Computational fluid dynamics (CFD) assisted performance evaluation of the Twincer™ disposable high-dose dry powder inhaler

Journal of Pharmacy and Pharmacology

Volumn 64, Issue 9, 2012, Pages 1316-1325

  De Boer, Anne H ^a   Hagedoorn, Paul ^a   Woolhouse, Robert ^b   Wynn, Ed ^b  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b ANSYS INC   (United States)

Author keywords

air classifier technology (ACT); computational fluid dynamics (CFD); dry powder inhaler (DPI); in vitro deposition; inhaler performance

Indexed keywords

COLISTIMETHATE;

ANALYTICAL EQUIPMENT; ARTICLE; CASCADE IMPACTOR; COMPUTATIONAL FLUID DYNAMICS; DISPERSION; DISPOSABLE EQUIPMENT; DOSE ENTRAINMENT; DRUG FORMULATION; DRUG RETENTION; FLOW RATE; FLOW SPLIT; INHALER RESISTANCE; LASER DIFFRACTION; PARTICLE RESIDENCE TIME; PARTICLE SIZE; PARTICLE TRAJECTORY; PHYSICAL CHEMISTRY; PHYSICAL PARAMETERS; PHYSICAL RESISTANCE; POWDER DISPERSION; POWDER INHALER; PRESSURE GRADIENT; PROCESS OPTIMIZATION; RETENTION BEHAVIOR;

ADMINISTRATION, INHALATION; ANTI-BACTERIAL AGENTS; COLISTIN; COMPUTER SIMULATION; DISPOSABLE EQUIPMENT; DRUG DELIVERY SYSTEMS; DRY POWDER INHALERS; EQUIPMENT DESIGN; HUMANS; HYDRODYNAMICS; MATERIALS TESTING; PARTICLE SIZE; PHYSICOCHEMICAL PHENOMENA; POWDERS;

EID: 84864680615     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2012.01511.x     Document Type: Article

References (21)

1. Newhouse MT, et al,. Inhalation of a dry powder tobramycin pulmosphere formulation in healthy volunteers. Chest 2003; 124: 360-366. (Pubitemid 36851374)
2. Geller DE, et al,. Novel tobramycin inhalation powder in cystic fibrosis subjects: pharmacokinetics and safety. Pediatr Pulmonol 2007; 42: 307-313. (Pubitemid 46608898)
3. de Boer AH, et al,. Design and in vitro performance testing of multiple classifier technology in a new disposable inhaler concept (Twincer) for high powder doses. Eur J Pharm Sci 2006; 28: 171-178.
4. Karanjkar A,. Design, development and optimization using computational fluid dynamics. Med Device Technol 2003; 13: 26-29.
5. Chan HK,. Dry powder aerosol delivery systems: current and future research directions. J Aerosol Med 2006; 19: 21-27.
6. Coates MS, et al,. Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 1: grid structure and mouthpiece length. J Pharm Sci 2004; 93: 2863-2876. (Pubitemid 39506635)
7. Coates MS, et al,. The role of capsule on the performance of a dry powder inhaler using computational and experimental analyses. Pharm Res 2005; 22: 923-932. (Pubitemid 40898102)
8. Coates MS, et al,. Influence of air flow on the performance of a dry powder inhaler using computational and experimental analysis. Pharm Res 2005; 22: 1445-1453. (Pubitemid 41215884)
9. Coates MS, et al,. Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 2: air inlet size. J Pharm Sci 2006; 95: 1382-1392. (Pubitemid 43874452)
10. Coates MS, et al,. Influence of mouthpiece geometry on the aerosol delivery performance of a dry powder inhaler. Pharm Res 2007; 24: 1450-1456. (Pubitemid 46988211)
11. Voss A, Finlay WH,. Deagglomeration of dry powder pharmaceutical aerosols. Int J Pharm 2002; 248: 39-50. (Pubitemid 35341408)
12. Wong W, et al,. Particle aerosolisation and break-up in dry powder inhalers 1: evaluation and modeling of venture effects for agglomerated systems. Pharm Res 2010; 27: 1367-1376.
13. Wong W, et al,. Particle aerosolisation and break-up in dry powder inhalers: evaluation and modelling of the influence of grid structures for agglomerated systems. J Pharm Sci 2011; 100: 4710-4721.
14. Boerefijn R, et al,. Disintegration of weak lactose agglomerates for inhalation applications. Int J Pharm 1998; 172: 199-209. (Pubitemid 28430257)
15. Coury JR, Aguiar ML,. Rupture of dry agglomerates. Powder Technol 1995; 85: 37-43.
16. Dickhoff BHJ, et al,. The effect of budesonide particle mass on drug particle detachment from carrier crystals in adhesive mixtures during inhalation. Eur J Pharm Biopharm 2002; 54: 245-248. (Pubitemid 34919400)
17. Westerman EM, et al,. Dry powder inhalation of colistin sulphomethate in healthy volunteers: a pilot study. Int J Pharm 2007; 335: 41-45. (Pubitemid 46482863)
18. Westerman EM, et al,. Dry powder inhalation of colistin in cystic fibrosis patients: a single dose pilot study. J Cyst Fibros 2007; 6: 284-292. (Pubitemid 46971893)
19. Hinds WC,. Aerosol Technology, Properties, Behavior and Measurement of Airborne Particles. New York, NY: John Wiley & Sons, Inc., 1982: 38-68.
20. Lowry OH, et al,. Protein measurement with the folin phenol reagent. Biol Chem 1951; 193: 265-275.
21. ANSYS. FLUENT Theory Guide R14.0. Canonsburg, PA: ANSYS Inc., 2011, sections 16.1 and 4.3.3.