Role of ATP binding and hydrolysis in the gating of the cystic fibrosis transmembrane conductance regulator

Annals of Thoracic Medicine

Volumn 7, Issue 3, 2012, Pages 115-121

  Gout, Taras ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

ATP binding cassette proteins; cystic fibrosis; cystic fibrosis transmembrane conductance regulator; gating mechanism

Indexed keywords

ABC TRANSPORTER; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANTIBIOTIC AGENT; CHLORIDE CHANNEL; GLYCOPROTEIN P; TOBRAMYCIN; TRANSMEMBRANE CONDUCTANCE REGULATOR;

CYSTIC FIBROSIS; ELECTROCHEMISTRY; GENE MUTATION; GENE THERAPY; GENE TRANSFER; HUMAN; PHARMACOGENOMICS; PSEUDOMONAS AERUGINOSA; RESPIRATORY TRACT INFECTION; REVIEW; THERMODYNAMICS;

EID: 84864666804     PISSN: 18171737     EISSN: 19983557     Source Type: Journal    
DOI: 10.4103/1817-1737.98842     Document Type: Review

References (26)

1. Welsh MJ, Robertson AD, Ostedgaard LS. Structural biology: The ABC of a versatile engine Nature 1998;396:623-4.
2. Andersen DH. Cystic fibrosis of the pancreas and its relation to celiac disease. Am J Dis Child 1938;56:344-99.
3. di Sant'Agnese PA, Darling RC, Perera GA, Shea E. Abnormal electrolyte composition of sweat in cystic fibrosis of the pancreas. Pediatrics 1953;12:549-63.
4. Finch E. The sweat test in the diagnosis of fibrocystic disease of the pancreas. J Clin Pathol 1957;10:270-2.
5. Riordan JR, Rommens JM, Kerem B, Alon N, Rozmahel R, Grzelczak Z, et al. Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA. Science 1989;245:1066-73.
6. Rommens JM, Iannuzzi MC, Kerem B, Drumm ML, Melmer G, Dean M, et al. Identification of the cystic fibrosis gene: Chromosome walking and jumping. Science 1989;245:1059-65.
7. Cystic Fibrosis Foundation [homepage on the Internet]. About Cystic Fibrosis. Available from: http://www.cff.org/AboutCF/ [Last cited on 2011 Sep 18].
8. Gadsby DC, Vergani P, Csanady L. The ABC protein turned chloride channel whose failure causes cystic fibrosis. Nature 2006;440:477-83.
9. Van Goor F, Straley KS, Cao D, Gonzalez J, Hadida S, Hazlewood A, et al. Rescue of ?F508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules. Am J Physiol Lung Cell Mol Physiol 2006;290:1117-30.
10. SeniorAE, Al-Shawi MK, Urbatsch IL. The catalytic cycle of P-glycoprotein. FEBS Lett 1995;377:285-9.
11. Higgins CF, Linton KJ. The ATP switch model for ABC transporters. Nat Struct Mol Biol 2004;11:918-26.
12. Ferrari S, Geddes DM, Alton EW. Barriers to and new approaches for gene therapy and gene delivery in cystic fibrosis. Adv Drug Deliv Rev 2002;54:1373-93.
13. Debouck C, Mecalf B. The impact of genomics on drug discovery. Ann Rev Pharmacol Toxicol 2000;40:193-208.
14. Dalemans W, Barbry P, Champigny G, Jallat S, Dott K, Dreyer D, et al. Altered chloride ion channel kinetics associated with the ?F508 cystic fibrosis mutation. Nature 1991;354:526-8.
15. Davidson AL, Shuman HA, Nikaido H. Mechanism of maltose transport in Escherichia coli: Transmembrane signaling by periplasmic binding proteins. Proc Natl Acad Sci USA 1992;89:2360-4.
16. Petronilli V, Ames GF. Binding protein-independent histidine permease mutants. Uncoupling of ATP hydrolysis from transmembrane signaling. J Biol Chem 1991;266:16293-6.
17. Basso C, Vergani P, Nairn AC, Gadsby DC. Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating. J Gen Physiol 2003;122:333-48.
18. Linton KJ, Higgins CF. Structure and function of ABC transporters: The ATP switch provides flexible control. Pflugers Arch 2007;453:555-67.
19. Aubin CN, Linsdell P. Positive charges at the intracellular mouth of the pore regulate anion conduction in the CFTR chloride channel. J Gen Physiol 2006;128:535-45.
20. Smith PC, Karpowich N, Millen L, Moody JE, Rosen J, Thomas PJ, et al. ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer. Mol Cell 2002;10:139-49.
21. Hanekop N, Zaitseva J, Jenewein S, Holland IB, Schmitt L. Molecular insights into the mechanism of ATP-hydrolysis by the NBD of the ABC-transporter HlyB. FEBS Lett 2006;580:1036-41.
22. Urbatsch IL, Tyndall GA, Tombline G, Senior AE. P-glycoprotein catalytic mechanism: Studies of the ADP-vanadate inhibited state. J Biol Chem 2003;278:23171-9.
23. Lamers MH, Winterwerp HH, Sixma TK. The alternating ATPase domains of MutS control DNA mismatch repair. EMBO J 2003;22:746-56.
24. Zaitseva J, Jenewein S, Wiedenmann A, Benabdelhak H, Holland IB, Schmitt L. Functional characterization and ATP induced dimerization of the isolated ABC-domain of the haemolysin B transporter. Biochemistry 2005;44:9680-90.
25. Sauna ZE, Ambudkar SV. About a switch: How P-glycoprotein (ABCB1) harnesses the energy of ATP binding and hydrolysis to do mechanical work. Mol Cancer Ther 2007;6:13-23.
26. Callaghan R, Ford RC, Kerr ID. The translocation mechanism of P-glycoprotein. FEBS Lett 2006;580:1056-63.