Monocyte activation is a feature of common variable immunodeficiency irrespective of plasma lipopolysaccharide levels

Clinical and Experimental Immunology

Volumn 169, Issue 3, 2012, Pages 263-272

  Barbosa, R R ^a   Silva, S P ^a,b   Silva, S L ^a,b   Tendeiro, R ^a   Melo, A C ^a   Pedro, E ^b   Barbosa, M P ^b   Santos, M C P ^a   Victorino, R M M ^a   Sousa, A E ^a  

^a INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^b HOSPITAL DE SANTA MARIA   (Portugal)

Author keywords

Common variable immunodeficiency; CVID; Monocyte activation; Plasma LPS; T cell activation

Indexed keywords

CD14 ANTIGEN; CD18 ANTIGEN; CD38 ANTIGEN; CD86 ANTIGEN; HLA DR ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; LIPOPOLYSACCHARIDE; PROGRAMMED DEATH 1 LIGAND 1;

ADULT; AGAMMAGLOBULINEMIA; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CELL ACTIVATION; CELL EXPANSION; CELL SUBPOPULATION; CLINICAL ARTICLE; CLINICAL FEATURE; COMMON VARIABLE IMMUNODEFICIENCY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MALE; MICROBIAL TRANSLOCATION; MONOCYTE; MONOCYTE ACTIVATION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ACUTE-PHASE PROTEINS; ADULT; AGAMMAGLOBULINEMIA; ANTIBODIES, BACTERIAL; ANTIGENS, CD14; CARRIER PROTEINS; COMMON VARIABLE IMMUNODEFICIENCY; CYTOKINES; ENDOTOXINS; FEMALE; GPI-LINKED PROTEINS; HUMANS; IMMUNOGLOBULIN G; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MONOCYTES; PROTEIN-TYROSINE KINASES; RECEPTORS, IGG; T-LYMPHOCYTE SUBSETS;

EID: 84864763958     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2012.04620.x     Document Type: Article

References (40)

1. Resnick ES, Moshier EL, Godbold JH, Cunningham-Rundles C. Morbidity and mortality in common variable immune deficiency over 4 decades. Blood 2012; 119:1650-7.
2. Park MA, Li JT, Hagan JB, Maddox DE, Abraham RS. Common variable immunodeficiency: a new look at an old disease. Lancet 2008; 372:489-502.
3. Barbosa RR, Silva SP, Silva SL etal. Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation. PLoS ONE 2011; 6:e22848.
4. Giovannetti A, Pierdominici M, Mazzetta F etal. Unravelling the complexity of T cell abnormalities in common variable immunodeficiency. J Immunol 2007; 178:3932-43.
5. Malamut G, Verkarre V, Suarez F etal. The enteropathy associated with common variable immunodeficiency: the delineated frontiers with celiac disease. Am J Gastroenterol 2010; 105:2262-75.
6. Brenchley JM, Price DA, Schacker TW etal. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006; 12:1365-71.
7. Auffray C, Sieweke MH, Geissmann F. Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol 2009; 27:669-92.
8. Said EA, Dupuy FP, Trautmann L etal. Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection. Nat Med 2010; 16:452-9.
9. Passlick B, Flieger D, Ziegler-Heitbrock HW. Identification and characterization of a novel monocyte subpopulation in human peripheral blood. Blood 1989; 74:2527-34.
10. Ancuta P, Rao R, Moses A etal. Fractalkine preferentially mediates arrest and migration of CD16+ monocytes. J Exp Med 2003; 197:1701-7.
11. Zawada AM, Rogacev KS, Rotter B etal. SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset. Blood 2011; 118:e50-61.
12. Ziegler-Heitbrock L, Ancuta P, Crowe S etal. Nomenclature of monocytes and dendritic cells in blood. Blood 2010; 116:e74-80.
13. Moniuszko M, Bodzenta-Lukaszyk A, Kowal K, Lenczewska D, Dabrowska M. Enhanced frequencies of CD14++CD16+, but not CD14+CD16+, peripheral blood monocytes in severe asthmatic patients. Clin Immunol 2009; 130:338-46.
14. Han J, Wang B, Han N etal. CD14(high)CD16(+) rather than CD14(low)CD16(+) monocytes correlate with disease progression in chronic HIV-infected patients. J Acquir Immune Defic Syndr 2009; 52:553-9.
15. Ancuta P, Kamat A, Kunstman KJ etal. Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients. PLoS ONE 2008; 3:e2516.
16. Scott-Taylor TH, Green MR, Eren E, Webster AD. Monocyte derived dendritic cell responses in common variable immunodeficiency. Clin Exp Immunol 2004; 138:484-90.
17. Scott-Taylor TH, Green MR, Raeiszadeh M, Workman S, Webster AD. Defective maturation of dendritic cells in common variable immunodeficiency. Clin Exp Immunol 2006; 145:420-7.
18. Cambronero R, Sewell WA, North ME, Webster AD, Farrant J. Up-regulation of IL-12 in monocytes: a fundamental defect in common variable immunodeficiency. J Immunol 2000; 164:488-94.
19. Martinez-Pomar N, Raga S, Ferrer J etal. Elevated serum interleukin (IL)-12p40 levels in common variable immunodeficiency disease and decreased peripheral blood dendritic cells: analysis of IL-12p40 and interferon-gamma gene. Clin Exp Immunol 2006; 144:233-8.
20. Viallard JF, Camou F, Andre M etal. Altered dendritic cell distribution in patients with common variable immunodeficiency. Arthritis Res Ther 2005; 7:R1052-5.
21. Bayry J, Lacroix-Desmazes S, Kazatchkine MD etal. Common variable immunodeficiency is associated with defective functions of dendritic cells. Blood 2004; 104:2441-3.
22. Nourizadeh M, Aghamohammadi A, Moazzeni SM etal. Altered dendritic cell function in response to sera of common variable immunodeficiency patients. Inflamm Res 2007; 56:527-32.
23. Cunningham-Rundles C, Radigan L. Deficient IL-12 and dendritic cell function in common variable immune deficiency. Clin Immunol 2005; 115:147-53.
24. Amoras AL, da Silva MT, Zollner RL, Kanegane H, Miyawaki T, Vilela MM. Expression of Fc gamma and complement receptors in monocytes of X-linked agammaglobulinaemia and common variable immunodeficiency patients. Clin Exp Immunol 2007; 150:422-8.
25. Yong PF, Workman S, Wahid F, Exley A, Webster AD, Ibrahim MA. Selective deficits in blood dendritic cell subsets in common variable immunodeficiency and X-linked agammaglobulinaemia but not specific polysaccharide antibody deficiency. Clin Immunol 2008; 127:34-42.
26. Conley ME. Genetics of hypogammaglobulinemia: what do we really know? Curr Opin Immunol 2009; 21:466-71.
27. Martini H, Enright V, Perro M etal. Importance of B cell co-stimulation in CD4(+) T cell differentiation: X-linked agammaglobulinaemia, a human model. Clin Exp Immunol 2011; 164:381-7.
28. Mechanic LJ, Dikman S, Cunningham-Rundles C. Granulomatous disease in common variable immunodeficiency. Ann Intern Med 1997; 127:613-7.
29. Kitchens RL, Thompson PA. Modulatory effects of sCD14 and LBP on LPS-host cell interactions. J Endotoxin Res 2005; 11:225-9.
30. Cros J, Cagnard N, Woollard K etal. Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity 2010; 33:375-86.
31. Trabattoni D, Saresella M, Biasin M etal. B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. Blood 2003; 101:2514-20.
32. Wang X, Zhang Z, Zhang S etal. B7-H1 up-regulation impairs myeloid DC and correlates with disease progression in chronic HIV-1 infection. Eur J Immunol 2008; 38:3226-36.
33. Tendeiro R, Foxall RB, Baptista AP etal. PD-1 and its ligand PD-L1 are progressively up-regulated on CD4 and CD8 T-cells in HIV-2 infection irrespective of the presence of viremia. AIDS 2012; 26:1065-71.
34. Keir ME, Butte MJ, Freeman GJ, Sharpe AH. PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol 2008; 26:677-704.
35. Wehr C, Kivioja T, Schmitt C etal. The EUROclass trial: defining subgroups in common variable immunodeficiency. Blood 2008; 111:77-85.
36. Trujillo CM, Muskus C, Arango J, Patino PJ, Montoya CJ. Quantitative and functional evaluation of innate immune responses in patients with common variable immunodeficiency. J Investig Allergol Clin Immunol 2011; 21:207-15.
37. Day CL, Kaufmann DE, Kiepiela P etal. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006; 443:350-4.
38. Petrovas C, Casazza JP, Brenchley JM etal. PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. J Exp Med 2006; 203:2281-92.
39. Trautmann L, Janbazian L, Chomont N etal. Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat Med 2006; 12:1198-202.
40. Pastor Rojo O, Lopez San Roman A, Albeniz Arbizu E, de la Hera Martinez A, Ripoll Sevillano E, Albillos Martinez A. Serum lipopolysaccharide-binding protein in endotoxemic patients with inflammatory bowel disease. Inflamm Bowel Dis 2007; 13:269-77.