A bidirectional model for communication in the neurovascular unit

Journal of Theoretical Biology

Volumn 311, Issue , 2012, Pages 80-93

  Witthoft, Alexandra ^a   Em Karniadakis, George ^b  

^a Brown University   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

Astrocytes; Neurovascular coupling; TRP channels

Indexed keywords

CALCIUM ION; GLUTAMIC ACID; POTASSIUM;

ANATOMY; BLOOD; COMMUNICATION; NEUROLOGY;

ARTERIOLE; ARTERY DIAMETER; ARTICLE; ASTROCYTE; BIOLOGICAL MODEL; BLOOD VESSEL REACTIVITY; BRAIN BLOOD VESSEL; CALCIUM SIGNALING; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MICROVASCULATURE; NEUROVASCULAR UNIT; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYNAPTIC POTENTIAL; VALIDATION STUDY; VASODILATATION;

ANIMALS; ASTROCYTES; BRAIN; CEREBROVASCULAR CIRCULATION; HEMODYNAMICS; HUMANS; MICROVESSELS; MODELS, CARDIOVASCULAR; MODELS, NEUROLOGICAL; NEURONS;

EID: 84864751081     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2012.07.014     Document Type: Article

References (40)

1. Barres B.A., Koroshetz W.J., Chun L.L.Y., Corey D.R. Ion channel expression by white matter glia: the type-1 astrocyte. Neuron 1990, 5(4):527-544.
2. Benfenati V., Amiry-Moghaddam M., Caprini M., Mylonakou M.N., Rapisarda C., Ottersen O.P., Ferroni S. Expression and functional characterization of transient receptor potential vanilloid-related channel 4 (TRPV4) in rat cortical astrocytes. Neuroscience 2007, 148:876-892.
3. Bennett M.R., Farnell L., Gibson W. Origins of blood volume change due to glutamatergic synaptic activity at astrocytes abutting on arteriolar smooth muscle cells. J. Theor. Biol. 2008, 250:172-185.
4. Bezzi, P., Carmignoto, G., Pasti, L., Vesce, S., DanielaRossi, Rizzini, B.L., 1998. Prostaglandins stimulate calcium-dependent glutamate release in astrocytes. Nature 391 (January), 281-285.
5. Brown L., Key B., Lovick T. Inhibition of vasomotion in hippocampal cerebral arterioles during increases in neuronal activity. Autonomic Neurosci.: Basic Clin. 2002, 95:137-140.
6. Cao, R., 2011. The Hemo-neural Hypothesis: Effects of Vasodilation on Astrocytes in Mammalian Neocortex. Ph.D. Thesis. Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, February.
7. Cao R., Higashikubo B.T., Cardin J., Knoblich U., Ramos R., Nelson M.T., Moore C.I. Pinacidil induces vascular dilation and hyperemia in vivo and does not impact biophysical properties of neurons and astrocytes in vitro. Cleveland Clin. J. Med. 2009, 76(April):S80-S85.
8. Dacey R.G., Duling B.R. A study of rat intracerebral arterioles: methods, morphology, and reactivity. Am. J. Physiol. 1982, 243:H598-H606.
9. Farr H., David T. Models of neurovascular coupling via potassium and EET signalling. J. Theor. Biol. 2011, 286:13-23.
10. Fernandes J., Lorenzo I.M., Andrade Y.N., Garcia-Elias A., Serra S.A., Fernández-Fernández J.M., Valverde M.A. IP3 sensitizes TRPV4 channel to the mechano-and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid. J. Cell Biol. 2008, 181(April (1)):143-155.
11. Filosa J.A., Bonev A.D., Nelson M.T. Calcium dynamics in cortical astrocytes and arterioles during neurovascular coupling. Circ. Res. 2004, 95(October):e73-e81.
12. Filosa J.A., Bonev A.D., Straub S.V., Meredith A.L., Wilkerson M.K., Aldrich R.W., Nelson M.T. Local potassium signaling couples neuronal activity to vasodilation in the brain. Nat. Neurosci. 2006, 9(11):1397-1403.
13. Gonzalez-Fernandez J.M., Ermentrout B. On the origin and dynamics of the vasomotion of small arteries. Math. Biosci. 1994, 119:127-167.
14. Haddock R., Hirst G., Hill C. Voltage independence of vasomotion in isolated irideal arterioles of the rat. J. Physiol. 2002, 540(1):219-229.
15. Halassa M.M., Fellin T., Takano H., Dong J.-H., Haydon P.G. Synaptic islands defined by the territory of a single astrocyte. J. Neurosci. 2007, 27(June (24)):6473-6477.
16. Hamill O.P., Martinac B. Molecular basis of mechanotransduction in living cells. Physiol. Rev. 2001, 81(April (2)):685-733.
17. Haydon P.G., Carmignoto G. Astrocyte control of synaptic transmission and neurovascular coupling. Physiol. Rev. 2006, 86:1009-1031.
18. + channel, Kir4. 1, expressed in astrocytes surrounds synapses and blood vessels in brain. Am. J. Physiol. Cell Physiol. 2001, 281(3):C922-C931.
19. Higashimori H., Sontheimer H. Role of Kir4. 1 channels in growth control of glia. Glia 2007, 55(16):1668-1679.
20. +-induced local and conducted responses in cerebral penetrating arterioles. Stroke 2002, 33(11):2692-2699.
21. 2+ stores in astrocytes. J. Neurosci. Res. 2004, 76(March):86-97.
22. Hudetz A.G., Conger K.A., Halsey J.H., Pal M., Dohan O., Kovach A.G.B. Pressure distribution in the pial arterial system of rats based on morphometric data and mathematical models. J. Cereb. Blood Flow Metab. 1987, 7(3):342-355.
23. Hundley W.G., Renaldo G.J., Levasseur J.E., Kontos H.A. Vasomotion in cerebral microcirculation of awake rabbits. Am. J. Physiol. Heart Circ. Physiol. 1988, 254(January (1)):H67-H71.
24. Koehler R.C., Gebremedhin D., Harder D.R. Role of astrocytes in cerebrovascular regulation. J. Appl. Physiol. 2006, 100:307-317.
25. Koenigsberger M., Sauser R., Bény J., Meister J. Role of the endothelium on arterial vasomotion. Biophys. J. 2005, 88(6):3845-3854.
26. Koenigsberger M., Sauser R., Bény J.-L., Meister J.-J. Effects of arterial wall stress on vasomotion. Biophys. J. 2006, 91(September):1663-1674.
27. Kofuji P., Newman E.A. Potassium buffering in the central nervous system. Neuroscience 2004, 129(4):1043-1054.
28. Kung C. A possible unifying principle for mechanosensation. Nature 2005, 436(August):647-654.
29. Lefer D.J., Lynch C.D., Lapinski K.C., Hutchins P.M. Enhanced vasomotion of cerebral arterioles in spontaneously hypertensive rats. Microvasc. Res. 1990, 39(March (2)):129-139.
30. 2+ dynamics and consequent glutamate release from rat astrocytes. Glia 2008, 56:821-835.
31. McCaslin A.F., Chen B.R., Radosevich A.J., Cauliand B., Hillman E.M. In vivo 3D morphology of astrocyte-vasculature interactions in the somatosensory cortex: implications for neurovascular coupling. J. Cereb. Blood Flow Metab. 2011, 31:795-806.
32. Moore C.I., Cao R. The hemo-neural hypothesis: on the role of blood flow in information processing. J. Neurophysiol. 2008, 99:2035-2047.
33. Morita-Tsuzuki Y., Bouskela E., Hardebo J.E. Vasomotion in the rat cerebral microcirculation recorded by laser-doppler flowmetry. Acta Physiol. Scand. 1992, 146(December (4)):431-439.
34. Nedergaard M., Ransom B., Goldman S.A. New roles for astrocytes: redefining the functional architecture of the brain. Trends Neurosci. 2003, 26(10):523-530.
35. Ngai A.C., Winn H.R. Modulation of cerebral arteriolar diameter by intraluminal flow and pressure. Circ. Res. 1995, 77:832-840.
36. Nilius B., Vriens J., Prenen J., Droogmans G., Voets T. TRPV4 calcium entry channel: a paradigm for gating diversity. Am. J. Physiol. Cell Physiol. 2004, 286:C195-C205.
37. Nilius B., Watanabe H., Vriens J. The TRPV4 channel: structure-function relationship and promiscuous gating behaviour. Eur. J. Physiol. 2003, 446:298-303.
38. Rivadulla C., de Labra C., Grieve K.L., Cudeiro J. Vasomotion and neurovascular coupling in the visual thalamus in vivo. PLoS ONE 2011, 6(12):e28746.
39. 2+. Cell Calcium 2003, 33:489-495.
40. Yang X., Choi M., Lin G., Karniadakis G.E. Adaptive ANOVA decomposition of stochastic incompressible and compressible flows. J. Comput. Phys. 2012, 231:1587-1614.