Toll-like receptor (TLR) 3 as a surrogate sensor of retroviral infection in human cells

Biochemical and Biophysical Research Communications

Volumn 424, Issue 3, 2012, Pages 519-523

  Miyauchi, Kosuke ^a,c   Urano, Emiko ^a   Takeda, Satoshi ^a   Murakami, Tsutomu ^a   Okada, Yoshiaki ^a   Cheng, Kui ^b   Yin, Hang ^b   Kubo, Masato ^c,d   Komano, Jun ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b UNIVERSITY OF COLORADO   (United States)

^c RIKEN YOKOHAMA INSTITUTE   (Japan)

^d TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Cytokines; Human; Interferon gamma induced protein 10 (IP 10) CXCL10; Retrovirus; Signal Transduction; Toll like receptor (TLR); Viral infections (major category)

Indexed keywords

GAMMA INTERFERON INDUCIBLE PROTEIN 10; PATTERN RECOGNITION RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TRIPARTITE MOTIF PROTEIN 5;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HOST RESISTANCE; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; RETROVIRUS INFECTION; SENSOR; SIGNAL TRANSDUCTION; XENOTROPIC MULV RELATED VIRUS;

CELL LINE; GENOME, VIRAL; HUMANS; RETROVIRIDAE; RETROVIRIDAE INFECTIONS; TOLL-LIKE RECEPTOR 3; XENOTROPIC MURINE LEUKEMIA VIRUS-RELATED VIRUS;

XENOTROPIC MURINE LEUKEMIA VIRUS;

EID: 84864756871     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.06.148     Document Type: Article

References (34)

1. Brennan K., Bowie A.G. Activation of host pattern recognition receptors by viruses. Curr. Opin. Microbiol. 2010, 13:503-507.
2. Kawai T., Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 2010, 11:373-384.
3. Kleinman M.E., Yamada K., Takeda A., et al. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature 2008, 452:591-597.
4. Guo X., Carroll J.W., Macdonald M.R., et al. The zinc finger antiviral protein directly binds to specific viral mRNAs through the CCCH zinc finger motifs. J. Virol. 2004, 78:12781-12787.
5. Wolf D., Goff S.P. Embryonic stem cells use ZFP809 to silence retroviral DNAs. Nature 2009, 458:1201-1204.
6. Lewinski M.K., Bushman F.D. Retroviral DNA integration-mechanism and consequences. Adv. Genet. 2005, 55:147-181.
7. Beignon A.S., McKenna K., Skoberne M., et al. Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions. J. Clin. Invest. 2005, 115:3265-3275.
8. Hardy A.W., Graham D.R., Shearer G.M., et al. HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulates HIV coreceptors by Toll-like receptor 7-induced IFN-alpha. Proc. Natl. Acad. Sci. USA 2007, 104:17453-17458.
9. Gringhuis S.I., van der Vlist M., van den Berg L.M., et al. HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells. Nature 2010, 11:419-426.
10. Kane M., Case L.K., Wang C., et al. Innate immune sensing of retroviral infection via toll-like receptor 7 occurs upon viral entry. Immunity 2011, 2011:29.
11. Lepelley A., Louis S., Sourisseau M., et al. Innate sensing of HIV-infected cells. PLoS 2011, 7:e1001284.
12. Colisson R., Barblu L., Gras C., Raynaud F., Hadj-Slimane R., Pique C., Hermine O., Lepelletier Y., Herbeuval J.P. Free HTLV-1 induces TLR7-dependent innate immune response and TRAIL relocalization in killer plasmacytoid dendritic cells. Blood 2010, 115:2177-2185.
13. Russell R.S., Liang C., Wainberg M.A. Is HIV-1 RNA dimerization a prerequisite for packaging? Yes, no, probably?. Retrovirology 2004, 1:23.
14. Greatorex J. The retroviral RNA dimer linkage: different structures may reflect different roles. Retrovirology 2004, 1:22.
15. Watts J.M., Dang K.K., Gorelick R.J., et al. Architecture and secondary structure of an entire HIV-1 RNA genome. Nature 2009, 460:711-716.
16. Cheng K., Wang X., Yin H. Small-molecule inhibitors of the TLR3/dsRNA complex. J. Am. Chem. Soc. 2011, 133:3764-3767.
17. Komano J., Miyauchi K., Matsuda Z., et al. Inhibiting the Arp2/3 complex limits infection of both intracellular mature vaccinia virus and primate lentiviruses. Mol. Biol. Cell 2004, 15:5197-5207.
18. Shimizu S., Urano E., Futahashi Y., et al. Inhibiting lentiviral replication by HEXIM1, a cellular negative regulator of the CDK9/cyclin T complex. AIDS 2007, 21:575-582.
19. Galli R., Starace D., Busa R., et al. TLR stimulation of prostate tumor cells induces chemokine-mediated recruitment of specific immune cell types. J. Immunol. 2010, 184:6658-6669.
20. Metzger M.J., Holguin C.J., Mendoza R., Miller A.D., et al. The prostate cancer-associated human retrovirus XMRV lacks direct transforming activity but can induce low rates of transformation in cultured cells. J. Virol. 2010, 84:1874-1880.
21. Groom H.C., Yap M.W., Galao R.P., Neil S.J., et al. Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors. Proc. Natl. Acad. Sci. USA 2010, 107:5166-5171.
22. Pertel T., Hausmann S., Morger D., Zuger S., et al. TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature 2011, 472:361-365.
23. Pichlmair A., Diebold S.S., Gschmeissner S., et al. Tubulovesicular structures within vesicular stomatitis virus G protein-pseudotyped lentiviral vector preparations carry DNA and stimulate antiviral responses via Toll-like receptor 9. J. Virol. 2007, 81:539-547.
24. Knouf E.C., Metzger M.J., Mitchell P.S., et al. Multiple integrated copies and high-level production of the human retrovirus XMRV (xenotropic murine leukemia virus-related virus) from 22Rv1 prostate carcinoma cells. J. Virol. 2009, 83:7353-7356.
25. Burzyn D., Rassa J.C., Kim D., et al. Toll-like receptor 4-dependent activation of dendritic cells by a retrovirus. J. Virol. 2004, 78:576-584.
26. Dunn G.P., Sheehan K.C., Old L.J., et al. IFN unresponsiveness in LNCaP cells due to the lack of JAK1 gene expression. Cancer Res. 2005, 65:3447-3453.
27. Rodriguez J.J., Goff S.P. Xenotropic murine leukemia virus-related virus establishes an efficient spreading infection and exhibits enhanced transcriptional activity in prostate carcinoma cells. J. Virol. 2009, 84:2556-2562.
28. Doehle B.P., Hladik F., McNevin J.P., et al. Human immunodeficiency virus type 1 mediates global disruption of innate antiviral signaling and immune defenses within infected cells. J. Virol. 2009, 83:10395-10405.
29. Bhosle S., Suppiah S., Molinaro R., et al. Evaluation of cellular determinants required for in vitro xenotropic murine leukemia virus-related virus entry into human prostate cancer and noncancerous cells. J. Virol. 2010, 84:6288-6296.
30. Kariko K., Bhuyan P., Capodici J., et al. Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3. J. Immunol. 2004, 172:6545-6549.
31. Alexopoulou L., Holt A.C., Medzhitov R., et al. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001, 413:732-738.
32. Kamiyama H., Kakoki K., Yoshii H., et al. Infection of XC cells by MLVs and Ebola virus is endosome-dependent but acidification-independent. PLoS One 2011, 6:e26180.
33. Andreadis S., Lavery T., Davis H.E., et al. Toward a more accurate quantitation of the activity of recombinant retroviruses: alternatives to titer and multiplicity of infection. J. Virol. 2000, 74:3431-3439.
34. Breckpot K., Escors D., Arce F., et al. HIV-1 lentiviral vector immunogenicity is mediated by Toll-like receptor 3 (TLR3) and TLR7. J. Virol. 2010, 84:5627-5636.