The Psychopharmacological Management of RLS in Psychiatric Conditions: A Review of the Literature

Journal of the American Psychiatric Nurses Association

Volumn 18, Issue 4, 2012, Pages 214-225

  Cuellar, Norma G ^a  

^a UNIVERSITY OF ALABAMA   (United States)

Author keywords

anxiety; depression; psychiatric disorders; restless legs syndrome; schizophrenia

Indexed keywords

EID: 84864750789     PISSN: 10783903     EISSN: 15325725     Source Type: Journal    
DOI: 10.1177/1078390312442569     Document Type: Article

References (75)

1. Aiken C. B.Pramipexole in psychiatry: A systematic review of the literature.Journal of Clinical Psychiatry. 2007;68:1230-1236.
2. Allen R.,Earley C. J.The role of iron in restless legs syndrome.Movement Disorders. 2007;22:S440-S448.
3. Allen R.,Picchietti D.,Henning W.,Trenkwalder C.,Walters A.,Montplaisir J.Restless legs syndrome: Diagnostic criteria, special considerations, and epidemiology. A report from the Restless Legs Syndrome Diagnosis and Epidemiology Workshop at the National Institutes of Health. Sleep Medicine; 2003; 2003. 101-119.
4. Diagnostic and statistical manual of mental disorders. 1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.Washington, DC: Author; 1994:.
5. Diagnostic and statistical manual of mental disorders. Washington, DC: Author; 2000:.
6. Bonin B.,Vandel P.,Kantelip J. P.Mirtazapine and restless leg syndrome: A case report.Therapie. 2000;55:655-656.
7. Brand S.,Lehtinen A.,Hatzinger M.,Holsboer-Trachsler E.Comparison of sleep EEG profiles of patients suffering from restless legs syndrome, restless legs syndrome and depressive symptoms, and major depressive disorders.Neuropsychobiology. 2010;61 (1): 41-48.
8. Broman J.-E.,Mallon L.,Hetta J.Restless legs syndrome and its relationship with insomnia symptoms and daytime distress: epidemiological survey in Sweden.Psychiatry & Clinical Neurosciences. 2008;62:472-475.
9. Brown L. K.,Dedrick D. L.,Doggett J. W.,Guido P. S.Antidepressant medication use and restless legs syndrome in patients presenting with insomnia.Sleep Medicine. 2005;6:443-450.
10. Buckner A. C.The use of dopamine agonist in the treatment of restless legs syndrome: Caution for practitioners and bipolar patients.Southern Medical Journal. 2008;101:785.
11. Celle S.,Roche F.,Kerleroux J.,Thomas-Anterion C.,Laurent B.,Rouch I.,Sforza E.Prevalence and clinical correlates of restless legs syndrome in an elderly French population: the synapse study.Journals of Gerontology Series A: Biological Sciences & Medical Sciences. 2010;65:167-173.
12. Cervenka S.,Palhagen S. E.,Comley R. A.,Panagiotidis G.,Cselenyi Z.,Matthews J. C.,. Farde L.Support for dopaminergic hypoactivity in restless legs syndrome: A PET study on D2-receptor binding.Brain. 2006;129:2017-2028.
13. Cho S.-J.,Hong J. P.,Hahm B.-J.,Jeon H. J.,Chang S. M.,Cho M. J.,Lee H. B.Restless legs syndrome in a community sample of Korean adults: Prevalence, impact on quality of life, and association with DSM-IV psychiatric disorders.Sleep. 2009;32:1069-1076.
14. Cohrs S.Sleep disturbances in patients with schizophrenia: Impact and effect of antipsychotics.CNS Drugs. 2008;22:939-962.
15. Connor J.,Wang X.-S.,Allen R. P.,Beard J. L.,Wiesinger J. A.,Felt B. T.,Earley C. J.Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome.Brain. 2009;132:2403-2412.
16. Cuellar N. G.,Ratcliffe S. J.,Chien D.Effects of depression on sleep quality, fatigue, and sleepiness in persons with restless legs syndrome.Journal of the American Psychiatric Nurses Association. 2006;12:262-271.
17. Cuellar N. G.,Strumpf N. E.,Ratcliffe S. J.Symptoms of restless legs syndrome in older adults: Outcomes on sleep quality, sleepiness, fatigue, depression, and quality of life.Journal of the American Geriatrics Society. 2007;55:1387-1392.
18. Desautels A.,Turecki G.,Montplaisir J.,Ftouhi-Paquin N.,Michaud M.,Chouinard V. A.,. Rouleau G. A.Dopaminergic neurotransmission and restless legs syndrome: A genetic association analysis.Neurology. 2001;57:1304-1306.
19. Driver-Dunckley E.,Connor D.,Hentz J.,Sabbagh M.,Silverberg N.,Hernandez J.,. Adler C.No evidence for cognitive dysfunction or depression in patients with mild restless legs syndrome.Movement Disorders. 2009;24:1840-1842.
20. Driver-Dunckley E.,Noble B. N.,Hentz J. G.,Evidente V. G. H.,Caviness J. N.,Parish J.,. Adler C.Gambling and increased sexual desire with dopaminergic medications in restless legs syndrome.Clinical Neuropharmacology. 2007;30:249-255.
21. Duggal H. S.,Mendhekar D. N.Clozapine-associated restless legs syndrome.Journal of Clinical Psychopharmacology. 2007;27:89-90.
22. Earley C.,Barker P.,Horska A.,Allen R.MRI- determined regional brain iron concentrations in early- and late-onset restless legs syndrome.Sleep Medicine. 2006;7:458-461.
23. Evans A. H.,Stegeman J. R.Punding in patients on dopamine agonists for restless legs syndrome.Movement Disorders. 2009;24:140-141.
24. Ferini-Strambi L.Treatment options for restless legs syndrome.Expert Opinion on Pharmacotherapy. 2009;10:545-554.
25. Gamaldo C.,Benbrook A. R.,Allen R. P.,Oguntimein O.,Earley C. J.Evaluating daytime alertness in individuals with restless legs syndrome (RLS) compared to sleep restricted controls.Sleep Medicine. 2009;10:134-138.
26. Glass J. R.,Sproule B. A.,Herrmann N.,Streiner D.,Busto U. E.Acute pharmacological effects of temazepam, diphenhydramine, and valerian in healthy elderly subjects.Journal of Clinical Psychopharmacology. 2003;23:260-268.
27. Gorman C. A.,Dyck P. J.,Pearson J. S.Symptom of restless legs.Archives of Internal Medicine. 1965;115:155-160.
28. Heiman E.,Christie M.Lithium aggravated nocturnal myoclonus and restless legs syndrome.American Journal of Psychiatry. 1986;143:1191-1192.
29. Hochman S.Depression of spinal sensory transmission during REM sleep: Dopaminergic involvement and insights into restless legs syndrome. Focus on "state-dependent changes in glutamate, glycine, GABA, and dopamine levels in cat lumbar spinal cord.".Journal of Neurophysiology. 2008;100:549-550.
30. Horiguchi J.,Yamashita H.,Mizuno S.,Kuramoto Y.,Kagaya A.,Yamawaki S.,Inami Y.Nocturnal eating/drinking syndrome and neuroleptic-induced restless legs syndrome.International Clinical Psychopharmacology. 1999;14 (1): 33-36.
31. Hornyak M.Depressive disorders in restless legs syndrome: Epidemiology, pathophysiology and management.CNS Drugs. 2010;24 (2): 89-98.
32. Kalaydjian A.,Bienvenu O. J.,Hening W. A.,Allen R. P.,Eaton W. W.,Lee H. B.Restless legs syndrome and the five-factor model of personality: Results from a community sample.Sleep Medicine. 2009;10:672-675.
33. Kang S.-G.,Lee H.-J.,Choi J.-E.,Park Y.-M.,Park J.-H.,Han C.,. Kim L.Association study between antipsychotics induced restless legs syndrome and polymorphisms of dopamine D1, D2, D3, and D4 receptor genes in schizophrenia.Neuropsychobiology. 2008;57 (1-2): 49-54.
34. Kang S.-G.,Lee H.-J.,Jung S. W.,Cho S. N.,Han C.,Kim Y.-K.,. Kim L.Characteristics and clinical correlates of restless legs syndrome in schizophrenia.Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2007;31:1078-1083.
35. Kang S.-G.,Lee H.-J.,Kim L.Restless legs syndrome and periodic limb movements during sleep probably associated with olanzapine.Journal of Psychopharmacology. 2009;23:597-601.
36. Kang S.-G.,Park Y.-M.,Choi J.-E.,Lim S.-W.,Lee H.-J.,Lee S.-H.,.. King L.Association study between antipsychotic-induced restless legs syndrome and polymorphisms of monoamine oxidase genes in schizophrenia.Human Psychopharmacology. 2010;25:397-403.
37. Khalid I.,Rana L.,Khalid T. J.,Roehrs T.Refractory restless legs syndrome likely caused by olanzapine.Journal of Clinical Sleep Medicine. 2009;5 (1): 68-69.
38. Kim S.-W.,Shin I.-S.,Kim J.-M.,Park K.-H.,Youn T.,Yoon J.-S.Factors potentiating the risk of mirtazapine-associated restless legs syndrome.Human Psychopharmacology. 2008;23:615-620.
39. Kim S.-W.,Shin I.-S.,Kim J.-M.,Yang S.-J.,Shin H.-Y.,Yoon J.-S.Bupropion may improve restless legs syndrome: A report of three cases.Clinical Neuropharmacology. 2005;28:298-301.
40. Kraus T.,Schuld A.,Pollmacher T.Periodic leg movements in sleep and restless legs syndrome probably caused by olanzapine.Journal of Clinical Psychopharmacology. 1999;19:478-479.
41. Lee H. B.,Hening W. A.,Allen R. P.,Kalaydjian A. E.,Earley C. J.,Eaton W. W.,Lyketsos C. G.Restless legs syndrome is associated with DSM-IV major depressive disorder and panic disorder in the community.Journal of Neuropsychiatry & Clinical Neurosciences. 2008;20:101-105.
42. Merlino G.,Serafini A.,Young J. J.,Robiony F.,Gigli G. L.,Valente M.Gabapentin enacarbil, a gabapentin prodrug for the treatment of the neurological symptoms associated with disorders such as restless legs syndrome.Current Opinion in Investigational Drugs. 2009;10:91-102.
43. Michaud M.,Soucy J.-P.,Chabli A.,Lavigne G.,Montplaisir J.SPECT imaging of striatal pre- and postsynaptic dopaminergic status in restless legs syndrome with periodic leg movements in sleep.Journal of Neurology. 2002;249:164-170.
44. Micozkadioglu H.,Ozdemir F. N.,Kut A.,Sezer S.,Saatci U.,Haberal M.Gabapentin versus levodopa for the treatment of restless legs syndrome in hemodialysis patients: An open-label study.Renal Failure. 2004;26:393-397.
45. Miyamoto M.,Miyamoto T.,Iwanami M.,Suzuki K.,Hirata K.Pathophysiology of restless legs syndrome.Brain & Nerve/Shinkei Kenkyu no Shinpo. 2009;61:523-532.
46. Ohayon M. M.,Roth T.Prevalence of restless legs syndrome and periodic limb movement disorder in the general population.Journal of Psychosomatic Research. 2002;53:547-554.
47. O'Keeffe S.,Noel J.,Lavan J.Restless legs syndrome in the elderly.Postgraduate Medical Journal. 1993;69:701-704.
48. Page R. L.,Ruscin J. M.,Bainbridge J. L.,Brieke A. A.Restless legs syndrome induced by escitalopram: Case report and review of the literature.Pharmacotherapy. 2008;28:271-280.
49. Phillips B.,Hening W.,Britz P.,Mannino D.Prevalence and correlates of restless legs syndrome: Results from the 2005 National Sleep Foundation Poll.Chest. 2006;129:76-80.
50. Picchietti D.,Winkelman J. W.Restless legs syndrome, periodic limb movements in sleep, and depression.Sleep. 2005;28:891-898.
51. Pinninti N. R.,Mago R.,Townsend J.,Doghramji K.Periodic restless legs syndrome associated with quetiapine use: A case report.Journal of Clinical Psychopharmacology. 2005;25:617-618.
52. Pourcher E.,Remillard S.,Cohen H.Compulsive habits in restless legs syndrome patients under dopaminergic treatment.Journal of the Neurological Sciences. 2010;290 (1-2): 52-56.
53. Provini F.,Antelmi E.,Vignatelli L.,Zaniboni A.,Naldi G.,Calandra-Buonaura G.,.. Montagna P.Association of restless legs syndrome with nocturnal eating: A case-control study.Movement Disorders. 2009;24:871-877.
54. Quickfall J.,Suchowersky O.Pathological gambling associated with dopamine agonist use in restless legs syndrome.Parkinsonism & Related Disorders. 2007;13:535-536.
55. Rothdach A. J.,Trenkwalder C.,Haberstock J.,Keil U.,Berger K.Prevalence and risk factors of RLS in an elderly population: The MEMO study.Neurology. 2000;54:1064-1068.
56. Salas R. E.,Allen R. P.,Earley C. J.,Gamaldo C. E.Drug hoarding: A case of atypical dopamine dysregulation syndrome in a RLS patient.Movement Disorders. 2009;24:627-628.
57. Saletu M.,Anderer P.,Saletu-Zyhlarz G.,Prause W.,Semler B.,Zoghlami A.,.. Saletu B.Restless legs syndrome (RLS) and periodic limb movement disorder (PLMD): Acute placebo-controlled sleep laboratory studies with clonazepam.European Neuropsychopharmacology. 2001;11:153-161.
58. Saletu M.,Anderer P.,Saletu B.,Hauer C.,Mandl M.,Oberndorfer S.,.. Saletu B.Sleep laboratory studies in restless legs syndrome patients as compared with normals and acute effects of ropinirole. 2. Findings on periodic leg movements, arousals and respiratory variables.Neuropsychobiology. 2000;41:190-199.
59. Saletu M.,Anderer P.,Saletu B.,Lindeck-Pozza L.,Hauer C.,Saletu-Zyhlarz G.EEG mapping in patients with restless legs syndrome as compared with normal controls.Psychiatry Research. 2002;115 (1-2): 49-61.
60. Sevim S.,Dogu O.,Kaleagasi H.,Aral M.,Metin O.,Camdeviren H.Correlation of anxiety and depression symptoms in patients with restless legs syndrome: A population based survey.Journal of Neurology, Neurosurgery & Psychiatry. 2004;75:226-230.
61. Silber M. H.,Ehrenberg B. L.,Allen R. P.,Buchfuhrer M. J.,Earley C. J.,Hening W. A.An algorithm for the management of restless legs syndrome.Mayo Clinic Proceedings. 2004;79:916-922.
62. Stefansson H.,Rye D. B.,Hicks A.,Petursson H.,Ingason A.,Thorgeirsson T. E.,.. Stefansson K.A genetic risk factor for periodic limb movements in sleep.New England Journal of Medicine. 2007;357:639-647.
63. Terao T.,Terao M.,Yoshimura R.,Abe K.Restless legs syndrome induced by lithium.Biological Psychiatry. 1991;30:1167-1170.
64. Tippmann-Peikert M.,Park J. G.,Boeve B. F.,Shepard J. W.,Silber M. H.Pathologic gambling in patients with restless legs syndrome treated with dopaminergic agonists.Neurology. 2007;68:301-303.
65. Trenkwalder C.,Hening W. A.,Montagna P.,Oertel W. H.,Allen R. P.,Walters A. S.,.. Sampaio C.Treatment of restless legs syndrome: An evidence-based review and implications for clinical practice.Movement Disorders. 2008;23:2267-2302.
66. Trenkwalder C.,Hogl B.,Winkelmann J.Recent advances in the diagnosis, genetics and treatment of restless legs syndrome.Journal of Neurology. 2009;256:539-553.
67. Turjanski N.,Lees A. J.,Brooks D. J.Striatal dopaminergic function in restless legs syndrome: 18F-dopa and 11C-raclopride PET studies.Neurology. 1999;52:932-937.
68. Ulfberg J.,Nystrom B.,Carter N.,Edling C.Prevalence of restless legs syndrome among men aged 18 to 64 years: An association with somatic disease and neuropsychiatric symptoms.Movement Disorders. 2001;16:1159-1163.
69. Urbano M.,Ware J. C.Restless legs syndrome caused by quetiapine successfully treated with ropinirole in 2 patients with bipolar disorder.Journal of Clinical Psychopharmacology. 2008;28:704-705.
70. Vandeputte M.,de Weerd A.Sleep disorders and depressive feelings: A global survey with the Beck Depression Scale.Sleep Medicine. 2003;4:343-345.
71. Wang J.,O'Reilly B.,Venkataraman R.,Mysliwiec V.,Mysliwiec A.Efficacy of oral iron in patients with restless legs syndrome and a low-normal ferritin: A randomized, double blind, placebo-controlled study.Sleep Medicine. 2009;10:973-975.
72. Wetter T. C.,Brunner J.,Bronisch T.Restless legs syndrome probably induced by risperidone treatment.Pharmacopsychiatry. 2002;35:109-111.
73. Winkelman J. W.,Finn L.,Young T.Prevalence and correlates of restless legs syndrome symptoms in the Wisconsin Sleep Cohort.Sleep Medicine. 2006;7:545-552.
74. Winkelmann J. W.,Prager M.,Lieb R.,Pfister H.,Spiegel B.,Wittchen H. U.,.. Strohle A."Anxietas tibiarum." Depression and anxiety disorders in patients with restless legs syndrome.Journal of Neurology. 2005;252:67-71.
75. Yang C.,White D. P.,Winkelman J. W.Antidepressants and periodic leg movements of sleep.Biological Psychiatry. 2005;58:510-514.