Effects of a Mikania laevigata extract on bone resorption and RANKL expression during experimental periodontitis in rats

Journal of Applied Oral Science

Volumn 20, Issue 3, 2012, Pages 340-346

  Benatti, Bruno B ^a   Campos Júnior, Jozafá C ^a   Silva Filho, Vilmar J ^a   Alves, Polyanna M ^a   Rodrigues, Isabela R ^a   Uber Bucek, Elizabeth ^b,c   Vieira, Silvio M ^d   Napimoga, Marcelo H ^e  

^a UNIVERSITY OF UBERABA   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA   (Brazil)

^d SÃO LEOPOLDO MANDIC INSTITUTE AND RESEARCH CENTER   (Brazil)

^e FEDERAL UNIVERSITY OF MARANHÃO   (Brazil)

Author keywords

Guaco; Periodontitis; Rats

Indexed keywords

EID: 84864680502     PISSN: 16787757     EISSN: 16787765     Source Type: Journal    
DOI: 10.1590/S1678-77572012000300008     Document Type: Article

References (29)

1. Albandar JM, Goldstein H. Multi-level statistical models in studies of periodontal diseases. J Periodontol. 1992;63:690-5.
2. Alves CF, Alves VBF, Assis IP, Clemente-Napimoga JT, Uber-Bucek E, Dal-Secco D, et al. Anti-inflammatory activity and possible mechanism of extract from Mikania laevigata in carrageenaninduced peritonitis. J Pharm Pharmacol. 2009;61:1097-104.
3. Axelsson P, Lindhe J. The significance of maintenance care in the treatment of periodontal disease. J Clin Periodontol. 1981;8:281-94.
4. Benatti BB, Silvério KG, Casati MZ, Sallum EA, Nociti FH Jr. Inflammatory and bone-related genes are modulated by aging in human periodontal ligament cells. Cytokine. 2009;46:176-81.
5. Bighetti AE, Antônio MA, Kohn LK, Rehder VL, Foglio MA, Possenti A, et al. Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz Bip. Phytomedicine. 2005;12:72-7.
6. Cai X, Li C, Du G, Cao Z. Protective effects of baicalin on ligatureinduced periodontitis in rats. J Periodontal Res. 2008;43:14-21.
7. Callens A. Growth factors in periodontal regeneration-a review. In: Lang NP, Karring T, Lindhe J, editors. Proceedings of the 2nd European Workshop on Periodontology. Berlin: Quintessence Books; 1997. p. 284-302.
8. Chakravarti A, Raquil MA, Tessier P, Poubelle PE. Surface RANKL of Toll-like receptor 4-stimulated human neutrophils activates osteoclastic bone resorption. Blood. 2009;8:1633-44.
9. Chung JY, Choo JH, Lee MH, Hwang JK. Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans. Phytomedicine. 2006;13:261-6.
10. Cobb CM. Non-surgical pocket therapy: mechanical. Ann Periodontol. 1996;1:443-90.
11. Garlet GP, Martins W Jr, Fonseca BA, Ferreira BR, Silva JS. Matrix metalloproteinases, their physiological inhibitors and osteoclast factors are differentially regulated by the cytokine profile in human periodontal disease. J Clin Periodontol. 2004;31:671-9.
12. Gurgel BC, Duarte PM, Nociti FH Jr, Sallum EA, Casati MZ, Sallum AW, et al. Impact of an anti-inflammatory therapy and its withdrawal on the progression of experimental periodontitis in rats. J Periodontol. 2004;75:1613-8.
13. Kasama T, Miwa Y, Isozaki T, Odai T, Adachi M, Kunkel SL. Neutrophil-derived cytokines: potential therapeutic targets in inflammation. Curr Drug Targets Inflamm Allergy. 2005;4:273-9.
14. Kyrkanides S, O'Banion MK, Subtelny JD. Nonsteroidal anti-inflammatory drugs in orthodontic tooth movement: metalloproteinase activity and collagen synthesis by endothelial cells. Am J Orthod Dentofacial Orthop. 2000;118:203-9.
15. Nagasawa TK, Kiji M, Yashiro R, Hormdee D, Lu H, Kunze M, et al. Roles of receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin in periodontal health and disease. Periodontol 2000. 2007;43:65-84.
16. Napimoga MH, Benatti BB, Lima FO, Alves PM, Campos AC, Pena-Dos-Santos DR, et al. Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and proinflammatory cytokines during experimental periodontitis in rats. Int Immunopharmacol. 2009;9:216-22.
17. Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007;70:461-77.
18. Offenbacher S, Heasman PA, Collins JG. Modulation of host PGE2 secretion as a determinant of periodontal disease expression. J Periodontol. 1993;64:432-44.
19. Ogasawara T, Yoshimine Y, Kiyoshima T, Kobayashi I, Matsuo K, Akamine A, et al. In situ expression of RANKL, RANK, osteoprotegerin and cytokines in osteoclasts of rat periodontal tissue. J Periodontal Res. 2004;39:42-9.
20. Pålsson-McDermott E, O'Neill LA. Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology. 2004;113:153-62.
21. Park M, Bae J, Lee DS. Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteria. Phytother Res. 2008;22:1446-9.
22. Petersen PE, Bourgeois D, Ogawa H, Estupinan-Day S, Ndiaye C. The global burden of oral diseases and risks to oral health. Bull World Health Organ. 2005;83:661-9.
23. Prabu GR, Gnanamani A, Sadulla S. Guaijaverin-a plant flavonoid as potential antiplaque agent against Streptococcus mutans. J Appl Microbiol. 2006;101:487-95.
24. Reddy MS, Geurs NC, Gunsolley JC. Periodontal host modulation with antiproteinase, anti-inflammatory, and bone-sparing agents. A systematic review. Ann Periodontol. 2003;8:12-37.
25. Slots J. The search for effective, safe and affordable periodontal therapy. Periodontol 2000. 2002;28:9-11.
26. Soares de Moura R, Costa SS, Jansen JM, Silva CA, Lopes CS, Bernardo-Filho M, et al. Bronchodilator activity of Mikania glomerata Sprengel on human bronchi and guinea-pig trachea. J Pharm Pharmacol. 2002;54(2):249-56.
27. Suyenaga ES, Reche E, Farias FM, Schapoval EE, Chaves CG, Henriques AT. Antiinflammatory investigation of some species of Mikania. Phytother Res. 2002;16:519-23.
28. Takayanagi H. Inflammatory bone destruction and osteoimmunology. J Periodontal Res. 2005;40:287-93.
29. Yatsuda R, Rosalen PL, Cury JA, Murata RM, Rehder VL, Melo LV, et al. Effects of Mikania genus plants on growth and cell adherence of mutans streptococci. J Ethnopharmacol. 2005;97:183-9.