    Kato, S.4    Konishi, M.5    Tomoda, A.6
  • 29
    • 33646768958 scopus 로고    scopus 로고
    • Mechanisms of agonist-induced constriction in isolated human mesenteric arteries
    • 10.1016/j.vph.2006.02.004, 16624627
    • Hall J, Jones TH, Channer KS, Jones RD. Mechanisms of agonist-induced constriction in isolated human mesenteric arteries. Vascul Pharmacol 2006, 44(6):427-433. 10.1016/j.vph.2006.02.004, 16624627.
    • (2006) Vascul Pharmacol , vol.44 , Issue.6 , pp. 427-433
    • Hall, J.1    Jones, T.H.2    Channer, K.S.3    Jones, R.D.4
  • 30
    • 14644408015 scopus 로고    scopus 로고
    • Depletion of Ca++ from intracellular stores of the rat portal vein stimulates a tonic contraction
    • Burt RP. Depletion of Ca++ from intracellular stores of the rat portal vein stimulates a tonic contraction. Eur J Pharmacol 2005, 510(1-2):97-105.
    • (2005) Eur J Pharmacol , vol.510 , Issue.1-2 , pp. 97-105
    • Burt, R.P.1
  • 31
    • 0000495137 scopus 로고    scopus 로고
    • Catecholamies, sympathomimetic drugs and adrenergic receptor antagonists
    • New York: McGraw-Hill, Hardman JG, Limbird LE, Gilmans AG, 10
    • Hoffman BB. Catecholamies, sympathomimetic drugs and adrenergic receptor antagonists. Goodman & Gilman's The Pharmacological Basis of Therapeutics 2001, 215-268. New York: McGraw-Hill, Hardman JG, Limbird LE, Gilmans AG, 10.
    • (2001) Goodman & Gilman's The Pharmacological Basis of Therapeutics , pp. 215-268
    • Hoffman, B.B.1
  • 32
    • 0032577956 scopus 로고    scopus 로고
    • Nitric oxide inhibits alpha2-adrenoceptor-mediated endothelium-dependent vasodilation
    • 10.1161/01.RES.82.12.1323, 9648729
    • Thorin E, Huang PL, Fishman MC, Bevan JA. Nitric oxide inhibits alpha2-adrenoceptor-mediated endothelium-dependent vasodilation. Circ Res 1998, 82(12):1323-1329. 10.1161/01.RES.82.12.1323, 9648729.
    • (1998) Circ Res , vol.82 , Issue.12 , pp. 1323-1329
    • Thorin, E.1    Huang, P.L.2    Fishman, M.C.3    Bevan, J.A.4
  • 33
    • 0036065962 scopus 로고    scopus 로고
    • Vasoprotection by nitric oxide: mechanisms and therapeutic potential
    • 10.1016/S0008-6363(02)00327-9, 12123764
    • Gewaltig MT, Kojda G. Vasoprotection by nitric oxide: mechanisms and therapeutic potential. Cardiovasc Res 2002, 55(2):250-260. 10.1016/S0008-6363(02)00327-9, 12123764.
    • (2002) Cardiovasc Res , vol.55 , Issue.2 , pp. 250-260
    • Gewaltig, M.T.1    Kojda, G.2
  • 34
    • 33845970583 scopus 로고    scopus 로고
    • Mechanisms of the anti-hypertensive effect of Hibiscus sabdariffa L. calyces
    • 10.1016/j.jep.2006.08.005, 16973321
    • Ajay M, Chai HJ, Mustafa AM, Gilani AH, Mustafa MR. Mechanisms of the anti-hypertensive effect of Hibiscus sabdariffa L. calyces. J Ethnopharmacol 2007, 109(3):388-393. 10.1016/j.jep.2006.08.005, 16973321.
    • (2007) J Ethnopharmacol , vol.109 , Issue.3 , pp. 388-393
    • Ajay, M.1    Chai, H.J.2    Mustafa, A.M.3    Gilani, A.H.4    Mustafa, M.R.5
  • 35
    • 0032433719 scopus 로고    scopus 로고
    • Antihypertensive and vasodilator actions of antioxidants in spontaneously hypertensive rats
    • 10.1016/S0895-7061(98)00183-6, 9880127
    • Akpaffiong MJ, Taylor AA. Antihypertensive and vasodilator actions of antioxidants in spontaneously hypertensive rats. Am J Hypertens 1998, 11(12):1450-1460. 10.1016/S0895-7061(98)00183-6, 9880127.
    • (1998) Am J Hypertens , vol.11 , Issue.12 , pp. 1450-1460
    • Akpaffiong, M.J.1    Taylor, A.A.2
  • 36
    • 4444257541 scopus 로고    scopus 로고
    • Reactive oxygen species in hypertension
    • 10.1016/j.amjhyper.2004.02.004, 15363831
    • Lassegue B, Griendling KK. Reactive oxygen species in hypertension. Am J Hypertens 2004, 17(9):852-860. 10.1016/j.amjhyper.2004.02.004, 15363831.
    • (2004) Am J Hypertens , vol.17 , Issue.9 , pp. 852-860
    • Lassegue, B.1    Griendling, K.K.2
  • 37
    • 0004865449 scopus 로고    scopus 로고
    • Flavonoids in medicinal plants
    • New York: Marcel Dekker, Rive-Evans CV, Packer L
    • Pietta P. Flavonoids in medicinal plants. Flavonoids in Health and Disease 1998, 61-110. New York: Marcel Dekker, Rive-Evans CV, Packer L.
    • (1998) Flavonoids in Health and Disease , pp. 61-110
    • Pietta, P.1
  • 38
    • 34548783921 scopus 로고    scopus 로고
    • Antispasmodic, bronchodilator and vasodilator activites of (+)-catechin, a naturally occurring flavonoid
    • 10.1007/BF02993965, 17879750
    • Ghayur MN, Khan H, Gilani AH. Antispasmodic, bronchodilator and vasodilator activites of (+)-catechin, a naturally occurring flavonoid. Arch Pharm Res 2007, 30(8):970-975. 10.1007/BF02993965, 17879750.
    • (2007) Arch Pharm Res , vol.30 , Issue.8 , pp. 970-975
    • Ghayur, M.N.1    Khan, H.2    Gilani, A.H.3


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