Abnormal retinal autoregulation is detected by provoked stimulation with flicker light in well-controlled patients with type 1 diabetes without retinopathy

Diabetes Research and Clinical Practice

Volumn 86, Issue 1, 2009, Pages 51-55

  Mandecka, Aleksandra ^a   Dawczynski, Jens ^a   Vilser, Walthard ^c   Blum, Marcus ^b   Müller, Nicolle ^a   Kloos, Christoph ^a   Wolf, Gunter ^a   Müller, Ulrich Alfons ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b HELIOS KLINIKUM ERFURT   (Germany)

^c IMEDOS   (Germany)

Author keywords

Diabetic retinopathy; Flicker light; Retinal vessel calibre; Vasodilation

Indexed keywords

HEMOGLOBIN A1C;

ADULT; ANALYZER; ARTERY DIAMETER; ARTICLE; AUTOREGULATION; BLOOD VESSEL DIAMETER; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES CONTROL; DIABETIC PATIENT; FEMALE; GLYCEMIC CONTROL; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LIGHT; MALE; PROVOCATION TEST; RETINA; RETINA BLOOD VESSEL; RETINOPATHY; VASODILATATION; VEIN DIAMETER;

ADULT; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 1; DIABETIC RETINOPATHY; FEMALE; HUMANS; MALE; RETINAL VESSELS; VASODILATION; YOUNG ADULT;

EID: 69849104448     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2009.06.017     Document Type: Article

References (27)

1. Dorner G.T., Garhofer G., Kiss B., Polska E., Polak K., Riva C.E., et al. Nitric oxide regulates retinal vascular tone in humans. Am. J. Physiol. 285 (2003) H631-H636
2. Polak K., Schmetterer L., and Riva C.E. Influence of flicker frequency on flicker induced changes of retinal vessel diameters. Invest. Ophthalmol. Vis. Sci. 43 (2002) 2721-2726
3. Dorner G.T., Garhofer G., Huemer K.H., Riva C.E., Woltz M., and Schmetterer L. Hyperglycemia affects flicker-induced vasodilation in the retina of healthy subjects. Vis. Res. 43 (2003) 1495-1500
4. Grunwald J.E., Brucjer A.J., Schwartz S.S., Braunstein S.N., Baker L., Petrig B.L., et al. Diabetic glycemic control and retinal blood flow. Diabetes 39 (1990) 602-607
5. Bursell S.E., Clermont A.C., Kinsley B.T., Simonson D.C., Aiello L.M., and Wolpert U.A. Retinal blood flow changes in patients with insulin-dependent diabetes mellitus and no diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 37 (1996) 886-897
6. Lorenzi M., Feke G.T., Cagliero E., Pitler L., Schaumberg D.A., Berisha F., et al. Retinal haemodynamics in individuals with well-controlled type 1 diabetes. Diabetologia 51 (2008) 361-364
7. Mandecka A., Dawczynski J., Blum M., Muller N., Kloos C., Wolf G., et al. Influence of flickering light on the retinal vessels in diabetic patients. Diabetes Care 30 (2007) 3048-3052
8. The effect of intensive diabetes treatment on the progression of diabetic retinopathy in insulin-dependent diabetes mellitus: the diabetes control and complications trial, Arch. Ophthalmol. 113 (1995) 36-51.
9. Nagel E., Vilser W., Fink A., and Riemer T. Static vessel analysis in nonmydriatic and mydriatic images. Klin. Monatsb. Augenheilkd. 224 5 (2007) 411-416
10. Formaz F., Riva C., and Geiser M. Diffuse luminance flicker increases retinal vessel diameter in humans. Curr. Eye Res. 16 (1997) 1252-1257
11. Polak K., Dorner G., Kiss B., Polska E., Findl O., Rainer G., et al. Evaluation of the Zeiss retinal vessel analyser. Br. J. Ophthalmol. 84 (2000) 1285-1290
12. Blum M., Bachmann K., Wintzer D., Riemer T., Vilser W., and Strobel J. Noninvasive measurement of the Bayliss effect in retinal autoregulation. Graefes Arch. Clin. Exp. Ophthalmol. 237 (1999) 296-300
13. Blum M., Bachmann K., Pietscher S., Braeuer-Burchhardt C., Vilser W., and Strobel J. Online measurement of retinal artery branches in type II diabetic patients. Initial clinical trials before and after laser coagulation. Ophthalmologe 94 (1997) 724-727
14. Garhoefer G., Zawinka C., Resch H., Kothy P., Schmetterer L., and Dorner G.T. Reduced response of renal vessel diameters to flicker stimulation in patients with diabetes. Br. J. Ophthalmol. 88 (2004) 887-891
15. Furchgott R.F., and Vanhoutte P.M. Endothelium-derived relaxing and contracting factors. FASEB J. 3 (1989) 2007-2018
16. Hink U., Li H., Mollnau H., Oelze M., Matheis E., Hartmann M., et al. Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ. Res. 88 (2001) E14-E22
17. De Mattia G., Bravi M.C., Laurenti O., Moretti A., Cipriani R., Gatti A., et al. Endothelial dysfunction and oxidative stress in type 1 and type 2 diabetic patients without clinical macrovascular complications. Diabetes Res. Clin. Pract. 79 2 (2008) 337-342
18. Schram M.T., Chaturvedi N., Schalkwijk C., Giorgino F., Ebeling P., Fuller J.H., et al. Vascular risk factors and markers of endothelial dysfunction as determinants of inflammatory markers in type 1 diabetes: the EURODIAB Prospective Complications Study. Diabetes Care 26 7 (2003) 2165-2173
19. Targher G., Bertolini L., Zoppini G., Zenari L., and Fralezza G. Increased plasma markers of inflammation and endothelial dysfunction and their association with microvascular complications in Type 1 diabetic patients without clinically manifest macroangiopathy. Diabet. Med. 22 8 (2005) 999-1004
20. Van Hecke M.V., Dekker J.M., Nijpels G., Moll A.C., Heine R.J., Bouter L.M., et al. Inflammation and endothelial dysfunction are associated with retinopathy: the Hoorn Study. Diabetologia 48 7 (2005) 1300-1306
21. Feng D., Bursell S.E., Clermont A.C., Lipinska I., Aiello L.P., Laffel L., et al. von Willebrand factor and retinal circulation in early-stage retinopathy of type 1 diabetes. Diabetes Care 23 11 (2000) 1694-1698
22. Spijkerman A.M., Gall M.A., Tarnow L., Twisk J.W., Lauritzen E., Lund-Andersen H., et al. Endothelial dysfunction and low-grade inflammation and the progression of retinopathy in Type 2 diabetes. Diabet. Med. 24 9 (2007) 969-976
23. Lip P.L., Belgore F., Blann A.D., Hope-Ross M.W., Gibson J.M., and Lip G.Y. Plasma VEGF and soluble VEGF receptor FLT-1 in proliferative retinopathy: relationship to endothelial dysfunction and laser treatment. Invest. Ophthalmol. Vis. Sci. 41 8 (2000) 2115-2119
24. Rogers S.L., Tikellis G., Cheung N., Tapp R., Shaw J., Zimmet P.Z., et al. Retinal arteriolar caliber predicts incident retinopathy: the Australian diabetes, obesity and lifestyle (AusDiab) study. Diabetes Care 31 4 (2008) 761-763
25. Kristinsson J.K., Gottfredsdottir M.S., and Stefansson E. Retinal vessel dilatation and elongation precedes diabetic macular edema. Br. J. Ophthalmol. 81 (1997) 274-278
26. Schmetterer L., and Woltz M. Ocular blood flow and associated functional deviations in diabetic retinopathy. Diabetologia 42 (1999) 387-405
27. 2+ uptake in rat retinal microvascular smooth muscle. Diabetologia 46 (2003) 1252-1259