On the inseparability of mental and physical health in aged persons: Lessons from depression and medical comorbidity

American Journal of Geriatric Psychiatry

Volumn 4, Issue 1, 1996, Pages 1-16

  Katz, Ira R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; AGING; BRAIN DISEASE; CEREBROVASCULAR DISEASE; CONFERENCE PAPER; DEPRESSION; GERIATRICS; HEALTH SERVICE; HEALTH STATUS; ILLNESS BEHAVIOR; MALNUTRITION; MENTAL HEALTH; NONHUMAN; POLICY; RISK FACTOR;

EID: 0030041478     PISSN: 10647481     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019442-199624410-00001     Document Type: Conference Paper

References (125)

1. Office of the Medical Applications of Research, National Institutes of Health, Bethesda, MD: Consensus Development Panel on Depression in Late Life: Diagnosis and treatment of depression in late life. JAMA 1992; 268:1018-1024
2. Jacobson S: Overselling depression to the old folks. Atlantic Monthly 1995; April:46-51
3. Schneider LS, Reynold CF, Lebowitz BD, et al (eds): Diagnosis and Treatment of Depression in Late Life: Results of the NIH Consensus Development Conference. Washington, DC, American Psychiatric Press, 1994
4. Conwell T, Olsen K, Caine ED, et al: Suicide in later life: psychological autopsy findings. Int Psychogeriatr 1991; 3:59-66
5. Lyness JM, Conwell Y, Nelson JG: Suicide attempts in elderly psychiatric inpatients. J Am Geriatr Soc 1992; 40:320-324
6. Barraclough BM, Bunch J, Nelson B, et al: A hundred cases of suicide: clinical aspects. Br J Psychiatry 1974; 125:355-373
7. Miller M: Geriatric suicide - the Arizona study. Gerontologist 1978; 18:488-495
8. Katz IR, Streim J, Parmelee P: Prevention of depression, recurrences, and complications in late life. Prev Med 1994; 23:743-750
9. Gurland BJ, Wilder DE, Berkman C: Depression and disability in the elderly: reciprocal relations and changes with age. International Journal of Geriatric Psychiatry 1988; 3:163-179
10. Wells KB, Stewart A, Hays RD, et al: The functioning and well-being of depressed patients. JAMA 1989; 262:914-919
11. Feibel JH, Springer CJ: Depression and failure to resume social activities after stroke. Arch Phys Med Rehabil 1982; 63:276-278
12. Parikh RM, Robinson RG, Lipsey JR, et al: The impact of poststroke depression on recovery in activities of daily living over a 2-year follow-up. Arch Neurol 1990; 47:786-789
13. Mayo NE, Korner-Bitensky NA, Becker R: Recovery time of independent function poststroke. Am J Phys Med Rehabil 1991; 70:5-12
14. Stern MJ, Pascale L, McLoone JB: Psychosocial adaptation following myocardial infarction. Journal of Chronic Diseases 1975; 29:513-526
15. Schleifer SJ, Macari-Hinson MM, Coyle DA, et al: The nature and course of depression following myocardial infarction. Arch Int Med 1989; 149:1785-1789
16. Schenkman B: Factors contributing to attrition rates in a pulmonary rehabilitation program. Heart Lung 1985; 14:53-58
17. Weaver TE, Narsavage GL: Physiological and psychological variables related to functional status in chronic obstructive pulmonary disease. Nurs Res 1992; 41:286-291
18. Mossey JM, Mutran E, Knott K, et al: Determinants of recovery 12 months after hip fracture: the importance of psychosocial factors. Am J Public Health 1989; 79:279-286
19. Mossey JM, Knott K, Craik R: The effects of persistent depressive symptoms of hip fracture recovery. J Gerontol 1990; 45:M163-M168
20. Starkstein SE, Mayberg HS, Leiguarda R, et al: A prospective longitudinal study of depression, cognitive decline, and physical impairments in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 1992; 55:377-382
21. Beckham JC, D'Amico CJ, Rice R, et al: Depression and level of functioning in patients with rheumatoid arthritis. Can J Psychiatry 1992; 37:539-543
22. Katz IR: Drug treatment of depression in the frail elderly: discussion of the NIH Consensus Development Conference on the Diagnosis and Treatment of Depression in Late Life. Psychopharmacol Bull 1993; 29:101-108
23. Borson S, McDonald GJ, Gayle T, et al: Improvement in mood, physical symptoms, and function with nortriptyline for depression in patients with chronic obstructive pulmonary disease. Psychosomatics 1992; 33:190-201
24. Williamson GM, Schultz R: Pain, activity restriction, and symptoms of depression among community-residing elderly adults. J Gerontol 1992; 47:P367-P372
25. Parmelee PA, Katz IR, Lawton MP: The relation of pain to depression among institutionalized aged. J Gerontol 1991; 46:15-21
26. Cohen-Mansfield J, Marx MS: Pain and depression in the nursing home: corroborating results. J Gerontol 1993; 48:P96-P97
27. Miller MD, Pollock BG, Rifai AH, et al: Longitudinal analysis of nortriptyline side effects in elderly depressed patients. J Geriatr Psychiatry Neurol 1991; 4:226-230
28. Costa D, Mogos I, Toma T: Efficacy and safety of mianserin in the treatment of depression of women with cancer. Acta Psychiatrica Scand 1985; 72(suppl 320):85-92
29. Morley JE, Kraenzle D: Causes of weight loss in a community nursing home. J Am Geriatr Soc 1994; 42:583-585
30. Katz IR, Beaston-Wimmer P, Parmelee PA, et al: Failure to thrive in the elderly: exploration of the concept and delineation of psychiatric components. J Geriatr Psychiatry Neurol 1993; 6:161-169
31. Maes M, Vandewoude M, Scharpé S, et al: Anthropometric and biochemical assessment of nutritional state in depression: evidence for lower visceral protein plasma levels in depression. J Affect Disord 1991; 23:25-33
32. 1-antitrypsin, haptoglobin, ceruloplasmin, and lower retinol binding protein plasma levels during depression: further evidence for the existence of an inflammatory response during that illness. J Affect Disord 1992; 24:183-192
33. McFarland BH, Freeborn DK, Mullooly JP, et al: Utilization patterns among long-term enrollees in a prepared group practice health maintenance organization. Med Care 1985; 23:1221-1233
34. Barksy AJ, Wyshak G, Klerman GL: Medical and psychiatric determinants of outpatient medical utilization. Med Care 1986; 24:548-563
35. Katon W: Depression: relationship to somatization and chronic medical illness. J Clin Psychiatry 1984; 45:4-11
36. Waxman HM, Carner EA, Blum A: Depressive symptoms and health service utilization among the community elderly. J Am Geriatr Soc 1983; 31:417-420
37. Manning WG, Wells KB: The effects of psychological distress and psychological well-being on use of medical services. Med Care 1992; 30:541-553
38. Koenig HG, Shelp F, Goli V, et al: Surviral and health care utilization in elderly medical inpatients with major depression. J Am Geriatr Soc 1989; 37:399-606
39. Fries BE, Mehr DR, Schneider D, et al: Mental dysfunction and resource use in nursing homes. Med Care 1993; 31:898-920
40. Gerety MB, Chiodo LK, Kanten DN, et al: Medical treatment preferences of nursing home residents: relationship to function and concordance with surrogate decision-makers. J Am Geriatr Soc 1993; 41:953-960
41. Hinrichsen GA, Henandez NA, Pollack S: Difficulties and rewards in family care of the depressed older adult. Gerontologist 1992; 32:486-492
42. Avery D, Winokur G: Mortality in depressed patients treated with electroconvulsive therapy and antidepressants. Arch Gen Psychiatry 1976; 33:1029-1037
43. Frasure-Smith N, Lesperance F, Talajic M: Depression following myocardial infarction: impact on 6-month survival. JAMA 1993; 270: 1819-1825
44. Frasure-Smith N, Lesperance F, Talajic M: Depression and 18-month prognosis after myocardial infarction. Circulation 1995; 91:999-1005
45. Katz IR, Lesher E, Kleban M, et al: Clinical features of depression in the nursing home. Int Psychogeriatr 1989; 1:5-15
46. Rovner BW, German PS, Brant LJ, et al: Depression and mortality in nursing homes. JAMA 1991; 265:993-996
47. Parmelee PA, Katz IR, Lawton MP: Depression and mortality among institutionalized aged. J Gerontol 1992; 47:P3-P10
48. Ashby D, Ames D, West CR, et al: Psychiatric morbidity as prediction of mortality for residents of local authority homes for the elderly. International Journal of Geriatric Psychiatry 1991; 6:567-575
49. Shah A, Phongsathorn V, George C, et al: Does psychiatric morbidity predict mortality in continuing care geriatric inpatients? International Journal of Geriatric Psychiatry 1993; 8:255-259
50. Samuels SC, Katz IR, Parmelee PA, et al: Use of the Hamilton and Montgomery-Asberg Depression Scales in the institutional elderly: relationship to measures of cognitive impairment, disability, physical illness, and mortality. (in press)
51. Stenstedt A: Involutional melancholia: an etiologic, clinical, and social study of endogenous depression in later life, with special reference to genetic factors. Acta Psychiatr Neur Scand Suppl 1959; 127:5-71
52. Hopkinson G: A genetic study of affective illness in patients over 50. Br J Psychiatry 1964; 110:244-254
53. Mendlewicz J: The age factor of depressive illness: some genetic considerations. J Gerontol 1976; 31:300-303
54. Lyness JM, Conwell Y, King C, et al: Age of onset and medical illness in older depressed inpatients. Int Psychogeriatr 1995; 7:63-74
55. Pearlson GD, Ross CA, Lohr WD, et al: Association between family history of affective disorder and the depressive syndrome of Alzheimer's disease. Am J Psychiatry 1990; 147:452-456
56. Moldin SO, Scheftner WA, Rice JP, et al: Association between major depressive disorder and physical illness. Psychol Med 1993; 23:755-761
57. Mayeux R, Stern Y, Sano M: The relationship of serotonin to depression in Parkinson's disease. Mov Dis 1988; 3:237-244
58. Zweig RM, Ross CA, Hedreen JC, et al: The neuropathology of aminergic nuclei in Alzheimer's disease. Ann Neurol 1988; 24:233-242
59. Zubenko GS, Moossy J: Major depression in primary dementia. Arch Neurol 1988; 45:1182-1186
60. Pearlson GD, Rabins PV, Kim WS, et al: Structural brain changes and cognitive deficits in elderly depressives with and without reversible dementia ("pseudodementia"). Psychol Med 1989; 19:573-584
61. Pearlson GD, Rabins PV, Burns A: Centrum semiovale white-matter CT changes associated with normal aging, Alzheimer's disease, and late-life depression with and without reversible dementia. Psychol Med 1991; 21:321-328
62. Dolan RJ, Calloway SP, Mann AH: Cerebral ventricular size: depressed subjects. Psychol Med 1985; 15:873-878
63. Alexopoulos GS, Young RC, Schindledecker RD: Brain computed tomography in geriatric depression and primary degenerative dementia. Biol Psychiatry 1992; 31:591-599
64. Shima S, Shikano T, Kitamura T, et al: Depression and ventricular enlargement. Acta Psychiatr Scand 1984; 70:274-277
65. Rossi A, Stratta P, Petruzzi C, et al: A computer-ized tomographic study in DSM-III affective disorders. J Affect Disord 1987; 12:259-262
66. Jacoby RJ, Dolan RJ, Baldy R, et al: Quantitative computed tomography in elderly depressed patients. Br J Psychiatry 1983; 143:124-127
67. Krishnan KR, McDonald WM, Escalona PR, et al: Magnetic resonance imaging of the caudate nuclei in depression: preliminary observations. Arch Gen Psychiatry 1992; 49:553-557
68. Zubenko GS, Sullivan P, Nelson JP, et al: Brain imaging abnormalities in mental disorders of late life. Arch Neurol 1990; 47:1107-1113
69. Rabins PV, Pearlson GD, Aylward E, et al: Cortical magnetic resonance imaging changes in elderly inpatients with major depression. Am J Psychiatry 1991; 148:617-620
70. Coffey CE, Wilkinson WE, Weiner RD, et al: Quantitative cerebral anatomy in depression: a controlled magnetic resonance imaging study. Arch Gen Psychiatry 1993; 50:7-16
71. Robinson RG, Schoemaker WJ, Schlumpf M, et al: Effect of experimental cerebral infarction in rat brain on catecholamines and behavior. Nature 1975; 225:332-334
72. Robinson RH: Differential behavioral and biochemical effects of right and left hemispheric cerebral infarction in the rat. Science 1979; 205:707-710
73. Robinson RG, Coyle JT: The differential effect of right vs. left hemispheric cerebral infarction on catecholamines and behavior in the rat. Brain Res 1980; 188:63-78
74. Robinson RG, Schoemaker WJ, Schlumpf M: Time course of changes in catecholamines following right hemispheric cerebral infarction in the rat. Brain Res 1980; 181:202-208
75. Starkstein SE, Robinson RG: Affective disorders and cerebral vascular disease. Br J Psychiatry 1989; 154:170-182
76. Schwartz JA, Speed NM, Brunberg JA, et al: Depression in stroke rehabilitation. Biol Psychiatry 1993; 33:694-699
77. 2 serotonin receptors after stroke: lateralized changes and relationship to depression. Am J Psychiatry 1988; 937-943
78. Bryer JB, Starkstein SE, Votypka V, et al: Reduction of CSF monoamine metabolites in post-stroke depression: a preliminary report. J Neuropsychiatry Clin Neurosci 1992; 4:440-442
79. Krishnan KRR, Goli V, Ellinwood EH, et al: Leukoencephalopathy in patients diagnosed as major depressive. Biol Psychiatry 1988; 25:519-522
80. Coffey CE, Figiel GS, Djang Wt, et al: Leukoencephalopathy in elderly depressed patients referred for ECT. Biol Psychiatry 1988; 24:143-161
81. Zubenko GS, Sullivan P, Nelson JP, et al: Brain imaging abnormalities in mental disorders of late life. Arch Neurology 1990; 47:1107-1111
82. Coffey CE, Figiel GS, Djang WT: Subcortical hyperintensity on magnetic resonance imaging: a comparison of normal and depressed elderly subjects. Am J Psychiatry 1990; 147:187-189
83. Figiel GS, Krishnan KR, Doraiswamy PM, et al: Subcortical hyperintensities on brain magnetic resonance imaging: a comparison between late-age onset and early-onset elderly depressed subjects. Neurobiol Aging 1991; 26:245-247
84. Fujikawa T, Yamawaki S, Touhouda Y: Incidence of silent cerebral infarction in patients with major depression. Stroke 1993; 24:1631-1634
85. Fazekas F, Niederkorn K, Schmidt R, et al: White-matter signal abnormalities in normal individuals: correlation with carotic ultrasonography, cerebral blood flow measurements, and cerebrovascular risk factors. Stroke 1988; 19:1285-1288
86. Miller D, Kumar A, Yousem D, et al: MRI high-intensity signals in late-life depression and Alzheimer's disease: a comparison of subjects without cerebrovascular risk factors. Am J Geriatr Psych 1994; 2:332-337
87. Krishnan KR: Neuroanatomic substrates of depression in the elderly. J Geriatr Psychiatry Neurol 1993; 6:39-58
88. Katz IR: Is there a hypoxic affective syndrome? A contribution from neurochemistry. Psychosomatics 1982; 23:846-853
89. Katz IR, Jain AK, Muhly C, et al: Models for the pathogenesis of psychiatric, affective, and behavioral symptoms in chronic illness: neurochemistry of secondary aging, in Biological Psychiatry 1985: Proceedings of the IVth World Congress of Biological Psychiatry. Edited by Shagass C, Josiassen RC, Bridger EH, et al. New York, Elsevier, 1985, pp 1406-1408
90. Katz IR, Friedman E, Parmelee P, et al: Amino acid levels in elderly nursing home residents. J Geriatr Psychiatry Neurol 1989; 2:215-222
91. Hart BL: Biological basis of the behavior of sick animals. Neurosci Biobehav Rev 1988; 12:123-137
92. Dantzer R, Kelley KW: Stress and immunity: an integrated view of relationships between the brain and the immune system. Life Sci 1989; 44:1995-2008
93. Plata-Salaman CR: Immunoregulators in the nervous system. Neurosci Biobehav Rev 1991; 15:185-215
94. Sapolsky R, Rivier C, Yamamoto G, et al: Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science 1987; 238:522-524
95. Berkenbosch F, van Oers J, del Ray A, et al: Corticotropin-releasing-factor-producing neurons in the rat activated by interleukin-1. Science 1987; 238:524-526
96. Krueger JM, Walter J, Dinarello CA, et al: Sleep-promoting effects of endogenous pyrogen (interleukin-1). Am J Physiol 1984; 246:R994-R999
97. Plata-Salaman C: Food intake suppression by immunomodulators. Neurosci Res 1988; 3:159-165
98. Crestani F, Suguy F, Dantzer R: Behavioral effects of peripherally injected interleukin-1: role of prostaglandins. Brain Res 1991; 542:330-335
99. Dunn AJ, Antoon M, Chapman Y: Reduction of exploratory behavior by intraperitoneal injection of interleukin-1 involves brain corticotropin-releasing factor. Brain Res Bull 1991; 26:539-542
100. del Cerro S, Borrell J: Interleukin-1 affects the behavioral despair responses in rats by an indirect mechanism which requires endogenous CRF. Brain Res 1990; 528:162-164
101. Shintani F, Kanba S, Nakaki T et al: Interleukin-1b augments release of norepinephrine, dopamine, and serotonin in the rat anterior hypothalamus. J Neurosci 1993; 13:3574-3581
102. Terao A, Oikawa M, Saito M: Cytokine-induced change in hypothalamic norepinephrine turnover: involvement of corticotrophin-releasing hormone and prostaglandins. Brain Res 1993; 622:257-261
103. Dunn AJ: Endotoxin-induced activation of cerebral catecholamine and serotonin metabolism: comparison with interleukin-1. J Pharmacol Exp Ther 1992; 261:964-969
104. Mohankumar PS, Quadri SK: Systemic administration of interleukin-1 stimulates norepinephrine release in the paraventricular nucleus. Life Sci 1993; 52:1961-1967
105. Gemma C, Ghezzi P, De Simoni MG: Activation of the hypothalamic serotonergic system by central interleukin-1. Eur J Pharmacol 1991; 209:139-140
106. Mohankumar PS, Thyagarajan S, Quadri SK: Interleukin-1b increases 5-hydroxyindoleacetic acid release in the hypothalamus in vivo. Brain Res Bull 1993; 31:745-748
107. Mohankumar PS, Thyagarajan S, Quadri SK: Interleukin-1 stimulates the release of dopamine and dihydroxyphenylacetic acid from the hypothalamus in vivo. Life Sci 1991; 48:925-930
108. Palazzolo DL, Quadri SK: Interleukin-1 stimulates catecholamine release from the hypothalamus. Life Sci 1990; 47:2105-2109
109. Palazzolo D, Quadri SK: Interleukin-1 inhibits serotonin release from the hypothalmus in vitro. Life Sci 1992; 51:1797-1802
110. Bluthe RM, Dantzer R, Kelley KW: Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat. Brain Res 1992; 573:318-320
111. Van Dam AM, Brouns M, Louisse S, et al: Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: a pathway for the induction of nonspecific symptoms of sickness? Brain Res 1992; 588:291-296
112. Bluthe RM, Dantzer R, Kelley KW: Interleukin-1 mediates behavioral but not metabolic effects of tumor necrosis factor alpha in mice. Eur J Pharmacol 1991; 209:281-283
113. Wekerle H, Linington C, Lassman H, et al: Cellular immune reactivity within the CNS. Trends Neurosci 1986; 9:271-277
114. Maes M, Scharpé S, Bosmans, et al: Disturbances in acute phase plasma proteins during melancholia: additional evidence for the presence of an inflammatory process during that illness. Prog Neuropsychopharmacol Biol Psychiatry 1992; 16:501-515
115. Maes M, Scharpé S, Meltzer HY, et al: Relationships between increased haptoglobin plasma levels and activation of cell-mediated immunity in depression. Biol Psychiatry 1993; 34:690-701
116. Maes M, Bosmans E, Suy E, et al: Depression-related disturbances in mitogen-induced lymphocyte responses and interleukin-1b and soluble interleukin-2 receptor production. Acta Psychiatrica Scand 1991; 84:379-386
117. Maes M, Bosmans E, Suy E, et al: Immune disturbances during major depression: upregulated expression of interleukin-2 receptors. Neuropsychobiology 1991; 24:115-120
118. Maes M, Bosmans E, Meltzer HY, et al: Interleukin-1b: a putative mediator of HPA-axis hyperactivity in major depression? Am J Psychiatry 1993; 150:1189-1193
119. Smith RS: The macrophage theory of depression. Med Hypotheses 1991; 35:298-306
120. Kent S, Bluthe RM, Kelley KW, et al: Sickness behavior as a new target for drug development. Trends Pharmacol Sci 1992; 13:24-28
121. Dantzer R, Bluthe RM, Kelley KW: Androgen-dependent vasopressinergic neurotransmission attenuates interleukin-1-induced sickness behavior. Brain Res 1991; 557:115-120
122. Opp MR, Obal F, Krueger: Effects of a-MSH on sleep, behavior, and brain temperature: interactions with II-1. Am J Physiol 1988; 255:R914-R922
123. De Sarro GB, Masuda Y, Ascioti C, et al: Behavioral and ECoG spectrum changes induced by intracerebral infusion of interferons and interleukin-2 in rats arc antagonized by naloxone. Neuropharmacology 1990; 29:167-179
124. Uehara A, Ishikawa Y, Okumura T, et al: Indomethacin blocks the anorexic action of interleukin-1. Eur J Pharmacol 1989; 170:257-260
125. Plata-Salaman CR: Dexamethasone inhibits food intake-suppression induced by low doses of interleukin-1-beta administered intracerebroventricularly. Brain Res Bull 1991; 27:737-738