Anorexic effect of peripheral cholecystokinin (CCK) varies with age and body composition (Short communication)

Acta Physiologica Hungarica

Volumn 99, Issue 2, 2012, Pages 166-172

  Balasko M ^a   Soos S Z ^a   Parniczky A ^a   Koncsecsko Gaspar M ^a   Szekely M ^a   Petervari E ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Aging; Anorexia; Body composition; CCK; Food intake; Satiety

Indexed keywords

ANOREXIGENIC AGENT; CHOLECYSTOKININ;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANOREXIA; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CACHEXIA; CALORIC RESTRICTION; CONTROLLED STUDY; ENERGY BALANCE; FEEDING BEHAVIOR; LIPID COMPOSITION; LIPID DIET; MALE; MUSCLE ATROPHY; MUSCLE MASS; NONHUMAN; OBESITY; RAT; SATIETY; WISTAR RAT;

ADIPOSITY; AGE FACTORS; AGING; ANIMALS; ANOREXIA; BODY COMPOSITION; CALORIC RESTRICTION; DIET, HIGH-FAT; ENERGY METABOLISM; FEEDING BEHAVIOR; HOMEOSTASIS; INJECTIONS, INTRAPERITONEAL; MALE; OBESITY; RATS; RATS, WISTAR; SATIETY RESPONSE; SINCALIDE;

EID: 84864662215     PISSN: 0231424X     EISSN: 15882683     Source Type: Journal    
DOI: 10.1556/APhysiol.99.2012.2.10     Document Type: Article

References (25)

1. Akimoto S, Miyasaka K: Age-associated changes of appetite-regulating peptides. Geriatr. Gerontol. Int. 10, S107-S119 (2010)
2. Chapman IM, MacIntosh CG, Morley JE, Horowitz M: The anorexia of ageing. Biogerontology 3, 67-71 (2002) (Pubitemid 34284980)
3. Clerc P, Coll Constans MG, Lulka H, Broussaud S, Guigné C, Leung-Theung-Long S, Perrin C, Knauf C, Carpéné C, Pénicaud L, Seva C, Burcelin R, Valet P, Fourmy D, Dufresne M: Involvement of cholecystokinin 2 receptor in food intake regulation: hyperphagia and increased fat deposition in cholecystokinin 2 receptordefi cient mice. Endocrinology 148, 1039-1049 (2007)
4. Di Francesco V, Zamboni M, Dioli A, Zoico E, Mazzali G, Omizzolo F, Bissoli L, Solerte SB, Benini L, Bosello O: Delayed postprandial gastric emptying and impaired gallbladder contraction together with elevated cholecystokinin and peptide YY serum levels sustain satiety and inhibit hunger in healthy elderly persons. J. Gerontol. A Biol. Sci. Med. Sci. 60 (12), 1581-1585 (2005) (Pubitemid 43146466)
5. Dockray GJ (2006) Gastrointestinal hormones: Cholecystokinin, somatostatin and ghrelin. In: Physiology of the Gastrointestinal Tract Vol. 1, ed. Johnson LR, Elsevier/Academic Press, Amsterdam, pp. 91-120
6. Gibbs J, Young R, Smith GP: Cholecystokinin decreases food intake in rats. J. Comp. Physiol. 84, 488-493 (1973)
7. Hirosue Y, Inui A, Teranishi A, Miura M, Nakajima M, Okita M, Nakajima Y, Himori N, Baba S, Kasuga M: Cholecystokinin octapeptide analogues suppress food intake via central CCK-A receptors in mice. Am. J. Physiol. 265, R481-R486 (1993) (Pubitemid 23294992)
8. Kmiec Z: Central regulation of food intake in ageing. J. Physiol. Pharmacol. 57, 7-16 (2006) (Pubitemid 46548798)
9. MacIntosh CG, Morley JE, Wishart J, Morris H, Jansen JB, Horowitz M, Chapman IM: Effect of exogenous cholecystokinin (CCK)-8 on food intake and plasma CCK, leptin, and insulin concentrations in older and young adults: evidence for increased CCK activity as a cause of the anorexia of aging. J. Clin. Endocrinol. Metab. 86, 5830-5837 (2001) (Pubitemid 33152631)
10. Moran TH, Bi S: Hyperphagia and obesity in OLETF rats lacking CCK-1 receptors. Phil. Trans. R. Soc. B 361, 1211-1218 (2006) (Pubitemid 44874229)
11. Moran TH, Chen J, Bi S (2006) Cholecystokinin and satiety. In: Handbook of Biologically Active Peptides, ed. Kastin AJ, Elsevier/Academic Press, Amsterdam, pp. 961-968
12. Morley JE, Silver AJ: Anorexia in the elderly. Neurobiol. Aging 9, 9-16 (1988) (Pubitemid 18063323)
13. Ohta M, Tanaka Y, Masuda M, Miyasaka K, Funakoshi A: Impaired release of cholecystokinin (CCK) from synaptosomes in old rats. Neurosci. Lett. 198, 161-164 (1995)
14. Pétervári E, Garami A, Soós S, Székely M, Balaskó M: Age-dependence of alpha-MSH-induced anorexia. Neuropeptides 44, 315-322 (2010)
15. Scarpace PJ, Matheny M, Shek EW: Impaired leptin signal transduction with age-related obesity. Neuropharmacology 39, 1872-1879 (2000) (Pubitemid 30398491)
16. Serra-Prat M, Palomera E, Clave P, Puig-Domingo M: Effect of age and frailty on ghrelin and cholecystokinin responses to a meal test. Am. J. Clin. Nutr. 89(5), 1410-1417 (2009)
17. Shiraishi T: CCK as a central satiety factor: behavioral and electrophysiological evidence. Physiol. Behav. 48, 879-885 (1990)
18. Silver AJ, Flood JF, Morley JE: Effect of gastrointestinal peptides on ingestion in old and young mice. Peptides 9, 221-225 (1988) (Pubitemid 19260225)
19. Soos S, Balasko M, Jech-Mihalffy A, Szekely M, Petervari E: Anorexic vs. metabolic effects of central leptin infusion in rats of various ages and nutritional states. J. Mol. Neurosci. 41, 97-104 (2010)
20. Soos S, Petervari E, Szekely M, Jech-Mihalffy A, Balasko M: Complex catabolic effects of central alpha-MSH infusion in rats of altered nutritional states: differences from leptin. J. Mol. Neurosci. 43, 209-216 (2011)
21. South EH, Ritter RC: Capsaicin application to central or peripheral vagal fi bers attenuates CCK satiety. Peptides 9, 601-612 (1988) (Pubitemid 19268152)
22. Székely M, Balaskó M, Soós S, Pétervá ri E (2012) Peptidergic Regulation of Food Intake: Changes Related to Age and Body Composition. In: Food Intake: Regulation, Assessing and Controlling, ed. Morrison JL, NOVA Publishers, pp. 83-104 https://www.novapublishers.com/catalog/ product-info.php?products-id=19499
23. Szekely M, Petervari E, Balasko M: Thermoregulation, energy balance, regulatory peptides: recent developments. Front. Biosci. (Schol. Ed.) 2, 1009-1046 (2010)
24. Szelényi Z, Barthó L, Székely M, Romanovsky AA: Cholecystokinin octapeptide (CCK-8) injected into a cerebral ventricle induces a fever-like thermoregulatory response mediated by type B CCK-receptors in the rat. Brain Res. 638, 69-77 (1994) (Pubitemid 24063289)
25. Winkels RM, Jolink-Stoppelenburg A, de Graaf K, Siebelink E, Mars M, de Groot L: Energy intake compensation after 3 weeks of restricted energy intake in young and elderly men. J. Am. Med. Dir. Assoc. 12 (4), 277-286 (2011)