Abnormal retinal vascular reactivity in individuals with impaired glucose tolerance: A preliminary study

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 9, 2012, Pages 5102-5108

  Patel, Sunni R ^a   Bellary, Srikanth ^a   Qin, Lu ^a   Balanos, George M ^b   McIntyre, David ^b   Gherghel, Doina ^a  

^a ASTON UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUTATHIONE; GLUTATHIONE DISULFIDE; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VON WILLEBRAND FACTOR;

ADULT; ARTERIAL WALL THICKNESS; ARTICLE; BLOOD PRESSURE MONITORING; BLOOD VESSEL REACTIVITY; BRACHIAL ARTERY; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FRAMINGHAM RISK SCORE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; REACTION TIME; RETINA BLOOD VESSEL;

ADULT; BIOLOGICAL MARKERS; BLOOD PRESSURE; BRACHIAL ARTERY; CAROTID INTIMA-MEDIA THICKNESS; ENDOTHELIUM, VASCULAR; EUROPE; FEMALE; GLUCOSE INTOLERANCE; GLUTATHIONE; HUMANS; LIPIDS; MALE; MICROCIRCULATION; MIDDLE AGED; REACTION TIME; RETINAL VESSELS; VON WILLEBRAND FACTOR;

EID: 84864715750     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-9512     Document Type: Article

References (45)

1. Zimmet, P, Shaw J, Alberti KG. Preventing type 2 diabetes and the dysmetabolic syndrome in the real world: a realistic view. Diabet Med. 2003;20:693-702.
2. Jarrett RJ. The cardiovascular risk associated with impaired glucose tolerance. Diabet Med. 1996;13(3 suppl 2):S15-S19.
3. Perry RC, Baron AD. Impaired glucose tolerance: why is it not a disease? Diabetes Care. 1999;22:883-885.
4. Liye H, Lvyun Z, Guangyao S, Luping R. Investigation of early change of endothelial function and related factors in individuals with hyperglycemia. Diabetes Res Clin Pract. 2011;92:194-197.
5. Singleton JR, Smith AG, Russell JW, Feldman EL. Microvascular complications of impaired glucose tolerance. Diabetes. 2003; 52:2867-2873.
6. O'Rourke MF, Safar ME. Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy. Hypertension. 2005;46:200-204.
7. Patel SR, Bellary S, Qin L, et al. Abnormal retinal vascular function and lipid levels in a sample of healthy UK South Asians. Br J Ophthalmol. 2011;95:1573-1576.
8. Heitmar R, Blann A, Cubbidge RP, Lip G, Gherghel D. Continuous retinal vessel diameter measurements-the future of retinal vessel assessment? Invest Ophthalmol Vis Sci. 2010; 51:5833-5839.
9. Caballero AE, Arora S, Saouaf R, et al. Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes. Diabetes. 1999;48:1856-1862.
10. Albutt, EC, Nattrass M, Northam BE. Glucose tolerance test and glycosylated haemoglobin measurement for diagnosis of diabetes mellitus-an assessment of the criteria of the WHO Expert Committee on Diabetes Mellitus 1980. Ann Clin Biochem. 1985;22(pt 1):67-73.
11. Sorensen KE, Dorup I, Hermann AP, Mosekilde L. Combined hormone replacement therapy does not protect women against the age-related decline in endothelium-dependent vasomotor function. Circulation. 1998;97:1234-1238.
12. Moens AL, Goovaerts I, Claeys MJ, Vrints CJ. Flow-mediated vasodilation: a diagnostic instrument, or an experimental tool? Chest. 2005;127:2254-2263.
13. Lloyd-Jones DM, Wilson PW, Larson MG, et al. Framingham risk score and prediction of lifetime risk for coronary heart disease. Am J Cardiol. 2004;94:20-24.
14. Gherghel D, Griffiths HR, Hilton EJ, Cunliffe IA, Hosking SL. Systemic reduction in glutathione levels occurs in patients with primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2005;46:877-883.
15. Blann AD. von Willebrand factor antigen: a radial immunodif-fusion method evaluated and compared with an ELISA method. Med Lab Sci. 1992;49:141-143.
16. O'Leary DH, Polak JF, Kronmal RA, et al. Thickening of the carotid wall: a marker for atherosclerosis in the elderly- Cardiovascular Health Study Collaborative Research Group. Stroke. 1996;27:224-231.
17. Garhofer G, Bek T, Boehm AG, et al. Use of the retinal vessel analyzer in ocular blood flow research. Acta Ophthalmol. 2010;88:717-722.
18. Nagel E, Vilser W, Lanzl I. Age, blood pressure, and vessel diameter as factors influencing the arterial retinal flicker response. Invest Ophthalmol Vis Sci. 2004;45:1486-1492.
19. Heitmar R, Blann A, Cubbidge R, Lip G, Gherghel D. Continuous retinal vessel diameter measurements-the future of retinal vessel assessment? Invest Ophthalmol Vis Sci. 2010; 51:5833-5839.
20. Corretti MC, Anderson TJ, Benjamin EJ, et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol. 2002;39:257-265.
21. Garhofer G, Zawinka C, Resch H, et al. Reduced response of retinal vessel diameters to flicker stimulation in patients with diabetes. Br J Ophthalmol. 2004;88:887-891.
22. Mandecka A, Dawczynski J, Vilser W, et al. Abnormal retinal autoregulation is detected by provoked stimulation with flicker light in well-controlled patients with type 1 diabetes without retinopathy. Diabetes Res Clin Pract. 2009;86:51-55.
23. Su Y, Liu XM, Sun YM, et al. The relationship between endothelial dysfunction and oxidative stress in diabetes and prediabetes. Int J Clin Pract. 2008;62:877-882.
24. Polak K, Dorner G, Kiss B, et al. Evaluation of the Zeiss retinal vessel analyser. Br J Ophthalmol. 2000;84:1285-1290.
25. Ilanne-Parikka P, Eriksson JG, Lindström J, et al. Effect of lifestyle intervention on the occurrence of metabolic syndrome and its components in the Finnish Diabetes Prevention Study. Diabetes Care. 2008;31:805-807.
26. Hanefeld M, Karasik A, Koehler C, Westermeier T, Chiasson JL. Metabolic syndrome and its single traits as risk factors for diabetes in people with impaired glucose tolerance: the STOP-NIDDM trial. Diab Vasc Dis Res. 2009;6:32-37.
27. DeFronzo RA, Abdul-Ghani M. Assessment and treatment of cardiovascular risk in prediabetes: impaired glucose tolerance and impaired fasting glucose. Am J Cardiol. 2011;108(3 suppl):3B-24B.
28. Tripathy D, Mohanty P, Dhindsa S, et al. Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects. Diabetes. 2003;52:2882-2887.
29. Pereira EC, Ferderbar S, Bertolami MC, et al. Biomarkers of oxidative stress and endothelial dysfunction in glucose intolerance and diabetes mellitus. Clin Biochem. 2008;41: 1454-1460.
30. Neri S, Calvagno S, Mauceri B, et al. Effects of antioxidants on postprandial oxidative stress and endothelial dysfunction in subjects with impaired glucose tolerance and type 2 diabetes. Eur J Nutr. 2010;49:409-416.
31. Montagnani M, Golovchenko I, Kim I, et al. Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells. J Biol Chem. 2002;277:1794-1799.
32. Rask-Madsen C, Li Q, Freund B, et al. Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab. 2010;11:379-389.
33. Brohall G, Oden A, Fagerberg B. Carotid artery intima-media thickness in patients with Type 2 diabetes mellitus and impaired glucose tolerance: a systematic review. Diabet Med. 2006;23:609-616.
34. Aydin Y, Berker D, Ustun I, et al. Evaluation of carotid intima media thickness in impaired fasting glucose and impaired glucose tolerance. Minerva Endocrinol. 2011;36:171-179.
35. Wong TY, Barr EL, Tapp RJ, et al. Retinopathy in persons with impaired glucose metabolism: the Australian Diabetes Obesity and Lifestyle (AusDiab) study. Am J Ophthalmol. 2005;140: 1157-1159.
36. Wong TY, Mohamed Q, Klein R, Couper DJ. Do retinopathy signs in non-diabetic individuals predict the subsequent risk of diabetes? Br J Ophthalmol. 2006;90:301-303.
37. Milman S, Crandall JP. Mechanisms of vascular complications in prediabetes. Med Clin North Am. 2011;95:309-325, vii.
38. Nagel E, Vilser W. Flicker observation light induces diameter response in retinal arterioles: a clinical methodological study. Br J Ophthalmol. 2004;88:54-56.
39. Gugleta K, Zawinka C, Rickenbacher I, et al. Analysis of retinal vasodilation after flicker light stimulation in relation to vasospastic propensity. Invest Ophthalmol Vis Sci. 2006;47: 4034-4041.
40. Kotliar KE, Nagel E, Vilser W, Lanzl IM. Functional in vivo assessment of retinal artery microirregularities in glaucoma. Acta Ophthalmologica. 2008;86:424-433.
41. Klijn CJM, Kappelle LJ, van Schooneveld MJ, et al. Venous stasis retinopathy in symptomatic carotid artery occlusion. Stroke. 2002;33:695-701.
42. de Jong FJ, Vernooij MW, Ikram MK, et al. Arteriolar oxygen saturation, cerebral blood flow, and retinal vessel diameters: The Rotterdam Study. Ophthalmology. 2008;115:887-892.
43. Krentz AJ, Clough G, Byrne CD. Interactions between microvascular and macrovascular disease in diabetes: patho-physiology and therapeutic implications. Diabetes Obes Metab. 2007;9:781-791.
44. Delles C, Michelson G, Harazny J, et al. Impaired endothelial function of the retinal vasculature in hypertensive patients. Stroke. 2004;35:1289-1293.
45. Patton N, Aslam T, Macgillivray T, et al. Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures. J Anat. 2005;206:319-348.