Injectable and biodegradable nanohybrid polymers with simultaneously enhanced stiffness and toughness for bone repair

Advanced Functional Materials

Volumn 22, Issue 15, 2012, Pages 3181-3190

  Cai, Lei ^a   Chen, Jihua ^b   Rondinone, Adam J ^b   Wang, Shanfeng ^a,b  

^a University of Tennessee Knoxville   (United States)

^b OAK RIDGE NATIONAL LABORATORY   (United States)

Author keywords

MC3T3 E1 cell functions; mechanical properties; photo crosslinking; poly(propylene fumarate) (PPF); polyhedral oligomeric silsesquioxane (POSS)

Indexed keywords

BIOLOGICAL PERFORMANCE; BONE REPAIR; BONE TISSUE ENGINEERING; CELL ATTACHMENTS; COMPRESSIVE MODULI; CROSS-LINKING DENSITY; CROSSLINKED; CRYSTALLINITIES; DEGRADATION BEHAVIOR; DOMAIN STRUCTURE; IN-VITRO; MC3T3-E1 CELL; NANOCAGES; NANOHYBRIDS; PHOTOCROSS-LINKING; POLYHEDRAL OLIGOMERIC SILSESQUIOXANES; POLYPROPYLENE FUMARATE; SILSESQUIOXANES; SURFACE CHARACTERISTICS; VISCOELASTIC BEHAVIORS;

BIODEGRADABLE POLYMERS; CROSSLINKING; DEGRADATION; DENSITY (SPECIFIC GRAVITY); GENE EXPRESSION; MECHANICAL PROPERTIES; OLIGOMERS; POLYCONDENSATION; PROPYLENE; SCAFFOLDS (BIOLOGY); STIFFNESS;

BIOMECHANICS;

EID: 84864760890     PISSN: 1616301X     EISSN: 16163028     Source Type: Journal    
DOI: 10.1002/adfm.201200457     Document Type: Article

References (51)

1. Y. Khan, M. J. Yaszemski, A. G. Mikos, C. T. Laurencin, J. Bone Jt. Surg. Am. Vol. 2008, 90A, 36.
2. X. F. Shi, A. G. Mikos, in An introduction to biomaterials (Eds:, S. A. Guelcher, J. O. Hollinger,), CRC Press Taylor & Francis Group, Boca Raton, FL, USA 2006 pp. 205-18.
3. F. K. Kasper, K. Tanahashi, J. P. Fisher, A. G. Mikos, Nat. Protoc. 2009, 4, 518.
4. S. Wang, L. Lu, M. J. Yaszemski, Biomacromolecules 2006, 7, 1976.
5. S. Wang, D. H. Kempen, N. K. Simha, J. L. Lewis, A. J. Windebank, M. J. Yaszemski, L. Lu, Biomacromolecules 2008, 9, 1229.
6. S. Wang, L. Lu, J. A. Gruetzmacher, B. L. Currier, M. J. Yaszemski, Macromolecules 2005, 38, 7358.
7. L. Cai, K. Wang, S. Wang, Biomaterials 2010, 31, 4457.
8. L. Cai, S. Wang, Biomaterials 2010, 31, 7423.
9. K. W. Lee, S. Wang, L. Lu, E. Jabbari, B. L. Currier, M. J. Yaszemski, Tissue Eng. 2006, 12, 2801.
10. K. W. Lee, S. Wang, B. Fox, E. L. Ritman, M. J. Yaszemski, L. Lu, Biomacromolecules 2007, 8, 1077.
11. K. W. Lee, S. Wang, M. Dadsetan, M. J. Yaszemski, L. Lu, Biomacromolecules 2010, 11, 682.
12. K. Wang, L. Cai, F. Hao, X. Xu, M. Cui, S. Wang, Biomacromolecules 2010, 11, 2748.
13. K. Wang, L. Cai, S. Wang, Polymer 2011, 52, 2827.
14. M. S. Wolfe, D. Dean, J. E. Chen, J. P. Fisher, S. Han, C. M. Rimnac, A. G. Mikos, J. Biomed. Mater. Res. 2002, 61, 159.
15. K. W. Lee, S. Wang, M. J. Yaszemski, L. Lu, Biomaterials 2008, 29, 2839.
16. Z. Y. Cai, D. A. Yang, N. Zhang, C. G. Ji, L. Zhu, T. Zhang, Acta Biomater. 2009, 5, 628.
17. S. J. Peter, L. Lu, D. J. Kim, A. G. Mikos, Biomaterials 2000, 21, 1207.
18. X. F. Shi, B. Sitharaman, Q. P. Pham, F. Liang, K. Wu, W. E. Billups, L. J. Wilson, A. G. Mikos, Biomaterials 2007, 28, 4078
19. G. Li, L. Wang, H. Ni, C. U. Jr. Pittman, J. Inorg. Organomet. Polym. 2001, 11, 123.
20. K. Pielichowski, J. Njuguna, B. Janowski, J. Pielichowski, Adv. Polym. Sci. 2006, 201, 225.
21. J. Wu, P. T. Mather, J. Macromol. Sci. Part C: Polym. Rev. 2009, 49, 25.
22. D. B. Cordes, P. D. Lickiss, F. Rataboul, Chem. Rev. 2010, 110, 2081.
23. S.-W. Kuo, F.-C. Chang, Prog. Polym. Sci. 2011, 36, 1649.
24. K. G. Williams, S. P. Gido, E. B. Coughlin, in Applications of Polyhedral Oligomeric Silsesquioxanes (Eds:, C. Hartmann-Thompson,), Springer, New York 2011. pp. 167-207.
25. J. Wu, T. S. Haddad, G.-M Kim, P. T. Mather, Macromolecules 2007, 40, 544.
26. E. T. Kopesky, T. S. Haddad, R. E. Cohen, G. H. McKinley, Macromolecules 2004, 37, 8992.
27. E. T. Kopesky, G. H. McKinley, R. Cohen, Polymer 2006, 47, 299.
28. X. Gu, J. Wu, P. T. Mather, Biomacromolecules 2011, 12, 3066.
29. Y. Liu, M. Tseng, M. Fangchiang, J. Polym. Sci. Part A: Polym. Chem. 2008, 46, 5157.
30. W. M. Saltzman, T. R. Kyriakides, in Principles of tissue engineering, 3rd ed. (Eds:, R. Lanza, R. Langer, J. Vacanti,), Elsevier Academic Press, San Diego, CA, USA 2007 pp. 279-296.
31. G. M. Harbers, D. W. Grainger, in An introduction to biomaterials (Eds.:, S. A. Guelcher, J. O. Hollinger,), CRC Press Taylor & Francis Group, Boca Raton, FL, USA 2006 pp. 15-45.
32. D. E. Discher, P. Janmey, Y. L. Wang, Science 2005, 310, 1139.
33. L. Cai, S. Wang, Polymer 2010, 51, 164.
34. L. Cai, A. S. Guinn, S. Wang, Acta Biomater. 2011, 7, 2185.
35. H. Xu, S.-W. Kuo, J.-S. Lee, F.-C. Chang, Macromolecules 2002, 35, 8788.
36. J. Fu, L. Shi, Y. Chen, S. Yuan, J. Wu, X. Liang, Q. Zhong, J. Appl. Polym. Sci. 2008, 109, 340.
37. H.-S. Ryu, D.-G. Kim, J.-C. Lee, Polymer 2010, 51, 2296.
38. G.-M. Kim, H. Qin, X. Fang, F. C. Sun, P. T. Mather, J. Polym. Sci. Part B: Polym. Phys. 2003, 41, 3299.
39. R. Misra, B. X. Fu, A. Plagge, S. E. Morgan, J. Polym. Sci. Part B: Polym. Phys. 2009, 47, 1088.
40. X. Wu, Y. Sun, W. Xie, Y. Liu, X. Song, Dental Mater. 2010, 26, 456.
41. B. B. Johnsen, A. J. Kinloch, R. D. Mohammed, A. C. Taylor, S. Sprenger, Polymer 2007, 48, 530.
42. M. D. Timmer, C. G. Ambrose, A. G. Mikos, Biomaterials 2003, 37, 571.
43. R. Y. Kannan, H. J. Salacinski, M. Odlyha, P. E. Butler, A.M. Seifalian, Biomaterials 2006, 27, 1971.
44. S. He, M. D. Timmer, M. J. Yaszemski, A.W. Yasko, P. S. Engel, A. G. Mikos, Polymer 2001, 42, 1251.
45. M. D. Timmer, H. Shin, R. A. Horch, C. G. Ambrose, A. G. Mikos, Biomacromolecules 2003, 4, 1026.
46. G. S. Stein, J. B. Lian, J. L. Stein, A. J. van Wijnen, M. Montecino, Physiol. Rev. 1996, 76, 593.
47. C. S. Chen, J. Cell Sci. 2008, 121, 3285.
48. B. Geiger B, J. P. Spatz, A. D. Bershadsky, Nat. Rev. Mol. Cell Biol. 2009, 10, 21.
49. C. B. Khatiwala, S. R. Peyton, M. Metzke, A. J. Putnam, J. Cell. Physiol. 2007, 211, 661.
50. R. Murugan, S. Ramakrishna, Compos. Sci. Technol. 2005, 65, 2385.
51. Standard Test Method for Plane-Strain Fracture Toughness of Metallic Materials, in Annual book of ASTM standards, E399-83, American Society of Testing Materials, Philadelphia PA 1983, pp. 680-701.