Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice

Atherosclerosis

Volumn 223, Issue 2, 2012, Pages 332-341

  Calpe Berdiel, Laura ^a   Zhao, Ying ^a,b   De Graauw, Marjo ^a   Ye, Dan ^a   Van Santbrink, Peter J ^a   Mommaas, A Mieke ^c   Foks, Amanda ^a   Bot, Martine ^a   Meurs, Illiana ^a   Kuiper, Johan ^a   Mack, Jody T ^d   Van Eck, Miranda ^a   Tew, Kenneth D ^d   Van Berkel, Theo J C ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b SOOCHOW UNIVERSITY   (China)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

ABCA2; Atherosclerosis; Cholesterol homeostasis; Macrophage; Transplantation

Indexed keywords

CASPASE 3; CHOLESTEROL; FILIPIN; LOW DENSITY LIPOPROTEIN RECEPTOR;

ABCA2 GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ROOT; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; BONE MARROW TRANSPLANTATION; CELL MIGRATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE COURSE; GENE; GENE DELETION; KNOCKOUT MOUSE; LIPID OXIDATION; LIPID STORAGE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; THORACIC AORTA;

ANIMALS; AORTA; AORTIC DISEASES; APOPTOSIS; ATHEROSCLEROSIS; ATP-BINDING CASSETTE TRANSPORTERS; BONE MARROW TRANSPLANTATION; CASPASE 3; CHOLESTEROL; DISEASE MODELS, ANIMAL; FILIPIN; FOAM CELLS; HOMEOSTASIS; IN SITU NICK-END LABELING; LIPOPROTEINS, LDL; LYSOSOMES; MACROPHAGES; MICE; MICE, KNOCKOUT; RECEPTORS, LDL; TIME FACTORS; TRANSPLANTATION CHIMERA; WHOLE-BODY IRRADIATION;

EID: 84864758486     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2012.05.039     Document Type: Article

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